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Limosilactobacillus mucosae FZJtZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul ross Catherine Stanton Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland teagasc Food Research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).the effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJtZ26M3,FGSYC17L3).*** FZJtZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJtZ26M3 *** pathology showed that *** FZJtZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJtZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJtZ26M3 ***,*** FZJtZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： ross tucker Matt Cross Keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RtP)in elite rugby is managed using a 6-stage graduated RtP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RtP)to identify whether a more conservative graduated RtP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RtP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RtP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RtP *** may guide a more conservative approach to RtP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

Structural Studies on the Cu–H System under Compression

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Engineering 2019年第3期5卷 505-509页

作者： Jack Binns Miriam Pena-Alvarez Mary-Ellen Donnelly Eugene Gregoryanz ross t. howie Philip Dalladay-Simpson Center for High Pressure Science and technology Advanced Research (HPStAR) Shanghai 201203 China Centre for Science at Extreme Conditions The University of Edinburgh Edinburgh EH9 3FD UK Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China

Hydrogen chemistry at extreme pressures is currently subject to extensive research due to the observed and predicted enhanced physical properties when hydrogen is incorporated in numerous binary systems. Despite the high reactivity of hydrogen, the noble metals (Cu, Ag, and Au) display an outstanding resilience to hydride formation, with no reports of a stable compound with a hydrogen molar ratio - 1 at room temperature. Here, through extreme compression and in situ laser heating of pure copper in a hydrogen atmosphere, we explore the affinity of these elements to adopt binary compounds. We report on the phase behavior and stabilities in the Cu–H system, analyzed via synchrotron X-ray diffraction, up to pressures of 50 GPa. We confirm the existence of the previously reported c0-CuH0.15, c1-CuH0.5, and e-Cu2H phases. Most notably, we report the highest hydrogen-content noble-metal hydride stable at room temperature to date: c2-CuH0.65, which was synthesized through laser heating. this study furthers our understanding of hydrogen-transition metal chemistry and may find applicability in future hydrogen-storage applications.

关键词： High pressure Hydrogen storage Noble metal chemistry

true polar wander in the Earth system

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Science China Earth Sciences 2023年第6期66卷 1165-1184页

作者： Chong WANG ross N.MItCHELL State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

true polar wander(tPW),or planetary reorientation,is the rotation of solid Earth(crust and mantle)about the liquid outer core in order to stabilize Earth’s rotation due to mass *** tPW is well-documented on Earth presently with satellites and for multiple planets and moons in the Solar System,the prevalence of tPW in Earth history remains *** a history of controversy,both the physical plausibility of tPW on Earth and an empirical basis for it are now *** resistance to the old idea likely stems from the fact that,like plate tectonics,tPW may influence much of the Earth system,thus acknowledging its existence requires rethinking how many different datasets are *** review summarizes the development of tPW as a concept and provides a framework for future research that no longer regards tPW like a ghost process that may or may not exist,but as an integral part of the Earth system that can relate shallow and deep processes that are otherwise only mysteriously ***,we focus on the temporal regularity of large tPW,and discuss its relationship with the supercontinent-megacontinent cycle based on previous *** suggest the assembly of megacontinents has a close linkage to large ***,supercontinent tenure and breakup have a close linkage to fast *** effects of tPW on sea level changes,paleoclimate,biological diversity,and other facets of the Earth system are presented and require interdisciplinary tests in the future.

关键词： true polar wander(tPW) Planetary reorientation Apparent polar wander(APW) Mantle convection Supercontinent cycle Megacontinent

Damage Curves Derived from Hurricane Ike in the West of Galveston Bay Based on Insurance Claims and Hydrodynamic Simulations

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International Journal of Disaster Risk Science 2023年第6期14卷 932-946页

作者： Chaoran Xu Benjamin t.Nelson-Mercer Jeremy D.Bricker Meri Davlasheridze Ashley D.ross Jianjun Jia State Key Laboratory of Estuarine and Coastal Research School of Marine SciencesEast China Normal UniversityShanghai 200241China Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA Department of Marine and Coastal Environmental Science Texas A&M University at GalvestonGalvestonTX 77553USA Faculty of Civil Engineering and Geosciences Delft University of Technology2628 CN DelftThe Netherlands

Hurricane Ike,which struck the United States in September 2008,was the ninth most expensive hurricane in terms of *** caused nearly USD 30 billion in damage after making landfall on the Bolivar Peninsula,*** used the Delft3dFM/SWAN hydrodynamic and spectral wave model to simulate the storm surge inundation around Galveston Bay during Hurricane *** curves were established through the relationship between eight hydrodynamic parameters(water depth,flow velocity,unit discharge,flow momentum flux,significant wave height,wave energy flux,total water depth(flow depth plus wave height),and total(flow plus wave)force)simulated by the model and National Flood Insurance Program(NFIP)insurance damage *** NFIP insurance database contains a large amount of building damage data,building stories,and elevation,as well as other information from the Ike *** found that the damage curves are sensitive to the model grid resolution,building elevation,and the number of *** also found that the resulting damage functions are steeper than those developed for residential structures in many other locations.

关键词： Delft3d-FM Flood risk Hurricane Ike Residential damage ratio SWAN Weibull function

Use of non-timber forest products from invasive alien Prosopis species(mesquite) and native trees in South Africa: implications for management

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Forest Ecosystems 2015年第3期2卷 197-207页

作者： ross t Shackleton David C Le Maitre Brian W van Wilgen David M Richardson Centre for Invasion Biology Department of Botany and ZoologyStellenbosch University Centre for Invasion Biology Natural Resources and the EnvironmentCSIR

Background: Prosopis species have been introduced to many areas outside their native range to provide benefits to local communities. Several Prosopis species and their hybrids(hereafter "mesquite") have, however, become naturalised and invasive and now generate substantial costs. Management options are limited because of the complex conflicts of interest regarding benefits and costs. Management policies and strategies must take account of such conflicts, but further insights are needed on the dimensions of uses and impacts before such information can be usefully applied. Current policy in South Africa allows for the growth and use of mesquite in one province,but not in others where its control is mandatory. We report on a study to quantify the direct use and perceptions of non-timber forest products(NtFPs) from mesquite and native trees in South ***: Semi-structures household interviews were conducted with various stakeholder groups to identify what tree products are used, to ascertain amounts used as well as to gauge perceptions of natural resource use between different tree species and use over ***: the direct household use value of native trees was higher than that of mesquite, and local stakeholders attached greater value to products from native trees than from mesquite. therefore, native trees are and will still be preferentially harvested, and mesquite is unlikely to offer protection to native species by providing an alternative source of products. Mesquite pods do, however, provide valuable additional resources(fodder and medicinal products). the use of both native trees and mesquite is decreasing as the incomes of poorer households rise and as alternative energy sources become available. the benefits and reliance on mesquite are not as high as previously assumed and the impacts from mesquite invasions create large problems for local ***: this study provides further evidence that the impacts of mesquite exceed the benefi

关键词： Biological invasions Conflicts of interests Cost v

Hydrologic Modeling Impacts of Post-mining Land Use Changes on Streamflow of Peace River, Florida

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Chinese Geographical Science 2015年第6期25卷 728-738页

作者： ZHANG Jing Mark ross Key Laboratory of Resource Environment and GIS in Beijing Capital Normal University Department of Civil and Environmental Engineering University of South Florida

Whether mining activity results in reduced flow of surface water in the Peace River Watershed of Florida has been the subject of much debate. With increased dependence of downstream users on surface water flow of the Peace River as a source of drinking water for four coastal counties in Southwest Florida and problems of water security, the debate has been intensified. It is possible to assess relationships of mining with streamflow in the upper reaches of the Peace River Basin using hydrologic modeling and identify mined sub-basins. In this work, land-use change impacts were simulated by the Hydrological Simulation Program—Fortran(HSPF) model based on geographical information system(GIS) tools, to compare pre- and post-mining streamflows at a study site of the Peace River in west-central Florida. the purpose of this study was to determine if land-use changes caused by mining have negatively impacted streamflow in the Peace River. Changes of land use were identified before and after mining activities. A coupled volume-water depth-discharge(V-h-Q) model based on stage/storage and stage/discharge was applied using HSPF for the pre-mining and post-mining models, respectively. Daily simulated post-mining hydrographs from HSPF were plotted with the calibrated pre-mining results and streamflow hydrographs from the 18 gauging stations, to compare timing of peaks, low flows and flow trends. Analyses of percent exceedances of flow frequency curves of the streams indicated that most streams had similar distributions for mined(reclaimed) and premining periods. In the streamflow change analysis, streamflows actually increased in mining-affected basins at nearly half the stations. Streamflows at other stations diminished. Overall from this comprehensive study, there were declines in streamflow at most gauging stations on the mainstem of the Peace River and its tributaries. the results of this study suggest that regional planning is urgently needed to propose reclamation schemes t

关键词：土地利用变化流域径流水文模拟采后安宁河佛罗里达州 FORtRAN 地理信息系统

Microstructure and Mechanical Properties of Cold Metal transfer Welding Similar and Dissimilar Aluminum Alloys

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 715-724页

作者： Ahmed Elrefaey Nigel G.ross LKR Leichtmetallkompetenzzentrum Ranshofen GmbH Austrian Institute of Technology

Integrating structures made from aluminum alloys in automotive industry requires a large amount of joining. As a consequence, the properties of the joints have a significant influence on the overall performance of the whole structure. Robot cold metal transfer welding is a relatively new joining technique and has been used in this work to join 6082-t4 and 5182-O aluminum alloy sheets by using ER5356 and ER4043 filler metals. Microstructure characterization was performed by optical microscopy and energy dispersive X-ray spectroscopy, and the mechanical properties were measured by tensile and hardness tests. A correlation is made between welding variables, mechanical properties and the microstructure of welded joints. Results indicate that robot cold metal transfer welding provides good joint efficiency with high welding speed, good tensile strength, and ductility. Owing to the low heat input of robot cold metal transfer welding process, the heat affected zone microstructure was quite similar to base metals, and weld metal microstructure was the controlling factor of joint efficiency. the best performing were the 5182/5182 joints welded with ER5356 and these had mechanical property coefficients of 100%, 98%, and 85% for yield strength, ultimate tensile strength, and elongation, respectively.

关键词： Aluminum CMt Welding Microstructure tensile property

Increased CD4/CD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer:A prospective pilot study

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 303-317页

作者： Daniel Skubleny Andrea Lin Saurabh Garg ross McLean Michael McCall Sunita Ghosh Jennifer L Spratlin Daniel Schiller Gina Rayat Department of Surgery University of AlbertaEdmonton T6G 2R3ABCanada Department of Surgery University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Laboratory Medicine and Pathology University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Oncology University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Oncology Cross Cancer InstituteUniversity of AlbertaEdmonton T5G 1Z2ABCanada

BACKGROUND Despite optimal neoadjuvant chemotherapy only 40%of gastric cancer tumours achieve complete or partial treatment *** the absence of treatment response,neoadjuvant chemotherapy in gastric cancer contributes to adverse events without additional survival benefit compared to adjuvant treatment or surgery *** strategies and methods are required to optimize the allocation of existing treatment regimens such as FLOt chemotherapy(5-Fluorouracil,Leucovorin,Oxaliplatin and Docetaxel).Predictive biomarkers detected using immunohistochemistry(IHC)methods may provide useful data regarding treatment *** to investigate the utility of CD4,CD8,Galectin-3 and E-cadherin in predicting neoadjuvant FLOt chemotherapy tumour response in gastric *** Forty-three adult patients with gastric adenocarcinoma,of which 18 underwent neoadjuvant chemotherapy,were included in a prospective clinical *** biopsies were obtained from gastric cancer and normal adjacent gastric *** in expression of Galectin-3,Ecadherin,CD4^(+)and CD8^(+)molecules between tumours with and without treatment response to neoadjuvant chemotherapy were assessed with *** response was graded by clinical pathologists using the tumour Regression Score according to the College of American Pathologists *** response was defined as complete or near complete tumour response,whereas partial or poor/no response was defined as *** IHC images were annotated and quantitatively assessed using QuPath *** expression between responsive and incomplete response tumours was assessed using a two-sided Wilcoxon *** expression was also compared between normal and cancer tissue and between 15 paired tumour samples before and after *** performed a preliminary multivariate analysis and power analysis to guide future *** analyses were completed using R *** the ratio betw

关键词： CD4 CD8 Galectin-3 Neoadjuvant chemotherapy treatment response Gastric cancer