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Covid-19 Vaccine Effectiveness in New York state

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四川生理科学杂志 2021年第10期43卷 1709-1709页

作者： Eli s rosenberg From the New York state Department of Health Albany (E.S.R. V.D. D.E. U.E.B. J.K. R.H. D.H. M.W. E.L. M.B.C. D.G. H.A.Z.) and the University at Albany School of Public Health State University of New York Rensselaer (E.S.R. E.L.) — both in New York.

Background:Population-based data from the United states on the effectiveness of the three coronavirus disease 2019(Covid19)vaccines currently authorized by the Food and Drug Administration are *** declines in effectiveness are due to waning immunity,the B.1.617.2(delta)variant of the severe acute respiratory syndrome coronavirus 2(sARs-CoV-2),or other causes is ***:We used data for 8,690,825 adults in New York state to assess the effectiveness of the BNT162b2,mRNA-1273,and ***2.s vaccines against laboratory-confirmed Covid-19 and hospitalization with Covid-19(i.e.,Covid-19 diagnosed at or after admission).We compared cohorts defined according to vaccine product received,age,and month of full vaccination with age-specific unvaccinated cohorts by linking statewide testing,hospital,and vaccine registry *** assessed vaccine effectiveness against Covid-19 from May 1 through september 3,2021,and against hospitalization with Covid-19 from May 1 through August 31,2021.

关键词： vaccine immunity acute

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白细胞介素-2用于肿瘤免疫疗法的最新近展

国际骨科学杂志 1989年第2期26卷 74-77页

作者： rosenberg s 刘绍魁

本文论述白细胞介素-2在免疫疗法中的作用。临床研究表明,大剂量白细胞介素-2或与LAK联合应用对治疗晚期肿瘤有效。

关键词：肿瘤免疫疗法白细胞介素近展晚期肿瘤细胞亚群剂量比免疫反应毒性反应肺转移实验动物模型

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IL-2对癌的免疫治疗:现状和未来展望

国外医学（免疫学分册） 1989年第1期12卷 35-38页

作者： rosenberg s A 刘玉欣

由于细胞免疫学和DNA 重组技术二个领域的快速发展人类癌的有效免疫治疗有了新的可能性。鉴于细胞免疫系统在组织排斥中的重要地位、淋巴因子在免疫调节中的作用、MHC 约束和非约束性细胞溶解的特征和淋巴因子及生长因子的分离,遗传修... 详细信息

由于细胞免疫学和DNA 重组技术二个领域的快速发展人类癌的有效免疫治疗有了新的可能性。鉴于细胞免疫系统在组织排斥中的重要地位、淋巴因子在免疫调节中的作用、MHC 约束和非约束性细胞溶解的特征和淋巴因子及生长因子的分离,遗传修饰、表达和纯化使得人们有更多可选择的途径去刺激带瘤宿主的抗肿瘤免疫反应。

关键词：癌症免疫疗法白细胞介素2

抗疟药物氯奎、阿的平、四氢-9-氨基(口了)啶与双链小牛胸腺DNA的结合

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生物化学杂志 1989年第6期5卷 549-554页

作者： stephen G.schulman Leonard s.rosenberg 佛罗里达大学药学院美国佛罗里达盖恩斯维尔

本文用体相微量量热计所得数据,估算了两种抗疟药物(antimalarial)分子和两种结构上相似的分子与DNA结合时的标准结合热焓。根据在不同离子强度下测定的表观结合常数获得了热力学结合常数。根据这些数据以及标准结合热焓计算出标准结合... 详细信息

本文用体相微量量热计所得数据,估算了两种抗疟药物(antimalarial)分子和两种结构上相似的分子与DNA结合时的标准结合热焓。根据在不同离子强度下测定的表观结合常数获得了热力学结合常数。根据这些数据以及标准结合热焓计算出标准结合自由能、标准结合熵。结果发现凡与DNA结合的分子,具有线性芳环结构的,结合时主要取决于热焓的大小。具有脂肪链或脂肪环结构的,结合时主要取决于熵变。

关键词：抗疟药物胸腺DNA 结合熵

Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis

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World Journal of Gastroenterology 2008年第11期14卷 1774-1780页

作者： Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli s rosenberg Kirk A Easley Frank A Anania Robin E Rutherford Division of Digestive Diseases Emory UniversityAtlanta GeorgiaUnited States Department of Internal Medicine Emory UniversityAtlantaGeorgiaUnited States Department of Biostatistics-Rollins school of Public Health Emory UniversityAtlanta GeorgiaUnited States

AIM： To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh （CTP） and model for end-stage liver disease （MELD） score to predict that outcome. METHODs： We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period. The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. REsULTs： Patients who reached the endpoint had a higher MELD score, a higher CTP score and were more likely to have undergone an urgent procedure. Among patients undergoing elective surgical procedures, no statistically significant difference was noted in the mean MELD （12.8 ＋ 3.9 vs 12.6 ＋ 4.7, P = 0.9） or in the mean CTP （7.6 ± 1.2 vs 7.7 ± 1.7, P = 0.8） between patients who reached the endpoint and those who did not. Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures （MELD： 22.4 ± 8.7 vs 15.2 ± 6.4, P = 0.0007; CTP： 9.9 ± 1.8 vs 8.5 ± 1.8, P = 0.008）. The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair, without a significant difference between them （AUC = 0.755 ± 0.066 for MELD vs AUC = 0.696 ± 0.070 for CTP, P = 0.3）. CONCLUsION： The CTP and MELD scores performed equally, but only fairly in predicting the outcome of urgent surgical procedures. Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with ***, but only fairly in predicting the outcome of urgent surgical procedures. Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis.

关键词： Liver cirrhosis Prognosis severity of illness index surgical procedures Operative Postoperative complications

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新一代航天器推进用高性能发动机

控制工程 1993年第3期 54-61+34页

作者： s.rosenberg L.schoenman 殷书平

一种新型的高性能可贮存双组元推进剂发动机的技术准备工作已经在三种不同的推力级上得到论证。经改进的高温材料和燃烧室设计可以在不牺牲脉冲占空比灵活性条件下免除燃料膜冷却,及与之相连的污染和性能损失。与使用二硅化物涂层的现... 详细信息

一种新型的高性能可贮存双组元推进剂发动机的技术准备工作已经在三种不同的推力级上得到论证。经改进的高温材料和燃烧室设计可以在不牺牲脉冲占空比灵活性条件下免除燃料膜冷却,及与之相连的污染和性能损失。与使用二硅化物涂层的现有铌燃烧室发动机设计相比较,以铼为基的燃烧室材料将允许工作温度提高到2204℃(4000℉)。用于喷注器、燃烧室和大面积比裙的不同材料间焊接的相应技术也已得到论证,并且已引入飞行型发动机设计中。本文讨论了5-,15-和100-Lbf 推力3种发动机的性能和寿命特性。5-和15-Lbf 推力发动机能够在面积比为150:1的情况下提供超过310Lbf/Lbm 的稳态比冲和优良的脉冲性能。100-Lbf 推力发动机在面积比为250:1的情况下提供320Lbf-sec/Lbm 的稳态比冲。

关键词：双组元推进剂面积比喷注器发动机燃烧室热风炉比冲比推力

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恶性淋巴瘤治疗的进展

中国肿瘤临床 1987年第3期 169-172页

作者： s·rosenberg stanford大学医学院教授

分两部分,一、何杰金淋巴瘤(简称HD)的治疗,二、非何杰金淋巴瘤(简称NHL)的治疗。根据stanford大学医学中心,加利福利亚州和苏格兰三处治疗恶性淋巴瘤的材料概括介绍。

关键词：淋巴瘤低度恶性 NHL 淋巴结外

Impact of social Determinants of Health on self-Perceived Resilience: An Exploratory study of Two Cohorts of Adults with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 33-48页

作者： Albert Osom Krysta s.Barton Katie sexton Lyndia Brumback Joyce P.Yi-Frazier Abby R.rosenberg Ruth Engelberg Jill M.steiner Department of Biostatistics University of WashingtonSeattleWA98195USA Biostatistics Epidemiology and Analytics for Research(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of Medicine University of WashingtonSeattleWA98195USA Center for Clinical and Translational Research Seattle Children’s Research InstituteSeattleWA98101USA Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Division of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Division of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

social determinants of health(sDOH)affect quality of *** investigated sDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).secondary analysis of data from two com-plementary studies:a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August *** was assessed through CD-RIsC10 score(range 0–40,higher scores reﬂect greater self-perceived resilience)and interview *** and sDOH(education,employment,living situa-tion,monetary stability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and *** used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview *** participants(N=127)mean age was 42±14 years;51%were female,87%*** was moderate(75%)or complex(25%);41%functional class C or ***(mean 30±7)varied by monetary stability:compared to people with difﬁculty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,ps higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough *** participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%*** was moderate(56%)or complex(44%);76%functional class C or *** discussed factors affecting resilience aligned with each of the major sDOH,prominently,economic stability and healthcare access and *** stability may be important for supporting self-perceived resi-lience in *** knowledge can inform the development of resilience interventions for this population.

关键词： social determinants of health adult congenital heart disease resilience ﬁnancial stability

联合应用自身LAK细胞和重组IL-2治疗转移癌

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国际肿瘤学杂志 1986年第5期13卷 297-299页

作者： rosenberg s A ,王山鸣

过继性免疫疗法是指将抗肿瘤活性细胞输入荷瘤宿主中,直接或间接消除所建立的肿瘤。在一些选择性动物模型中,过继性疗法可导致已形成的原发癌和转移癌消退,但由于难以得到大量具有特异抗肿瘤活性的人体自身细胞,因此这方法很难用于人类... 详细信息

过继性免疫疗法是指将抗肿瘤活性细胞输入荷瘤宿主中,直接或间接消除所建立的肿瘤。在一些选择性动物模型中,过继性疗法可导致已形成的原发癌和转移癌消退,但由于难以得到大量具有特异抗肿瘤活性的人体自身细胞,因此这方法很难用于人类肿瘤的治

关键词： LAK 细胞 IL-2 联合应用治疗后转移癌