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Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats

Journal of Biophysical Chemistry 2012年第2期3卷 174-182页

作者： Carolina Restini rosana Reis Claudio Costa-Neto Norberto Garcia-Cairasco José Cortes-de-Oliveira Lusiane Bendhack Universidade de Ribeiraão Preto—UNAERP. Curso de Medicina Ribeirāo Preto Brasil Faculdade de Ciências Farmacêuticas de Ribeiro Preto-USP Ribeiro Preto Brasil Faculdade de Medicina de Ribeirão Preto-USP Ribeir&atildeo Preto Brasil Faculdade de Medicina de Ribeiro Preto-USP Ribeiro Preto Brasil

Epidemiological studies have found that the risk for cardiovascular disease is increased in patients with epilepsy. The Renin Angiontensin System (RAS), an important player in vascular tone control, is also involved in many neurological disorders, including seizures and epilepsy. Although it has been reported that Angiotensin II (Ang II) release and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models with neurological disorders, there are no data on the vascular function. We evaluated Ang I and Ang II-mediated vascular responses and to correlate their contractile responses to the pres- ence of endothelium and the protein levels of components of the RAS (AT1, AT2, Mas and ACE) in aorta isolated from genetically epileptic rats (WAR strain). The major finding was that the vascular contractile response induced by Ang I and Ang II is endothelium-dependent. Ang II induced contractions in aortas from Wistar rats either with intact endothelium (E+) (1.16 ± 0.04 g, n = 6) and endothelium-denuded (E-) (1.24 ± 0.04 g, n = 6). Maximum contractile response (ME) induced by Ang I was lower in Wistar E+ (0.45 ± 0.03 g, n = 6) compared with Wistar E- (1.13 ± 0.08 g, n = 6). Ang I and Ang II failed to induce contraction in WAR E+, whereas the ME induced by Ang I in WAR E- was lower (0.52 ± 0.04 g, n = 11) than in the Wistar. ME induced by Ang II in aortas from WAR was also lower (0.40 ± 0.03 g, n = 11) compared with Wistar. AT1 receptor expression in both E+ WAR and Wistar was lower than in both E- WAR and Wistar. AT2 and Mas receptor expression was higher in Wistar E- and E+ as compared to WAR E- and E+. ACE expression was higher in both E+ WAR and Wistar, but it was lower in both E- WAR and Wistar. Endothelium impairs the contractile response induced by Angiotensin in WAR, suggesting that endothelial relaxing factors play important role on the aorta contraction.

关键词： Endothelium Aorta Myogenic Tone Angiotensin Angiotensin II Receptor Epilepsy

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Phase angle through electrical bioimpedance as a predictor of cellularity in inflammatory bowel disease

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Artificial Intelligence in Gastroenterology 2021年第4期2卷 111-123页

作者： Sabrina A Fernandes Carina Rossoni Vivian W Koch Marcello Imbrizi rosana Evangelista-Poderoso Leticia Pereira Pinto Letiia Pereira Pinto Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Institute of Environmental Health(ISAMB) Faculty of MedicineUniversity of LisbonLisbon 1649-028Portugal Gastroenterology Department Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology Department Grupo Hospitalar ConceicaoPorto Alegre 91350-250Brazil Coloproctology Department State University of Campinas(UNICAMP-SP)São Paulo 13056-405Brazil Library Faculty of Medical Sciences State University of Campinas(UNICAMP-SP)São Paulo 13083-887Brazil Department of Surgery State University of Campinas(UNICAMP-SP)and Faculty of Medical Sciences(FCM)São Paulo 13056-405Brazil

It is estimated in Western industrialized countries that inflammatory bowel disease(IBD)has a prevalence of 1 for every 200 *** the past,the fat mass disproportionate increase in relation to the fat-free mass was considered uncommon in patients with IBD,due to the observation of the disease being more common with weight loss and ***,more in-depth investigations demonstrate that the fat/lean mass disproportion stands out both in prevalence in patients with new diagnoses of ulcerative colitis or Crohn's disease as well as a factor of poor prognosis to the natural evolution of the disease or to the therapeutic *** important aspect associated with obesity in IBD is the increased risk of drug clearance[including anti-tumor necrosis factor(TNF)and anti-integrin agents],resulting in short half-life and low trough drug concentrations,since the levels of TNF secreted by adipocytes sequester anti-TNF agents,which could result in suboptimal response to *** view of these characteristic aspects of the inflammatory process of IBD,the identification of cellular functioning is necessary,which can be associated with the staging of the underlying disease,biochemical parameters,and body composition,helping as an indicator for a more accurate clinical and nutritional conduct.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Phase angle Cellularity Bioelectrical impedance

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Effect of Pre-Analytical Conditions on Salivary Nitrite Levels

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American Journal of Analytical Chemistry 2011年第6期2卷 683-688页

作者： rosana Andrea Morelatto Tomás Enrique Benavidez Ana María Baruzzi Velia Matilde Solís Silvia Adriana López de Blanc 不详

The aim of the present paper was to analyze the influence of sampling and storage procedures on nitrite con- centration values in the saliva of healthy persons. The samples were obtained and stored under varied condi- tions, and processed using the Griess method. Results: when the salivary nitrite concentration was measured immediately after collection a significant dependence on the collection time was observed. A mean value of 94 μmol/L (range 3 - 625) was obtained at 8:30 am. This value decreased significantly with time (p < 0.05) reaching a value of 68 at 12:30 noon. Concerning the sample storage, a significant increase in the nitrite concentration was observed after 2 hrs, either at 4?C or at room temperature (p < 0.05). In spite of the high variability between individuals the values for each individual showed a marked constancy independent of the sampling day. According to our results, by controlling pre-analytical parameters, principally sampling and storage procedures, reproducibility is improved.

关键词： Salivary Nitrite Saliva Oral Cancer Storage Conditions

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Non-pharmacological cognitive intervention for aging and dementia:Current perspectives

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World Journal of Clinical Cases 2013年第8期1卷 233-241页

作者： Jorge Alves rosana Magalh?es álvaro Machado óscar F Gon?alves Adriana Sampaio Agavni Petrosyan Neuropsychophysiology Lab CIPsiSchool of PsychologyUniversity of Minho4710-057BragaPortugal Department of Neurology Hospital de Braga4710-243 BragaPortugal Department of Counseling and Applied Educational Psychology Bouvé College of Health SciencesNortheastern UniversityBostonMA 02115United States Department of Cognitive Sciences University of California at IrvineIrvineCA 92717United States

In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive(e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia(mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well.

关键词： Dementia Aging Cognitive intervention Cognition Non-pharmacological therapies

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ZSM5 as a Potential Catalyst for Glycerol Pyrolysis

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Journal of Sustainable Bioenergy Systems 2014年第1期4卷 61-67页

作者： Margarida L.Castello Jo Dweck Donato A.G.Aranda rosana C.L.Pereira Manoel J.R.Guimaraes Neto Chemical School Federal University of Rio de JaneiroRio de JaneiroBrazil Fluminense Federal Institute—Campus Macae MacaeBrazil Petrobras’Research Center Rio de JaneiroBrazil

Glycerol is a substance known to humankind for many years now, and among other products, in which composition it is used, are the pharmaceutical, cosmetic, food, paints and varnishes REF _Ref382993082 \r \h [1]REF _Ref382993086 \r \h [6]. The abundance of its supply leads to search for new uses, whether as a plasticizer for biodegradable polymers REF _Ref382993096 \r \h [7], its transformation into other substances like propylene and derivatives or other hydrocarbons [8] [9], the production of hydrogen for energy purposes REF _Ref382993109 \r \h [10], or even direct burning, making glycerol a fuel for boilers, for example. The aim of this work was to investigate the action of the zeolite ZSM5 on glycerol fast pyrolysis at 600°C. The tests were done with a mixture of glycerol-ZSM5 recently prepared using approximately equal volumes of glycerol and the catalyst, and the effluent gases from the fast pyrolysis have been analyzed in a chromatography/mass spectrometry (GC/MS) system. Experiments showed that ZSM5 acts in the pyrolysis of glycerol leading to a large number of substances, from oxygenated products to hydrocarbons, which are part of typical compositions of naphtha, diesel and gasoline petroleum derived products.

关键词： Glycerol ZSM5 Pyrolysis

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Can gadoxetic acid–enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?

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World Journal of Hepatology 2020年第9期12卷 661-671页

作者： Viviane Brandão Amorim Daniella Braz Parente Fernando Fernandes Paiva Jaime Araújo Oliveira Neto Amanda Almeida Miranda Cláudia Cravo Moreira Flávia Ferreira Fernandes Carlos Frederico FerreiraCampos Nathalie Carvalho Leite Renata de Mello Perez rosana Souza Rodrigues Research Department D’Or Institute for Research and EducationRio de Janeiro 22281Brazil Radiology Department Brazilian National Cancer InstituteRio de Janeiro 20230-130Brazil Radiology Department Fleury Group S.A.Rio de Janeiro 20765-000Brazil Radiology Department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil São Carlos Institute of Physics University of São PauloSão Carlos 13560-970Brazil Radiology Department Quinta D'Or HospitalRio de Janeiro 20941-150Brazil Radiology Department Centro de Diagnóstico Médico do MaranhãoMaranhão 65074-441Brazil Department of Clinical Medicine Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology and Hepatology Department Hospital Federal de BonsucessoRio de Janeiro 21041-030Brazil Department of Pathology and Laboratories University of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil Internal Medicine Department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology Department Hospital Universitário Pedro ErnestoUniversity of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major cause of liver disease *** diagnosis of nonalcoholic steatohepatitis(NASH),the most severe form of NAFLD,is crucial and has prognostic and therapeutic ***,currently this diagnosis is based on liver biopsy and has several *** To evaluate the performance of gadoxetic acid–enhanced magnetic resonance imaging(GA-MRI)in differentiating isolated steatosis from NASH in patients with *** In this prospective study,56 patients with NAFLD(18 with isolated steatosis and 38 with NASH)underwent *** contrast enhancement index(CEI)was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA ***-group differences in mean CEI were examined using Student's t *** area under the receiver operator characteristic curve and the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging were *** The mean CEI for all subjects was 1.82±*** mean CEI was significantly lower in patients with NASH than in those with isolated steatosis(P=0.008).Two CEI cut-off points were used:2.00(89%sensitivity)to characterize isolated *** values between 1.66 and 2.00 indicated liver biopsy,and the procedure could be avoided in 40%of patients with *** GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis,and could help to avoid liver biopsy in patients with NAFLD.

关键词： Fatty liver Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gadoxetic

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Chronic pain profile: An interaction between biological and psychosocial factors

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Pain Studies and Treatment 2013年第2期1卷 9-16页

作者： Marcus A. Alcantara rosana F. Sampaio Mariana A. P. Souza Fabiana C. M. Silva Renata N. Kirkwood Department of Occupational Therapy Institute of Health Sciences Universidade Federal do Triangulo Mineiro (UFTM) Uberaba Brazil Department of Physical Therapy Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil Department of Physical Therapy Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) Diamantina Brazil Post Graduate Program in Rehabilitation Sciences Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil Kinesiology Department University of Waterloo Waterloo Canada Post Graduate Program in Rehabilitation Sciences Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil

OBJECTIVE: To Identify subgroups of workers with chronic pain based on the interaction of different pain dimensions (sensory, affective, evaluative and mixed), depression, beliefs regarding pain, physical incapacity and socio-demographic-clinical data. METHODS:An observational cross-sectional study was carried out with a convenience sample made up of 115 patients with work-related musculoskeletal disorders (WRMD). The participants answered the McGill Pain Questionnaire, Beck Depression Inventory, Survey of Pain Attitudes, Roland-Morris Disability Questionnaire and a form for socio-demographic and clinical data. RESULTS: Four distinct subgroups were identified, two of which reported pain of a sensory-affective nature and two reported predominantly sensory pain. The individuals in subgroups I and III reported higher levels for all variables analyzed, while the first cluster had the highest mean scores. The subgroup II exhibited moderate degrees of physical disability and a high sick leave index, although the members of this group were less depressed and less dependent upon analgesics. Lower levels of pain, physical disability and depression were associated to subgroup IV, which also had the greatest proportion of males. Beliefs were similar among the subgroups. CONCLUSIONS: Patients with moderate to strong chronic pain associated to sensory and affective components exhibited a higher degree of disability and depression. The results suggest that the chronification process of pain and its functional consequences vary between individuals and are influenced by emotional factors.

关键词： Disability Evaluation Functioning Chronic Pain Musculoskeletal Diseases Depression

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Prevalence and Incidence of Hand Osteoarthritis and Upper Limb Complaints in Patients with Knee Osteoarthritis. Correlations among Functionality, Grip Strength, Changes in Body Mass Index and Symptoms among Patients in an Educational Osteoarthritis Program

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Open Journal of Orthopedics 2016年第1期6卷 1-9页

作者： Vinicius Canello Kuhn Daniele dos Santos Scarcella rosana Mayumi Suzuki Ligia Cortez de Almeida Nádia Lucila Rocha Brito Marcia Uchoa de Rezende Department of Orthopedics and Traumatology Hospital das Clínicas Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil

Objective: To evaluate the prevalence of hand osteoarthritis (hOA) in a population with knee osteoarthritis (KOA) at baseline and one year following the administration of a multi-professional OA educational program correlating symptoms and changes in BMI with function questionnaires of the upper limbs and direct grip strength measurements. Design: Epidemiological study of the prevalence of hand OA in patients with knee osteoarthritis. The Stanford Health Assessment Questionnaire instruments (HAQ);Disabilities of the Arm, Shoulder and Hand* (DASH);grip strength;and finger pinch were utilized, and the upper limbs symptoms were verified at baseline and one year following the educational program. Results: The prevalence of hOA was 23.7% at baseline and 47.4% at one year (incidence of 31.8% per year). The HAQ indicated that patients who did not alter or increased their BMI experienced worsened global strength, whereas patients who reduced BMI improved global strength (p = 0.041). Patients with higher initial BMIs experienced less improvement in the HAQ (r = -0.148, p = 0.041). The DASH results improved, but the right and left tripod grip worsened in all patients, irrespective of BMI change (p < 0.05) or symptoms at baseline and reassessment (p < 0.05). Pinch strength (right and left tripod and left pulp-pulp) was higher in patients without symptoms at baseline (p = 0.048, p = 0.045 and 0.033, respectively). Conclusions: The prevalence of hand OA increased for patients with OA undergoing an educational program irrespective of improved upper function and regardless of BMI change. Patients who decreased their BMI improved their global strength.

关键词： Hand Deformities Acquired Hand Strength Osteoarthritis Knee Prevalence Incidence Health Education

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The Application of Scales in the Diagnosis of Perceived Needs in the Elderly with Mild Cognitive Impairment

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Open Journal of Nursing 2016年第8期6卷 573-581页

作者： Josélia Braz dos Santos Ferreira Selma Petra Chaves Sa Luciana Krauss Rezende rosana Moreira de Sant’Anna Ana Maria Domingos Rosimere Ferreira Santana University Hospital Antônio Pedro Universidade Federal Fluminense (UFF) Niterói Brazil Afonso Aurora Costa Nursing School Universidade Federal Fluminense (UFF) Niterói Brazil Ana Neri School of Nursing Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil

The study evaluated the use of the Mini-Mental State Examination scale (MMSE), Tinettiscale, and Motor Scale for the Elderly (EMTI) toassist in the diagnosis of potential needs observed in elderlies with Mild Cognitive Impairment. This was aquasi-experimental research, conducted in a Basic Health Unit in thecityof Rio de Janeiro in 2014. The sample population consisted of 22 elderlies aged 64 to 88 years and 86.36% females. The SAS statistical software (version 9.3.1) and Kruskal-Wallis test were used at a 95% confidence interval and a significance level of 0.05 and demonstrated significant differences in the evaluations performed before and after the intervention. The detected diagnoses were: impaired memory, the risk of falls, and willingness to improved relationships, among others. The evaluations showed MMSE results that were suggestive of cognitive impairment in 22.73% of the elderlies;the Tinetti scale showed a high risk of falls in 31.82% of theelderlies;and EMTI with 88.36 points, which was equivalent to the normal low classification. The intervention took place through ten weekly activity sessions after the initial evaluations. In the second evaluation, the Tinetti showed 59.09% of the elderlies with a moderate risk of falls and the EMTI as the normal average classification with 90.32 points. It was concluded that the scales offered diagnostic possibilities, which allowed for the implementation of necessary interventions according to the detected problems.

关键词： Nursing Diagnosis Mild Cognitive Impairment Sensory-Motor Performance Postural Balance Elderlies

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巴西雨林自然保护区河流中杀虫剂残毒:对水生生物和人类健康的影响评价

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AMBIO－人类环境杂志 2003年第4期32卷 258-263页

作者： rosana Moraes Sara Elfvendahl Henrik Kylin Sverker Molander 周立志 Chalmers技术大学环境系统分析系瑞典农业大学环境评价系

1998年11月,1999年3月和2000年元月分别在巴西雨林自然保护区河流的水体、沉积物和鱼体中检测杀虫剂残毒,每种杀虫剂浓度与基于急性毒性测试的生态毒理基准进行了比较,并且还与规定标准进行比较,以确定它们对水生生物和人类潜在影响的... 详细信息

1998年11月,1999年3月和2000年元月分别在巴西雨林自然保护区河流的水体、沉积物和鱼体中检测杀虫剂残毒,每种杀虫剂浓度与基于急性毒性测试的生态毒理基准进行了比较,并且还与规定标准进行比较,以确定它们对水生生物和人类潜在影响的程度。在所有的7个调查地点都检测出杀虫剂及其代谢产物,在水体以及沉积物样品中检测出总共27种杀虫剂及其代谢物的残毒,鱼类富集其中莱些最持久稳固的残毒。水体和沉积物中检测出的杀虫剂残毒浓度表明水生生物保护的问题需要引起重视,水体中的几种杀虫剂含量超过了巴西以及欧盟当局规定的指标,表明对人类的健康也有影响。

关键词：巴西雨林自然保护区河流杀虫剂残毒水生生物人类健康环境影响评价

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