检索结果-南通市图书馆

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Women in visual neural regeneration research

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Performance enhancement of futuristic airplanes by nature inspired biomimetic fish scale arrays--A design approach

在线全文

学校读者我要写书评

暂无评论

Biomimetic Intelligence & Robotics 2022年第2期2卷 32-47页

作者： Ganesh Natarajan S Bruce Ralphin rose j Department of Mechanical Engineering Anna University Regional Campus TirunelveliTamilnaduIndia

Biomimetics has an immense potential to drive the next generation of technologies forward by propounding competent solutions from *** decades,the nonsmooth topography of most living creatures has been critical to their existence and *** to human-made smooth surfaces,when adapted for fluid flow applications,nonsmooth surfaces can enhance the overall aerodynamic performance by reducing the drag ***,the bioinspired scale structure of fish has been identified as a key biomimetic derivative for improving the aerodynamic efficiency in various cross-domain *** study investigates the aerodynamics of a fish scale array(FSA)NACA 0021 model at a specific Reynolds number(Re)of approximately 2.46×105 that is meant for laminar flow conditions using Computational Fluid Dynamics(CFD)tools and a subsonic wind tunnel facility.A 3D printed biomimetic FSA film is developed and affixed on the NACA 0021 wing profile for the experimental investigation,followed by flow visualization through the smoke tunnel *** proved qualitatively under specific aerodynamic conditions,the creation of velocity streaks has a major role in the drag reduction *** obtain a clear perspective of flow across the overlapping fish scale structures,the results are focused on the central and overlapping regions of the FSA *** experiment has proved the existence of a combined formation of low and high velocity streaks in central and overlapping *** FSA 0021 model showed a maximum drag reduction of 9.57%,which was attributed to the streak formation phenomenon observed in the overlapping FSA configuration.

关键词： Biomimetics Aerodynamics Fish scale arrays Drag reduction Bioinspired design

Dynamic stability characterization of re-entry modules at hypersonic mach numbers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Modeling, Simulation, and Scientific Computing 2017年第1期8卷 153-164页

作者： j.Vinoth j.Bruce Ralphin rose Department of Aeronautical Engineering Regional Campus Anna UniversityTirunelveli Tamil Nadu 627007India

At the time of re-entry modules entering into the atmosphere from space,a small perturbation introduces dynamic oscillations on the vehicle because of their extreme traveling *** dynamic stability characteristics of re-entry modules at hypersonic Mach numbers is of considerable relevance to their initial *** the present paper,the dynamic stability of blunt cone model about 10◦is examined with wide range of design parameters such as nose bluntness,semi-vertex angle and center of rotation through theoretical and experimental *** approximations are made over a model based on the standard Newtonian *** are conducted at 0.25m hypersonic wind tunnel at M=8.3 and the following trends are observed from the experimental ***,the incremental higher nose bluntness,semi-vertex angle and center of rotation reduce the dynamic *** higher hypersonic Mach numbers(M>10),dynamic stability characteristics of the re-entry module are insensitive to the free stream Mach ***,it is observed that the dynamic stability is increased in proportion to the vibration amplitude at hypersonic speeds.

关键词： Re-entry dynamic stability Newtonian theory flexure pivot center of rotation least square method

Analysis of Bio-inspired Fishbone Based Corrugated Rib for Adaptive Camber Morphing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Bionic Engineering 2023年第3期20卷 1083-1102页

作者： R.jini Raj j.Bruce Ralphin rose A.Vasudevan Department of Mechanical Engineering Anna University Regional CampusTirunelveli627007India Saveetha School of Engineering SIMATSChennai600124India

Bioinspired active camber morphing is an innovative solution for the aerodynamic performance enhancement of flight vehicles such as Micro Aerial Vehicles(MAVs)and Unmanned Aerial Vehicles(UAVs).In the present article,a bio-inspired Fish Bone Active Camber(FishBAC)corrugated rib design concept with and without a spine for an Unmanned Aerial Vehicle(UAV)is *** wing model is composed of multiple corrugated ribs and a splitted spar for connecting each *** rib geometry is subjected to static structural analysis using ANSYS Finite Element Analysis(FEA)module under the unit load *** deformation modes are first extracted from the solution of the wind tunnel test and the elastically deformed NACA 4412 profile will be used to perform Fluid-Structure Interaction(FSI)studies as a partly coupled *** corrugated rib with spine design is a stable structure as inspired from nature species that can withstand elastic and inertial *** fluid dynamics(CFD)simulation is performed to compute the coefficient of lift(Cl),coefficient of drag(Cd)at different Angle of Attack(AoA)for a modified NACA 4412 airfoil and the pressure loads acting on the deformed shape is *** Cl obtained for the modified airfoil at lower AoA is about 60–80%higher and the maximum Cl(Clmax)is 62%higher than the baseline *** Cd of modified airfoil is reduced about 20%at the AoAα=3°as compared with the baseline *** proposed corrugated rib structure has been successfully 3D printed with Polylactic Acid plus(PLA+)material and the wind tunnel testing is done to validate the Cl,Cd values obtained through CFD simulations and the results are presented.

关键词： Bioinspired design Active morphing Fish bone Wind tunnel CFD

A numerical optimization of high altitude testing facility for wind tunnel experiments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Aeronautics 2015年第3期28卷 636-648页

作者： j.Bruce Ralphin rose G.R.jinu C.j.Brindha Department of Aeronautical Engineering Regional Centre of Anna University Department of Mechanical Engineering University College of EngineeringNagercoil Department of Aeronautical Engineering The Raajas Engineering College

Abstract High altitude test facilities are required to test the high area ratio nozzles operating at the upper stages of rocket in the nozzle full flow conditions. It is typically achieved by creating the ambient pressure equal or less than the nozzle exit pressure. On average, air/GN2 is used as active gas for ejector system that is stored in the high pressure cylinders. The wind tunnel facilities are used for conducting aerodynamic simulation experiments at/under various flow velocities and operating conditions. However, constructing both of these facilities require more laboratory space and expensive instruments. Because of this demerit, a novel scheme is implemented for conducting wind tunnel experiments by using the existing infrastructure available in the high altitude testing （HAT） facility. This article presents the details about the methods implemented for suitably modifying the sub-scale HAT facility to conduct wind tunnel experiments. Hence, the design of nozzle for required area ratio A/A＊, realization of test section and the optimized configuration are focused in the present analysis. Specific insights into various rocket models including high thrust cryogenic engines and their holding mechanisms to conduct wind tunnel experiments in the HAT facility are analyzed. A detailed CFD analysis is done to propose this conversion without affecting the existing functional requirements of the HAT facility.

关键词： CFD Enclosed free-jet section Ground testing High altitude testing (HAT)facility Optimization

Mechanisms of Organelle Inheritance in Dividing Plant Cells

在线全文

学校读者我要写书评

暂无评论

journal of Integrative Plant Biology 2007年第8期49卷 1208-1218页

作者： Michael B Sheahan Ray j rose David W McCurdy School of Environmental and Life Sciences The University of NewcastleCallaghan NSW 2308Australia Australian Research Council Centre of Excellence for Integrative Legume ResearchSchool of Environmental and Life SciencesThe University of NewcastleCallaghan NSW 2308Australia School of Environmental and Life Sciences The University of NewcastleCallaghan NSW 2308Australia

Organelles form essential compartments of all eukaryotic cells. Mechanisms that ensure the unbiased inheritance of organelles during cell division are therefore necessary to maintain the viability of future cell generations. Although inheritance of organelles represents a fundamental component of the cell cycle, surprisingly little is known about the underlying mechanisms that facilitate unbiased organelle inheritance. Evidence from a select number of studies, however, indicates that ordered organelle inheritance strategies exist in dividing cells of higher plants. The basic requirement for unbiased organelle inheritance is the duplication of organelle volume and distribution of the resulting organelle populations in a manner that facilitates unbiased partitioning of the organelle population to each daughter cell. Often, partitioning strategies are specific to the organelle, being influenced by the functional requirements of the organelle and whether the cells are mitotically active or re-entering into the cell cycle. Organelle partitioning mechanisms frequently depend on interactions with either the actin or microtubule cytoskeleton. In this focused review, we attempt to summarize key findings regarding organelle partitioning strategies in dividing cells of higher plants. We particularly concentrate on the role of the cytoskeleton in mediating unbiased organelle partitioning.

关键词： Actin cytoskeleton cell division green fluorescent protein-fimbrin ABD2 organelle partitioning protoplast

Performance analysis of lobed nozzle ejectors for high altitude simulation of rocket engines

在线全文

学校读者我要写书评

暂无评论

International journal of Modeling, Simulation, and Scientific Computing 2014年第4期5卷 139-157页

作者： j.Bruce Ralphin rose j.Veni Grace Department of Aeronautical Engineering Regional Centre of Anna University Tirunelveli India627007

Ejectors are used in high altitude testing of rocket engines to create vacuum for simulat-ing the engine test in vacuum *** performance of an ejector plays a vital role in creating vacuum at the exit of the engine nozzle and the nozzle design exit pressure at the time of ***,the performance of ejectors has to be improved to reduce the consumption of active *** this investigation,the performance of an ejector has been improved by changing the exit shear plane of the ***,conical nozzles are used for creating the required *** of 4 no’s,6 no’s and 8 numbers for an equivalent area ratio=5.88 are used to increase the shear *** influence of shear plane variation in the suction pressure is studied by a detailed CFD analysis.

关键词： High altitude testing lobed nozzles ejector performance thrust augmentation