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The Beauty of Being a Variant： H2A.Z and the SWR1 Complex in Plants

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Molecular Plant 2009年第4期2卷 565-577页

作者： rosana March-Diaz Jose C. Reyes Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) CSIC Americo Vespucio s/n E-41092 Sevilla Spain

Numerous studies have shown that the nucleosome is a dynamic structure that strongly influences gene expression. Dynamism concerns different nucleosomal characteristics, including position, posttranslational modifications, and histone composition. Thus, within the nucleosome, canonical histones can be exchanged by histone variant proteins with specific functions--a process known as ‘histone replacement＇. The histone variant H2A.Z has an important function in transcription and, during the last few years, its role in plant development and immune response has become evident. Compiling genetic and biochemical studies from several laboratories has revealed that plants contain a multiprotein complex, similar to the SWR1/SRCAP complex from yeast and animals, involved in H2A.Z deposition. Despite intense research in different organisms, the mechanism by which H2A.Z influences transcription is still unknown. However, recent results from Arabidopsis have shown a strong inverse correlation between H2A.Z and DNA methylation, suggesting that H2A.Z might protect genes from silencing.

关键词： Chromatin structure and remodeling epigenetics gene regulation floral induction.

Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats

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Food Science and Human Wellness 2023年第6期12卷 2022-2028页

作者： Maria rosana Ramirez Debora Manuale Juan Carlos Yori Instituto Universitario de Ciencias de la Salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina Consejo Nacional de Investigaciones Científi cas Técnicas(CONICET) Buenos Aires C1033AAJArgentina Instituto de Investigaciones en Catálisis y Petroquímica(INCAPE)FIQ-UNL-CONICET Parque Tecnológico Litoral Centro 3000Santa FeArgentina Facultad de Ingeniería Química Universidad nacional del Litoral 3000Santa FeArgentina

This present study was conducted to evaluate the metabolic effects of isolated fi ber of carrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,control group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were collected at the time of sacrifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respect to body weight were *** kits were used to determine serum glucose concentration,lipid profi le(cholesterol,HDL-cholesterol,triglycerides),and the two main aminotransferases glutamic-oxalacetic transaminase(GOT)/glutamate-pyruvate transaminase(GPT).A histopathological assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induces a decrease in glucose levels in the supplemented *** the exception of total high-density lipoprotein cholesterol,the other lipid fractions decrease signifi cantly in rats *** supplementation did not induce changes in the dissected organs of the supplemented *** conclusion supplementation of fiber,improves glucose control,lower plasma lipid concentrations and reduced body weight in normal rats.

关键词： Carrot fiber Oral supplementation Animal studies

Olfactory dysfunction in dementia

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World Journal of Clinical Cases 2014年第11期2卷 661-667页

作者： Jorge Alves Agavni Petrosyan rosana Magalhes Cognitive Rehabilitation Center 4710-228 Braga Portugal Department of Cognitive Sciences Univer-sity of California at Irvine Irvine CA 92717 United States

The natural aging process brings about some inevitable consequences, such as olfactory dysfunction, which is also frequently linked to numerous neurodegenerative disorders. Many age-related dementia, such as Alzheimer's disease, Vascular dementia, Parkinson's disease, and Frontotemporal Dementia often display olfactory dysfunction. Despite the overwhelming evidence of above mentioned facts, the symptomatic relevance and potential clinical and pre-clinical value of olfactory dysfunction remains overlooked by many clinicians and public alike. Olfactory dysfunction has strong practical implications on daily activities and, although not as prominent as in other mammals, olfaction is still an evolutionarily relevant sense involved in human survival(e.g., smelling gas; bad food). In this work, we provide a brief review of current research related to the olfactory dysfunction profiles in different types of dementia. Additionally, we present a compilation of accessible, easy to use olfaction assessment tools; and highlight future directions in terms of improving clinical diagnosis in patient care and research.

关键词： Dementia Aging Olfaction Olfactory dysfunction

Gut microbiota-derived metabolites are novel targets for improving insulin resistance

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World Journal of Diabetes 2022年第1期13卷 65-69页

作者： rosana MC Bastos Érika B Rangel Hospital Israelita Albert Einstein São Paulo 05652-001SPBrazil Nephrology Division Federal University of São PauloSão Paulo 04023-900SPBrazil

The gut microbiota plays a key role in metabolic ***-microbiota-derived metabolites are found in different dietary sources,including:Carbohydrate(acetate,propionate,butyrate,also known as short-chain fatty acids,as well as succinate);protein(hydrogen sulfide,indole,and phenylacetic acid);and lipids(resveratrol-,ferulic acid-,linoleic acid-,catechin-and berry-derived metabolites).Insulin resistance,which is a global pandemic metabolic disease that progresses to type 2 diabetes mellitus,can be directly targeted by these ***-derived metabolites have broad effects locally and in distinct organs,in particular skeletal muscle,adipose tissue,and *** metabolites can modulate glucose metabolism,including the increase in glucose uptake and lipid oxidation in skeletal muscle,and decrease in lipogenesis and gluconeogenesis associated with lipid oxidation in the liver through activation of phosphatidylinositol 3-kinase-serine/threonine-protein kinase B and AMP-activated protein *** adipose tissue,gut-microbiota-derived metabolites stimulate adipogenesis and thermogenesis,inhibit lipolysis,and attenuate ***,an increase in energy expenditure and fat oxidation occurs in the whole ***,the therapeutic potential of current pharmacological and non-pharmacological approaches used to treat diabetes mellitus can be tested to target specific metabolites derived from intestinal bacteria,which may ultimately ameliorate the hyperglycemic burden.

关键词： Insulin resistance Gut microbiota Metabolites Host metabolism Metabolic organs Novel targets

The use of a simple anal sling in the management of anal incontinence

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Gastroenterology Report 2014年第2期2卷 136-139页

作者： Jose Manuel Devesa rosana Vicente Colorectal Unit University Hospital Ramony CajalMadridSpain Colorectal Unit Hospital Ruber InternacionalMadridSpain

*** patients presenting with anal incontinence(AI)are frail,with attendant comorbidities precluding the use of complicated,expensive reconstructive *** these cases,revisiting a simple approach—designed to provide some sort of effective barrier to stool—is worthwhile where the options include a customized peri-anal sling or the use of an anal *** of an unselected cohort of 33 patients(mean age 54 years;range 27–86 years)with AI is presented,these patients having undergone insertion of an elastic band peri-anal sling between December 2004 and December *** post-operative assessment included the Jorge-Wexner score of incontinence,anorectal manometry and the Rockwood Fecal Incontinence Quality of Life(FIQoL)*** follow-up period ranged from 50 to 108 months with a mean of 65 *** post-operative complications included spontaneous disruption of the sling at the fourth and seventh post-operative day in two patients and local infection in a further two *** complications included skin erosion in two patients,(one occurring 3 years post-operatively)and breakage of the sling in a further seven *** was performed in 13 cases,and re-implantation in 10 *** differences were noted in resting or squeeze manometry,with significant improvement in the Jorge-Wexner scores in 32 cases and in all of the four Rockwood quality of life *** anal sling is an effective and simple surgical option for the management of selected cases presenting with anal ***-term data are awaited comparing this technique with other standard surgical alternatives.

关键词： anal incontinence peri-anal sling Thiersch

Rice Germination and Its Impact on Technological and Nutritional Properties:A Review

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Rice science 2022年第3期29卷 201-215页

作者： LucasÁvila do NASCIMENTO Abhilasha ABHILASHA Jaspreet SINGH Moacir Cardoso ELIAS rosana COLUSSI Department of Agroindustrial Science and Technology Federal University of PelotasPelotasUniversity Campuss/n96010-900PelotasRSBrazil Riddet Institute and Massey Institute of Food Science and Technology Massey UniversityPalmerston NorthNew Zealand Center for Chemical Pharmaceutical and Food SciencesFederal University of PelotasPelotasUniversity Campuss/n96010-900PelotasRSBrazil

Grain germination is a process involving numerous factors that influence the biochemical processes inside the plant *** review covered the abiotic factors that lead to the germination and significantly impact the nutritional properties and digestion behavior of rice *** macro-and micro-nutrients can be changed depending on the intensity of the applied variables during *** instance,germination time can increase the protein content in the grain and concurrently reduce its protein *** most cases,the number of bioactive compounds present in rice grains are increased regardless of germination *** can promote the complexation of nutrients and thus negatively interfere with the digestibility of *** review highlighted the influence of the germination process on the nutritional quality of rice grains,providing information about the germination conditions and their impacts on the anabolic and catabolic reactions of the grain,emphasizing the health benefits.

关键词： germinated rice nutritional aspect germination condition digestibility advantage

Soar un crimen/ rosana Acquaroni.

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El sue?o de Otto / rosana Acquaroni

2008年

作者： Acquaroni rosana 1547-1616.

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El sue?o de Otto / Rosana Acquaroni

Recycling Plastics for Economical Housing

2008年

作者： Acquaroni rosana. 1547-1616.

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Journal of Civil Engineering and Architecture 2011年第7期5卷 636-642页

作者： rosana Gaggino Ricardo Arguello Economical Housing Experimental Centre （CEVE） Institute of the National Council Jor Scientific and Technical Research（CONICET） Argentine

Abstract： The search for ＂new materials＂ to manufacture building elements for economical housing is the aim of this work. These materials are the following recycled plastics： Low-density polyethylene （LDPE）, recycled out of discarded soft drink packs： Polyethylene-terephthalate （PET）, recycled out of discarded soft drink bottles; and several plastics, from the printed films used like packages of candies （remainder of production plant by faults in the thickness of the films or in the inked process of themt. These conveniently grounded plastics were taken as ＂arids＂ to be mixed with Normal Portland cement, replacing heavy sand and gravel habitually used in these mixtures. These materials are used in constructive elements such as bricks, blocks and plates for economical houses closures or traditional construction. The developed constructive elements offer high thermal insulation, so they can be used in closures with a smaller thickness than conventional bricks and blocks. Besides, they have a lower specific weight than these traditiunal constructive elements. Recycling means lowering costs, making part of the environment contaminating waste useful and providing the unemployed and/or unqualified work force with jobs through uncomplicated technologies. Therefore, this recycling technology has an economic as well as an ecological purpose.

关键词： Constructive elements plastics recycling ecological housing building technology.