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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： rosemary Arnold Jenifer Murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

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Screening of Rodents from Rural Communities of Lagos and Ogun State Nigeria of Lassa Virus RNA

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Open Journal of Medical Microbiology 2024年第2期14卷 120-130页

作者： Fatai Sarafa Emmanuel Tochukwu Onyeje Joseph Ojonugwa Shaibu Olumuyiwa Babalola Salu rosemary Ajuma Audu Sunday Aremu Omilabu Department of Medical Microbiology and Parasitology College of Medicine University of Lagos Lagos Nigeria Centre for Human Virology and Genomics Research Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Human and Zoonotic Virology Central Research Laboratory and Department of Medical Microbiology and Parasitology College of Medicine University of Lagos Lagos Nigeria

Background: In recent times, there has been an increase in the number of Lassa fever cases resulting from the several episodes of Lassa fever epidemics ravaging Nigeria and other West African countries. The presence of Lassa virus in rodents other than the major reservoir (Mastomys natalensis) has been a public health concern as to the actual burden of the disease. It is therefore of a public health necessity to explore the LASV RNA habouring potential of several species of rodents in endemic as well as non-endemic areas for proper prevention of emergence of outbreaks in non-endemic areas. Objectives: The aim of this study was to detect the presence of LASV RNA in different species of rodents in Ikorodu, Lagos state and Abeokuta, Ogun state. Methods: A total of ninety one (91) rodents were captured from Ikorodu, Lagos State (61 rodents) and Abeokuta, Ogun State (30 rodents), euthanized, bled, and plasma obtained for the detection of LASV RNA by Reverse Transcriptase Polymerase Chain Reaction. Results: A total of 91 rodents consisting of 77 Rattus rattus and 14 Crocidura spp. The S segment of LASV RNA was not in any of the 91 rodents’ plasma samples. Conclusion: The rodents captured within the rural communities of Ikorodu, Lagos State and Abeokuta, Ogun State were found not to habour the LASV RNA. This study is limited by the relatively small sample size. Similar studies should be encouraged both in endemic and non-endemic areas in order to understand the actual burden of Lassa fever as well as put into check future epidemics.

关键词： Lassa Virus Lassa Fever Mastomys natalensis Transmission Lagos State Ogun State

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Using intersectional gender analysis to identify challenges in tuberculosis care at four health care facilities in Uganda

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Infectious Diseases of Poverty 2024年第1期13卷 91-91页

作者： Winters Muttamba Samson Omongot Irene Najingo Roseline Nuwarinda Esther Buregyeya Mariam Otmani del Barrio rosemary Morgan Bruce Kirenga Sarah Ssali Makerere University Lung Institute Makerere University Kampala Uganda Division of Infection and Global Health School of Medicine University of St Andrews St. Andrews UK Infectious Disease Institute Makerere University Kampala Uganda School of Public Health Makerere University Kampala Uganda UNICEF UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) World Health Organization Geneva Switzerland Johns Hopkins Bloomberg School of Public Health Baltimore MD USA School of Women and Gender Studies Makerere University Kampala Uganda

Background Tuberculosis(TB)care could be considered as a continuum from symptom recognition,decision to seek care,diagnosis,treatment initiation and treatment completion,with care along the continuum influenced by several *** dimensions could influence TB care,and indeed,more men than women are diagnosed with TB each *** study was done to identify social stratifiers that intersect with gender to influence TB *** A cross-sectional qualitative study was done at four health facilities in 3 districts in central Uganda between October 2020 and December *** was collected from patients seeking a diagnosis or on TB treat-ment through focus group discussions and key informant *** themes around gender guided by a gender and intersectionality lens were developed and thereafter thematic content analysis was *** Women have increased vulnerability to TB due to bio mass exposure through roles like *** have increased access to health care services as they interface with the health care system frequently given their role as child bearers and child care *** have a duty to provide for their families and this most often is prioritised over healthcare seeking,and together with belief that they are powerful beings leads to poor healthcare seeking hab-its and delays in healthcare *** on when and where to seek care were not straightforward for women,who most often rely on their husbands/partners to make *** Men and women experience challenges to TB care,and that these challenges are deeply rooted in roles assigned to them and further compounded by *** challenges need to be addressed through intersec-tional gender responsive interventions if TB control is to be improved.

关键词： Tuberculosis Gender Intersectionality Masculinity

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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染患者时安全有效

12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染...

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第十届全国疑难及重症肝病大会

作者： Kathleen B.Schwarz Philip Rosenthal Karen F.Murray Jonathan Robert Honegger Winita Hardikar rosemary hague Naveen Mittal Benedetta Massetto Diana Brainard Rebecca Begley Bandita Parhy Jiang Shao Michael R.Narkewicz Girish S.Rao Suzanne Whitworth Sanjay Bansal William F.Balistreri Johns Hopkins Hospital University of California San Francisco University of Washington School of Medicine and Seattle Children's Hospital The Ohio State University Medical Center The Royal Children's Hospital

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC...

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC)用于6至<12岁的患者中时的数据,其SVR12率分别为99%-100%。本研究评估了全口服LDV/SOF FDC疗法用于3至<6岁

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SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias rosemary E Faulkes Rachel Brown Owen Cain M Thamara P R Perera Keith J Roberts Rebeca Sanabria-Mateos David C Bartlett Yuk Ting Ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby V M Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SIMAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SIMAP500 risk score is *** SIMAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the RETREAT score(c-index=0.73).SIMAP500 is indicative of the time to disease *** SIMAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

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Valorization of the agro-industrial by-products of bacupari(Garcinia brasiliensis(Mart.))through production of flour with bioactive properties

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Food Bioscience 2022年第1期45卷 377-385页

作者： Anely Maciel de Melo Rafaela Cristina Turola Barbi Bruno Patrício Costa Mˆonica Ikeda Danielle Carpine rosemary Hoffmann Ribani Food Engineering Graduate Program Federal University of ParanaDepartment of Chemical Engineering81531-990CuritibaPRBrazil

Brazil has a wide variety of fruits that remain insufficiently *** encourage the use of one such fruit,the bacupari((Garcinia brasiliensis(Mart.)),the current study produced flours from its by-products(the peel and seed)at two maturation stages and subsequently evaluated their proximate composition,physical,antioxidant,bioactive,microstructural and thermal *** results revealed that the flours have a high in fiber content(>15%)and are a potential source of protein(>5%).Seed flour has an energy value similar to that of wheat flour and other conventional *** flour micrographs indicate the presence of starch,a fact confirmed by viscosity *** flours contain phenolic compounds and exhibit antioxidant activity,especially the unripe peel *** the compounds identified by chromatography,those present in the greatest concentrations were quinine(≅111μg/g),p-coumaric acid(≅25μg/g),m-coumaric acid(≅15μg/g),and formononetin(≅21μg/g),all of which are known to have several human health *** flour crystallinity diminished as the fruit *** flour exhibited similar thermal transitions but less thermal stability than seed *** summary,this study revealed that flours produced from the peel and seeds of bacupari,which are generated in large quantities as agro-industrial by-products,can be used as alternative ingredients in various sectors of the food industry.

关键词： Antioxidant activity Bacupari fruit Seed Peel Phenolic compounds

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Coming of Age in America rosemary

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当代外语研究 1998年第8期 27-30页

作者： rosemary Adang

rosemary, Glad to read your answers to the questions raised by the readers across China！Mydaughter is now in the *** wrote home an email a *** her email hasbeen a great pleasure fot my *** is her latest message sent ... 详细信息

关键词： Coming of Age in America rosemary

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America's Love-Hate Relation-ship with Its Lawyers rosemary Adang

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当代外语研究 1998年第10期 34-36页

作者： rosemary Adang

Hi American Professor, I’m a law student in China. In association with my field of study, I’d like toshare with you some of my reflections on the current situation here: China hasbeen constructing its legal system since the 1949 liberation and is now adapting itinto the new market economy. Once almost unheard of , the hiring of an

关键词： America’s Love-Hate Relation-ship with Its Lawyers rosemary Adang

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Relationship between Serum Leptin and Adiponectin Levels in Obese Nigerians with Type 2 Diabetes Subjects

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Journal of Diabetes Mellitus 2023年第3期13卷 248-256页

作者： rosemary Temidayo Ikem Ugochukwu rosemary Mosanya Gbadebo Oladimeji David Ajani Okechukwu Obumneme Ezekpo David Olubukunmi Soyoye Department of Medicine Obafemi Awolowo University Ile Ife Nigeria Department of Orthopaedic Surgery & Traumatology Obafemi Awolowo University Teaching Hospitals Complex Ile Ife Nigeria Department of Medicine Afe Babalola University Ado Ekiti & Federal Medical Teaching Hospital Ido Ekiti Nigeria Department of Medicine Afe Babalola University & Multi-System Hospital Ado Ekiti Nigeria

Background: Obesity is rising globally, independent of ethnicity, race and age, and is associated with increased risk of cardiovascular mortality and morbidity especially in persons living with diabetes. The effect of adipokines such as leptin, resistin and adiponectin which are secreted by adipose tissue factors has been linked to the increased risk of the cardiovascular mortality and morbidity. Aim: This study aims to assess the levels of serum leptin and serum adiponectin in obese type 2 diabetes subjects, and their relationship with cardio-metabolic component (using lipid profile). Method: This is a cross-sectional comparative hospital-based study in which one hundred and fifty participants grouped into 60 obese, 60 non-obese none diabetic and 30 non-obese non-diabetic adults with similar age from the Endocrinology outpatient’s clinic, General outpatient department (GOPD) and staff clinic of Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). Anthropometric parameters and other relevant clinical details of all subjects were obtained. Fasting venous blood samples were taken from all subjects for the determination of fasting plasma glucose (FPG), fasting lipid profile, glycosylated haemoglobin levels (HbA1C), fasting serum insulin, leptin, and adiponectin. Data was analysed using the Statistical Package of Social Sciences (SPSS) version 23.0. Results: Twenty-eight (46.7%)) subjects were males while 32 subjects (53.3%) were females (in obese groups). There was no statistical difference between these two groups for both sexes (p = 1.000). The age range for all subjects was 34 to 64 years with their mean age being 52 ± 7.3 years, and for type 2 subjects and the obese non-diabetic 50.7 ± 7.3 years respectively. The mean body mass index of the non-obese and non-diabetic was 23.7 ± 4 Kg/m2 while the anthropometric measurements of the obese two groups were similar. The lipid profile, serum leptin and adiponectin in both the obese groups

关键词： Obesity Type 2 DM Leptin Adipokines

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Shanghai and New York:Mid-Century Urban Avant-Gardes

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Built Heritage 2019年第3期3卷 49-61页

作者： rosemary Wakeman History Department&Urban Studies Program Fordham UniversityNew YorkUnited States

This article examines the cultural and architectural exchanges between Shanghai and New York in the mid-20^(th) century and their iconic roles as avant-garde global *** considers the cultural and architectural free-thinkers and the groundbreaking movements they led,as well as their influence on the character and identity of both *** Deco was the emblematic symbol of these modern *** article analyses the new technologies and theatrical perspective,the performative and spectacular qualities of Art Deco as the signature styles and cultural heritage of both cities.

关键词： Art Deco New York avant-garde Radio City Music Hall Park Hotel lighting design technology Cathay Cinema cityscape film

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