检索结果-南通市图书馆

Structural Relationship between Brittle Deformation and Paleozoic to Mesozoic Basalt Dykes in the Precambrian Basement of the Southern Continental Part of the Cameroon Volcanic Line

引用

International Journal of Geosciences 2017年第3期8卷 318-331页

作者： Nicole Armelle Wambo Simeni Depesquidoux Tchaptchet Tchato rose noel ngo belnoun Jean Pierre Tchouankoue Alembert Alexandre Ganwa Department of Earth Sciences University of Ngaoundere Ngaoundere Cameroon Department of Earth Sciences University of Yaoundé I Yaoundé Cameroon

The work is a vivid description of the structural relationship between brittle deformation of the Precambrian basement in the southern continental part of the Cameroon Line and intrusive Paleozoic and Mesozoic basalt dykes swarms. A multidisciplinary approach that involves a combination of remote sensing techniques and field studies show that the major trend of brittle structures correspond to well-known regional structures: N70°E (Adamawa Shear Zone), N135°E (upper Benue trend) and N30°E (Cameroon Volcanic Line) corresponding to E-W and N-S directions respectively. Basalt dykes are associated to NE-SW, E-W and NW-SE oriented fractures. An integration of the available information on brittle structures and basalt dykes directions suggest an emplacement of the Mesozoic and Paleozoic basalt dykes structurally controlled by Precambrian structures that were originated through Riedel’s fracture kinematic model with dextral strike-slip Adamawa Shear Zone as the main shear zone during late stage of the Pan-African collision. Spatially, the restriction of the basalt dykes to the corridor of the Adamawa Shear Zone indicate that a rejuvenation of Precambrian faults may very well be the origin of the dykes with possibility that they may have been reworked several times during the Phanerozoic eon.

关键词： Basalt Dykes Brittle Tectonics Adamawa Shear Zone Riedel Model Western Gondwana

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In drug-induced, immune-mediated hepatitis, interleukin-33 reduces hepatitis and improves survival independently and as a consequence of FoxP3+ T-cell activity

引用

Cellular & Molecular Immunology 2019年第8期16卷 706-717页

作者： Merylin Cottagiri Maeva Nyandjo Matthew Stephens Joel J.Mantilla Hirohisa Saito Ian R.Mackay noel R.rose Dolores B.Njoku Department of Anesthesiology and Critical Care Medicine Johns Hopkins University1800 Orleans StreetSuite 6349BaltimoreMD 21287USA RIKEN Center for Developmental Biology 2-2-3 Minatojima MinamimachiChuo-kuKobeJapan650-0047 Department of Biochemistry and Molecular Biology School of Biomedical SciencesMonash UniversityMelbourneAustralia Department of Pathology Brigham and Women’s HospitalHarvard Medical School75 Francis St.BostonMA 02115USA Department of Pathology Johns Hopkins University720 Rutland AvenueBaltimoreMD 21205USA

Immune-mediated,drug-induced hepatitis is a rare complication of halogenated volatile anesthetic ***-4-regulated Th2-polarized reactions initiate this type and other types of hepatitis,while the mechanisms that regulate the severity remain ***-33 is an innate,IL-4-inducing,Th2-polarizing cytokine that has been detected in patients with liver failure and has been associated with upregulated ST2+Foxp3+CD4+CD25+T cells;however,roles for IL-33 in drug-induced hepatitis are *** investigated IL-33 in an anesthetic,immune-mediated hepatitis modeled in BALB/c,IL-33−/−and ST2−/−mice,as well as in patients with anesthetic *** hepatic IL-33 and ST2 levels were elevated in BALB/c mice(p<0.05)with hepatitis,and anti-IL-33 diminished hepatitis(p<0.05)without reducing IL-33 *** complete absence of IL-33 reduced IL-10(p<0.05)and ST2+Foxp3+CD4+CD25+T cells(p<0.05),as well as reduced the overall survival(p<0.05),suggesting suppressive roles for IL-33 in anesthetic,immune-mediated *** of the mice demonstrated similar levels of CD4+T-cell proliferation following direct Tcell receptor stimulation,but we detected splenic IL-33 and ST2-negative Foxp3+CD4+CD25+T cells in ST2−/−mice that developed less hepatitis than BALB/c mice(p<0.05),suggesting that ST2-negative Foxp3+CD4+CD25+T cells reduced *** patients,serum IL-33 and IPEX levels were correlated in controls(r2=0.5,p<0.05),similar to the levels in mice,but not in anesthetic hepatitis patients(r2=0.01),who had elevated IL-33(p<0.001)and decreased IPEX(p<0.01).Our results suggest that,in anesthetic,immune-mediated hepatitis,IL-33 does not regulate the CD4+T-cell proliferation that initiates hepatitis,but IL-33,likely independent of ST2,reduces hepatitis via upregulation of Foxp3+CD4+CD25+T *** studies are needed to translate the role of IL-33 to human liver disease.

关键词： IL-33 hepatitis drug-induced immune-mediated Foxp3+Tregs autoimmunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：