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High- and Low-Rearing Rats Differ in the Brain Excitability Controlled by the Allosteric Benzodiazepine Site in the GABA_(A) Receptor

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Journal of Behavioral and Brain Science 2012年第3期2卷 315-325页

作者： rosana Alves Jose Gilberto Barbosa de Carvalho Marco Antonio Campana Venditti Departamento de Psicobiologia Escola Paulista de MedicinaUniversidade Federal de Sao PauloRua BotucatuBrazil

Rearing is an exploratory behavior induced by novelty, such as exposure to an open field. Stimulation of certain brain regions, including the hippocampus, induces both rearing and clonic convulsions. Brain excitability is controlled by gamma-aminobutyric acid (GABA) inhibitory neurotransmission through its ionotropic GABAA/allosteric benzodiazepine site. Drugs that decrease GABAA receptor fast inhibitory neurotransmission induce clonic convulsions and rearing when injected into the hippocampus. Therefore, individual differences in rearing behavior may be related to the susceptibility to clonic convulsions, which could involve differences in brain excitability controlled by GABAA/allosteric benzodiazepine site receptors. Adult, male Wistar rats were divided into high- (HR) and low-rearing (LR) groups based on the number of rearings in the open field test. Groups of HR and LR rats were challenged with convulsant drugs that antagonize GABA neurotransmission via different mechanisms of action (3-mercaptopropionic acid, a glutamate decarboxilase inhibitor;bicuculline, a GABAA receptor antagonist;pentylenetetrazol and picrotoxin, both GABAA receptor chloride channel blockers and DMCM, a benzodiazepine inverse agonist). The convulsant doses that induced 50% of clonic convulsions were determined for each drug. The LR rats had a higher susceptibility (a lower convulsant dose 50%) to clonic convulsions induced by DMCM than the HR rats, but there were no differences between the groups in the susceptibility to tonic convulsions induced by the same drug. There were no significant differences in the convulsant dose 50% for clonic convulsions between the groups for all other drugs injected. In another experiment, additional HR and LR rats were injected with a sedative-hypnotic dose of diazepam, which caused a significantly higher hypnotic effect (sleeping-time) in the LR rats than in the HR rats. The LR group was also shown to have a significantly lower density of [3H]-Flunitrazep

关键词： Open Field Rearing Behavior Clonic Convulsion Diazepam Sleep Benzodiazepine DMCM GABA_(A) Receptor [^(3)H]-Flunitrazepam Binding Hippocampus Novelty Stress

Study of the Potential Value of flex affinis （Aquifoliaceae） as a Novel Source for the Food and Pharmaceutical Industries

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Journal of Life Sciences 2014年第1期8卷 10-14页

作者： Laura Cogoi Renzo Martino Gustavo Giberti Claudia Anesini rosana Filip Institute of Drug Chemistry and Metabolism National Research Council Faculty of Pharmacy and Biochemistry University of Buenos A ires Buenos A ires 956 (1113) Argentina

llex paraguariensis St. Hilaire （Aquifoliaceae） is processed industrially to produce the commercial product ＂yerba mate＂ which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others, llex affinis grows in the same habitat and is used as substitute or adulterant ofI. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.

关键词： llex affinis llex paraguariensis polyphenols chlorogenic acid antiproliferative activity.

La sombra de un fotógrafo

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服装美学史(一)(从美学角度看服装史的发展)

2009年

作者： Acquaroni rosana. 1547-1616.

来源：畅想之星图书光盘版（南... 评论

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国外纺织技术 1984年第15期 2-7页

作者： rosana Pistolese 章敏

美索不达米亚有关服装史的书籍,仅仅提供了人类所设想和真实存在的过去五千年来零星片断的记载。面对许多瑰丽壮观的考古发现,我们依然对古代文明的高尚趣味、新颖样式和美妙设想惊叹不已。一则由于它们反映了人类进化的惊人进程,二则... 详细信息

美索不达米亚有关服装史的书籍,仅仅提供了人类所设想和真实存在的过去五千年来零星片断的记载。面对许多瑰丽壮观的考古发现,我们依然对古代文明的高尚趣味、新颖样式和美妙设想惊叹不已。一则由于它们反映了人类进化的惊人进程,二则由于我们的一知半解,所以古代世界就愈显得丰富多彩、引人入胜了。

关键词：服装史王朝装饰品尼基苏美尔人尼罗河流苏亚述人亚述利亚人男人苏美尔语法老埃及人假发巴比伦穿着

Evaluation of the Maintenance Management Associated with the Performance of a Public Building

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Journal of Civil Engineering and Architecture 2017年第5期11卷 448-454页

作者： Marina Villanueva Elaine Vazquez Justino Nobrega rosana Miranda Jose Artur Mussi Lais Alves Department of Civil Construction Federal University of Rio de Janeiro Rio de Janeiro R J 21941-909 Brazil Department of Industrial Engineering Veiga de Almeida University Rio de Janeiro R J 20271-020 Brazil DVSST Department Post Graduate Studies on Safety Engineering Federal University of Rio de Janeiro Rio de Janeiro R J21941-909 Brazil Department of Civil Engineering Federal Center of Technological Education Celso Suckow da Fonseca Rio de Janeiro R J20271-110 Brazil

The lack of proper maintenance in buildings is responsible for various anomalies, which can cause property and personal damage. The objective of this study is to analyze the maintenance management of the administration building at the Technological Park UFRJ/Brazil, trying to emphasize the relation between maintenance and good performance of the building and to demonstrate the need to develop a consistent maintenance system to achieve an efficient maintenance management. The study allowed to present strategies and possibilities of interventions, in addition to proposing the essential aspects for the development of a structured maintenance system. After reviewing the issue of building maintenance under the various perspectives presented, the importance of planning a preventive building maintenance, according to standards, to achieve the level of performance expected for the building, besides being essential the search for tools and methods that can increase the efficiency of management can be concluded. It is also pertinent to conclude that prevention is the most effective solution against the depreciation factors that affect a building, being the most economical viable, and ensuring other benefits for the building and its users, such as security, property valuation and attendance to the warranty period.

关键词： Maintenance performance maintenance management Technological Park UFRJ/Brazil.

服装美学史(三)(从美学角度看服装史的发展)

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国外纺织技术 1984年第17期 8-15页

作者： rosana Pistolese 章敏

古代希腊由于与克里特、迈锡尼、阿迦安(Achaean)、多利亚(Dorian)和东方文化等五种文化的频频交往;以及多次大规模的迁徒和对希腊本土发动的侵略战争,特别是多利安人和阿迦安人的入侵;更有那不计其数的为财产而起的部落纷争——所有这... 详细信息

古代希腊由于与克里特、迈锡尼、阿迦安(Achaean)、多利亚(Dorian)和东方文化等五种文化的频频交往;以及多次大规模的迁徒和对希腊本土发动的侵略战争,特别是多利安人和阿迦安人的入侵;更有那不计其数的为财产而起的部落纷争——所有这些因素导致

关键词：罗马帝国罗马人拉斯希腊人伊特拉斯坎人服装史

服装美学史(四) (从美学角度看服装史的发展)

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国外纺织技术 1984年第18期 1-7页

作者： rosana Pistolese 章敏

拜占廷时期由于财富的垄断与集中,罗马的势力日趋衰退。到公元200年时,靠吸收古希腊文化而得以蓬勃兴盛的罗马文明仅残留下了一具军事政体的躯壳,岌岌可危的罗马帝国在戴克里先(Diocletian)当权时曾一度稍见起色,但这位君王的所谓功绩... 详细信息

拜占廷时期由于财富的垄断与集中,罗马的势力日趋衰退。到公元200年时,靠吸收古希腊文化而得以蓬勃兴盛的罗马文明仅残留下了一具军事政体的躯壳,岌岌可危的罗马帝国在戴克里先(Diocletian)当权时曾一度稍见起色,但这位君王的所谓功绩也不外乎搞独裁暴政,仰仗东方朝廷的一些专制制度,残民害理,姿意践踏朝政王法。

关键词：罗马帝国艺术风格拜占廷帝国服装基督教徒

Contamination Precautions for Chemicals Which May Be Used in Drinking Water Treatment

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Journal of Materials Science and Chemical Engineering 2015年第11期3卷 63-71页

作者： Fernando B. Mainier Leandro Pontual rosana Therezinha Q. de Oliveira Isabela de Oliveira Santos Universidade Federal Fluminense Escola de Engenharia Niter&oacute i Brazil

The present study aims to treat some aspects of environmental contamination under the focus of the principle of precaution, which is based on ideas and discussion about the concerns of society regarding ethics, the environment, water resources, the risk of contamination, and the uncertainties of technological applications in all areas of human knowledge. In the assessment of these scenarios it was decided to evaluate, under a critical view, the chemicals used in the treatment of drinking water, which could cause health problems, directly or indirectly, in the population. Some samples of commercial aluminium sulphate were analysed, concluding that there was a need for physical and chemical assessments to identify the origins of the raw materials used in its manufacturing process.

关键词： Aluminium Sulphate Contamination Drinking Water Principle of Precaution

Successfully non-surgical management of flail chest as first manifestation of multiple myeloma: A case report

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World Journal of Critical Care Medicine 2019年第5期8卷 82-86页

作者： rosana Munoz-Bermúdez Eugenia Abella Flavio Zuccarino Joan Ramon Masclans Juan Nolla-Salas Critical Care Hospital del Mar Barcelona 08003 Spain Hematology Hospital del Mar Barcelona 08003 Spain Radiology Hospital del Mar Barcelona 08003 Spain

BACKGROUND Multiple myeloma is a malignant neoplasm of the bone marrow characterized by neoplastic proliferation of monoclonal plasma cells with a high relationship with destructive bone disease. We present a case of a patient diagnosed with multiple myeloma and sternal fracture in association with multiple bilateral rib fractures and thoracic kyphosis, who developed a severe acute respiratory failure, thus complicating the initial presentation of multiple myeloma. We discuss the therapeutic implications of this uncommon presentation. CASE SUMMARY A 56-year-old man presented to Hematological Department after he had been experiencing worsening back pain over the last five months, with easy fatigability and progressive weight loss. He had no history of previous trauma. The chemical blood tests were compatible with a diagnosis of multiple myeloma. A radiographic bone survey of all major bones revealed, in addition to multiple bilateral rib fractures, a sternal fracture and compression fracture at T9, T10, T11 and L1 vertebrae. Subcutaneous fat biopsy was positive for amyloid. We started treatment with bortezomib and dexamethasone. After 24 h of treatment, he presented dyspnea secondary to flail chest. He required urgent intubation and ventilatory support being transferred to intensive care unit for further management. The patient remained connected to mechanical ventilation (positive pressure) as treatment which stabilized the thorax. A second cycle of bortezomib plus dexamethasone was started and analgesia was optimized. The condition of the patient improved, as evidenced by callus formation on successive computed tomography scans. The patient was taken off the ventilator one month later, and he was extubated successfully, being able to breathe unaided without paradoxical motion. CONCLUSION This case highlights the importance of combination between bortezomib and dexamethasone to induce remission of multiple myeloma and the initiation of positive airway pressure with

关键词： Multiple myeloma Flail chest Bortezomib Mechanical ventilation Case report