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The complexities underlying age-related macular degeneration： could amyloid beta play an important role？

Neural Regeneration Research 2017年第4期12卷 538-548页

作者： Savannah A. Lynn Eloise Keeling rosie Munday Gagandeep Gabha Helen Griffiths Andrew J.Lotery J.Arjuna Ratnayaka Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton United Kingdom Eye Unit University Southampton NHS Trust Southampton United Kingdom

e-related macular degeneration （AMD） causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer＇s-linked amyloid beta （Aβ） group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer＇s disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that Aβ fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of Aβ were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of Aβ accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of Aβ-mediated retinopathy. Furthermore, we discuss our findings revealing how Aβ behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose Aβ as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for latestage AMD.

关键词： amyloid beta (Aβ) retinal neurons retina mouse models age related macular degeneration(AMD)

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Towards a Climate Service for the Tea Industry:A Collaborative Approach between the UK and China

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Advances in Atmospheric Sciences 2024年第12期41卷 2289-2299页

作者： Stacey NEW Shaojuan LI Tongwen ZHAO Elisabeth THOMPSON Nicola BOWN Tim MITCHELL Amy WATERSON Jennifer H WEEKS Jing YANG rosie OAKES Tianjun ZHOU Nicola GOLDING UK Met Office Exeter EX13PBUK Yunnan University of Finance and Economics Yunnan Key Laboratory for Plateau Mountain Land UseKunming 650021China University of Leeds LeedsLS29JTUK Beijing Normal University Beijing 100875China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China

Tea is an important global commodity,with important tea-growing regions spanning across South America,Africa,and Asia,and burgeoning smaller-scale and artisanal tea production in the UK and *** each of these regions,the quality and quantity of tea production,with their economic and social consequences,are highly sensitive to variations in the climate on both short-term weather,seasonal and climate change *** provision of tailored climate information in a timely and accessible manner through the development,delivery and use of climate services can help tea-farmers and other relevant stakeholders better understand the impacts of climate variability and climate change on decision-making and a range of adaptive *** paper presents an overview of the Tea-CUP project(Co-developing Useful Predictions),a joint initiative between UK and Chinese partners,which aims to develop and implement solutions for improving robust ***-production principles are core,ensuring that the resultant climate services are usable and useful;users'needs are met through close engagement and joint research and *** paper also reports on the exchange of knowledge and experiences,such as between tea growers in China and the UK,which has resulted from this collaborative work,fostering global knowledge sharing,enriching understanding,and driving innovation by integrating diverse perspectives and expertise from different *** is an unintended but valuable side-effect of the collaborative approach taken and highlights the benefits of a highly relational and multidisciplinary approach to climate services development that will inform future work in the field.

关键词： climate services co-production tea industry knowledge exchange

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全身磁共振成像可有效判定、识别结直肠癌患者的转移

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英国医学杂志中文版 2020年第5期23卷 294-295页

作者： Rob Cook Peter Davidson rosie Martin 李婕琳(译) Bazian Economist Intelligence Unit HealthcareLondonUK Wessex Institute University of SouthamptonSouthamptonUK 首都医科大学附属北京友谊医院消化科

研究Taylor S,Mallett S,Beare S et *** accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer:the prospective Streamline C *** Gastroenterol Hepatol 2019;4:529-37.该项目由NIHR健康技术评估计划(NIHR Health Technology Assessment Programme)资助(项目号10/68/01)。阅读完整版NIHR Signal,见https://***/content/signal-000797/identifying-metastatic-disease-in-colorectal-cancer-withwhole-body-mri.

关键词： al. colorectal cancer

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Adipokines and prediction of diabetes:from bench to bedside(Abstract)

Adipokines and prediction of diabetes:from bench to bedside(...

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2006年中华医学会糖尿病分会第十次全国糖尿病学术会议

作者： Karen SL Lam rosie TT Endocrinology & Metabolism Department of Medicine Universityof Hong Kong

The adipose tissue is now recognised as a major production site of hormones and cytokines which regulate body metabolism and energy homeostasis. There is also increasing evidence suggesting that dysregulation of adipo...

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NIHR信号新型气道通气设备用于院外复苏不亚于气管插管

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英国医学杂志中文版 2020年第7期23卷 414-415页

作者： Rob Cook Vaughan Thomas rosie Martin 景晨萌(译) Bazian Economist Intelligence Unit healthcare20 Cabot SquareLondon E144QW Wessex Institute University of SouthamptonAlpha HouseEnterprise RoadSouthampton Science ParkSouthamptonS0167NS 北京新世纪妇儿医院麻醉科

为何进行此项研究?院外心跳骤停通常是致死性的。2014年经英格兰急救医疗机构复苏约30000人次,成功率仅为8%。呼吸停止时维持气道通气的最佳方法尚不确定。维持通气措施包括基本的口对口人工呼吸或球囊面罩辅助技术,气管插管被视为高级... 详细信息

为何进行此项研究?院外心跳骤停通常是致死性的。2014年经英格兰急救医疗机构复苏约30000人次,成功率仅为8%。呼吸停止时维持气道通气的最佳方法尚不确定。维持通气措施包括基本的口对口人工呼吸或球囊面罩辅助技术,气管插管被视为高级呼吸辅助的处置标准,只有受过专业技术培训、经常应用的医护人员才能实施。

关键词：口对口人工呼吸呼吸停止急救医疗气道通气专业技术培训气管插管 NIH 辅助技术

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Bilateral Long Bone Fractures in a Patient with Sarcoid: A Case Report

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Open Journal of Orthopedics 2013年第1期3卷 49-52页

作者： Denosshan Sri George Tamvakopoulos rosie Guy Adrian Butler-Manuel QEII Hospital Welwyn Garden City UK 2Spire Sussex Hospital Hastings UK. QEII Hospital Welwyn Garden City United Kingdom 2Spire Sussex Hospital United Kingdom. Spire Sussex Hospital Hastings UK.

Although there have been many reports of small bone and vertebral involvement in sarcoidosis, long bone pathology is rare. We report a case of almost identical bilateral fractures of the proximal femoral diaphysis during separated in time through a low-energy mode of injury, and explore the difficulties encountered when seeking radiological and tissue diagnosis.

关键词： Sarcoidosis Osseous Sarcoidosis Bilateral Long Bone Fractures Alendronate Pathological Fractures

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The Boston lymphatic center’s early experience with lymph node transplantation to the upper extremity

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Plastic and Aesthetic Research 2022年第1期9卷 553-563页

作者： rosie Friedman Monica Morgenstern Valeria P.Bustos Aaron Fleishman Kathy Shillue Leo L.Tsai Jonathan F.Critchlow Dhruv Singhal Division of Plastic and Reconstructive Surgery Department of SurgeryBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA Division of Magnetic Resonance Imaging Department of RadiologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA Department of Surgery Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Aim:Although vascularized lymph node transplantation(VLNT)has gained recognition as an effective treatment option for lymphedema,no consensus on the timing of transplant with other lymphatic procedures has been *** aim of this study is to describe our institutional experience with VLNT,including our staged approach and report postoperative ***:A retrospective review of patients who underwent VLNT for upper extremity lymphedema from May 2017 to April 2022 was *** were divided into fat-or fluid-dominant phenotypes based on preoperative *** with a minimum of 12-month follow-up were *** were reviewed for demographic,intraoperative,and surveillance ***:Twenty-three patients underwent VLNT of the upper extremity during the study period,of which eighteen met the study *** patients had fluid-dominant disease and nine patients had fat-dominant disease and had undergone prior debulking at our ***-dominant patients demonstrated slight reductions in limb volume and hours in compression,and improvement in quality-of-life scores at twelve ***-dominant patients who underwent prior debulking had a slight increase in limb volume without a change in hours of compression,and demonstrated improvements in quality-of-life scores in nearly all ***,17% of patients discontinued compression therapy *** in extremity edema was present in 83% of postoperative ***:VLNT had varying effects on limb measurements while reliably improving quality-of-life and allowing for the potential of discontinuing *** a staged approach wherein debulking is performed upfront may be particularly beneficial for patients with fat-dominant disease.

关键词： Lymphedema vascularized lymph node transplant lymphatic surgery

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Cyberlife 1st ed.

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1994年

作者： Sams Publishing Joe Williams rosie Piga

来源：畅想之星图书光盘版（南... 评论

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柬埔寨：慢品千年吴哥滋味

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中国烹饪 2015年第9期 114-117页

作者： rosie

要懂柬埔寨，只知道现代史是不够的。妈妈小时候经常在电视上看到“欢迎西哈努克亲王”的场景，但这一次真正带她踏上这片神秘而古老的土地，我们都被吴哥王朝的魅力所折服。建成至今902年的吴哥城几近完好，战乱没有毁掉它，上天眷顾... 详细信息

要懂柬埔寨，只知道现代史是不够的。妈妈小时候经常在电视上看到“欢迎西哈努克亲王”的场景，但这一次真正带她踏上这片神秘而古老的土地，我们都被吴哥王朝的魅力所折服。建成至今902年的吴哥城几近完好，战乱没有毁掉它，上天眷顾，这里也不曾有天灾。就连我们喝到的棕糖水都是完全原始、带着腥味的味道，想象着一千年前的吴哥人，同我们一样用这简单的饮料解渴，穿越时光，大概就是如此。

关键词：柬埔寨滋味糖水味道腥味饮料

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计步器可以帮助人们在锻炼计划中变得更加主动积极

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英国医学杂志中文版 2020年第9期23卷 535-536页

作者： Rob Cook Peter Davidson rosie Martin 宁新惠(译) Bazian.Economist Intelligence Unit healthcare LondonUK Wessex Institute University of SouthamptonSouthamptonUK 北京市第六医院心内科

为什么需要做这项研究?2型糖尿病等代谢性疾病与超重、肥胖以及心血管疾病密切相关。管理以上疾病的第一步就是改善饮食习惯和增加体力活动。对于心血管病或代谢病患者来说,可穿戴技术的使用,正成为一种鼓励他们更加主动积极的颇受欢迎... 详细信息

为什么需要做这项研究?2型糖尿病等代谢性疾病与超重、肥胖以及心血管疾病密切相关。管理以上疾病的第一步就是改善饮食习惯和增加体力活动。对于心血管病或代谢病患者来说,可穿戴技术的使用,正成为一种鼓励他们更加主动积极的颇受欢迎的方法。

关键词：体力活动可穿戴技术心血管疾病饮食习惯心血管病代谢性疾病 2型糖尿病计步器

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