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水泵技术 1990年第2期 35-44页

作者： Dosch,jb 宁远节

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严重妊娠同种免疫的处理

国外医学（输血及血液学分册） 1989年第2期12卷 89-90页

作者： Gravenhorst jb 兰炯采

筛选方法,宫内治疗,加强新生儿护理,以及对分娩Rh(D)阳性婴儿后的Rh(D)阴性产妇注射抗(D)免疫球蛋白,使得溶血病的产期死亡率从60年代的150/10万出生儿降到1983年的6/10万出生儿以下。这与诊断及治疗水平的提高有关。诊断 D-抗体:母亲... 详细信息

筛选方法,宫内治疗,加强新生儿护理,以及对分娩Rh(D)阳性婴儿后的Rh(D)阴性产妇注射抗(D)免疫球蛋白,使得溶血病的产期死亡率从60年代的150/10万出生儿降到1983年的6/10万出生儿以下。这与诊断及治疗水平的提高有关。诊断 D-抗体:母亲抗-D抗体的间接抗人球蛋白试验(IAGT)效价的预测价值不大。母亲抗-D抗体的量虽有临床意义,但红细胞的破坏程度除与抗-D量有关外,还与抗-D的IgG亚类有关。抗-D的IgG亚类对于致敏细胞与吞噬细胞的IgG受体结合的影响甚大。致敏细胞发生细胞毒溶解或被吞噬,不仅与红细胞膜上结合的抗体量有关,也与IgG抗体的亚类有关。在体外,可以借助于依赖抗体的细胞介导的细胞毒试验(ADCC)

关键词：宫内治疗妊娠溶血病

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对预防碘缺乏病最佳方案的研究

地方病译丛 1992年第2期13卷 27-28页

作者： jb Stanbury 陈祖培

预防碘缺乏病是符合费用—效益原则的,但是还需要做进一步的工作来判断在特定条件下防治规划的需要,增进流行病学资料的准确性,更好地确定碘缺乏病的病理生理结局。1 儿童碘油治疗后碘的清除率在多数防治规划中,几乎对所有防治对象都给... 详细信息

预防碘缺乏病是符合费用—效益原则的,但是还需要做进一步的工作来判断在特定条件下防治规划的需要,增进流行病学资料的准确性,更好地确定碘缺乏病的病理生理结局。1 儿童碘油治疗后碘的清除率在多数防治规划中,几乎对所有防治对象都给了碘油,或者只给了妇女和儿童。

关键词：碘缺乏防治

地震危险性分析中局部场地特征影响的校正方法

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世界地震译丛 1991年第4期22卷 12-17页

作者： Savy.,jb 马桂华

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图书馆员硕士网络课程:美国经验

世界社会科学 2002年第1期 83-84页

作者： jb.罗宾斯,陈源美国佛罗里达州立大学图书馆和信息学院系中国社会科学院文献信息中心主任〔美〕研究实习员

美国大多数图书馆与信息学的研究生院中开设的硕士课程 ,其教学大纲、内容或整套课程都可以通过万维网 (WorldWideWeb)获得。约有 10所学校将整套硕士学位课程放在网上 ,少数学校还在全美及世界范围内宣传并鼓励人们接入这些课程。这些... 详细信息

美国大多数图书馆与信息学的研究生院中开设的硕士课程 ,其教学大纲、内容或整套课程都可以通过万维网 (WorldWideWeb)获得。约有 10所学校将整套硕士学位课程放在网上 ,少数学校还在全美及世界范围内宣传并鼓励人们接入这些课程。这些获得认可的硕士学位课程的特点是其采用技术的多样性和对学生的要求。本文就作者所知的一些国际性高质量课程作了简要介绍 ,探讨了这些网络课程运作的方方面面 ,特别是对以电脑为媒介开展远程教育的教学效果的认识、课程学习者需要考虑的一些重要因素以及网络研究生课程继续发展的重要性

关键词：网络课程远程教育硕士图书馆美国

Chromosomal changes detected by fluorescence in situ hybridization in patients with acute lymphoblastic leukemia

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Chinese Medical Journal 2003年第9期116卷 1298-1303页

作者：张丽君 PARKHURST jb KERN WF SCOTTKV NICCUMD MULVIHILLJJ 李师伯 Departments of Pediatrics University of Oklahoma Health Sciences Centerthe OklahomaOK 73104USA Department of Hematologythe First Affiliated Hospital of China Medical UniversityShenyang 110001China(Zhang LJ) Departments of Pediatrics University of Oklahoma Health Sciences Centerthe OklahomaOK 73104USA Departments of Pathology University of Oklahoma Health Sciences Centerthe OklahomaOK 73104USA

Objectives To investigate patients with acute lymphoblastic leukemia (ALL) for TEL/AML1 fusion, BCR/ABL fusion, MLL gene rearrangements, and numerical changes of chromosomes 4, 10, 17 and 21 by fluorescence in situ hybridization (FISH) and to determine the relationship and the significance of those findings.Methods Fifty-one American patients (34 men and 17 women) were included in this study. Of them there were 41 patients with pro-B cell type ALL, 9 with B cell type ALL and 1 with T cell type ALL. Chromosome metaphases of each sample were prepared according to standard protocols. Fluorescence in situ hybridization was performed using commercially available DNA probes, including whole chromosome painting probes, locus specific probes, specific chromosome centromere probes and dual color/multiple color translocation fusion probes. The digital image analysis was carried out using Cytovision and Quips FISH programs.Results An overall incidence of chromosomal anomalies, including t (9; 22), MLL gene rearrangements, t (12;21), and numerical chromosomal anomalies of chromosomes 4, 10, 17 and 21 was found in 33 patients (65%). Thirty-one of them were pediatric patients and two adults. The t (12;21) was the commonest chromosomal anomaly detected in this population; 14 out of the 45 pediatric patients (31%) were positive for TEL/AML1 fusion, among which three had an additional derivative 21 [t (12;21) ], four had a deletion of 12p and two had an extra copy of chromosome 21. All 14 patients with positive TEL/AML1 fusion had ALL pre-B cell or B-cell lineage according to standard immunotyping. The percentage of cells with fusion signals ranged from 20% to 80%. All fourteen patients positive for TEL/AML1 gene fusion were mosaic. Three out of the 14 patients positive for the TEL/AML1 gene fusion were originally reported to be culture failures and none of the remaining eleven samples had been found to have chromosome 12 abnormalities by conventional cytogenet

关键词： acute lymphoblastic leukemia·fluorescence in situ hybridization·chromosome rearrangements

Molecular characterization of an insulin receptor-encoding gene,Hc-daf-2,from the parasitic nematode Haemonchus contortus

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Molecular characterization of an insulin receptor-encoding g...

肠道在休克和多器官功能衰竭中的作用(综述)

中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十一次学术研讨会

作者： Lok jb Gasser RB Campbell BE Sandeman MR School of Veterinary Medicine University of PennsylvaniaUSA Department of Veterinary Science The University of MelbourneAustralia School of Applied Sciences and Engineering Monash UniversityAustralia

Insulin-like signaling pathway regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage in free-living nematode Caenorhabditis elegans. Daf-2,a key gene in the insulin-like signaling pathway that mediates the development and reproduction, encoding an insulin receptor family *** is postulated that parasitic nematode life-span regulation by insulin-like signaling is analogous to free-living nematode Caenorhabditis *** the present study, we used a genomic approach to determine the structures of daf-2 orthologues(designated Hc-daf-2) and their transcriptional level,a full-length cDNA inferred to encode an ortholog of daf-2 was isolated from the parasitic nematode Haemonchus *** full-length cDNA sequence of Hc-daf-2 was 5462bp in length containing a 5’-UTR of 697bp,a 3’-UTR of 550bp and 4215 bp of protein-coding region,encoding a protein of 1405 amino *** BLASTx analyses revealed that the predicted protein sequence had 48- 63%identities/similarities to daf-2 ortholog of Ascaris sum,Brugia malayi,Loa loa,***, Parastrongyloides trichosuri and Trichinella *** of Hc-DAF-2 with predicted amino acid sequences of daf-2,insulin receptor of human and Drosophila found that Hc-DAF-2 has a putative signal peptide,a cysteine-rich region in the putative ligand-binding domain,a proteolysis site,a transmembrane domain and a tyrosine kinase *** trees constructed based on predicted amino acid sequences of Hc-DAF-2 and daf-2 ortholog from other 27 animal species including 7 nematode species for which full-length cDNA sequences are available in GenBank showed that Hc-DAF-2 is grouped with strong bootstrap support(99%) within nematode cluster excluding from non-nematode species. Transcriptional analysis by RT-PCR detected the transcriptional expression of Hc-daf-2 in all developmental stages and both sexes of *** including egg,L1,L2,L3,female L4,male L4,

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国际外科学杂志 1992年第2期23卷 78-79页

作者： Antonsson jb 唐胜平

机体遭受应激时,为保证心、脑等重要器官而减少了皮肤、皮下组织和内脏器官的氧输送,尤其是肠道粘膜的氧合作用。肠粘膜的氧合障碍和缺血性损坏是不可逆性休克和多器官功能衰竭(MSOF)的始动因素。本文就肠道在休克和 MSOF 中的作用进行... 详细信息

机体遭受应激时,为保证心、脑等重要器官而减少了皮肤、皮下组织和内脏器官的氧输送,尤其是肠道粘膜的氧合作用。肠粘膜的氧合障碍和缺血性损坏是不可逆性休克和多器官功能衰竭(MSOF)的始动因素。本文就肠道在休克和 MSOF 中的作用进行综述。肠道的血流、供氧和耗氧:胃肠道血流占心排血量的15%～20%,受内源性、外源性和血管活性物质三种不同机制调节。

关键词：多器官功能衰竭肠粘膜肠道粘膜缺血性损害心源性休克血管活性物质氧输送血管紧张素内毒素移位内毒素血症

Oral anticoagulation after intracerebral hemorrhage

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中华物理医学与康复杂志 2018年第3期40卷 190-190页

作者： Biffi A Kuramatsu jb Leasure

BACKGROUND AND OBJECTIVE Studies have shown that intracerebral hemorrhage(ICH)accounts for 10 to 20%of all acute cerebrovascular events,as well as a significant amount of stroke related disability and *** have also demonstrated that oral anticoagulation treatment(OAT)is associated with an increased risk of *** study was designed to determine whether the resumption of OAT

关键词：出血 ICH 脑血管证明燕麦事件