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The promise of neuroprotection by dietary restriction in glaucoma

Neural Regeneration Research 2022年第1期17卷 45-47页

作者： rossella russo Carlo Nucci Annagrazia Adornetto Preclinical and Translational Pharmacology Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly

Glaucoma,a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells,is the most common neurodegenerative cause of irreversible blindness worldwide.The therapeutic management of glaucoma,which is limited to lowering intraocular pressure,is still a challenge since visual loss progresses in a significant percentage of treated patients.Restricted dietary regimens have received considerable attention as adjuvant strategy for attenuating or delaying the progression of neurodegenerative diseases.Here we discuss the literature exploring the effects of modified eating patterns on retinal aging and resistance to stressor stimuli.

关键词： aging caloric restriction fasting glaucoma neurodegeneration retina retinal ganglion cells

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Neuroinflammation as a target for glaucoma therapy

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Neural Regeneration Research 2019年第3期14卷 391-394页

作者： Adornetto Annagrazia rossella russo Parisi Vincenzo Department of Pharmacy Health and Nutritional Sciences Section of Preclinical and Translational Pharmacology University of Calabria Visual Neurophysiology and Neurophthalmology Research Unit IRCCS G.B.Bietti Foundation

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation-involving the activation and proliferation of resident glial cells(astrocytes, Muller cells and microglia) and the release of a plethora of anti-and pro-inflammatory cytokines, chemokines and reactive oxygen species-has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma.

关键词： glaucoma retinal ganglion cells neuroinflammation neurodegeneration microglia oxidative stress inflammasome immune response

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