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Biquinho pepper(Capsium chinense):Bioactive compounds,in vivo and in vitro antioxidant capacities and anti-cholesterol oxidation kinetics in fish balls during frozen storage

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Food Bioscience 2022年第3期47卷 512-523页

作者： Bárbara Jardim Mariano Vanessa Sales de Oliveira Davy William Hidalgo Chávez rosane nora castro Cristiano Jorge Riger Jéssica Sodré Mendes Marcelo da Costa Souza Alexandra Christine Helena Frankland Sawaya Geni Rodrigues Sampaio Elizabeth Aparecida Ferraz da Silva Torres Tatiana Saldanha Department of Food Technology Institute of TechnologyUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Chemistry Institute of ChemistryUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Biochemistry Institute of ChemistryUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Botany Institute of Biological Sciences and HealthUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Faculty of Pharmaceutical Science University of CampinasUNICAMPCampinasSPBrazil Department of Nutrition School of Public HealthUniversity of São Paulo (USP)Ave.Dr.Arnaldo715São PauloSP01246-904Brazil

The present study reports bioactive constituents from biquinho pepper,such as carotenoids,capsaicinoids,and capsinoids,identified by *** pepper extract showed an antioxidant potential by DPPH(33.17±0.08%),ORAC(32.35±0.02μM TE/g),β-carotene/linoleic acid(55.80±1.30%),and FRAP(315.88±4.23μmol TE/g)***,in vivo antioxidant analyses demonstrated that the pepper extract(170μg/mL)decreased the damage promoted by H_(2)O_(2) in Saccharomyces cerevisiae *** balls were prepared using different concentrations of pepper(0.0%,0.5%,0.75%,1.0%)to investigate its antioxidant effect during frozen *** pepper effectively reduced the formation of cholesterol oxides and preserved essential fatty acids,mainly in samples containing 1.0%of ***,this treatment was more efficient than sodium erythorbate(p0.8).

关键词： Bioactive compounds Capsicum chinense Cholesterol oxides Frozen storage Natural antioxidants Unsaturated lipids

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Effects of Ranolazine on Carbohydrate Metabolism in the Isolated Perfused Rat Liver

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Open Journal of Medicinal Chemistry 2014年第4期4卷 87-95页

作者： Márcio Shigueaki Mito Cristiane Vizioli de castro rosane Marina Peralta Adelar Bracht Laboratory of Liver Metabolism Department of Biochemistry University of Maringá Maringá Brazil

The action mechanism of ranolazine, an antiangina drug, could be at least partly metabolic, including inhibition of fatty acid oxidation and stimulation of glucose utilization in the heart. The purpose of the present work was to investigate if ranolazine affects hepatic carbohydrate metabolism. For this purpose, the hemoglobin-free isolated perfused rat liver was used as the experimental system. Ranolazine increased glycolysis and glycogenolysis and decreased gluconeogenesis. These effects were accompanied by an inhibition of oxygen consumption. The drug also changed the redox state of the NAD+-NADH couple. For the cytosol, increased NADH/NAD+ ratios were observed both under glycolytic conditions as well as under gluconeogenic conditions. For the mitochondria, increased NADH/NAD+ ratios were found in the present work in the absence of exogenous fatty acids in contrast with the previous observation of a decreasing effect when the liver was actively oxidizing exogenous oleate. It seems likely that ranolazine inhibits gluconeogenesis and increases glycolysis in consequence of its inhibitory actions on energy metabolism and fatty acid oxidation and by deviating reducing equivalents in favour of its own biotransformation. This is in line with the earlier postulates that ranolazine diminishes fatty acid oxidation, shifting the energy source from fatty acids to glucose.

关键词： Glycogenolysis Glycolysis NAD+-NADH Redox Potentials Gluconeogenesis Ketogenesis

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Rethinking cytokine function during hepatitis A and hepatitis C infections

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Advances in Bioscience and Biotechnology 2013年第7期4卷 13-18页

作者： nora A. Fierro Flor P. castro-Garcia Arturo Panduro Unidad de Inmunovirologia Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara Mexico Universidad de Guadalajara Guadalajara Mexico Universidad de Guadalajara Guadalajara Mexico Servicio de Biologia Molecular en Medicina Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara Mexico

Hepatitis A virus (HAV) and hepatitis C virus (HCV) are both viruses with hepatotropic lifestyles. HAV induces an acute infection that results in the elimination of the virus by the host whereas HCV is typically able to establish a persistent infection that may result in cirrhosis and hepatocellular carcinoma. The mechanisms responsible for this difference are unknown. However, given HAV and HCV are both non-cytophatic viruses, the observed symptoms and liver injury during the infections are the result of specific immune responses under the control of cytokines. Thus, the production of cytokines during hepatotropic viral infections may constitute a mechanism leading to different outcomes. Therefore, understanding the differences in the cytokine patterns induced in response to HAV and HCV is likely to provide important insights into the cytokine-mediated mechanisms underlying the long-term persistence of HCV, the broad spectrum of clinical manifestations induced by HAV and the resolution of HAV infection during the acute phase. Herein, we focus on discoveries that hold promise in identifying cytokines as therapeutic targets for the treatment of viral hepatitis.

关键词： Hepatitis A Virus Hepatitis C Virus Cytokines

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Air Pollution in the Brazilian Road Transport and Its Environmental and Social Consequences

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Journal of Environmental Protection 2014年第15期5卷 1466-1476页

作者： Geórgia Amaral Mothé Marcelo Silva Sthel Maria Priscila Pessanha de castro rosane Toledo Alexandre Stumbo Marcelo Gomes Israel Esquef Helion Vargas Laboratory of Physical Sciences North Fluminense State University Center for Science and Technology Campos dos Goytacazes Brazil Laboratory of Chemical Sciences North Fluminense State University Center for Science and Technology Campos dos Goytacazes Brazil

The use of fossil fuels has been greatly increased since the eighteenth century with advent of the industrial revolution. Currently, the use of these fuels is responsible for, on average, 80% of energy generation in human society, producing large emission of pollutant gases and particulate material. Thus the transport sector is a major source of air pollution worldwide. This issue causes serious damages to the environment through phenomena such as acid rain, global warming and photochemical smog. Moreover, the emission of pollutants is also related to damages in human health. Brazil is a country with great territorial dimensions and its transport array is eminently by road, so it is a major consumer of fossil fuels, such as diesel, which has been producing serious environmental and social problems. Thus, this paper presents an analysis of the emission of gaseous pollutants and particulate matter from the transport sector (buses and trucks), gaseous pollutants such as NO2 and SO2 were detected in ppmv concentrations using electrochemical sensors. The composition constituents of the particulate materials emitted in diesel combustion and their respective concentrations were determined by X rays fluorescence spectrometry (XRF). The identified elements were: S, Fe, Si, Ca, Zn, P, Ni, Cr, Ti, Mn and Cu.

关键词： Pollutant Gases Particulate Materials Electrochemical Sensors X-Ray Fluorescence

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Production and Quality of Menthol Mint Essential Oil and Antifungal and Antigerminative Activity

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American Journal of Plant Sciences 2014年第21期5卷 3311-3318页

作者： Marco A. A. Souza Marcela J. Lemos Diego M. C. Brito Manlio S. Fernandes rosane N. castro Sonia R. Souza Department of Chemistry Universidade Federal Rural do Rio de Janeiro Seropédica Brazil Soil Department Universidade Federal Rural do Rio de Janeiro Seropédica Brazil

Agricultural products certified as organic and free of pesticides cannot use synthetic chemicals in the production process. In this context, the search for new natural products appears as an alternative to the use of conventional pesticides, aiming to combat agricultural diseases. Menthol is a natural product obtained from plants that has importance in different branches of industry, mainly due to the feeling of freshness it provides in contact with skin and mucous. Menthol (70% - 90%) is the main compound of the menthol mint essential oil, followed by menthyl acetate (7% - 12%), which is an indicator of maturation. There are references to the period of maturation of menthol mint essential oil corresponds the period of flowering, on the other hand, are also presented evidence that the maturation of menthol mint essential oil is controlled by leaf expansion, namely with the physiological age of each leaf. Besides evaluating the essential oil production and quality extracted by hydrodistillation of young leaves (3rd to 5th node) and adult (6th to 8th node), was also proposed in this work to study the effect of menthol mint essential oil on the development of fungi of agricultural significance and commercial seeds of lettuce and tomato. After the extraction of the essential oil, was noted that adult leaves presented a higher content of essential oil, combined with the best commercial quality, showing higher levels of menthyl acetate and menthol. The menthol mint essential oil exhibited average fungitoxicity and antigerminative activity on Fusarium oxysporum, Rhizoctonia solani and Sclerotium rolfsii. On the other hand, menthol and terpineol, two essential oil components, showed the maximum fungitoxicity activity under this species and no inhibitory effect on the germination of lettuce and tomato.

关键词： Mentha arvensis Antigerminative Activity Antifungal Activity Gas Chromatography

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Chemical Composition of the Essential Oil and Nitrogen Metabolism of Menthol Mint under Different Phosphorus Levels

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American Journal of Plant Sciences 2014年第15期5卷 2312-2322页

作者： Marco A. A. Souza Osmário J. L. Araújo Diego M. C. Brito Manlio S. Fernandes rosane N. castro Sonia R. Souza Department of Chemistry Universidade Federal Rural do Rio de Janeiro Seropédica Brazil Soil Department Universidade Federal Rural do Rio de Janeiro Seropédica Brazil

The purpose of this work was to evaluate the effects of different phosphorus levels (0.05, 0.5, 1 and 2 mM) under nitrogen metabolism and the essential oil profile of menthol mint (Mentha arvensis L.). The relationship between the leaf maturity and the essential oil profile was also explored. The experiment was conducted in a hydroponic system located in a grow chamber during 41 days and after the harvest, nitrate reductase activity, and the -N, amino-N, and soluble sugars levels of each plant part were evaluated. Also the essential oil from young leaves (6th to 8th node) and adult leaves (3rd to the 5th node) was analyzed. An uptake mechanism related to the increase in fresh weight of the roots was promoted with the use of low P levels (0.05 and 0.50 mmol·L-1). With 1 mmol·L-1 P plants showed in all parts an increased nitrate reductase activity and high levels of nitrate and amino-N in leaves. Plants submitted to the lowest P level (0.05 mmol·L-1) presented high levels of menthol. In leaves from 6th to 8th node (mature leaves) menthol level was approximately 87% of the essential oil however leaves from the 3rd to the 5th node (young leaves) showed high levels of pulegone, that can be toxic for humans. The results indicate that the essential oil quality in menthol mint is influenced by the leaf maturity and the P levels. Also it was showed that the oil extracted from mature leaves of plants under low P levels has the best commercial profile.

关键词： Mentha arvensis L. Lamiaceae Gas Chromatography Hydropony Menthol

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The in Vitro Antioxidant Capacities of Hydroalcoholic Extracts from Roots and Leaves of Smallanthus sonchifolius (Yacon) Do Not Correlate with Their in Vivo Antioxidant Action in Diabetic Rats

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Journal of Biosciences and Medicines 2016年第2期4卷 15-27页

作者： Ana Carla Broetto Biazon Mariana Marques Nogueira Wendt Júlia Rosa Moreira Cristiane Vizioli castro Ghizoni Andreia Assunção Soares Sandra da Silva Silveira Anacharis Babeto de Sá-Nakanishi Ciomar Aparecida Bersani Amado rosane Marina Peralta Adelar Bracht Jurandir Fernando Comar Pharmacy Department Faculdades Integrado Campo Mourao Brazil Biochemistry Department University of Maringá Maringá Brazil Pharmacology and Therapeutics Department University of Maringá Maringá Brazil

Leaf and root extracts of Smallanthus sonchifolius (yacon), have antihyper-glycemic activity and antioxidant properties. The present study aims to compare the in vivo hepatic antioxidant activity of hydroalcoholic extracts of yacon leaves and roots in rats with streptozotocin-induced diabetes in terms of their in vitro antioxidant capacity. Rats were treated during 14 days with 1060 mg·Kg-1 root extract or 400 mg·Kg-1 leaf extract. The latter was richer in phenolics and possessed a much higher in vitro antioxidant activity. Both extracts prevented hyperglycemia in diabetic rats. The liver of diabetic rats presented increased levels of protein carbonyls and ROS and decreased activities of antioxidant enzymes. Treatment with both root and leaf extracts restored the protein carbonyl levels to normality. The root extract also restored the ROS levels to normality, but the leaf extract was not effective. The root extract was also more effective in restoring the activity of at least two important antioxidant enzymes (glucose 6-phosphate dehydrogenase and glutathione peroxidase). In terms of the antioxidant load (which was 17 times lower in the root extract treatment), the in vivo action of the root extract was more effective than the leaf extract in reducing the hepatic oxidative stress that accompanies diabetes.

关键词： Smallanthus sonchifolius Yacon Streptozotocin-Induced Diabetes Liver Oxidative Status

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