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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da costa Sousa Gabriela Conceiçao de Almeida danilo Cesar Martins Mota rosiane andrade da costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo daniel Pletzer Letícia Chaves de Souza Glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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Personalized medicine:Clinical oncology on molecular view of treatment

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World Journal of Clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick costa Dos Santos da Silva Nathalia de andrade Simon AndréAlves Dos Santos Gabriel De Melo Olegário Jayne Ferreira da Silva Naide Oliveira Sousa Manuel Alvarez Troncoso Corbacho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

Cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia Molecular biology Personalized medicine Molecular Markers Cancer

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Production, Detection and Cross-Reactivity of Anti-Polysaccharide Antibodies from Environmental Fungi

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Advances in Bioscience and Biotechnology 2014年第10期5卷 815-822页

作者： Rafael andrade Menolli Thais Soprani Ayala Pablo Rodrigo da Rosa Claudia Rejane Lima de Macedo costa Erica Fernanda Osaku rosiane G. Mello Zibetti Centro de Ciências Médicas e Farmacêuticas Universidade Estadual do Oeste do Paraná Cascavel Brasil Centro de Ciências Biológicas e da Saúde Universidade Estadual do Oeste do Paraná Cascavel Brasil Faculdades Pequeno Príncipe Curitiba Brasil

The diagnosis of Invasive Fungal Disease (IFD) is difficult because the sensitivity of conventional culture and cytology methods for the detection of Aspergillus is poor, and because serological methods exhibit cross-reactivity with environmental fungi. Fungal polysaccharides are of particular interest in the serologic diagnosis of IFD, especially galactomannan (GM) and glucan, which have been recognized as useful tools for the diagnosis of fungal infections. Further investigation into polysaccharide antibody cross-reactivity is important in improving diagnostic tests. Our aim was to verify the production of antibodies against fungal antigens in mice immunized with exopolysaccharides (EPS) obtained from three fungal species (Aspergillus terreus, Paecilomyces variotii and Curvularia brachyspora). ELISA assays were performed to evaluate homologous and heterologous reactions and showed anti-polysaccharide antibodies production. EPS from A. terreus was immunogenic enough to immunize the animal and lead to antibody production against this EPS. In addition, no cross-reactivity was observed with EPS obtained from P. variotii and C. brachyspora. The EPS from P. variotii did not exhibit good immunogenicity, whereas EPS from C. brachyspora showed good immunogenicity, and heterologous reactions were detected on the ELISA assays performed using the EPS from this species. The results indicate that immunization can occur for environmental fungal polysaccharides, generating antibodies may be interfere in serological diagnosis that are based on detection of fungal polysaccharides, mainly glucans and galactomannans.

关键词： Exopolysaccharides Environmental Fungi Immunization

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Fluid flow simulation of industrial fixed bed mixed-flow grain dryer using k-ω SST turbulence model

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International Journal of Agricultural and Biological Engineering 2021年第2期14卷 226-230页

作者： Anderson Rodrigo Visconcini Cid Marcos Gonçalves andrade Alexandre Marconi de Souza costa Post-graduation Department of Mechanical Engineering University of MaringáAv.Colombo3790-Bloco 14-Sala 2487020-900Maringá-PRBrazil

The fluid dynamics analysis on industrial,mixed-flow grain dryers with fixed bed using computational techniques is necessary to assist the design of such equipment contributing to cost reduction in the dryer projects and agricultural drying operations that involve the production of grains in the *** study presents a Computational Fluid Dynamic(CFD)solution for air flow analysis in an industrial *** air flow at the inlet and outlet of the dryer was investigated using the k-ωSST turbulence *** dryer region with soybean was considered as a laminar porous medium flow in the permanent and isothermal regime,having for the model a simplified geometry with the tower considered as a porous medium and the air inlet and outlet as a turbulent fluid *** flow was treated with a permanent and isothermal *** flow and pressures were used according to design *** validate the k-ωSST turbulence model,the velocity profile at the dryer inlet was obtained experimentally,which presented results with good agreement between the numerical and the experimental *** model obtained satisfactory results of the computational validation of the air flow in the dryer with good convergence requiring a minimum of computational effort,being suitable for the simulation of industrial-scale dryers,as to its air flow through a tower,operating with fixed bed soybean in the steady and isothermal regime.

关键词： computational methods fixed bed porous medium soybean dryer turbulent flow

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Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

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Contribution of inrush current to mechanical failure of power transformers windings

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High Voltage 2019年第4期4卷 300-307页

作者： Rafael M.R.Barros Edson Gda costa Jalberth F.Araujo Filipe L.Mde andrade Tarso V.Ferreira Department of Electrical Engineering Federal University of Campina GrandeAprigio Veloso St.882Campina GrandeBrazil

This work presents a study regarding the contribution of inrush current to the occurrence of mechanical fatigue in windings of a power transformer and,consequently,the impact of that phenomenon on the equipment's *** order to perform the study,electromagnetic transient simulations were used to determine the inrush current in a three-phase transformer ***,three-dimensional simulations,based on the finite element method,were performed to determine the electromechanical stresses in the equipment windings,under the effect of the inrush ***,the methods of critical plans and Palmgren–Miner were applied to perform the fatigue *** the results,the impact of inrush current on the integrity of the transformer's windings was determined,as well as,to estimate the reduction of lifespan of the equipment due to inrush *** number of inrushes needed for the total reduction of lifespan of the equipment due to mechanical fatigue was also *** results can be used in the transformers design stage,with the purpose of assisting the evaluation of mechanical withstand of equipment,which can minimise the possibility of failure and increase its lifespan.

关键词： winding fatigue power

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Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR

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World Journal of Gastroenterology 2009年第27期15卷 3411-3416页

作者： Maria Angela Bellomo-Brandao Paula D andrade Sandra CB costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel Department of Pediatrics Faculty of Medical Sciences State University of Campinas (UNICAMP)Campinas-SP 13083-970 Brazil Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP)Campinas-SP 13083-970 Brazil Department of Pathology Faculty of Medical Sciences State University of Campinas (UNICAMP) Campinas-SP 13083-970 Brazil Department of Pediatrics Children's Institute of Medical School of the University of So Paulo (USP) So Paulo-SP 05403-000 Brazil

AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these ***: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and ***: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low.

关键词： Cytomegalovirus Hepatitis Neonatal Cholestasis Liver Children Immunohistochemistry Polymerase chain reaction

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Thermal behaviour analysis in a porcelainhoused ZnO surge arrester by computer simulations and thermography

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High Voltage 2019年第3期4卷 173-177页

作者： Arthur F.andrade Edson G.costa Josué M.B.Fernandes Helem M.M.Alves Cícero R.C.Amorim Filho Centre of Electrical Engineering and Informatics Federal University of Campina GrandeCampina GrandeBrazil Department of Electrical Engineering Federal University of Campina GrandeCampina GrandeBrazil

In this article,an analysis of heat transfer in a porcelain-housed ZnO surge arrester is *** to the fact that ZnO-based surge arresters are key components for protection and reliability of electrical systems,it is necessary to seek techniques to assure correct *** porcelain-housed arresters,the air gap leads to an increased thermal resistance between the ambient and the varistor ***,a thermal analysis must consider convection and radiation heat transfer mechanisms,besides heat *** study proposes the use of computational simulations in combination with thermography as a tool for a temperature-based estimation of the varistor *** the analysis,temperature rise tests were performed in a 69-kV ceramic-housed arrester to measure material emissivity and produce data to fit the simulated ***,the thermal response of the surge arresters subject to an impulsive energy input was *** simulations allow to relate varistors temperature and housing temperature with regard to a specified amount of dissipated *** obtained results show that the used technique can be an effective method for arrester monitoring and may allow to define assessing criteria for a porcelain-housed arrester based on housing temperature measurements.

关键词： behaviour specified ambient

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Biochemical Changes of Cubiu Fruits (Solanum sessiliflorum Dunal, Solanaceae) According to Different Tissue Portions and Ripening Stages

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Food and Nutrition Sciences 2016年第12期7卷 1191-1219页

作者： Moacir Couto de andrade Júnior Jerusa Souza andrade Suely de Souza costa Post-Graduation Department Universidade Nilton Lins Manaus Brazil Department of Food Technology Instituto Nacional de Pesquisas da Amazonia (INPA) Manaus Brazil Department of Agricultural Sciences Instituto Nacional de Pesquisas da Amazonia (INPA) Manaus Brazil

Cubiu fruits (Solanum sessiliflorum Dunal, Solanaceae) are known for their high nutritional value and low caloric content. This work aimed at evaluating biochemical indices of cubiu fruits according to different tissues (peel, pulp and placenta) and ripening stages (green, turning, ripe and fully ripe). The fruits were randomly harvested to investigate sensory aspects (colorimetry, blanching effect, pigments) and biochemical indices (moisture and dry matter, Total Soluble Solids (TSS), pH, Titratable Acidity (TA), TSS/TA ratio, ascorbic acid, Alcohol-Insoluble Solids (AIS), pectinesterase activity and pectin content). The analyses were performed at the laboratory of Instituto Nacional de Pesquisas da Amazonia (INPA), Manaus, Brazil. The blanching process preserved pulp colors at all ripening stages. Chlorophylls were higher in green peels;flavonoids and carotenoids, in fully ripe peels. Anthocyanins were entirely absent. Pulp (turning fruits) showed the highest moisture content (91.05), followed by ripe pulp (90.70) and fully ripe pulp (90.62). Pulp TSS changed little whereas placenta TSS declined and were associated with increased TA and pH reduction (fully ripe fruits). Pulp pH and TA varied little whereas placenta pH was notably low and TA was remarkably high (fully ripe fruits). Pulp TSS/TA ratio showed predominance of TSS while in placenta, there was predominance of organic acids. AIS, precursors of pectin, were stable during ripening. The statistical analysis of dietary fiber content showed one modal value in the AIS. In pulp, pectinesterase activity correlated inversely with pectin content. Cubiu fruits were significant sources of bioactive compounds, e.g. chlorophylls, flavonoids and carotenoids, predominantly in the peel and the pulp;soluble functional fibers, e.g. pectin (g/100 g fresh weight), particularly in the green peel (1.00) and the fully ripe pulp (1.12), and other versatile molecules, e.g. ascorbic acid (mg/100 g fresh weight), especially in the f

关键词： Cocona Fruit Placenta Medicinal Plant Pectinesterase Activity Vitamin C

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Light intensity and hydrogel soil amendment differentially affect growth and photosynthesis of successional tree species

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Journal of Forestry Research 2023年第1期34卷 257-268页

作者： Léo Vieira Leonel Fabrício de Oliveira Reis Fábio Afonso Mazzei Moura de Assis Figueiredo Tiago Massi Ferraz Sebastiao de Oliveira Maia Júnior Patrick costa Silva Jailma Ribeiro de andrade Graduate Program in Agroecology State University of MaranhaoAv.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuísMaranhao 65055-310Brazil State University of Maranhao Av.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuísMaranhao 65055-310Brazil Graduate Program in Agriculture and Environment State University of MaranhaoPraca Goncalves Diass/nCentroBalsasMaranhao 65800-000Brazil

Global climate changes have increased temperatures,radiation indexes,and consequently,irregularities in rainfall in mainly tropical countries,considerably hindering plant establishment in recovering degraded *** objective of this study was to evaluate the growth and physiological characteristics of one species of each successional group:pioneer,secondary,and climax when subjected to different light intensities and hydrogel as a soil conditioner during rainy and dry *** experiment was conducted in the ecotone between Brazil’s two largest biomes,the Cerrado and the Amazon in the State of Maranh?*** parameters consisted of three species:Guazuma ulmifolia Lam.(pioneer),Astronium fraxinifolium Schott(secondary),and Cariniana rubra Gardner ex Miers(climax).There were two light intensities:70%and 100%,and two planting conditions:with and without soil conditioner(hydrogel).Gas exchanges were higher during the rainy season;the pioneer and secondary species had greater heights and photosynthetic rates in the dry period;the climax species had the lowest gas exchange and lowest recovery as rainfall *** pioneer and secondary species showed higher physiological plasticity,denoting better adaption to environments with high *** improved the photosynthetic performance of these species in the dry season and in areas with 100%sunlight.

关键词： Irradiance Hydrogel Photosynthetic efficiency Physiological plasticity

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