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World Journal of Gastroenterology 2014年第27期20卷 8783-8789页

作者： rosy wang Rupert Leong Gastroenterology and Liver Services Concord Hospital

To examine and evaluate recent evidence regarding the epidemiology, pathogenesis and management of colorectal cancer(CRC) development in inflammatory bowel disease(IBD)-primary sclerosing cholangitis(PSC) patients. Using the PubMed database, a literature search was conducted for relevant articles in English from the past 10 years. Relevant studies investigating PSC as a risk factor for CRC in IBD in the context of incidence and prevalence, pathogenesis, prevention and prognosis were included in this review. Recent evidence increasingly points to PSC as a significant risk factor in the development of CRC in patients with concomitant IBD. PSC may be an important risk factor for CRC in different populations worldwide. The mechanism for this increase in risk is still unclear. The efficacy of UDCA as a chemopreventive agent remains controversial. Liver transplantation does not halt the development of CRC, although there is not enough evidence to suggest that it is associated with increased incidence of CRC. While routine colonoscopic surveillance should be performed in patients with concurrent PSC and IBD, more high-level evidence is required to support the benefits of the procedure. While many new developments have taken place in the last decade, the pathogenesis and optimal management of CRC development in IBD-PSC patients remain unclear.

关键词： Primary sclerosing cholangitis Ulcerative colitis

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross Keith Stokes Lindsay Starling rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of injury.We aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be appropriate.Methods:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive seasons.Players were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,respectively.Symptom,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer vs.shorter).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or improving.Results:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and HIA3.Cognitive and balance performance were not associated with longer return and did not affect median days absence.Conclusion:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP times.This may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

Chronic otitis media and subsequent hearing loss in children from the Himalayan region residing in Buddhist Monastic schools of Nepal

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Journal of Otology 2020年第4期15卷 144-148页

作者： Milan Maharjan Samjhana Phuyal Mana Shrestha rosy Bajracharya Ear Care Nepal JawalakhelLalitpur-4Nepal

Objectives:The main objective of the study was to ascertain the prevalence of chronic otitis media and determine the corresponding hearing loss in children from Nepal’s Himalayan region now residing in Buddhist Monastic schools of Nepal.Methods:The study was conducted among children at Buddhist monastic school in different parts of Nepal.A total of 3174 children aged between 5 and 15 years,who were originally from the Himalayan region of Nepal and were currently residing in monastic schools,were screened for ear problems and hearing loss.They were examined by otoscope to diagnose chronic otitis media.Hearing was evaluated by pure tone audiometer,and 0.5e4 kHz air conduction hearing threshold was measured and documented.Results:Of the total of 3174 children who were screened for ear diseases and hearing loss,monks constituted 76.21%(n?2419)and Nuns 23.78%(n?755).Chronic otitis media was the most common otoscopic finding during the screening,and it affected a total of 344(10.83%)children.Out of these 344,hearing loss of varying degrees was observed in 5.42%(n?172)children.Conclusion:There is high prevalence of chronic otitis media in children belonging to the Himalayan region of Nepal,and it is the main cause of avoidable hearing loss.Timely diagnosis and treatment of chronic otitis media could prevent unnecessary hearing loss in these children.

关键词： Chronic otitis media Hearing loss School children Nepal,prevalence

Synthesis, characterization, cytotoxicity, DNA cleavage and antimicrobial activity of homodinuclear lanthanide complexes of phenylthioacetic acid

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Journal of Rare Earths 2013年第10期31卷 1009-1016页

作者： T. F. Abbs Fen Reji A. Jeena Pearl Bojaxa A. rosy Department of Chemistry & Research Centre Nesamony Memorial Christian College Department of Chemistry& Research Centre Scott Christian College Department of Botany & Research Centre Holy Cross College (Autonomous)

Lanthanide complexes of Eu（III）, Gd（III）, Nd（III）, Sm（III）, and Tb（III） with phenylthioacetic acid were synthesized and characterized by elemental analysis, mass, infrared radiation （IR）, electronic spectra, molar conductance, thermogravimetric analysis （TGA）, and powder X-ray diffraction （XRD）. The results showed that the lanthanide complexes were homodinuclear in nature. The two lanthanide ions were bridged by eight oxygen atoms from four carboxylate groups. Thermal decomposition profiles were consis- tent with the proposed formulations. Powder XRD studies showed that all the complexes were amorphous in nature. Antimicrobial studies indicated that these complexes exhibited more activity than the ligand itself. The DNA cleavage activity of the ligand and its complexes were assayed on CT DNA using gel electrophoresis in the presence of H202. The result showed that the Eu（Ⅲ） and Nd（Ⅲ） complexes completely cleaved the DNA. The anticancer activities of the complexes were also studied towards human cervical cancer cell line （HeLa） and colon cancer cells （HCT116） and it was found that the Eu（Ⅲ） and Nd（Ⅲ） complexes were more active than the corresponding Gd（Ⅲ）, Sm（Ⅲ）, Tb（Ⅲ） complexes and the free ligand on both the cancer cells.

关键词： lanthanide complexes phenylthioacetic acid antimicrobial DNA cleavage anticancer rare earths

MULTISPECTRAL UNMIXING OF FLUORESCENCE MOLECULAR TOMOGRAPHY DATA

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 353-364页

作者： MARIA SIMANTIRAKI rosy FAVICCHIO STELIOS PSYCHARAKIS GIANNIS ZACHARAKIS JORGE RIPOLL Institute of Electronic Structure and Laser Foundation for Research and Technology Hellas 71110 HeraklionCreteGreece Institute of Molecular Biology and Biotechnology Foundation for Research and Technology Hellas 71110 HeraklionCreteGreece

Even though multispectral imaging is considered very significant in biological imaging,it is only commonly used in microscopy in a 2D approach.Here,we present a Fluorescence Molecular Tomography system capable of recording simultaneously tomographic data at several spectral windows,enabling multispectral tomography.3D reconstructed data from several spectral windows is used to construct a linear unmixing algorithm for multispectral deconvolution of overlapping fluorescence signals.The method is applied on tomographic 3D fluorescence concentration maps in tissue-mimicking phantoms,yielding absolute quantification of the concentration of each individual fluorophore.Results are compared to the case when unmixing is performed in the raw 2D data instead of the reconstructed 3D concentration map,showing greater accuracy when unmixing algorithms are applied in the reconstructed data.Both the reflection and transmission geometries are considered.

关键词： Optical tomography multispectral imaging in vivo imaging fluorescence quantification.

Role of conventional therapies in the era of biological treatment in Crohn’s disease

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World Journal of Gastroenterology 2011年第14期17卷 1797-1806页

作者： Paolo Gionchetti Carlo Calabrese rosy Tambasco Ramona Brugnera Giulia Straforini Giuseppina Liguori Giulia Spuri Fornarini Donatella Riso Massimo Campieri Fernando Rizzello Department of Clinical Medicine University of Bologna40138 BolognaItaly

Outstanding progress regarding the pathophysiology of Crohn's disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when available,that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease and refractoriness to therapy increase. The advent of biological drugs has opened new therapeutic horizons for treating CD,modifying the treatment goals. However,the large majority of patients with CD will be managed through conventional therapy,even if they are a prelude to biological therapy.

关键词：生物治疗疗法传统对照试验病理生理学生物药物 CD 耐火度

Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 65-68页

作者： Sivanpillay Mahadevan Sivaraj Velayutham Vimalraj Palanichamy Saravanaboopathy Shanmugasundaram Rajendran Sathyanesan Jeswanth Palaniappan Ravichandran rosy Vennilla Rajagopalan Surendran Institute of Surgical Gastroenterology and Liver Transplantation New Gastroenterology BlockGovernment Stanley Medical College Hospital

BACKGROUND:Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy,its association with infective complications and non-infective complications like pancreatic fistula is still controversial.METHODS:Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed.In all patients intraoperative bile from the bile duct was cultured.Preoperative,intra-operative,and post-operative variables were recorded and analyzed.RESULTS:Bile culture showed positive growth in 35 patients and negative growth in 41.Twenty patients in the positive group underwent ERCP and stenting.The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8),wound infection (n=27),bacteremia (n=10),and renal insufficiency (n=9).There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7),delayed gastric emptying (n=9),and post-operative hemorrhage (n=3).The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).CONCLUSIONS:Pre-operative biliary drainage is significantly associated with bile infection,and bile infection increases the overall rates of infective complications and renal insufficiency.Because of the high incidence of complications is associated with infected bile,routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy.Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intraoperative bile culture report.Because of its significant association with infected bile,biliary stenting should be used in strictly selected cases.

关键词： bactibilia Whipples pancreaticoduodenectomy perioperative outcomes

Filling out your UCAS form

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当代学生 2003年第3期 26-27页

作者： rosy Dawn

填写申请表格是申请留学过程中最基本的一步,但是许多学生都觉得填写申请表是件很难的事情。确实有不少院校的申请表格都不够完美,有待改进,尤其是申请英国的大学时填写的学校联招办的申请表格,常常让人感到迷惑,甚至不知所措。不过,作... 详细信息

填写申请表格是申请留学过程中最基本的一步,但是许多学生都觉得填写申请表是件很难的事情。确实有不少院校的申请表格都不够完美,有待改进,尤其是申请英国的大学时填写的学校联招办的申请表格,常常让人感到迷惑,甚至不知所措。不过,作为申请出国的骄子,总不至于被区区申请表格难倒吧。

关键词： Filling out your UCAS form

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Quintessential Italy

当代学生 2003年第5期 24-25页

作者： rosy Dawn

Halting in the churches and piazzas,glancing back at the twenty-five centuries ofhistory,walking into the romantic cafes,tasting the delicious pizza and spaghetti,listening to the Italian opera,spending Italy’smost c... 详细信息

关键词： Quintessential Italy 意大利

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Coloful Spain

当代学生 2003年第9期 50-51页

作者： rosy dawn

Madrid,Barcelona,Columbus,Pablo Picasso,Visigothic building,Don Quixote,Bullfighting,Sherry…It is too many to let us remember this ancient country in southwestern Europe-Spainindeed,and the place of writing spoke is ... 详细信息

关键词：西班牙体育运动 Coloful Spain