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Liver resection versus radiofrequency ablation in the treatment of cirrhotic patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 270-277页

作者： Amilcare Parisi Jacopo Desiderio Stefano Trastulli Elisa Castellani rosario Pasquale Roberto Cirocchi Carlo Boselli Giuseppe Noya Department of Digestive Surgery and Liver Unit St. Maria Hospital Department of General and Oncologic Surgery University of Perugia St. Maria della Misericordia Hospital Department of General and Urgent Surgery University of Perugia

BACKGROUND: Hepatocellular carcinoma is the most common type of primary liver tumor and its incidence is increasing worldwide. The study aimed to compare patients subjected to liver resection or radiofrequency ablation. METHODS: One hundred and forty cirrhotic patients in stage A or B of Child-Pugh with single nodular or multinodular hepatocellular carcinoma were included in this retrospective study. Among them, 87 underwent surgical resection, and 53 underwent percutaneous radiofrequency ablation. Patient charac-teristics, survival, and recurrence-free survival were analyzed. RESULTS: Recurrence-free survival was longer in the resection group in comparison to the radiofrequency group with a median recurrence-free time of 36 versus 26 months, respectively (P=0.01, HR=1.52, 95% CI: 1.05-2.25). In the resection group, median survival was 46 months, with the 1-, 3- and 5-year survival rates of 89.7%, 72.4% and 40.2%. In the radiofrequency group, median survival was 32 months, with the 1-, 3- and 5-year survival rates of 83.0%, 43.4% and 22.6% (P<0.01). CONCLUSIONS: Surgical resection improves the overall survival and recurrence-free survival in comparison with radiofrequency ablation. New evidences are needed to define the real role of the percutaneous technique as an alternative to surgery.

关键词： hepatocellular carcinoma liver resection radiofrequency ablation

Colloidal and rheological characterization of SWCNT in biological media

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International Journal of Smart and Nano Materials 2019年第4期10卷 300-315页

作者： Arisbel Cerpa Isabel Lado Oriella Quiroga Rodrigo Moreno rosario García Sebastián Cerdán Nehal I.Abu-Lail Industrial and Aerospace Engineering Department European UniversityMadridSpain Synthesis and Colloidal Processing Group Institute of Ceramics and GlassICV-CSICMadridSpain Geology and Geochemical Department.Science Faculty Autonomous University of MadridMadridSpain Department of Endocrine and Nervous System Pathophysiology Institute of Biomedical Research“Alberto Sols”CSICMadridSpain Department of Biomedical Engineering University of Texas at San AntonioSan AntonioTXUSA

Wereport on the colloidal and rheological characterization of suspensions of commercial single-walled carbon nanotubes(SWCNT)and oxidized single walled carbon nanotubes(SWCNT-oxi24h),in water and fetal bovine serum(FBS).The effects of two surfactants,dodecyl-benzene sodium sulfonate(SBDS)and sodium dodecyl sulfate(SDS)at different concentrations(0.5-2.0%)on the zeta potential and the rheology of the suspensions is also *** suspensions were characterized by Transmission Electron Microscopy(TEM)and Atomic Force Microscopy(AFM).The colloidal stability was determined by measurements of zeta potential in the physiological pH range 6.0

关键词： SWCNT viscosity zeta potential surfactant molecular dynamics simulation

Nitrogen Release from Slow-Release Fertilizers in Soils with Different Microbial Activities

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Pedosphere 2018年第2期28卷 332-340页

作者： Pierfrancesco NARDI Ulderico NERI Giovanni DI MATTEO Alessandra TRINCHERA rosario NAPOLI Roberta FARINA Guntur V. SUBBARAO Anna BENEDETTI CREA-Council for Agricultural Research and Economics Research Center for Agriculture and Environment Via della Navicella 2Rome 00184 (Italy) Japan International Research Center for Agricultural Sciences (JIRCAS) Tsukuba 305-8686 (Japan)

Soil microbial activity is recognized as an important factor affecting nitrogen (N) release from slow-release fertilizers. However,studies on the effect of size and activity of soil microflora on fertilizer degradation have provided contrasting results. To date, no clear relationships exist between soil microbial activity and the release of N from slow-release fertilizers. Hence, the aim of this study was to better understand such relationships by determining the release of N from three slow-release fertilizers in soils with different microbial activities. Soils were amended with urea-formaldehyde (UF), isobutylidene diurea (IBDU), and crotonylidene diurea (CDU). Urea, a soluble fertilizer, was used as the control. Fertilized soil samples were placed in a leaching system, and the release of N was determined by measuring ammonium-N and nitrate-N concentrations in leachates during 90 d of incubation. Non-linear regression was used to fit N leaching rate to a first-order model. In all the treated soils, N was released in the order: urea (89%–100%) > IBDU (59%–94%) >UF (46%–73%) > CDU (44%–56%). At the end of incubation, N released from CDU did not differ (P > 0.05) among soils. On the contrary, UF and IBDU released significantly lower (P < 0.05) amounts of N in the soil with higher microbial activity and lower *** rate constant (K_0) for UF was lower (P < 0.05) in the soil with lower pH. Taken together, our results indicated that soil microbial size and microbial activity had a marginal effect on fertilizer mineralization.

关键词： ammonium-N crotonylidene diurea isobutylidene diurea nitrate-N non-linear regression urea-formaldehyde

Updating the orbital ephemeris of the dipping source XB 1254–690 and the distance to the source

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Research in Astronomy and Astrophysics 2017年第10期17卷 97-108页

作者： Angelo F.Gambino rosario Iaria Tiziana Di Salvo Marco Matranga Luciano Burderi Fabio Pintore Alessandro Riggio Andrea Sanna Universita degli Studi di Palermo Dipartimento di Fisica e Chimica Universita degli Studi di Cagliari Dipartimento di Fisica INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano

XB 1254-690 is a dipping low mass X-ray binary system hosting a neutron star and showing type I X-ray bursts. We aim at obtaining a more accurate orbital ephemeris and at constraining the orbital period derivative of the system for the first time. In addition, we want to better constrain the distance to the source in order to locate the system in a well defined evolutive scenario. We apply, for the first time, an orbital timing technique to XB 1254-690, using the arrival times of the dips present in the light curves that have been collected during 26 yr of X-ray pointed observations acquired from different space missions. We estimate the dip arrival times using a statistical method that weights the count-rate inside the dip with respect to the level of persistent emission outside the dip. We fit the obtained delays as a function of the orbital cycles both with a linear and a quadratic function. We infer the orbital ephemeris of XB 1254-690, improving the accuracy of the orbital period with respect to previous estimates. We infer a mass of M2 = 0.42 ± 0.04 M for the donor star, in agreement with estimations already present in literature, assuming that the star is in thermal equilibrium while it transfers part of its mass via the inner Lagrangian point, and assuming a neutron star mass of 1.4 Mo. Using these assumptions, we also constrain the distance to the source, finding a value of 7.6±0.8 kpc. Finally, we discuss the evolution of the system, suggesting that it is compatible with a conservative mass transfer driven by magnetic braking.

关键词： stars: neutron -- stars: individual (XB 1254-690) -- X-rays: binaries -- X-rays: stars --Astrometry and celestial mechanics: ephemerides

Comparison of Control Techniques in a Weight Lifting Exoskeleton

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Journal of Bionic Engineering 2019年第4期16卷 663-673页

作者： Irving Rosales-Diaz Jesus Ricardo Lopez-Gutierrez Angel Eduardo Zamora Suarez Sergio rosario Salazar Antonio Osorio-Cordero Hipolito Aguilar-Sierra Rogelio Lozano CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico CONACYT-CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico Polytechnic University of Tulancingo St.Ingenierias 100Col.Huapalcalco43629TulancingoHidalgoMexico Centre de Recherches de Royalieu UTC-HEUDIASyCCompiegne60205France

The back pain is the most common injury in human activities where heavy objects must be lifted or must be suspended for a long time.A weight lifting exoskeleton also known as force augmentation exoskeleton is designed to reduce the strain on the back and the limbs and reduce the risk to suffer *** the other hand,different kinds of controllers have been implemented to achieve whit this goal,for example,a conventional PD Control,PD Control with Gravity Compensation,PD Control with Adaptive Desired Gravity Compensation and PD Control with Robust *** paper aims to evaluate and compare the performance from the previously cited controllers used to reduce the strain in the back,through the implementation of each controller in a three Degrees Of Freedom(DOF)exoskeleton powered by pneumatic muscle actuators;some numerical simulations as well as experimental trials have been conducted and three different performance indices were used in order to determine the effectiveness of each one with respect to the simple PD controller when the mass to be lifted is unknown.

关键词： augmenting force device exoskeleton robot pneumatic artificial muscles adaptive control robust control

Vapour-Liquid Equilibrium with a New Ebulliometer：Ester＋Alcohol System at 0.5 MPa

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Chinese Journal of Chemical Engineering 2010年第6期18卷 1000-1007页

作者： P. Susial A. Sosa-rosario R. Rios-Santana School of Industrial Engineering University of Las Palmas de Gran Canada Canary Islands Spain

A new dynamic ebulliometer is used to determine vapor-liquid equilibrium(VLE) data experimentally. In the equipment,both phases are recirculated. Its operation is a consequence of the Cotrell pump effect produced when the mixture is heated in a double-walled inverted vessel. The reliability of the apparatus is tested with the mixtures studied previously by various authors. VLE data for the binary systems of methyl acetate + methanol and the methyl acetate + ethanol at 0.5 MPa are determined. The experimental data are confirmed with the point-to-point test of van Ness,applying the Fortran program of Frendslund et al. In addition,the experimental results are com-pared with the UNIFAC(including different versions) and ASOG prediction models.

关键词： vapor-liquid equilibrium vapor-liquid equilibrium apparatus vapor pressure alcohol

A Process for Extracting Non-Taxonomic Relationships of Ontologies from Text

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Intelligent Information Management 2011年第4期3卷 119-124页

作者： Ivo Serra rosario Girardi 不详

Manual construction of ontologies by domain experts and knowledge engineers is an expensive and time consuming task so, automatic and/or semiautomatic approaches are needed. Ontology learning looks for identifying ontology elements like non-taxonomic relationships from information sources. These relationships correspond to slots in a frame-based ontology. This article proposes an initial process for semiautomatic extraction of non-taxonomic relationships of ontologies from textual sources. It uses Natural Language Processing (NLP) techniques to identify good candidates of non-taxonomic relationships and a data mining technique to suggest their possible best level in the ontology hierarchy. Once the extraction of these relationships is essentially a retrieval task, the metrics of this field like recall, precision and f-measure are used to perform evaluation.

关键词： Ontology Ontology Learning Non-Taxonomic Relationships Natural Language Processing

Vehicles PEMFC Power System Mathematical Model for Integrated Design

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Journal of Energy and Power Engineering 2013年第4期7卷 746-751页

作者： Vincenzo Di Dio Diego La Cascia rosario Liga rosario Miceli Department of Energy Information Engineering and Mathematical Models (DEIM) University of Palermo Palermo 90133 Italy

In this paper, the mathematical dynamical model of a PEMFC （proton exchange membrane fuel cells） stack, integrated with an automotive synchronous electrical power drive, developed in Matlab environment, is shown. Lots of simulations have been executed in many load conditions. In this paper, the load conditions regarding an electrical vehicle for disabled people is reported. The innovation in this field concerns the integration, in the PEMFC stack mathematical dynamic model, of a synchronous electrical power drive for automotive purposes. Goal of the simulator design has been to create an useful tool which is able to evaluate the behaviour of the whole system so as to optimize the components choose. As regards the simulations with a synchronous electrical power drive, the complete mathematical model allows to evaluate the PEMFC stack performances and electrochemical efficiency.

关键词： Proton exchange membrane fuel cells mathematical model automotive synchronous electrical power drive test cycle.

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine