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***转录普查(烟草项目之欧洲定序eST)

中国烟草学报 2007年第3期13卷 39-39页

作者： DORLHAC De BORNe F COATeS S ross J VeRRIeR J L JONeS L JULIO e DeLON R 吴晓芸（翻译）曹建平（校译）康婧（校译）艾继涛（校译）赵百东（校译） Altadis-Instkih du Bbac Domaine de la Tour 769 route de Sainte Alvere 241000 Bergerac法国 Advanced Bchnologies （Cambridge） Ltd 210 Cambridge Science Park Milton Road Cambridge CB40WA 英国不详

摘要: 烟草基因组研究在今后几年里有望能提高我们对烟气中不受欢迎化学组分相关的烟草基因之间的交互作用的认识。烟草的基因表达、原料烟叶的化学组分以及卷烟燃烧产物之间有着密切的联系。

关键词：烟草定序欧洲普查转录化学组分交互作用基因表达

假性剥脱综合征的结膜杯状细胞形态学和泪膜稳定性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 41-42页

作者：张晓光 Kozobolis V.P Christodoulakis e.V Naoumidi I.I e.V.Christodoulakis Department of Ophthalmolog yHeraklion Universi ty HospitalPOBox 220871003HeraklionCreteGreece

Background:Tear secretion and tear film stability seem to be influenced by pseudoexfoliation syndrome (PeX).Histopathological evaluation of conjunctival goblet cells in PeX patients might explain the influ ence on tear film ***:In a prospective,c ross-sectional study,40eyes of 40patients with PeX(study group)had mea-surement of Schirmer test with anesthesia and break-up time prior to cataract *** th e end of an uneventful operation,a 1×1.5mm sample of conju nctival tissue was obtained and light and electron microscopy were *** were compared with a control *** evaluation was *** imary outcome mea-sures included Schirmer test with an esthesia,break-up time,goblet cell density and morphological character of conjunctiva and conjunctival goble t ***:Both Schirmer test and break-up time valu es were significantly lower(P=0.01and P=0.001)in the PeX patients(mean 10.6mm and 8.6s respectively)than in the control group(13.4mm and 12.3s respectively).The number of goblet cells in patients wi th PeX compared with the control group showed no statisti cally significant differ-ence(P=0.66).Use of trichrome stain revealed sig nif-icant differences in the staining pr operties of goblet cells between patients with PeX and contro *** electron mi-croscopy,typical pseudoexfoliati on filaments were found in the connective tissue of conjunctiv a of PeX ***-markable changes of mucin pockets in the study group were also noticed;they had extremely irregular distribu-tion,various forms of size and appearance and even com-plete ***:Pseudoexfoliation seems to alter basic features of goblet cell morphology,thus af-fecting tear film *** studies are necessary to determine the exact mechanism.

关键词：结膜杯状细胞剥脱综合征泪膜稳定性白内障手术破膜时间泪液分泌表皮剥脱结膜组织组织学评价试验测量

卒中存活者体力活动和锻炼建议：美国心脏协会／美国卒中协会针对医疗专业人员的声明

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国际脑血管病杂志 2014年第10期22卷 721-740页

作者： Sandra A. Billinger ross Arena Julie Bemhardt Janice J. eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko gillian e. Mead elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭张通不详中国康复研究中心北京100068

目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示，卒中存活者会经历体力下降（physical deconditioning）并导致久坐的生活方式。因此，本更新版科学声明旨在为医务人员提供全面的指导，使其更好地理... 详细信息

目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示，卒中存活者会经历体力下降（physical deconditioning）并导致久坐的生活方式。因此，本更新版科学声明旨在为医务人员提供全面的指导，使其更好地理解体力活动的益处，并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会（American Heart Association，AHA）卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述，参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见，对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练，包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量，同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是，体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。

关键词： AHA科学声明有氧锻炼体力锻炼体力活动康复力量训练

丁酸梭菌早期干预对大肠杆菌攻毒肉仔鸡肠道菌群和短链脂肪酸的影响

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饲料工业 2021年第11期42卷 44-52页

作者：舒均兰徐娥桂国弘肖明飞肖英平唐青松贵州大学动物科学学院动物营养与饲料研究所贵州贵阳550025 贵州省农业职业学院贵州贵阳551400 浙江省农业科学院农产品质量标准研究所浙江杭州310021

试验旨在研究丁酸梭菌(Clostridium butyricum)早期干预对产肠毒素大肠杆菌(enterotoxigenic escherichia coli,eTeC)攻毒肉仔鸡肠道短链脂肪酸(SFAs)和菌群结构的影响。选用1日龄ross肉仔鸡200只,分为两组,每组100只,试验前3 d,其中一... 详细信息

试验旨在研究丁酸梭菌(Clostridium butyricum)早期干预对产肠毒素大肠杆菌(enterotoxigenic escherichia coli,eTeC)攻毒肉仔鸡肠道短链脂肪酸(SFAs)和菌群结构的影响。选用1日龄ross肉仔鸡200只,分为两组,每组100只,试验前3 d,其中一组每天灌喂1 mL浓度为109 CFU/mL的丁酸梭菌,另外一组灌喂1 mL生理盐水。7日龄时,将灌喂生理盐水的肉仔鸡分成对照组(Control)和大肠杆菌组(eC);灌喂丁酸梭菌的肉仔鸡分成丁酸梭菌组(CB)和丁酸梭菌+大肠杆菌组(CB+eC)。7日龄至试验结束,eC组和CB+eC组灌喂1 mL(108 CFU/mL)产肠毒素大肠杆菌菌液进行攻毒,Control组和CB灌喂1 mL生理盐水。eTeC攻毒后第3 d和7 d屠宰取样。结果显示:①在肉仔鸡盲肠中,10日龄时,与Control组相比,CB组中乙酸含量极显著提高(PeC组中的乙酸含量显著降低(PeC组中丁酸的含量较为相近,均极显著高于Control组和eC组(PeC组中的乙酸、丙酸、丁酸显著降低(P<0.05)。②10日龄时,在CB组中,瘤胃球菌属相对丰度最高,显著高于其他各试验组(P<0.05)。由此可见,丁酸梭菌早期干预大肠杆菌攻毒的肉仔鸡可一定程度上促进肠道短链脂肪酸的生成和改善盲肠菌群结构。

关键词：丁酸梭菌肉仔鸡大肠杆菌短链脂肪酸菌群结构

Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： gerie J.glas Janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg Jan M.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert g.Loef David P.Mackie Perenlei enkhbaatar Nadia Depetris Anders Perner eva Herrero Lucia Cachafeiro Marc Jeschke Jeffrey Lipman Matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa Manoel Silva Junior Cintia M.C.grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu Jeanne Morgane Bacus Maite Chaussard Marcus Lehnhardt Bassem Daniel Mikhail Jochen gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda e.Painting Marcus J.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN geNT Watersportlaan 5–9000 gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl gustav Carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands Martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.Monash University MelbourneVIC 3004Australia gH St-Louis-Lariboisière APHPParis 75010France Bg Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation general Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France Bg University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PeeP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PeeP levels≥5 cmH_(2)O;80%of patients had maximum airway pressuresernational cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care