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Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

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Neural Regeneration Research 2023年第8期18卷 1691-1696页

作者： Paula M.Calvo rosendo g.hernández Rosa R.de la Cruz Angel M.Pastor Departamento de Fisiología Facultad de BiologíaUniversidad de SevillaSevillaSpain

Vascular endothelial growth factor(VEgF)was discovered by its angiogenic ***,during evolution,it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates lacking a circulatory *** aimed at reviewing recent evidence indicating that VEgF has neuroprotective effects in neurons exposed to a variety of *** particular interest is the link established between VEgF and motoneurons,especially after the design of the VEgFδ/δmutant *** mice are characterized by low levels of VEgF and develop muscle weakness and motoneuron degeneration resembling amyotrophic lateral *** administration of VEgF through several routes to animal models of amyotrophic lateral sclerosis delays motor impairment and motoneuron degeneration and increases life *** are new recent advances in the role of VEgF in the physiology of *** experimental aims use the extraocular(abducens)motoneurons lesioned by axotomy as a model for studying VEgF *** abducens motoneurons exhibit severe alterations in their discharge activity and a loss of synaptic *** exogenous administration of VEgF to axotomized abducens motoneurons,either from the transected nerve or intraventricularly,fully restores the synaptic and discharge properties of abducens motoneurons,despite being *** addition,when an anti-VEgF neutralizing antibody is delivered from the muscle to intact,uninjured abducens motoneurons,these cells display alterations in their discharge pattern and a loss of synaptic boutons that resemble the state of *** these data indicate that VEgF is an essential neurotrophic factor for motoneurons.

关键词： abducens nucleus amyotrophic lateral sclerosis cell death extracellular single-unit recordings eye movements neurodegeneration oculomotor trophic factors

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Estimation of Equivalent Model of Photovoltaic Array Using Unscented Kalman Filters

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 819-827页

作者： M.A.gonzález-Cagigal JoséA.rosendo-Macías A.gómez-Expósito the Department of Electrical Engineering University of SevilleSpainand A.Gómez-Expósito is also with ENGREEN Laboratory of Engineering for Energy and Environmental SustainabilitySevilleSpain

This paper proposes the use of the unscented Kalman filter to estimate the equivalent model of a photovoltaic(PV)array,using external measurements of current and voltage at the inverter *** estimated model is of interest to predict the power output of PV plants,in both planning and operation scenarios,and thus improves the efficient operation of power systems with high penetration of renewable *** proposed technique has been assessed in several simulated scenarios under different operating *** results show that accurate estimates are provided for the model parameters,even in the presence of measurement noise and abrupt variations under the external conditions.

关键词： Equivalent model parameter estimation photovoltaic energy unscented Kalman filter

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Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the Quality of Soursop (Annona muricata L.) Fruit

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo Ángel Elpidio Díaz-Jasso rosendo Balois-Morales Verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-Consejo Nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSJ),Mitogen-activated protein kinase YODA(YODA_ARATH),R-man-delonitrile lyase-like(MgL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSJ)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

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Social determinants of gastrointestinal malformation mortality in Brazil:a national study

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World Journal of Pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla gerk Amanda rosendo Luiza Telles Aricia gomes Miranda Madeleine Carroll Bruna Oliveira Trindade Sarah Bueno Motter Esther Freire gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira David P Mooney Joaquim Bustorff-Silva Program in global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of Medicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of Pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação Médica(IDOMED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of Medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research Methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital disorder,potentially fatal without *** study aims to evaluate the relationship between gastrointestinal congenital malformation(gICM)mortality,health indicators,and socioeconomic factors in *** gICM admissions(Q39-Q45)between 2012 and 2019 were collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare workforce density were also accounted *** Surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed'NeoSurg'.Socioeconomic variables were combined to create a socioeconomic index termed SocEcon'.Simple linear regression was used to investigate if the temporal changes of both indexes were *** correlation between mortality and the different indicators in Brazil was evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 gICM *** Southeast led with 6147 cases,followed by the Northeast(2660),South(1727),North(1427),and Midwest(843).The North and Northeast reported the highest mortality,lowest NeoSurg,and SocEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and Midwest experienced the most substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(pghlights the correlation between social determinants of health and gICM mortality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

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Lineament analysis as a seismic precursor:The El Mayor Cucapah earthquake of April 4,2010(MW7.2),Baja California,Mexico

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geodesy and geodynamics 2023年第2期14卷 121-129页

作者： rosendo Romero-Andrade Manuel E.Trejo-Soto Karan Nayak Daniel hernández-Andrade Naccieli Bojorquez-Pacheco Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacan RosalesSinaloaMexico

An earthquake called the MW7.2“El Mayor Cucapah”earthquake on April 4,2010 has been analyzed for seismic *** changes in the lineament system concerning its pattern and time intervals were analyzed during the earthquake preparation period and occurrence using the automated lineament detection *** Landsat 5 TM images were processed using LESSA and ADALgEO software obtaining similar *** statistical analysis revealed the stress accumulation due to plate interaction during earthquake *** study shows that the number of extracted lineaments changes rapidly about 23 months before the earthquake,and the systems return to the initial stage after 23 *** lineaments coincide with the extension of the San Andreas Fault as NW direction is the dominant ***,it can be concluded that the featural changes within the Rose diagram corresponding to the different strokes direction along with oriented elongation lines as disclosed in the present study using satellite images could be identified as a mid-term and/or short-term precursors of the ***,even though the dynamism of the El Mayor Cucapah earthquake is found in the extracted lineaments,it is possible to isolate more significant earthquakes even if new ones appear near the ***,using two algorithms for lineament detection allows for the tectonics to corroborate the obtained lineaments and dynamism.

关键词： Lineament analysis Earthquake Landsat images Seismic precursor

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Quality assessment of Continuous Operating Reference Stations(CORS)-gPS stations in Mexico

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geodesy and geodynamics 2022年第3期13卷 275-287页

作者： Daniel hernández-Andrade rosendo Romero-Andrade gopal Sharma Manuel E.Trejo-Soto Juan L.Cabanillas-Zavala Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacán RosalesSinaloaMexico North Eastern Space Applications Centre Umiam793103MeghalayaIndia

The present analysis provided the quality assessment of 65 Continuous Operating Reference Stations(CORS) situated in and around Mexico using the data of about ten years(January 2010 to January 2020).To accomplish the assessment,we considered 4 quality indexes for performing the quality check,incluing the multipath effect on L1 and L2 bands,signal-to-noise ratio in both bands,cycle slips,and ***,a new reference parameter named regio nal values for Mexico(RVM) was calculated for the stations situated in ***,an exhaustive analysis of the quality indicators in the worst and best cases was *** signal degradation was proved by a long-term time series and cru stal defo rmation analysis in gAMIT/gLOBK *** results showed a stro ng correlation between integrity,cycle slips and daily observations time,and the multipath effect is strong in the case of outdated *** study indicates that the estimated quality indexes and values could be the basis for establishing new CORS in Mexico,and the errors corrections which cannot be mitigated in the postprocessing stage would greatly help utilize the data for different scientific *** results were supported by deformation analysis in part of Baja California Peninsula in Mexico indicating northern and eastern velocity vector of -3.08±0.02 mm/yr,-7.85±0.02 mm/yr and-0.07±0.03 mm/yr,-9.33±0.02 mm/yr respectively at MPR1 and INEg stations.

关键词： Multipath effect Signal-to-Noise ratio Cycle slip Integrity Regional quality indicators IgS indicators

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Parameter Estimation for Hot-spot Thermal Model of Power Transformers Using Unscented Kalman Filters

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 634-642页

作者： MiguelÁngel gonzález-Cagigal JoséAntonio rosendo-Macías Antonio gómez-Expósito Department of Electrical Engineering University of SevilleSevilleSpain ENgREEN Laboratory of Engineering for Energy and Environmental Sustainability SevilleSpain

This paper presents a parameter estimation technique for the hot-spot thermal model of power *** proposed technique is based on the unscented formulation of the Kalman filter,jointly considering the state variables and parameters of the dynamic thermal model.A two-stage estimation technique that takes advantage of different loading conditions is developed,in order to increase the number of parameters which can be *** results are presented,which show that the observable parameters are estimated with an error of less than 3%.The parameter estimation procedure is mainly intended for factory testing,allowing the manufacturer to enhance the thermal model of power transformers and,therefore,its customers to increase the lifetime of these *** proposed technique could be additionally considered in field applications if the necessary temperature measurements are available.

关键词： Parameter estimation power transformer unscented Kalman filter thermal model

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Atmospheric-pressure dielectric barrier discharge generation by a full-bridge flying capacitor multilevel inverter

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Plasma Science and Technology 2017年第7期19卷 40-49页

作者： rosendo PE?A-EgUILUZ José A LóPEZ-FERNández Antonio MERCADO-CABRERA Bethsabet JARAMILLO-SIERRA Régulo LóPEZ-CALLEJAS Benjamín RODRígUEZ-Méndez Raúl VALENCIA-ALVARADO Allan A FLORES-FUENTES Arturo E MU?OZ-CASTRO Plasma Physics Laboratory Instituto Nacional de Investigaciones Nucleares Tecnológico de Estudios Superiores de Tianguistenco Universidad Autónoma del Estado de México

A new configuration of a resonant full-bridge flying capacitor multicell inverter has been designed and constructed with the aim of achieving an extended output voltage frequency range with low harmonic distortion and reduced semiconductor commutation losses. This configuration was tested as a power supply for two different coaxial dielectric barrier discharge reactors, one of them employed for electric characterization and the other one for inorganic compound elimination in an aqueous solution. Two different gas mixtures, 90% Ar-10% 02 and 80% Ar-20% 02, were individually supplied during the experiments; the results showed a high- efficiency removal of meta-cresol （m-cresol） to the order of 98%, which was obtained by adding more oxygen to the plasma gas mixture.

关键词： plasma applications water pollution plasma sources power supply circuits electricdischarges

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Novel electrode structure in a DBD reactor applied to the degradation of phenol in aqueous solution

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Plasma Science and Technology 2017年第7期19卷 71-84页

作者： Antonio MERCADO-CABRERA rosendo PE?A-EgUILUZ Régulo LóPEZ-CALLEJAS Bethsabet JARAMILLO-SIERRA Raúl VALENCIA-ALVARADO Benjamín RODRígUEZ-Méndez Arturo E MU?OZ-CASTRO Instituto Nacional de Investigaciones Nucleares Plasma Physics Laboratory Tecnológico de Estudios Superiores de Tianguistenco

Phenol degradation experimental results are presented in a similar wastewater aqueous solution using a non-thermal plasma reactor in a coaxial dielectric barrier discharge. The novelty of the work is that one of the electrodes of the reactor has the shape of a hollow screw which shows an enhanced efficiency compared with a traditional smooth structure. The experimentation was carried out with gas mixtures of 90% Ar-10% O2, 80% At-20% 02 and 0% Ar-100% 02. After one hour of treatment the removal efficiency was 76%, 92%, and 97%, respectively, assessed with a gas chromatographic mass spectrometry technique. For both reactors used, the ozone concentration was measured. The screw electrode required less energy, for all gas mixtures, than the smooth electrode, to maintain the same ozone concentration. On the other hand, it was also observed that in both electrodes the electrical conductivity of the solution changed slightly from ,-0.0115 S m^-1 up to -0.0430 S m^-1 after one hour of treatment. The advantages of using the hollow screw electrode structure compared with the smooth electrode were：（1） lower typical power consumption, （2） the generation of a uniform plasma throughout the reactor benefiting the phenol degradation, （3） a relatively lower temperature of the aqueous solution during the process, and （4） the plasma generation length is larger.

关键词： DBD gas discharges removal organic compounds discharge in liquids

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Evaluation of the regional distribution of the pediatric surgery workforce and surgical load in Brazil

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World Journal of Pediatric Surgery 2023年第2期6卷 85-91页

作者： Joaquim Bustorff-Silva Marcio Lopes Miranda Amanda rosendo Ayla gerk Antonio goncalves Oliveira-filho Pediatric Surgery State University of Campinas Medical SchoolCampinasBrazilPediatric SurgeryState University of Campinas Medical SchoolCampinasBrazil Medicine Pontificia Universidad Católica ArgentinaBuenos AiresArgentina

Objective The purpose of this study is to examine the regional distribution of the pediatric surgery workforce and the expected local demand for pediatric surgical procedures in *** We collected data on the pediatric surgical workforce,surgical volume,gross Domestic Product per capita,and mortality for gastrointestinal tract malformations(MgITM)across the different regions of Brazil for *** Data from the Federal Medical Council reported 1515 pediatric surgery registries in Brazil,corresponding to 1414 pediatric surgeons(some pediatric surgeons are registered in more than one state),or 2.4 pediatric surgeons per 100000 children 14 years of age and *** were 828 men and 586 *** mean age was 51.5±12.8 years,and the mean time from graduation was 3.4±5.7 *** is a higher concentration of pediatric surgeons in the wealthier Central-West,South,and Southeast *** surgical volume ranged from 88 to 245 operations/year(average 146 operations/year)depending on the *** these,only nine(6.1%)were high-complexity(including neonatal)*** tended to be higher in the poorer North and Northeast regions than in other regions of *** Our findings suggest significant disparities in the surgical workforce and workload across Brazil related to socioeconomic *** with an increased surgical workforce were associated with lower *** average number of complex operations performed annually by each pediatric surgeon was considerably *** investment and well-defined health policies are imperative to enhance the quality of surgical care in the different regions of Brazil.

关键词： pediatric operations distribution

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