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Par-4 Sensitizes Human Colon Cancer Cells to Chemoradiotherapy

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The role of endoscopy in the management of hereditary diffuse gastric cancer syndrome

Journal of Cancer Therapy（癌症治疗） 2011年第4期

作者： Daniel Contract Heath Mackley rosalyn bryson irby

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World Journal of Gastroenterology 2019年第23期25卷 2878-2886页

作者： Shria Kumar Jessica M Long Gregory G Ginsberg bryson W Katona Division of Gastroenterology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States Division of Hematology and Oncology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States

Hereditary diffuse gastric cancer(HDGC) syndrome is an inherited cancer risk syndrome associated with path-ogenic germline CDH1 variants. Given the high risk for developing diffuse gastric cancer, CDH1 carriers are recommended to undergo prophylactic total gastrectomy for cancer risk reduction. Current guidelines recommend upper endoscopy in CDH1 carriers prior to surgery and then annually for individuals deferring prophylactic total *** of individuals from HDGC families without CDH1 pathogenic variants remains less clear, and management of families with CDH1 pathogenic variants in the absence of a family history of gastric cancer is particularly problematic at present. Despite adherence to surveillance protocols, endoscopic detection of cancer foci in HDGC is suboptimal and imperfect for facilitating decision-making. Alternative endoscopic modalities, such as chromoendoscopy,endoscopic ultrasound, and other non-white light methods have been utilized,but are of limited utility to further improve cancer detection and risk stratification in HDGC. Herein, we review what is known and what remains unclear about endoscopic surveillance for HDGC, among individuals with and without germline CDH1 pathogenic variants. Ultimately, the use of endoscopy in the management of HDGC remains a challenging arena, but one in which further research to improve surveillance is crucial.

关键词： CDH1 gene Hereditary diffuse gastric cancer Gastric cancer Endoscopic screening Endoscopy

Generating routes for autonomous driving in vehicle-to-infrastructure communications

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Digital Communications and Networks 2020年第4期6卷 444-451页

作者： Jianjun Yang Tinggui Chen bryson Payne Ping Guo Yanping Zhang Juan Guo Department of Computer Science and Information Systems University of North GeorgiaOakwood30566USA Zhejiang Gongshang University HangzhouChina Department of Computer Science and Information Systems University of North GeorgiaDahlonega30597USA Department of Computer Science University of Illinois at SpringfieldSpringfieldILUSA Department of Computer Science Gonzaga UniversitySpokaneWAUSA

The study of vehicular networks has attracted considerable interest in academia and the *** the broad area,connected vehicles and autonomous driving are technologies based on wireless data communication between vehicles or between vehicles and infrastructures.A Vehicle-to-Infrastructure(V2I)system consists of communications and computing over vehicles and related *** such a system,wireless sensors are installed in some selected points along roads or driving *** autonomous driving,it is crucial for a vehicle to figure out the ideal routes by the communications between its equipped sensors and infrastructures then the vehicle is automatically moving along the *** this paper,we propose a Bezier curve based recursive algorithm,which effectively creates routes for vehicles through the communication between the On-Board Unit(OBU)and the Road-Side Units(RSUs).In addition,this approach generates a very low *** conduct simulations to test the proposed algorithm in various *** experiment results demonstrate that our algorithm creates almost ideal routes.

关键词： Autonomous driving Vehicles and infrastructures Bezier curve Recursive algorithm On board unit Road side unit

National assessment of Canadian pandemic preparedness: Employing InFluNet to identify high-risk areas for inter-wave vaccine distribution

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Infectious Disease Modelling 2017年第3期2卷 341-352页

作者： Patrick Saunders-Hastings bryson Quinn Hayes Robert Smith Daniel Krewski University of Ottawa McLaughlin Centre for Population Health Risk Assessment850 Peter Morand CrescentOttawaOntarioK1G 5Z3Canada University of Ottawa School of EpidemiologyPublic Healthand Preventive MedicineFaculty of Medicine451 Smyth RoadOttawaONK1H 8M5Canada University of Ottawa Department of Mathematics585 King Edward AvenueOttawaONK1N 6N5Canada Risk Sciences International 55 Metcalfe StreetSuite 700OttawaONK1P 6L5Canada

Background:Influenza pandemics emerge at irregular and unpredictable intervals to cause substantial health,economic and social *** health-system response is vital to mitigating the consequences of future ***:We developed a mathematical model to assess the preparedness of Canadian health systems to accommodate pandemic-related increases in patient *** identify vulnerable areas,assess the potential of inter-wave vaccination to mitigate impacts and evaluate the association between demographic and health-system characteristics in order to identify predictors of pandemic ***:Modelled average attack rates were 23.7e37.2%with no intervention and 2.5 e6.4%with *** acute-care demand was 7.5e19.5%of capacity with no intervention and 0.6e2.6%with *** peak ICU demand was 39.3e101.8%with no intervention and 2.9e13.3%with *** mortality was 2258 e7944 with no intervention and 88e472 with *** of Southern Ontario were identified as most vulnerable to surges in patient *** strongest predictors of peak acute-care demand and ICU demand were acute-care bed capacity(R=0.8697;r^2=0.7564)and ICU bed capacity(R=0.8151;r^2=0.6644),*** characteristics had mild associations with predicted pandemic ***:Inter-wave vaccination provided adequate acute-care resource protection under all scenarios;ICU resource adequacy was protected under mild disease assumptions,but moderate and severe diseases caused demand to exceed expected availability in 21%and 49%of study areas,*** study informs priority vaccine distribution strategies for pandemic planning,emphasizing the need for targeted early vaccine distribution to high-risk individuals and areas.

关键词： consequences distribution Canadian

Communication after cancellations in orthopaedics: The patient perspective

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World Journal of Orthopedics 2014年第1期5卷 45-50页

作者： Saurabh S Mehta David J bryson Jitendra Mangwani Lucy Cutler Department of Orthopaedics University Hospitals of Leicester NHS Trust Leicester General Hospital Department of Orthopaedics University Hospitals of Leicester NHS Trust Leicester Royal Infirmary

AIM: To examine patients' perceptions on communication surrounding the cancellation of orthopaedic operations and to identify areas for improvement in ***: A prospective survey was undertaken at a university teaching hospital within the department of Trauma and Orthopaedics. Patients admitted to an acute orthopaedic unit, whose operations were cancelled, were surveyed to assess patient satisfaction and preferences for notification of cancellation of their operations. Patients with an abbreviated mental test score of < 9, patients unable to complete the survey independently, those under 16 years of age, and any patient notified of the cancellation by any of the authors were excluded from this study. Patients were surveyed themorning after their operation had been cancelled thus ensuring that every opportunity was given for the medical staff to discuss the cancellation with the patient. The survey included questions on whether or not patients were notified of the cancellation of their surgery, the qualifications of the person discussing the cancellation, and patient preferences on the process. Satisfaction was assessed via 5-point Likert scale ***: Sixty-five consecutive patients had their operations cancelled on 75 occasions. Fifty-four point seven percent of the patients who had cancellations were notified by a nurse and 32% by a doctor. No formal communication occurred for 13.3% cancellations and no explanation was provided for a further 16%. Patients reported that they were dissatisfied with the explanation provided for 36 of the 75(48%) cancellations. Of those patients who were dissatisfied, 25(69.4%) were notified by a nurse. Twenty-three of the 24(96%) patients notified by a doctor were satisfied with the explanation and that communication. Of those patients who were notified by a nurse 83% patients reported that they would have preferred it if a doctor had discussed the cancellation with them. There was a significant difference

关键词： Communication Patient satisfaction Orthopaedic surgery Cancellation

The Affordable Care Act: Disparities in emergency department use for mental health diagnoses in young adults

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World Journal of Emergency Medicine 2017年第3期8卷 206-213页

作者： Justin Yanuck bryson Hicks Craig Anderson John Billimek Shahram Lotfi pour Bharath Chakravarthy Division of Emergency Medicine University of California Division of General Internal Medicine and Department of Family Medicine Irvine School of Medicine

BACKGROUND: There is little consensus as to the effects of insurance expansion on emergency department(ED) utilization for mental health purposes. We aimed to study the race specifi c association between the dependent coverage provision of the Affordable Care Act(ACA) and changes in young adults' usage of emergency department services for psychiatric ***: We utilized a Quasi-Experimental analysis of ED use in California from 2009–2011 for behavioral health diagnoses of individuals aged 19 to 31 years. Analysis used a difference-indifferences approach comparing those targeted by the ACA dependent provision(19–25 years) and those who were not(27 to 31 years), evaluating changes in ED visit rates per 1 000 in California. Primary outcomes measured included the quarterly ED visit rates with any psychiatric diagnosis. Subgroups were analyzed for differences based on race and ***: The ACA dependent provision was associated with 0.05 per 1 000 people fewer psychiatric ED visits among the treatment group(19–25 years) compared to the control group(27–31 years). Hispanics and Asian/Pacific Islanders were the only racial subgroups who did not see this significant reduction and were the only racial subgroups that did not see significant gains in the proportion of psychiatric ED visits covered by private ***: The ACA dependent provision was associated with a modest reduction in the growth rate of ED use for psychiatric reasons, however, racial disparities in the effect of this provision exist for patients of Hispanic and Asian/Pacifi c Islander racial groups.

关键词： Affordable Care Act Mental health Disparities Health Policy

Excerpt from The Lost Continent

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考试与评价（英语高考专刊） 2018年第8期 43-44,37,38页

作者： Bill bryson

The Tree of Death and Eternal Life

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Journal of Philosophy Study 2012年第3期2卷 145-162页

作者： Ken A. bryson Cape Breton University

The ＂Tree of Death＂ is a metaphor I use to unlock my Christian assumptions on how the dead attain eternal existence in the afterlife state. The tree＇s unconcealedness, in this life and presumably the next, along with the moral habits an agent develops in this life explain the obstinacy of the dead, that is, how the agent＇s irrevocable decision to side with the God of Abraham, or not, is possible. For that to be the case, the existential relationships that generate personal identity in this life must accompany （individuate） the subject in the next life. In Christian philosophy, the person-making process mirrors the relationships of the Blessed Trinity. While Martin Heidegger is not a Christian philosopher, his view on truth and being＇s unconcealedness provides a useful piece of the argument to continue the Thomistic case for personal immortality. Heidegger is not a catholic philosopher, but the focus he places on being＇s unconcealedness is consonant with the focus Thomas Aquinas puts on the intelligibility of being. While Heidegger＇s discussion of being is rooted in Dasein＇s finitude, the Thomistic interpretation of being situates unconcealedness within the perspective of God＇s creative act. His vision resets the possibility of applying Heidegger＇s fundamental ontology beyond temporality. The paper develops through a discussion of the Tree＇s ＂branches, trunk, and roots＂ to conclude that the Christian perspective transforms Heidegger＇s view of death into ＂the ultimate possibility of possibility.＂

关键词： being's unconcealedness eternal life final decision God human death immortality person-makingprocess personal identity

结肠上皮内CD4^+CD8^-/CD4^-CD8^-αβT淋巴细胞及细胞因子在sGVHD发生发展中的改变

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中华微生物学和免疫学杂志 2002年第5期22卷 537-540页

作者：张利宁 JS.bryson 山东大学医学院免疫学研究所 Department of Microbiology and Immunology Kentucky University

目的　探讨自身或同基因型骨髓移植后用环孢霉素A(CsA)短期治疗诱导的移植物抗宿主病 (GVHD)及用于预防白血病复发的机制。方法　从小鼠同基因型GVHD的主要靶器官———结肠分离上皮内淋巴细胞 (IEL) ,分析其细胞表型和细胞因子在GVHD... 详细信息

目的　探讨自身或同基因型骨髓移植后用环孢霉素A(CsA)短期治疗诱导的移植物抗宿主病 (GVHD)及用于预防白血病复发的机制。方法　从小鼠同基因型GVHD的主要靶器官———结肠分离上皮内淋巴细胞 (IEL) ,分析其细胞表型和细胞因子在GVHD诱导、发生中的改变 ,以探讨CsA诱导同基因型GVHD的机制。结果　GVHD时IEL中CD4 + CD8- αβT细胞明显增加 ,而CD4 - CD8- 双阴性αβT细胞明显降低 (P <0 .0 0 1) ,CD4 + CD8- αβ CD4 - CD8- αβT细胞的比例从正常的 1.0～ 1.5增加到 13～ 2 5 ,此时 ,细胞因子IL 12、IFN γ、TNF α表达明显增高。CD4 + CD8- αβ CD4 - CD8- αβT细胞的比例失调及细胞因子的改变始于CsA诱导后第 3周 ,但γδT细胞无明显改变。结论　结肠上皮内CD4 + αβ CD4 - CD8- αβT细胞的平衡对肠道的稳定是非常重要的。

关键词： sGVHD 同基因型骨髓移植移植物抗宿主疾病 T淋巴细胞细胞因子结肠损伤