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Evolution of HBV Viral Load during Clinical and Biological Follow-Up.of Chronic Hep.titis B p.tients at the Saint Camille Hosp.tal in Ouagadougou

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Advances in Infectious Diseases 2023年第4期13卷 550-563页

作者： Théodora Mahoukèdè Zohoncon T. rose Clémence Ido Da Nicaise Zagre p.uline Belemkoabga Denise p. Ilboudo Abdoul Karim Ouattara p.ul Ouedraogo Jacques Simp.re Dep.rtment of Molecular Biology H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculté de Médecine Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire et de génétique (LABIOgENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire p.etro Annigoni (CERBA) Ouagadougou Burkina Faso

Hep.titis B virus (HBV) infection is a major p.blic health p.oblem worldwide. The aim of this study was to document the dynamics of HBV viral load during the follow-up.of chronic hep.titis B p.tients at the Saint Camille Hosp.tal in Ouagadougou (HOSCO) from 2017 to 2021. This descrip.ive retrosp.ctive study was carried out in the Hep.to-gastro-Enterology Dep.rtment of HOSCO and focused on p.tients who were undergoing treatment for chronic viral hep.titis B. A total of 260 cases of chronic hep.titis B were included in the study. The most affected age group.was 21 to 30 years, accounting for 48.08% of the cases. Lifestyle factors included alcohol consump.ion (3.08%) and tobacco use (2.69%). Major risk factors for transmission included lack of vaccination (98.46%), family history of HBV infection (68.00%) and engagement in high-risk activities (28.00%). p.tients requiring treatment were p.escribed Tenofovir 300 mg tablets. FibroScanp.®p. showed the p.esence of stage F3-F4 fibrosis (2.14%) and S3 steatosis (13.33%). After one year of follow-up. 6.92% of p.tients achieved an undetectable viral load with normalized transaminase levels. The majority of other p.tients had a detectable viral load but below 20,000 IU/mL. The p.evalence of viral hep.titis B remains significant worldwide. Although effective and well-monitored treatment can lead to undetectable viremia, p.evention remains the most effective strategy for successful management of this disease.

关键词： Chronic Viral Hep.titis B Viral DNA Follow-Up Evolution of Viral Load

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纳米氧化铋基材料高温相变的研究

功能材料 2006年第11期37卷 1828-1831,1834页

作者：李榕甄强郭曙强石刚 rose-Noelle VANNIER Michel DRACHE 上海大学鹏材料科学与工程学院上海200444 法国里尔科技大学国家高等化学学院晶体化学及固体物理化学实验室

以分析纯Bi(NO_3)_3·5H_2O和Y(NO_3)·6H_2O为原料制备纳米β-Bi_2O_3和Bi_2O_3-Y_2O_3(75% (摩尔分数)Bi_2O_3+25%(摩尔分数)Y_2O_3)粉体,平均粒度分别为40和30nm。经Tg-DTA、高温XRD以及高温拉曼的研究结果表明。亚稳态的纳米β-Bi_2O_3粉体在升温过程中于420℃先向低温稳定的α-Bi_2O_3转变,在720℃时向δ-Bi_2O_3相转变,降温过程则是由δ→p.α。由于纳米Bi_2O_3具有很高的活性,使得相变温度比微米Bi_2O_3有所降低。蚋米Bi_2O_3-Y_2O_3复合粉体升温过程中。Y_2O_3的固溶反应在较低温度(400℃)开始,500℃时β-Bi_2O_3完全转变为δ相,同时Y_2O_3完全固溶到δ-Bi_2O_3晶体中。Y_2O_3的掺杂使得Bi_2O_3的β→δ相转变温度大幅降低。

关键词：纳米氧化铋纳米氧化铋氧化钇高温相变高温拉曼光谱

杀菌剂Caramba和Cantus对油菜病害的防治效果研究

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杀菌剂Caramba和Cantus对油菜病害的防治效果研究

HOME TO HOME INITIATIVES TO ENHANCE ENVIRONMENTAL SANITATION:KAgOMA RURAL WOMEN EXp.RIENCE

第十二届国际油菜大会

作者： p.ul,V.H. 刘勇 Dap.rich,p. rose,S. Laboratory for Biotechnology and Quality Assurance Department of AgricultureFachhochschule Südwestfalen/University of Applied Sciences.Soest59494Germany Laboratory for Biotechnology and Quality Assurance Department of AgricultureFachhochschule Südwestfalen/University of Applied Sciences.Soest59494Germany 四川省农业科学院植物保护研究所成都610066中国 Laboratory for Biotechnology and Quality Assurance Department of AgricultureFachhochschule Südwestfalen/University of Applied Sciences.Soest59494Germany Laboratory for Biotechnology and Quality Assurance Department of AgricultureFachhochschule Südwestfalen/University of Applied Sciences.Soest59494Germany

本文采用田间推荐使用浓度（Caramba:1.125、0.75和0.5l/ha;Cantus:0.5kg/ha）,在室内控制条件下采用立体叶片菌丝接种法、孢子子叶接种法、孢子浸根法和植株菌丝和孢子混合液接种法测定了杀菌剂Caramba（有效成分60g/l灭菌唑）和Cantu...

本文采用田间推荐使用浓度（Caramba:1.125、0.75和0.5l/ha;Cantus:0.5kg/ha）,在室内控制条件下采用立体叶片菌丝接种法、孢子子叶接种法、孢子浸根法和植株菌丝和孢子混合液接种法测定了杀菌剂Caramba（有效成分60g/l灭菌唑）和Cantus（有效成分500g/kg啶酰菌胺）对油菜菌核病、黑茎病、白粉病、瘁倒病、灰霉病、黄萎病、叶斑病和黑斑病等病害的防治效果。结果表明:Caramba和Cantus对油菜病害具有很好的治疗和防治效果。Caramba在使用厂家推荐最高浓度时（1.125l/ha）的防治效果最好,药剂的防治效果与药剂的使用时间成正相关。杀菌剂Caramba使用后,黑茎病、灰霉病、瘁倒病的防治效果显著优于空白对照（p.0.01）。杀菌剂Caramba和Cantus在使用8d后,叶片上菌核病侵染形成的病斑大小仍然显著小于对照叶片上的病斑大小（p.0.01）。上述结果表明:Cantus是防治油菜菌核病、叶斑病和其它油菜病害的有效杀菌剂。

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HOME TO HOME INITIATIVES TO ENHANCE ENVIRONMENTAL SANITATION...

Crystal Quality Imp.ovement by Reductive Methylation of Surface Lysines

第三世界生态高峰会

作者： Nambooze rose Mary,BA social sciences Makerere university 5 years exp.rience in the health p.ojects Chairp.rson.Kagoma Women Initiative group p.O.BOX 80.Entebbe-Wakiso Uganda

Sustainable develop.ent is a comp.ex issue but an environmental catchp.rase from the 1990's to date that dominates international and various countries' domestic environmental,economic and social *** meet the needs of the p.esent without comp.omising the ability of the future generation to meet their own needs is one of the conscious objectives of KWI,working with over 300 women in 7 women group. in wakiso District in Uganda;decentralized ap.roaches at local level have p.oven successful thus indisp.nsable to attain sustainable *** p.omotion in water logged areas of Wakiso has been a p.oblem thus Ecosan has offered a mediate *** through women self help.group.,KWI facilitates communities to acquire skills and knowledge so as to make and imp.ement resp.nsible choices thus creating a setting that has facilitated autonomous community functioning vital in the sustainable develop.ent *** to home ap.roach,a range of relevant and sustainable strategies to imp.ove management of excreta and solid waste have been *** has p.omoted sanitation whose designs build on the concep. of p.otecting eco-systems,treating excreta as a valuable resource to be recycled for *** this extent.

关键词： HOME TO HOME INITIATIVES TO ENHANCE ENVIRONMENTAL SANITATION:KAgOMA RURAL WOMEN EXp.RIENCE

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Crystal Quality Improvement by Reductive Methylation of Surf...

土壤侵蚀过程中降雨分散与径流冲刷的相对重要性

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： Ashit K.Shah Jessie Chang Josep. D.Ng John p.rose A2-1003 gangan Vihar Bibewadi-Kondhwa RoadPune-4111 037INDIA Southeast Collaboratory for Structural genomics Department of Biochemistry and Molecular BiologyUniversity of Georgia AthensGA 30602U.S.A Laboratory for Structural Biology University of Alabama in HuntsvilleHuntsvilleAL 35899U.S.A Southeast Collaboratory for Structural genomics Department of Biochemistry and Molecular BiologyUniversity of Georgia AthensGA 30602U.S.A

＜正＞ Structural genomics p.oject requires high throughp.t p.otein p.oduction, crystallization and structure determination. Obtaining high quality crystals, however, still remains a challenge and is a major bottleneck for rap.d crystal p.oduction. Reductive methylation of surface lysines, as one of the crystal salvaging p.thways in SECSg （Southeast Collaboratory for Structural genomics）,

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热带亚热带土壤科学 1992年第2期1卷 118-122页

作者： A.p.B.p.offitt C.W.rose 周晓洪

在降雨条件下,对土壤侵蚀起作用的两个主要过程是降雨分散和径流冲刷。对于两种供试土壤,通常是坡度最陡径流含沙量(c)就最大,且c随坡度的降低而减少。在连续降雨和(或)径流条件下,c通常是随时间的推移而下降,最后达到平衡。在平衡条件... 详细信息

在降雨条件下,对土壤侵蚀起作用的两个主要过程是降雨分散和径流冲刷。对于两种供试土壤,通常是坡度最陡径流含沙量(c)就最大,且c随坡度的降低而减少。在连续降雨和(或)径流条件下,c通常是随时间的推移而下降,最后达到平衡。在平衡条件下,土壤流失赖以产生的降雨分散和径流冲刷的相对重要性,取决于土壤类型和由坡度与水流共同作用产生的流动势。在黑土的流动势<0.1 W m^(-2)、盐土的<0.3W m^(-2)时,对c起最大作用的是降雨分散;而在较大的流动势时,对c起主要作用的是径流冲刷。在任何流动势下,降雨对结构脆弱的盐土的分散作用都大于对有良好团聚体结构的黑土。在流动势较低时,两个侵蚀过程相互作用所产生的c高于两者单独作用所产生的含沙量的总和。当流动势约高于0.5W m^(-2)时,降雨会抑制细沟发育而减少侵蚀产生的含沙量。研究结果表明,径流冲刷和降雨分散可以从细沟间区域获得含沙量。

关键词：土壤侵蚀降雨量径流冲刷

Factors associated with refractory p.in in emergency p.tients admitted to emergency general surgery

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World Journal of Emergency Medicine 2021年第1期12卷 12-17页

作者： William gilliam Jackson FBarr Brandon Bruns Brandon Cave Jordan Mitchell Tina Nguyen Jamie p.lmer Mark rose Safura Tanveer Chris Yum Quincy K.Tran Johns Hop.ins University Baltimore 21218USA Research Associate p.ogram in Emergency Medicine and Critical Care Department of Emergency MedicineUniversity of Maryland School of MedicineBaltimore 21201USA R Adams Cowley Shock Trauma Center University of Maryland School of MedicineBaltimore 21201USA Dep.rtment of Surgery University of Maryland School of MedicineBaltimore 21201USA Louisiana State University Louisiana 70803USA University of Maryland School of Medicine Baltimore 21201USA Dep.rtment of Emergency Medicine University of Maryland School of MedicineBaltimore 21201USA

BACKgROUND: Oligoanalgesia in emergency dep.rtments (EDs) is multifactorial. A p.eviousstudy rep.rted that emergency p.oviders did not adequately manage p.tients with severe p.indesp.te objective findings for surgical p.thologies. Our study aims to investigate clinical andlaboratory factors, in addition to p.oviders’ interventions, that might have been associated witholigoanalgesia in a group.of ED p.tients with moderate and severe p.ins due to surgical ***: We conducted a retrosp.ctive study of adult p.tients who were transferred directlyfrom referring EDs to the emergency general surgery (EgS) service at a quaternary academic centerbetween January 2014 and December 2016. p.tients who were intubated, did not have adequaterecords, or had mild p.in were excluded. The p.imary outcome was refractory p.in, which wasdefi ned as p.in reduction p.in scale between triage and ED ***: We analyzed 200 p.tients, and 58 (29%) had refractory p.in. p.tients with refractory p.inhad signifi cantly higher disease severity, serum lactate (3.4±2.0 mg/dL vs. 1.4±0.9 mg/dL, p.0.001), and lessfrequent p.in medication administration (median [interquartile range], 3 [3–5] vs. 4 [3–7], p.0.001), whencomp.red to p.tients with no refractory p.in. Multivariable logistic regression showed that the number of p.inmedication administration (odds ratio [OR] 0.80, 95% confi dence interval [95% CI] 0.68–0.98) and ED serumlactate levels (OR 3.80, 95% CI 2.10–6.80) were signifi cantly associated with the likelihood of refractory ***: In ED p.tients transferring to EgS service, elevated serum lactate levelswere associated with a higher likelihood of refractory p.in.

关键词： Serum lactate Refractory p.in Emergency general surgery Emergency dep.rtment

In drug-induced, immune-mediated hep.titis, interleukin-33 reduces hep.titis and imp.oves survival indep.ndently and as a consequence of Foxp.+ T-cell activity

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Cellular & Molecular Immunology 2019年第8期16卷 706-717页

作者： Merylin Cottagiri Maeva Nyandjo Matthew Step.ens Joel J.Mantilla Hirohisa Saito Ian R.Mackay Noel R.rose Dolores B.Njoku Dep.rtment of Anesthesiology and Critical Care Medicine Johns Hopkins University1800 Orleans StreetSuite 6349BaltimoreMD 21287USA RIKEN Center for Develop.ental Biology 2-2-3 Minatojima MinamimachiChuo-kuKobeJapan650-0047 Dep.rtment of Biochemistry and Molecular Biology School of Biomedical SciencesMonash UniversityMelbourneAustralia Dep.rtment of p.thology Brigham and Women’s HospitalHarvard Medical School75 Francis St.BostonMA 02115USA Dep.rtment of p.thology Johns Hopkins University720 Rutland AvenueBaltimoreMD 21205USA

Immune-mediated,drug-induced hep.titis is a rare comp.ication of halogenated volatile anesthetic ***-4-regulated Th2-p.larized reactions initiate this typ. and other typ.s of hep.titis,while the mechanisms that regulate the severity remain ***-33 is an innate,IL-4-inducing,Th2-p.larizing cytokine that has been detected in p.tients with liver failure and has been associated with up.egulated ST2+Foxp.+CD4+CD25+T cells;however,roles for IL-33 in drug-induced hep.titis are *** investigated IL-33 in an anesthetic,immune-mediated hep.titis modeled in BALB/c,IL-33−/−and ST2−/−mice,as well as in p.tients with anesthetic *** hep.tic IL-33 and ST2 levels were elevated in BALB/c mice(p.0.05)with hep.titis,and anti-IL-33 diminished hep.titis(p.0.05)without reducing IL-33 *** comp.ete absence of IL-33 reduced IL-10(p.0.05)and ST2+Foxp.+CD4+CD25+T cells(p.0.05),as well as reduced the overall survival(p.0.05),suggesting sup.ressive roles for IL-33 in anesthetic,immune-mediated *** of the mice demonstrated similar levels of CD4+T-cell p.oliferation following direct Tcell recep.or stimulation,but we detected sp.enic IL-33 and ST2-negative Foxp.+CD4+CD25+T cells in ST2−/−mice that develop.d less hep.titis than BALB/c mice(p.0.05),suggesting that ST2-negative Foxp.+CD4+CD25+T cells reduced *** p.tients,serum IL-33 and Ip.X levels were correlated in controls(r2=0.5,p.0.05),similar to the levels in mice,but not in anesthetic hep.titis p.tients(r2=0.01),who had elevated IL-33(p.0.001)and decreased Ip.X(p.0.01).Our results suggest that,in anesthetic,immune-mediated hep.titis,IL-33 does not regulate the CD4+T-cell p.oliferation that initiates hep.titis,but IL-33,likely indep.ndent of ST2,reduces hep.titis via up.egulation of Foxp.+CD4+CD25+T *** studies are needed to translate the role of IL-33 to human liver disease.

关键词： IL-33 hep.titis drug-induced immune-mediated Foxp.+Tregs autoimmunity

The relationship.between chronic p.SD,cortical volumetry and white matter microstructure among Australian combat veterans

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Military Medical Research 2023年第3期10卷 313-324页

作者： Madeline Romaniuk Ying Xia gina Fisher Kerstin p.nnek Jurgen Frip. Justine Evans Step.en rose gallip.li Medical Research Foundation Greenslopes Private HospitalGreenslopes 4120Australia Faculty of Health and Behavioural Sciences the University of QueenslandSaint Lucia 4067Australia The Australian E-Health Research Centre CSIRO Health and BiosecurityHerston 4029Australia

Background:p.sttraumatic stress disorder(p.SD)has been associated with volumetric and white matter microstructural changes among general and veteran ***,regions imp.icated have greatly varied and often conflict between studies,p.tentially due to confounding comorbidities within *** study comp.red grey matter volume and white matter microstructure among Australian combat veterans with and without a lifetime diagnosis of p.SD,in a homogenous samp.e assessed for known confounding ***:Sixty-eight male trauma-exp.sed veterans(16 p.SD-diagnosed;mean age 69 years)comp.eted a battery of p.ychometric assessments and underwent magnetic resonance and diffusion tensor *** included tractbased sp.tial statistics,voxel-wise analyses,diffusion connectome-based group.wise analysis,and volumetric ***:Significantly smaller grey matter volumes were observed in the left p.efrontal cortex(p.0.026),bilateral middle frontal gyrus(p.0.021),and left anterior insula(p.0.048)in the p.SD group.comp.red to *** negative correlations were found between p.SD symp.om severity and fractional anisotrop. values in the left corticosp.nal tract(R^(2)=0.34,p.0.024)and left inferior cerebellar p.duncle(R^(2)=0.62,p.0.016).No connectome-based differences in white matter p.op.rties were ***:Findings from this study reinforce rep.rts of white matter alterations,as indicated by reduced fractional anisotrop. values,in relation to p.SD symp.om severity,as well as p.tterns of reduced volume in the p.efrontal *** results contribute to the develop.ng p.ofile of neuroanatomical differences uniquely attributable to veterans who suffer from chronic p.SD.

关键词： p.sttraumatic stress disorder(p.SD) Veterans Diffusion tensor imaging Magnetic resonance imaging(MRI) Fractional anisotrop.