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Advances in selenium supplementation:From selenium-enriched yeast to potential selenium-enriched insects,and selenium nanoparticles

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Animal Nutrition 2023年第3期14卷 193-203页

作者： Luca Ferrari Donata M.I.R.Cattaneo rossella abbate Michele Manoni Matteo Ottoboni Alice Luciano Christoph von Holst Luciano Pinotti Department of Veterinary Medicine and Animal Sciences(DIVAS) Universita degli Studi di Milano26900 LodiItaly European Commission Joint Research Centre(JRC)2440 GeelBelgium CRC I-WE(Coordinating Research Centre:Innovation for Well-Being and Environment) Universita degli Studi di Milano20133 MilanItaly

Selenium(Se)is an essential micronutrient that plays an important role in animal and human development and physiological *** review surveys the role of Se in the environment,plants and animal bodies,and discusses data on Se biofortification with different sources of supplementation,from inorganic to organic forms,with special focus on Se-enriched yeast(Se-yeast).Although Se-yeast remains one of the main sources of organic Se,other emerging and innovative sources are reviewed,such as Se-enriched insects and Se-nanoparticles and their potential use in animal ***-enriched insects are discussed as an option for supplying Se in organic form to livestock ***-nanoparticles are also discussed,as they represent a more biocompatible and less toxic source of inorganic Se for animal organisms,compared to selenite and *** also provide up to date information on the legal framework in the EU,USA,and Canada of Se that is contained in feed *** the scientific evidence available in the literature,it can be concluded that among the inorganic forms,sodium selenite is still one of the main options,whereas Se-yeast remains the primary organic ***,other potential sources such as Se-enriched insects and Se-nanoparticles are being investigated as they could potentially combine a high bioavailability and reduced Se emissions in the environment.

关键词： Selenium Selenium-enriched yeast Selenium nanoparticle Selenium-enriched insect Speciation analysis

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Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis

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World Journal of Gastroenterology 2006年第10期12卷 1607-1612页

作者： Maria Rosa Biagini Alessandro Tozzi rossella Marcucci Rita Paniccia Sandra Fedi Stefano Milani Andrea Galli Elisabetta Ceni Marco Capanni Raffaele Manta Rosanna abbate Calogero Surrenti Department of Clinical Pathophysiology Gastroenterology Unit University of FlorenceAOU CareggiFlorenceItaly Thrombosis Center Department of Critical Area University of FlorenceAOU CareggiFlorenceItaly

AIM： To assess the hypercoagulability in PBC and its relationship with homocysteine （HCY） and various components of the haemostatic system. METHODS： We investigated 51 PBC patients （43F/8M; mean age： 63±13.9 yr） and 102 healthy subjects （86 women/16 men, 63±13 yr）, and evaluated the haemostatic process in whole blood by the Sonoclot analysis and the platelet function by PFA-100 device. We then measured HCY （fasting and after methionine loading）, tissue factor （TF）, thrombin-antithrombin complexes （TAT）, D-dimer （D-D）, thrombomodulin （TH）, folic acid, vitamin B6 and B12 plasma levels. C677T 5,10-methylenetetrahydrofolate reductase （HTHFR） polymorphism was analyzed. RESULTS： Sonoclot RATE values of patients were significantly （P〈 0.001） higher than those of controls. Sonoclot time to peak values and PFA-100 closure times were comparable in patients and controls. TAT, TF and HCY levels, both in the fasting and post-methionine loading, were significantly （P〈0.001） higher in patients than in controls. Vitamin deficiencies were detected in 45/51 patients （88.2%）. The prevalence of the homozygous TT677 MTHFR genotype was significantly higher in patients （31.4%） than in controls （17.5%）（P〈 0.05）. Sonodot RATE values correlated significantly with HCY levels and TF.CONCLUSION： In PBC, hyper-HCY is related to hypovitaminosis and genetic predisposing factors. Increased TF and HCY levels and signs of endothelial activation areassociated with hypercoagulability and may have an important role in blood clotting activation.

关键词： Homocysteinemia Hypercoagulability Primary biliary cirrhosis Tissue factor Folic acid

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