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Reduced upper limb lean mass on dual energy X-ray absorptiometry predicts adverse outcomes in male liver transplant recipients

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World Journal of Transplantation 2022年第6期12卷 120-130页

作者： Penelope Hey Rudolf Hoermann Paul Gow Timothy P Hanrahan Adam G Testro ross Apostolov Marie Sinclair Liver Transplant Unit Austin HealthHeidelberg 3084Australia department of Medicine University of MelbourneMelbourne 3052Australia

BACKGROUNd Pre-transplant muscle wasting measured by computed tomography has been associated with adverse clinical outcomes after liver transplantation including increased rates of sepsis and hospitalisation *** limb lean mass(LM)measured by dual-energy X-ray absorptiometry(dEXA)was recently identified as a novel predictor of sarcopenia-associated mortality in men waitlisted for *** To investigate the use of dEXA LM in predicting gender-stratified early posttransplant *** Liver transplant recipients who underwent pre-transplant dEXA body composition imaging between 2002 and 2017 were *** included posttransplant mortality and graft failure,bacterial infections,acute cellular rejection(ACR)and intensive care and total hospital length of *** Four hundred and sixty-nine patients met inclusion criteria of which 338 were male(72%).Median age was 55.0 years(interquartile range 47.4,59.7)and model for end-stage liver disease(MELd)score *** time from assessment to transplantation was 7 mo(3.5,12).Upper limb LM was inversely associated with bacterial infections at 180 d post-transplant(hazard ratio=0.42;95%confidence interval:0.20-0.89;P=0.024)in males *** was a negative correlation between upper limb LM and intensive care(τb=-0.090,P=0.015)and total hospital length of stay(τb=-0.10,P=0.0078)in *** women,neither MELd nor body composition parameters were associated with post-transplant adverse outcomes or increased length of *** composition parameters,MELd and age were not associated with 90-d mortality or graft failure in either *** were no significant predictors of early *** Sarcopenia is an independent and potentially modifiable predictor of increased post-transplant bacterial infections and hospital length of stay in men with *** upper limb LM provides a novel measure of muscle wasting that has prognostic value in this *** lack of association in women req

关键词： dual-energy X-ray absorptiometry Sarcopenia Body composition Liver transplantation Survival

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COMPARING EURO-NORMS TO MILITARY STANdARdS

COMPARING EURO-NORMS TO MILITARY STANDARDS

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1997 International Symposium on Electromagnetic Compatibility

作者： diethard hansen detlef Ristau EURO EMC SERVICE（EES） dr.hansen GmbH Potsdamer Str.18A D-14513 TeltowGermany

＜正＞A comparison of commercial euro-standards and international military standards is made with respect to dual purpose equipment and CE certification under the European EMC directive 89/336/EEC. *** Europe has implemented equal legal and normative conditions for trade（import,export） throughout the European Union,which

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青贮饲料pH值无线监测装置设计与试验

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农业机械学报 2015年第S1期46卷 79-83页

作者：孟繁佳 Fabian ross 中国农业大学信息与电气工程学院北京100083 波恩大学农业工程系波恩53115

pH值是评价青贮饲料品质的重要指标之一。设计了青贮饲料pH值无线监测装置,实现了对青贮饲料在发酵过程中pH值变化的同步实时获取。在对仪器进行标定试验后,选用玉米秸秆和青草饲料样本对实际测量结果进行验证,结果表明:饲料pH值测量值... 详细信息

pH值是评价青贮饲料品质的重要指标之一。设计了青贮饲料pH值无线监测装置,实现了对青贮饲料在发酵过程中pH值变化的同步实时获取。在对仪器进行标定试验后,选用玉米秸秆和青草饲料样本对实际测量结果进行验证,结果表明:饲料pH值测量值与准确值呈严格线性相关关系,玉米秸秆和青草饲料样本,r分别为0.997 3和0.995 7,pH值无线监测装置可准确测量青贮饲料pH值。分别对玉米秸秆和青草饲料青贮发酵过程中pH值的变化过程进行监测,结果表明:对于玉米秸秆,其pH值初始值为5.4,从发酵的第0.5天到第2天pH值从5.4快速下降到4.0,之后pH值下降趋缓,最终稳定于3.8左右;对于青草饲料样本,其pH值初始值为5.9,从发酵的第0.8天到第3天pH值从6.0下降到5.2,发酵7 d后,pH值稳定于5.1。

关键词：青贮饲料 pH值无线监测装置

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dietary stimulation of the endogenous somatotropic axis in weaner and growerfinisher pigs using medium chain triglycerides and cysteamine hydrochloride

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Journal of Animal Science and Biotechnology 2017年第2期8卷 405-416页

作者： david W.Miller Zoe Prosser Edward Y.W.Chee Christian F.hansen Frank R.dunshea Bruce P.Mullan John R.Pluske School of Veterinary and Life Sciences Murdoch UniversityMurdochWA6150Australia department of Large Animal Sciences Faculty of Health and Medical SciencesUniversity of CopenhagenGroennegaardsvej 21870 Frederiksberg CDenmark Melbourne School of Land and Environment University of MelbourneParkvilleVlC 3051Australia department of Agriculture and Food Western Australia Bentley Delivery CenterLocked Bag4BentleyWA 6983Australia

Background： Three experiments were conducted to examine the overall hypothesis that addition of medium chain triglycerides（MCT） and cysteamine hydrochloride（CSH） into the diets of young and growing pigs would stimulate the endogenous somatotropic axis to improve growth and ***： In Experiment 1, weaner pigs were given either a 5 d dietary supplement of 5 % MCT（n = 8） or a control diet（n = 8）. MCT increased the plasma concentration of growth hormone（GH; P ＆lt; 0.05） and the GH secretagogue,ghrelin（P ＆lt; 0.05）. Additionally, the MCT treatment reduced scouring（P ＆lt; 0.05）, maintained villous height in the small intestine（P ＆lt; 0.05） and stabilised daily weight gain（P ＆lt; 0.05）, compared to the controls. Experiment 2compared the effects of 4 levels（0, 1, 3 and 6 % v/v） of MCT supplementation in grower-finisher male pigs, of approximately 35 kg live weight（n = 15 per treatment）. Blood samples taken after 7 wk of treatment showed that the MCT supplementation increased circulating ghrelin（P ＆lt; 0.001）, GH（P ＆lt; 0.01） and insulin（P ＆lt; 0.05）concentrations in a dose-dependent manner. daily weight gain, feed intake and feed conversion ratio were not affected by the MCT diets. In Experiment 3, 64 female pigs of approximately 60 kg live weight were allocated to one of three dietary treatments： control（n = 20）; 6 % MCT（n = 21）; and 70 mg/kg CSH（n = 21）. After 3 wk of supplementation, the MCT treated pigs had a higher plasma concentration of ghrelin compared to the control and CSH pigs（P ＆lt; 0.05）. Plasma concentrations of GH and weight were not affected by any of the dietary ***： Evidence is provided in Experiment 1 to support the use of dietary MCT supplements, perhaps acting via stimulation of somatotropic endocrine pathways, to minimise weaning-associated disorders such as slowing of growth and diarrhoea. In Experiments 2 and 3, although there was no effect on weight gain or feed conversion ratio in either experiment, MCT and CSH incr

关键词： Ghrelin Growth Pig Somatotropin

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TNF<i>α</i>and IL1<i>β</i>Stimulate differential Gene Expression in Endometrial Stromal Cells

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Advances in Biological Chemistry 2015年第2期5卷 126-141页

作者： Abha J. Chalpe Chad d. Law Jennifer N. dumdie Keith A. hansen Kathleen M. Eyster division of Basic Biomedical Sciences Sanford School of Medicine The University of South Dakota Vermillion SD USA department of Obstetrics and Gynecology Sanford School of Medicine The University of South Dakota Sioux Falls SD USA

The purpose of this study was to test the hypothesis that specific macrophage-secreted cytokines cause gene expression changes in endometrial stromal cells that reproduce the effects of macro-phages in the development of endometriosis. Telomerase-immortalized human endometrial stromal cells (T-HESC) were treated with tumor necrosis factor α (TNFα, 5 ng/ml) and interleukin 1β (IL1β, 1 ng/ml). differential expression of 249 genes was identified by dNA microarray. Ontologies such as peptidases, cell adhesion, cell death/cell cycle, growth factors, cytoskeletal organization, defense/immune system, signal transduction, and transcriptional regulation which are related to the development of endometriosis were represented by these genes. The up-regulation of interleukin 8 (IL8), interleukin 6 (IL6), IL1β and matrix metallopro-teinase 3 (MMP3) in response to TNFα ± ILIβ in T-HESC cells was confirmed by real time RT-PCR. TNFα ± ILIβ did not affect the migration or invasion of T-HESC cells. This study reinforces our previous investigations on communication between cells of the immune system and endometrial stromal cells and their potential role in the development of endometriosis.

关键词： Cytokines Endometriosis Endometrium Endometrial Stromal Cells Microarray Gene Expression

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腮腺肿瘤(一)

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中华口腔医学杂志 1957年第3期5卷 261-267页

作者： d.E.ross 江勋

一、诊断腮腺肿瘤的诊断通常是不困难的,但腮腺内和其周围的某些病理改变也会使肿瘤的诊断发生了困难。在耳周部发生的皮脂囊肿和包含囊肿常易造成误诊。必须注意在腮腺的周围、深部,甚致在腮腺的实质内有许多淋巴结,因此我

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Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2018年第2期24卷 179-194页

作者： Kirstine S Tolbol Maria NB Kristiansen Henrik H hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh Gubra Aps Horsholm DK-2970Denmark department of Biomedical Sciences Faculty of Health SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Section for Metabolic Imaging and Liver Metabolism The Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark department of Chemistry Faculty of ScienceUniversity of CopenhagenCopenhagen DK-2200Denmark

AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of *** Male wild-type C57 BL/6 J mice(dIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BId), obeticholic acid(OCA, 30 mg/kg PO, Qd), or elafibranor(30 mg/kg PO, Qd) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 *** Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in dIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid *** dIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of dIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical d

关键词： Nonalcoholic steatohepatitis disease models Pathology Fibrosis Liver biopsy Transcriptomics Pharmacodynamics Glucagon-like peptide-1 receptor Peroxisome proliferator-activated receptor Farnesoid X receptor

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Type 1 diabetes and polyglandular autoimmune syndrome: A review

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World Journal of diabetes 2015年第1期6卷 67-79页

作者： Martin P hansen Nina Matheis George J Kahaly department of Medicine I Johannes Gutenberg University Medical Center

Type 1 diabetes(T1d) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1 d as a monoglandular disease and the relation to polyglandular autoimmune syndrome(PAS) have also been wellexplored. The incidence of T1 d has steadily increased in most parts of the world, especially in industrialized nations. T1 d is frequently associated with autoimmune endocrine and non-endocrine diseases and patients with T1 d are at a higher risk for developing several glandular autoimmune diseases. Familial clustering is observed, which suggests that there is a genetic predisposition. Various hypotheses pertaining to viral- and bacterialinduced pancreatic autoimmunity have been proposed, however a definitive delineation of the autoimmune pathomechanism is still lacking. In patients with PAS, pancreatic and endocrine autoantigens either colocalize on one antigen-presenting cell or are expressed on two/various target cells sharing a common amino acid, which facilitates binding to and activation of T cells. The most prevalent PAS phenotype is the adult type 3 variant or PAS type Ⅲ, which encompasses T1 d and autoimmune thyroid disease. This review discusses the findings of recent studies showing noticeable differences in the genetic background and clinical phenotype of T1 d either as an isolated autoimmune endocrinopathy or within the scope of polyglandular autoimmune syndrome.

关键词： Autoimmune thyroid disease Polyglandularautoimmune syndrome Addison's disease Susceptibilitygenes Type 1 diabetes

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国外使用中曲率导航钻具钻三口水平井的实例

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钻采工艺 1993年第4期16卷 75-79,82页

作者：王建文 K.C.ross d.B.deom G.R.Nazzal 四川石油管理局钻采工艺研究所四川资中641202 Conoco公司 Eastman Christensen

本文介绍国外使用中曲率导航钻具组合钻成3口水平井的设计和实例。

关键词：北海科特尔油田中曲率半径液压马达导航钻具组合水平井

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田间卫生处理不能减少芒果核象甲的为害

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世界热带农业信息 1993年第1期 31-33页

作者： J.d.hansen 林文有

在夏威夷进行试验,以评价田间卫生对降低芒果核象甲为害芒果的效果。结果期间,每周2次清除四株隔离芒果树的落地果和种子。在下一个季节,把得到的有关芒果核象甲为害数据与对照果园相比较。结果表明,田间卫生不能减少该虫的为害程度,因... 详细信息

在夏威夷进行试验,以评价田间卫生对降低芒果核象甲为害芒果的效果。结果期间,每周2次清除四株隔离芒果树的落地果和种子。在下一个季节,把得到的有关芒果核象甲为害数据与对照果园相比较。结果表明,田间卫生不能减少该虫的为害程度,因为所有参试树果实的最大受害率比非参试树果实的受害率还大。显然,成虫比想象的更为分散。

关键词：芒果核卫生处理受害率象甲科芒果树为害程度芒果园雄成虫越冬场所生活史

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