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Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 329-340页

作者： Mariangela Torniai Silvia Rinaldi Francesca Morgese Giulia Ricci Azzurra Onofri Christian Grohé rossana Berardi Department of Medical Oncology UniversitàPolitecnica delle Marche60100 AnconaItaly Department of Respiratory Diseases Ev.Lungenklinik BerlinUniversitätsmedizin ChariteLindenberger Weg 2713125 BerlinGermany

Neuroendocrine tumors(NETs)represent a spectrum of rare neoplasms arising in different organism *** on the site of onset,they also can be distinguished using lab exams(secreting ***),clinical symptoms(functioning ***),behavioral,morphological characteristics(tumor cells’architectural growth patterns,mitotic and Ki-67 index,presence of necrosis),and grade of cellular *** aim of this review is to focus on the main signaling pathways targeted by medical treatments of advanced sporadic gastro-entero-pancreatic(GEP)and bronchopulmonary(BP)neuroendocrine *** scientific literature regarding treatment of advanced GEP and BP-NETs has been extensively reviewed using MEDLINE and PubMed databases,selecting principal and more recent research articles,clinical trials,and updated *** analogues represent a valid approach to control symptoms in functioning tumors and to inhibit tumor progression in certain categories on the basis of the typical somatostatin receptor expression observed in *** pathogenesis of NETs has been the subject of increased interest in recent *** driver mutations pathway genes have been identified as important factors in the carcinogenesis process and,therefore,as potential targets for new anticancer *** mutations have been shown in epidermal growth factor receptor,stem cell factor receptor,platelet-derived growth factor receptor,vascular endothelial growth factor,basic-fibroblastic growth factor,transforming growth factor,insulin-like growth factor-1,and their *** M-Tor inhibition pathway modulation has led to the approval of drugs in this field such as *** drugs and several combination regimens with targeted and newer biological agents are being developed and tested in recently conducted and ongoing trials.

关键词： Gastrointestinal and bronchopulmonary neuroendocrine tumors advanced disease medical treatment targeted agents

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空间的多层体验北京万科赢嘉会所

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室内设计与装修 2013年第4期 36-43页

作者： Lyndon Neri rossana Hu

万科是中国最大的住宅开发商，每年负责超过1200万m^2的新项目，如恩近期为其完成了一个项目。位于万科北京总部内的赢嘉会所，是一栋五层楼高，在原有办公楼结构基础上的改造加新建的多功能贵宾销售会所。近些年来万科开始支持世界级... 详细信息

万科是中国最大的住宅开发商，每年负责超过1200万m^2的新项目，如恩近期为其完成了一个项目。位于万科北京总部内的赢嘉会所，是一栋五层楼高，在原有办公楼结构基础上的改造加新建的多功能贵宾销售会所。近些年来万科开始支持世界级的设计及可持续性，这可以说是一个具有里程碑意义的项目。在万科希望能在外观上呈现崭新的设计形象以及在室内能拥有多样化和灵活性并存的长期使用功能的要求下，如恩创造出了一个全新的外立面，

关键词：会所北京空间结构基础可持续性多功能开发商办公楼

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基于风险识别与管理的安全培训实践

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中国安全生产科学技术 2014年第S2期10卷 37-40页

作者：曹民权杨洋邱明 Danny Vejar rossana Abad 中国石油拉美<厄瓜多尔>安第斯石油公司北京100034

对石油石化行业而言,风险管理的核心就是安全风险管理。安全风险管理的前提是风险识别。基于岗位风险识别群体的感知风险,和通过组织安全数据库识别的"现实的风险"揭示,是风险识别的有效途径。组织安全风险识别是科学识别培训需求的重... 详细信息

对石油石化行业而言,风险管理的核心就是安全风险管理。安全风险管理的前提是风险识别。基于岗位风险识别群体的感知风险,和通过组织安全数据库识别的"现实的风险"揭示,是风险识别的有效途径。组织安全风险识别是科学识别培训需求的重要途径,从而实现培训有效管理和安全文化提升。

关键词：意大利劳工模型风险感知安全数据库培训

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Zygomatic Implant-Supported Prosthesis: When the Prosthetic Rehabilitation Affects the Function: A Case Report

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Open Journal of Stomatology 2017年第10期7卷 448-454页

作者： Wilson Matsumoto rossana Pereira De Almeida Alexandre Elias Trivellato Cassio Edvard Sverzut Takami Hirono Hotta Dental Materials and Prosthodontic Department Dental School of Ribeir&atilde o Preto University of S&atilde o Paulo S&atilde o Paulo Brazil Oral and Maxillofacial Surgery Traumatology and Periodontology Department Dental School of Ribeir&atilde o Preto University of S&atilde o Paulo S&atilde o Paulo Brazil

The oral rehabilitation of edentulous patients can be done in different ways depending on the alveolar ridge morphology and patient expectations. The objective of this clinical case was to report prosthetic and functional adaptation difficulties when conventional complete denture was changed to a zygomatic implant-supported prosthesis. We report a 52-year-old male singer with an atrophic maxilla who was rehabilitated with zygomatic implant-supported prosthesis using 4 implants. However, the thickness of the prosthesis in the palatal region and the space between the prosthesis and soft tissue caused difficulty in speaking and singing. The palatal region of the prosthesis was trimmed and the anterior region of the prosthesis was relined. These procedures were performed to make room for the tongue and minimize the passage of air during speech. Adaptations in the shape of the prosthesis must be made to enable its use, without compromising its strength.

关键词： Zygomatic Implant Branemark Protocol Implant Prosthesis

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Fulminant ulcerative colitis in a healthy pregnant woman

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世界胃肠病学杂志：英文版 2015年第19期21卷 6060-6064页

作者： rossana Orabona Adriana Valcamonico Marianna Salemme Stefania Manenti Guido AM Tiberio Tiziana Frusca Maternal Fetal Medicine Unit Department of Obstetrics and Gynecology University of Brescia Pathology Department University of Brescia Surgical Clinic Department of Clinical and Experimental Sciences University of Brescia

This case report concerns a 25-year-old patient with6-7 bloody stools/d, abdominal pain, tachycardia,and weight loss occurring during the third trimester of pregnancy. Severe ulcerative colitis complicated by toxic megacolon and gravidic sepsis was diagnosed by clinical evaluation, colonoscopy, and rectal biopsy that were performed safely without risk for the mother or baby. The patient underwent a cesarean section at28+6 wk gestation. The baby was transferred to the neonatal intensive care unit of our hospital and survived without complications. Fulminant colitis was managed conservatively by combined colonoscopic decompression and medical treatment. Although current European guidelines describe toxic megacolon as an indication for emergency surgery for both pregnant and non-pregnant women, thanks to careful monitoring, endoscopic decompression, and intensive medical therapy with nutritional support, we prevented the woman from having to undergo emergency pancolectomy. Our report seems to suggest that conservative management may be a helpful tool in preventing pancolectomy if the patient's condition improves quickly. Otherwise, surgery is mandatory.

关键词： Ulcerative colitis Toxic megacolon Pregnancy Cesarean section Colonoscopy

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暧昧的蜕变 Muse俱乐部

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室内设计与装修 2007年第3期 57-63页

作者： Lyndon Neri rossana Hu 侯麦

“同乐坊”位于海防路、西康路、余姚路的三角地带。上个世纪二三十年代这里曾云集了一大批“弄堂工厂”，如今在“修旧如旧”的原则的指导下，它成为了上海新的时尚地标，酒吧林立，香港著名艺人刘嘉玲新开的Muse Club正是坐落在这一... 详细信息

“同乐坊”位于海防路、西康路、余姚路的三角地带。上个世纪二三十年代这里曾云集了一大批“弄堂工厂”，如今在“修旧如旧”的原则的指导下，它成为了上海新的时尚地标，酒吧林立，香港著名艺人刘嘉玲新开的Muse Club正是坐落在这一“生活艺术化、艺术生活化”的创意新天地中。

关键词： Muse 俱乐部蜕变艺术化生活化

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Clinical and environmental isolates of Burkholderia pseudomallei from Brazil: Genotyping and detection of virulence gene

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 945-951页

作者： Tereza de Jesus Pinheiro Gomes Bandeira Debora de Souza Collares Maia Castelo-Branco Marcos Fabio Gadelha Rocha rossana de Aguiar Cordeiro Crister Jose Ocadaque Manoel de Araújo Neto Paiva Raimunda Samia Nogueira Brilhante Jose Júlio Costa Sidrim Specialized Medical Mycology Center Postgraduate Program in Medical Microbiology Federal University of Ceará Christus School of Medicine Postgraduate Program in Veterinary Sciences State University of Ceará Federal Institute of Education Science and Technology of Ceará

Objective: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei(***) recovered in Ceara, Brazil, and screen these isolates for the presence of type three secretion system virulence ***: Nineteen *** isolates(9 from clinical cases and 10 from soils)were *** amplified polymorphic DNA was performed with primers OPQ-2, OPQ-4 and OPQ-16 to evaluate the genetic diversity, and type three secretion system gene was detected through polymerase chain ***: Random amplified polymorphic DNA showed a genetic relatedness of approximately 50% among the tested *** isolates, which were grouped into two clades, of which the biggest ones comprised 18/19 isolates for primer OPQ-2, and 17/19 isolates for primer *** OPQ-4 grouped the isolates into three clades comprising 1/19, 3/19 and 15/19 ***, type three secretion system gene was detected in all tested ***: This is an effort to type *** strains from Ceara, which is important for better understanding this pathogen, contributing for the epidemiological surveillance of melioidosis in this endemic region.

关键词： Burkholderia pseudomallei Melioidosis RAPD TTSS gene

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New findings on thymic epithelial tumors:Something is changing

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World Journal of Clinical Oncology 2015年第5期6卷 96-98页

作者： rossana Berardi Francesca Morgese Marina Chiara Garassino Stefano Cascinu Department of Medical Oncology Università Politecnica Marche Istituto Nazionale Tumori I-20122 MilanItaly

Thymic epithelial tumors(TETs) are uncommon neoplasms with a wide range of anatomical, clinical, histological and molecular malignant entities. To date the management of TETs within clinical practice is based on a multimodal therapeutic strategy including surgery, chemotherapy and radiotherapy with a multidisciplinary approach and prognostic evaluation is mainly based on Masaoka staging and World Health Organization classification. Therefore novel strategies are needed, especially for refractory and/or recurrent TETs and for thymic carcinomas that present a poor prognosis. Personalized approaches are currely being developed and molecular targets are emerging from recent integrated genomic analyses. Targeted therapy will represent an important treatment option for TETs with an aggressive histology. To date, data indicate that vascular endothelial growth factor molecules, insulinlike growth factor 1 receptor, cyclin-dependent kinases and mammalian target of rapamycin may be potentially useful as targeted biological therapies.

关键词： Thymic epithelial tumors Thymoma Thymic carcinoma Targeted therapy Programmed cell death-1

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Phthalate Metabolites in Amniotic Fluid and Maternal Urine Samples

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Journal of Environmental Protection 2014年第14期5卷 1411-1418页

作者： Giovanna Tranfo Enrico Paci Daniela Pigini rossana Claudia Bonanni Silvia Capanna Caterina De Carolis Sergio Iavicoli INAIL Research Monteporzio Catone Italy Gynaecology and Obstetrics II Azienda Ospedaliera San Giovanni-Addolorata Rome Italy

The objective of this study was to determine the concentrations of the metabolites of four selected phthalates, widely used industrial chemicals which possess endocrine-disrupting properties, in samples of amniotic fluid and maternal urine collected in the same day, in order to verify if the latter can be considered a measure of the fetal exposure. The quantitative determination of the metabolites was carried out by HPLC-MS/MS with isotopic dilution from 70 pregnant volunteers. Detectable concentrations of phthalates metabolites were found in amniotic fluids. As phthalate monoesters are excreted in the urine conjugated with glucuronic acid, an enzymatic hydrolysis is carried out before analysis. Amniotic fluids were tested with and without hydrolysis and only the free phthalate metabolites, not conjugated with glucuronic acid, were found. The concentration of metabolites after enzymatic hydrolysis in maternal urine is not correlated to those of amniotic fluids, but the free form concentrations are. These results suggest that only the free forms can cross the placenta. A significant number of mothers showed urine phthalate monoesters concentrations higher than non-pregnant women.

关键词： Chemical Exposure Amniotic Fluid Urine Phthalate Metabolite Glucuronic Acid

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人工智能经济学：对劳动世界的未来产生的影响

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中国劳动 2019年第11期 60-88页

作者： Ekkehardt Ernst rossana Merola Daniel Samaan 国际劳工组织研究司

当前,基于人工智能技术进步的变革浪潮使人们更加担心失业和不平等将日益加剧。本文讨论了造成这些恐慌的基本原因,强调了人工智能的特殊性,并将以前的自动化和自动化浪潮与当前人工智能的广泛应用所带来的进步进行了比较。在全球范围内... 详细信息

当前,基于人工智能技术进步的变革浪潮使人们更加担心失业和不平等将日益加剧。本文讨论了造成这些恐慌的基本原因,强调了人工智能的特殊性,并将以前的自动化和自动化浪潮与当前人工智能的广泛应用所带来的进步进行了比较。在全球范围内,包括发展中国家,人工智能的应用能够大幅度降低资本成本,激发生产力提高的潜力,进而为生产力的提高提供巨大的机会。同时,如果要广泛分享基于人工智能的技术进步带来的益处,就需要解决进一步加剧的不平等的风险。因此,技能政策的进一步完善是必要的,但仅靠技能政策解决上述风险是不够的。为此,需要创新数字经济监管形式,以防止市场的进一步集中,确保对数据和隐私提供适当的保护,通过整合使用利润共享、(数字)资本税、减少工作时间等政策措施使社会能够共享生产力增长的红利。本文认为,如果政策决策者和社会各方参与者能够将这些新技术的特性加以考虑的话,我们应当对人工智能带来的机遇和风险持有适度乐观的态度。

关键词：人工智能技术失业不平等生产率增长

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