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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán rosario carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

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Camalote Grass (Paspalum fasciculatum Willd) as a Sustainable Raw Material for the Production of Lignocellulosic Ethanol

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Journal of Sustainable Bioenergy Systems 2024年第2期14卷 23-33页

作者： María Luz May-Reyes Cintya Valerio-Cárdenas Gloria Ivette Bolio-López Manuel Mateo Hernández-Villegas Miguel Ángel Velázquez-carmona Patricia De la Cruz-Burelo Research and Postgraduate Coordination Universidad Popular de la Chontalpa Crdenas Tabasco Mexico

The current trend of replacing a percentage of gasoline with ethanol has promoted the development of new processes for its production from lignocellulosic biomass. This work reports the production of ethanol from the Camalote grass (Paspalum fasciculatum Willd). The lignocellulosic biomass was subjected to acid hydrolysis at 125C and 15 psi with H2SO4 concentrations at 5%, 10%, and 20%, obtaining an average of reducing sugars (pentoses and hexoses) from the hydrolyzed juice with 12.3%, 10%, and 17% Brix, respectively. The sugars were fermented using yeast of the Saccharomyces cerevisiae at 30C for 48 hours. Finally, the ethanol was distilled at 78C, and the average yields were obtained through analysis of variance with a 95% confidence level. The values indicate that there is a significant difference (p > 0.05), the Tukey study shows that all the % v/v averages are different from each other. For H2SO4 concentration at 5% (10.33 ± 2), H2SO4 at 10% (9.33 ± 1.8), and H2SO4 at 20% (6.33 ± 2). The acidity analysis for the ethanol obtained from each treatment gave a value of 1.8 mg/L of acetic acid in all cases.

关键词： Lignocellulosic Ethanol Lignocellulosic Biomass Camalote Grass Acid Hydrolysis Energy Crops

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Knowledge Mining:A Cross-disciplinary Survey

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Machine Intelligence Research 2022年第2期19卷 89-114页

作者： Yong Rui Vicente Ivan Sanchez carmona Mohsen Pourvali Yun Xing Wei-Wen Yi Hui-Bin Ruan Yu Zhang Lenovo Research Beijing 100094China

Knowledge mining is a widely active research area across disciplines such as natural language processing(NLP), data mining(DM), and machine learning(ML). The overall objective of extracting knowledge from data source is to create a structured representation that allows researchers to better understand such data and operate upon it to build applications. Each mentioned discipline has come up with an ample body of research, proposing different methods that can be applied to different data types. A significant number of surveys have been carried out to summarize research works in each discipline. However, no survey has presented a cross-disciplinary review where traits from different fields were exposed to further stimulate research ideas and to try to build bridges among these *** this work, we present such a survey.

关键词： Knowledge mining knowledge extraction information extraction association rule interpretability

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Vee-tail conceptual design criteria for commercial transport aeroplanes

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Chinese Journal of Aeronautics 2019年第3期32卷 595-610页

作者： Alejandro SANCHEZ-carmona Cristina CUERNO-REJADO Faculty of Aerospace Engineering Department of Aircraft and Spacecraft Technical University of Madrid (Universidad Poltécnica de Madrid)

Vee-tail configuration is an unconventional tail configuration for commercial transport aviation, the use of which could suppose reductions on CO2 emissions. The conceptual design criteria have been selected inspired on the certification requirements established by the aviation regulation in force. They are static stability in cruise, control after Critical Engine Failure(CEF),control in crosswind landing, and trim in these three conditions. The study is carried out through a combination of semi-empirical techniques and Vortex-Lattice Methods(VLM) and thus this analyses the consequences of applying these criteria to a reference aeroplane substituting its conventional tail by a parametrised Vee-tail configuration. The Vee-tail is defined by four parameters:span, root chord, taper ratio and dihedral angle. The results of the study establish a relation between the parameters in order to accomplish the proposed conceptual design criteria. To sum up, minimum and maximum limits are obtained for dihedral angle depending on the combination of the rest of parameters. In addition, a design restriction to the yawing trailing-edge tail control is reached when the results are analysed, demonstrating that its minimum size must be between 60%and 80% of the half-span of the tail, depending on the Vee-tail geometry.

关键词： Commercial transport aeroplane Conceptual aircraft design Tail design requirements Unconventional tail design Vee-tail

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Extracellular vesicles small RNA clusters:hit the nail on the head of liver cancer detection

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 100-102页

作者： Artur Słomka Bingduo Wang Tudor Mocan Maria González-carmona Christian P.Strassburg Veronika Lukacs-Kornek Miroslaw T.Kornek Department of Pathophysiology Nicolaus Copernicus University in ToruńLudwik Rydygier Collegium MedicumBydgoszczPoland Department of Internal Medicine I University Hospital of the Rheinische Friedrich-Wilhelms-UniversityBonnGermany Octavian Fodor Institute for Gastroenterology and Hepatology Iuliu HaţieganuUniversity of Medicine and PharmacyCluj-NapocaRomania Institute of Experimental Immunology University Hospital of the Rheinische Friedrich-Wilhelms-UniversityBonnGermany

There is a very urgent need and clinical demand of robust biomarkers in cancer screening,especially in early hepatocellular carcinoma(HCC)surveillance as outlined by various professional international associations as the European Association for the study of the Liver(EASL),or the Asian Pacific Association for the Study of the Liver(APASL)and national professional organisations as the American Association for the Study of Liver Diseases(AASLD),besides *** data on primarily HCC is still depicting this cancer entity as the sixth most frequently diagnosed cancer,with over 900,000 new cases and over 830,000 deaths worldwide(1).This type of cancer,therefore,remains at the forefront of malignant ***,every element of patient management,including early diagnosis and prognosis of treatment response and survival,is a challenge.

关键词： Liver diagnosis clinical

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Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： Francisco Javier Pérez Lara Rogelio Zubizarreta Jimenez Tatiana Prieto-Puga Arjona Pilar Gutierrez Delgado Juan Manuel Hernández carmona Jose Manuel Hernández Gonzalez Maria Pitarch Martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive *** approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is *** To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic *** For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to *** Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was *** difference was statistically ***,the insertion of mesh did not improve results for the non-accessible *** For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for *** parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

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Plant Cover and Soil Biochemical Properties in a Mine Tailing Pond Five Years After Application of Marble Wastes and Organic Amendments

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Pedosphere 2012年第1期22卷 22-32页

作者： R.ZORNOZA A.FAZ D.M.carmona S.KABAS S.MARTíNEZ-MARTíINEZ J.A.ACOSTA Sustainable Use Managementand Reclamation of Soil and Water Research Group.Department of Agrarian Science and Technology.Technical University of Cartagena.Paseo Alfonso XIII5230203 Cartagena.Murcia(Spain) Universidad Pontificia Bolivariana.Environmental Research Group.Circular 1a No.70-01.Medelín(Colombia)

Tailing ponds pose environmental hazards,such as toxic metals which can contaminate the surroundings through wind and water erosions and *** chemical and biochemical properties,together with extractable and soluble metals were measured five years after reclamation of a polluted soil affected by former mining *** abandoned mine site contains large amounts of Fe-oxyhydroxides,sulphates,and heavy *** a consequence,soils remain bare and the soil organic matter content is low(< 3 g kg 1).Marble waste,pig manure and sewage sludge were applied in *** cover and richness,and soil chemical,biochemical and biological parameters were analysed five years *** showed that all soil biochemical properties as well as vegetation cover and richness were higher in treated soils than in the untreated contaminated plots(control),although organic matter,pH values and extractable metals concentrations were similar among *** cadmium and zinc were lower in the amended plots than in *** a general pattern,soil amended with pig manure showed higher values of most biochemical properties compared to sewage sludge application,while the doses did not have a great effect,being only significant for β-glucosidase,phosphodiesterase and *** correlations were found between vegetation cover,richness and soil biochemical properties,suggesting a high interdependence between plant colonization and reactivation of biogeochemical cycles during five *** study confirms the high effectiveness of an initial application of the amendments tested to initialize the recovery of ecosystems in bare mine soils under Mediterranean semiarid *** research also shows the high sensitivity of certain biochemical properties in order to evaluate soil quality and reactivation of nutrients cycles in reclaimed mine soils.

关键词：污染土壤生化特性尾矿库大理石有机改良剂植被土壤有机质含量矿山

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Influence of different sports on fat mass and lean mass in growing girls

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Journal of Sport and Health Science 2017年第2期6卷 213-218页

作者： Esther Ubago-Guisado Esmeralda Mata Javier Sánchez-Sánchez María Plaza-carmona María Martín-García Leonor Gallardo IGOID Research Group University of Castilla-La Mancha Toledo 45071 Spain GENUD Toledo Research Group University of Castilla-La Mancha Toledo 45071 Spain School of Sport UCAM Universidad Catoica San Antonio Murcia 30107 Spain

Purpose: The aim of this study was to analyze and compare the effects of different sports(swimming, football, basketball, and handball) on fat mass and lean mass in prepubertal and pubertal ***: Two hundred girls(10.6 ± 1.5 years old, Tanner stages I–III) participated in the study and were divided into 5 groups: 40 swimmers, 40 football players, 40 basketball players, 40 handball players, and 40 controls. Fat and lean masses at whole body, arms, trunk, and legs were measured using dual-energy X-ray absorptiometry(DXA). Pubertal status was determined using Tanner test. Effects of different sports on fat and lean masses were assessed through analysis of covariance with height as covariates. Analyses were performed separately in 2 groups depending on the Tanner stage(prepubertal and pubertal).Results: The girls of the control group had less lean mass and more fat mass compared to the girls who play sports(p < 0.05). There were differences in body fat between sports. The swimmers and football players had less body fat(p < 0.05). On the other hand, handball players showed the highest values in lean mass(p < 0.05).Conclusion: Impact sports(football, basketball, and handball) and low-impact sports(swimming) provide an appropriate development of lean mass in growing girls. We can conclude that people practicing sports at early ages ensure a lower fat mass and higher lean mass compared to those who do not practice. These results may be useful as a preventive method of adult obesity.

关键词：运动员体脂肪肉质量发育期青春期骨密度仪预防方法女孩

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Pupal emergence pattern in cactophilic Drosophila and the effect of host plants

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Insect Science 2018年第6期25卷 1108-1118页

作者： Eduardo M.Soto Julián Padrò Pablo Milla carmona Diego T.Tuero Valeria P.Carreira Ignacio M.Soto Departamento de Ecologia Genética y Evoluciòn Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresIEGEBA-CONICETBuenos AiresArgentina

Drosophila buzzatii and *** are sibling cactophilie *** former breeds primarily on prickly pears (genus Opuntia)whereas the latter breeds on columnar cacti of the genera Cereus and Trichocereus,although with certain degree of niche *** examined the interspecific differences in diurnal temporal patterns of adult emergence from puparia and evaluated whether this behavior is affected by rearing in the different cactus hosts available in *** detected important host-dependent genetic variation for this trait differentially affecting the emergence schedule of these *** pattern of emergence time was directly correlated with developmental time and negatively correlated with adult wing size,suggesting that early emergences are at least indirectly correlated with increased *** discussed our results in terms of their putative effects on fitness and the genetic-metabolic pathways that would be presumably affected by host's nutritional-chemical differences.

关键词： alkaloids cactus circadian cycle life history traits phenotypic plasticity pupae

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