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Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment

World Journal of Gastroenterology 2021年第17期27卷 1905-1919页

作者： Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli Alessia Gallo Rosalia Busà rosaria Tinnirello Pier Giulio Conaldi Gioacchin Iannolo Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy Department of Regenerative Medicine Fondazione Ri.MEDPalermo 90127Italy Neuroscience Unit CNR Institute of Biomedicine and Molecular ImmunologyPalermo 90146Italy

Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and *** have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue *** evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/*** recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic *** use of MSCs is a valid approach to combat organ inflammation in different *** addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the *** particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)*** herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting.

关键词： Mesenchymal stromal cell COVID-19 SARS-CoV-2 Organ failure Inflammation Transplantation

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Ambulatory diastolic blood pressure:a marker of comorbidity in elderly fit hypertensive individuals?

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Journal of Geriatric Cardiology 2022年第4期19卷 254-264页

作者： Alfredo De Giorgi rosaria Cappadona Caterina Savriè Benedetta Boari Ruana Tiseo Giulia Marta Viglione Christian Molino Elisa Misurati Mauro Pasin Roberto Manfredini Fabio Fabbian Clinica Medica Unit Azienda Ospedaliero-Universitaria S.AnnaFerraraItaly Department of Medical Sciences University of FerraraFerraraItaly

BACKGROUND Masked diastolic hypotension is a new blood pressure(BP)pattern detected by ambulatory blood pressure monitoring(ABPM)in elderly *** aim of this study was to relate ABPM and comorbidity in a cohort of fit elderly subjects attending an outpatient hypertension *** Comorbidity was assessed by Charlson comorbidity index(CCI)and CHA_(2)DS_(2)VASc *** subjects evaluated with ABPM were aged≥65 *** and CHA_(2)DS_(2)VASc score were *** hypotension was defined as mean am-bulatory diastolic BP<65 mmHg and logistic regression analysis was carried out in order to detect and independent relationship between comorbidity burden and night-time diastolic BP<65 *** We studied 174 hypertensive elderly patients aged 72.1±5.2 years,men were 93(53.4%).Mean CCI was 0.91±1.14 and mean CHA_(2)DS_(2)VASc score of 2.68±*** with night-time mean diastolic values<65 mmHg were higher in females[54.7%vs.45.3%,P=0.048;odds ratio(OR)=1.914,95%CI:1.047−3.500].Logistic regression analysis showed that only CHA_(2)DS_(2)-VASc score was independently associated with night-time mean diastolic values<65 mmHg(OR=1.518,95%CI:1.161−1.985;P=0.002),but CCI was *** ABPM and comorbidity evaluation appear associated in elderly fit subjects with masked ***-orbid women appear to have higher risk for low ambulatory BP.

关键词： hypertensive morbidity diastolic

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Coupling effects in QD dimers at sub-nanometer interparticle distance

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Nano Research 2020年第4期13卷 1071-1080页

作者： Carlo Nazareno Dibenedetto Elisabetta Fanizza rosaria Brescia Yuval Kolodny Sergei Remennik Annamaria Panniello Nicoletta Depalo Shira Yochelis Roberto Comparelli Angela Agostiano Maria Lucia Curri Yossi Paltiel Marinella Striccoli CNR-Istituto per i Processi Chimico-Fisici SS Bari Via Orabona 470125-BariItaly Dipartimento di Chimica Universita degli Studi di Bari Aldo MoroVia Orabona 470125-BariItaly Electron Microscopy Facility Istituto Italiano di Tecnologiavia Morego 3016163 GenovaItaly Department of Applied Physics and the Center for Nanoscience and Nanotechnology Hebrew University of JerusalemJerusalem 9190401Israel

Currently,intensive research efforts focus on the fabrication of meso-structures of assembled colloidal quantum dots(QDs)with original optical and electronic *** collective features originate from the QDs coupling,depending on the number of connected units and their ***,the development of general methodologies to assemble colloidal QD with precise stoichiometry and particle-particle spacing remains a key ***,we demonstrate that dimers of CdSe QDs,stable in solution,can be obtained by engineering QD surface chemistry,reducing the surface steric hindrance and favoring the link between two *** connection is made by using alkyl dithiols as bifunctional linkers and different chain lengths are used to tune the interparticle distance from few nm down to 0.5 *** spectroscopic investigation highlights that coupling phenomena between the QDs in dimers are strongly dependent on the interparticle distance and QD size,ultimately affecting the exciton dissociation efficiency.

关键词： quantum dots dimers surface chemistry dithiols coupling

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Towards a better understanding of anesthesia emergence mechanisms: Research and clinical implications

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World Journal of Methodology 2018年第2期8卷 9-16页

作者： Marco Cascella Sabrina Bimonte Maria rosaria Muzio Division of Anesthesia and Pain Management Department of Supportive CareIstituto Nazionale Tumori "Fondazione G.Pascale"-IRCSS Division of Infantile Neuropsychiatry UOMI-Maternal and Infant HealthASL NA3 SUD Torre del Greco

Emergence from anesthesia(AE) is the ending stage of anesthesia featuring the transition from unconsciousness to complete wakefulness and recovery of consciousness(RoC). A wide range of undesirable complications, including coughing, respiratory/cardiovascular events, and mental status changes such as emergence delirium, and delayed RoC, may occur during this critical phase. In general anesthesia processes, induction and AE represent a neurobiological example of "hysteresis". Indeed, AE mechanisms should not be simply considered as reverse events of those occurring in the induction phase. Anesthesia-induced loss of consciousness(LoC) and AE until RoC are quite distinct phenomena with, in part, a distinct neurobiology. Althoughanaesthetics produce LoC mostly by affecting cortical connectivity, arousal processes at the end of anesthesia are triggered by structures deep in the brain, rather than being induced within the neocortex. This work aimed to provide an overview on AE processes research, in terms of mechanisms, and EEG findings. Because most of the research in this field concerns preclinical investigations, translational suggestions and research perspectives are proposed. However, little is known about the relationship between AE neurobiology, and potential complications occurring during the emergence, and after the RoC. Thus, another scope of this review is to underline why a better understanding of AE mechanisms could have significant clinical implications, such as improving the patients' quality of recovery, and avoiding early and late postoperative complications.

关键词： Delirium Anesthesia Isoflurane Propofol Consciousness Awareness Electroencephalography

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When sepsis affects the heart: A case report and literature review

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World Journal of Clinical Cases 2015年第8期3卷 743-750页

作者： Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio Pinto U.O.C.di Medicina Interna e Cardioangiologia University of Palermo

A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient.

关键词： Sepsis Shock Hypotension Troponin Myocardial dysfunction

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Prevalence of functional gastrointestinal disorders in children with celiac disease on different types of gluten-free diets

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World Journal of Gastroenterology 2022年第46期28卷 6589-6598页

作者： Francesca Fiori Nastro Maria rosaria Serra Sabrina Cenni Daniela Pacella Massimo Martinelli Erasmo Miele Annamaria Staiano Carlo Tolone Renata Auricchio Caterina Strisciuglio Department of Translational Medical Science Section of PediatricsUniversity of Naples“Federico Ⅱ”Naples 80100Italy Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80100Italy Department of Public Health University of Naples“Federico Ⅱ”Naples 80100Italy Department of Woman Child and General and Specialistic SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

BACKGROUND Functional gastrointestinal disorders(FGIDs)are common during the pediatric *** are not related to biochemical or structural ***,since they have a high prevalence,several studies have evaluated an overlap between FGIDs and organic *** with celiac disease(CD)have been shown to be at an increased risk for functional abdominal pain,even if they adhere well to a gluten-free diet(GFD).Little information is available for the pediatric age *** aims of our study were to evaluate the prevalence of FGIDS in CD children 1 year after diagnosis and to compare the prevalence of FGIDs in CD children on a GFD with processed foods compared with those on a GFD with natural *** To assess the prevalence of FGIDs in children with CD after 1 year of follow-up and to compare the prevalence of FGIDs in children with CD on a GFD with processed foods and in children on a GFD with natural *** We recruited pediatric patients aged 1-18 years with a new CD *** were randomized to two groups:Group A on a GFD with processed foods(diet 1);and group B on a GFD with natural products(diet 2).Clinical monitoring,diet assessment and the questionnaire on pediatric gastrointestinal symptoms-Rome IV version were performed at diagnosis(T0)and after 12 mo of follow-up(T1).Dietary intake was assessed using a 3-d food diary *** from the diaries were evaluated using WinFood nutrient analysis *** assessed the prevalence of FGIDs at T1 and the correlation with the type of *** We registered 104 CD children,with 55 patients in group A(53.0%)and 49 patients in group B(47.0%).Initially,30 of the 55(54.5%)CD children were symptomatic in group A,while 25 of 49(51.0%)were symptomatic in group *** T1,in spite of a low or negative serology for CD,FGIDs prevalence was 10/55(18.0%)in group A and 8/49(16.3%)in group B,with no statistically significant difference between the two groups(P=0.780).At T1 the

关键词： Functional gastrointestinal disorders Celiac disease Gluten free diet Gastrointestinal symptoms Children

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Strongly Balanced 4-Kite Designs Nested into OQ-Systems

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Applied Mathematics 2013年第4期4卷 703-706页

作者： Mario Gionfriddo Lorenzo Milazzo rosaria Rota Dipartimento di Matematica e Informatica Universitá di Catania Catania Italy Dipartimento di Matematica Universitá di Roma Tre Roma Italy

In this paper we determine the spectrum for octagon quadrangle systems [OQS] which can be partitioned into two strongly balanced 4-kitedesigns.

关键词： Graphs Designs 4-Kite

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Use of residual lignocellulosic biomass for energetic uses and environmental remediation through pyrolysis

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Energy Storage and Saving 2022年第3期1卷 129-135页

作者： Nezly Martelo Mirari Antxustegi Eriz Corro Marya Baloch rosaria Volpe Antonio Gagliano Alberto Fichera María Gonzalez Alriols Biorefinery Processes Research Group(BioRP) Chemical and Environmental Engineering DepartmentUniversity of the Basque CountryUPV/EHUSan Sebastian20018Spain Department of Electrical Electronics and Computer EngineeringUniversity of CataniaCatania95125Italy

This study analyzes the potential of an agricultural residue,hazelnut shells,as raw material in a combined ther-mochemical process to obtain pyro-gas and biochar for environmental *** novelty of this study relies on the definition of a pyrolytic polygeneration process to simultaneously attain an energy-type product and abiochar to maximize the versatility of the products and their *** this aim,the heating value of the gas and its potential to feed a micro combined heat and power(micro-CHP)system was ***,the resulting biochar was chemically activated and tested as adsorbent for the removal of contaminants from an aqueous *** show that the pyro-gas from the shell-type residue was suitable to be used as feed stream in a micro-CHP unit,which was able to operate near the full-load(91.9%)with electrical and thermal efficiencies of 27.6%and 57.9%,*** the case of the biochar fraction,poor results were found for the char prior to ***,once it was activated with KOH,the resulting activated carbon presented high effectiveness as adsorbent and complete removal of the measured compound(methylene blue)was achieved.

关键词： Residual lignocellulosic biomass Bioenergy Pollutants removal Micro-CHP Biogas Biochar

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The Insurance Market of Natural Hazards for Residential Properties in Italy

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Open Journal of Earthquake Research 2016年第1期5卷 35-61页

作者： Fabrizio Terenzio Gizzi Maria rosaria Potenza Cinzia Zotta Institute for Archaeological and Monumental Heritage (IBAM) National Research Council (CNR) Potenza Italy

Insurance is an effective complementary countermeasure for unexpected losses brought about by natural hazards. Coverage can be a useful tool considering in particular that public funds available to compensate for damages are limited and the consequences of catastrophes are becoming more severe over the time. Bearing this in mind, the authors performed a study aiming to clear up the main aspects and limits of the insurance market of natural hazards for residential properties in Italy. The opening sections of the paper give an overview of both the historical extreme events in Europe and Italy, and the reasons for the low insurance penetration rate in Italy. After that, the paper goes to the core of the research casting light upon the insurance market in Italy and examining the features and possible drawbacks of the available insurance covers. In this paper, the geophysical (seismic and volcanic) and hydrological (landslide and flood) hazards are analysed, and the residential stock is taken as a reference. After deepening in the local insurance market, the research focuses on the possible suggestions to stakeholders of how to increase the insurance penetration rate by taking advantage of the international experiences.

关键词： Natural Hazards Damages Risk Perception Risk Management European Insurance Schemes

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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

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Neuroscience Bulletin 2018年第2期34卷 270-282页

作者： Maria Antonietta Panaro Alessandra Aloisi Giuseppe Nicolardi Dario Domenico Lofrumento Francesco De Nuccio Velia La Pesa Antonia Cianciulli rosaria Rinaldi Rosa Calvello Vania Fontani Salvatore Rinaldi Department of Biosciences Biotechnologies and Biophar- maceutics University of Bari Bari Italy CNR Institute for Microelectronics and Microsystems Via Monteroni (Campus Ecotekne) 73100 Lecce Italy Department of Biological and Environmental Sciences and Technologies Section of Human Anatomy University of Salento Lecce Italy Neuropathology Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute Via Olgettina 60 20132 Milan Italy Department of Mathematics and Physics University of Salento Via Amesano 73100 Lecce Italy CNR Institute of Nanoscience NEST Piazza San Silvestro 12 56127 Pisa Italy Department of Regenerative Medicine Rinaldi Fontani Institute Viale Belfiore 43 50144 Florence Italy Research Department Rinaldi Fontani Foundation Viale Belfiore 43 50144 Florence Italy IRF (Shanghai) Medical Sciences 3000 Long Dong Avenue Zhangjiang High-Tech Park Shanghai China

In this study, the effects of Radio Electric Asymmetric Conveyer(REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes(REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage inmice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TORGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

关键词： Parkinson’s disease Neurodegeneration Neuroinflammation REAC TO-RGN-N treatment

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