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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用:FPR促进胶质瘤细胞的成瘤性

G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用...

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第三届中国肿瘤学术大会

作者：卞修武周烨乐颖英龚旺华张夏 Pablo Iribarren rosalba salcedo O.M.Zack Howard WilliamFarrar 王吉民第三军医大学西南医院病理学研究所第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院实验免疫学实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院基础研究计划室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚... 详细信息

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚。本研究探讨FPR在胶质瘤生长和血管生成中的作用。方法:本研究首先采用免疫组织（细胞）化学和RT-PCR方法,检测不同分化程度的人胶质瘤组织和细胞系中FPR基因和蛋白表达;采用FMLP结合（激活）FPR后,用细胞趋化试验检测瘤细胞迁移情况,用Western免疫印迹、电泳运动漂移分析（EMSA）、ELASIA等技术检测细胞检测信号转导通路相关信号分子磷酸化改变、HIF1α和NFkB核转位、DNA-NFkB复合物形成以及VEGF产生。应用荧光显微分光技术检测Ca2+流变化,用流式细胞术检测细胞FPR,小管形成试验观察肿瘤细胞诱导内皮细胞HUVEC小管形成情况。用siRNA干扰胶质瘤细胞FPR的功能性表达,观察受干扰细胞在无胸腺裸小鼠的移植瘤形成和生长情况。结果:在人高度恶性的胶质瘤（WHO Ⅲ级和Ⅳ级）组织中的瘤细胞检测到了FPR表达,但在低级别（WHO Ⅱ级）胶质瘤表达阴性;体外研究结果与原位肿瘤相似,即,仅高度恶性起源的胶质瘤细胞系表达该受体（mRNA和蛋白）。激活胶质瘤细胞FPR后,瘤细胞的趋化运动增强,细胞信号转导MAPKs和PI3K通路激活,包括ERK1/2、JNK和Akt.快速磷酸化;FPR激活还诱导了NFkB核转位、形成了DNA-NFkB复合物,并刺激了HIF-1α核转位,使瘤细胞血管内皮细胞生长因子（VEGF）基因和蛋白表达增多。胶质母细胞瘤瘤细胞培养上清能诱导内皮细胞迁移和小管形成,而这种作用可被抗VEGF抗体阻断,提示FPR激活后瘤细胞所产生的VEGF在启动恶性胶质瘤的血管生成中有重要作用。进一步的体内实验显示,高表达FPR的胶质母细胞瘤细胞系U87接种到元胸腺裸小鼠后成瘤性和生长速率高于低表达FPR的SHG-44细胞。采用siRNA干扰FPR表达和功能后,肿瘤生长明显受抑制,进一步验证了上述结果。此外,本研究还证明,坏死的胶质瘤细胞释放出可激活存活胶质瘤细胞所表达的FPR的因子,提示FPR可能还是肿瘤微环境中FPR激动剂的感受器,以利肿瘤生长。结论:高度恶性的胶质瘤细胞表达功能性FPR,并对该瘤成瘤、生长和血管生成有促进作用密切关系。上述结果对于我们认识恶性胶质瘤侵袭生长和血管生成特性以及基于FPR设计治疗措施可能有重要意义。

关键词：胶质瘤坏死小干扰RNA (siRNA)血管生成趋化作用

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News about non-secretory exocytosis: mechanisms, properties, and functions

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Journal of Molecular Cell Biology 2019年第9期11卷 736-746页

作者： rosalba D'Alessandro Jacopo Meldolesi Scientific Institute S.De Beilis Via Turi 277013Castellana GrotteItaly Scientific Institute San Raffaele and Vita Salute San Raffaele University Via Olgettina 5820132MilanItaly

The fusion by exocytosis of many vesicles to the plasma membrane induces the discharge to the extracellular space of their abundant luminal *** exocytic vesicles,however,do not contain cargoes,and thus,their fusion is not followed by ***,two distinct processes of exocytosis exist,one secretory and the other *** present review deals with the knowledge of non-secretory exocytosis developed during recent *** such developments are the dual generation of the exocytic vesicles,initially released either from the trans-Golgi network or by endocytosis;their traffic with activation of receptors,channels,pumps,and transporters;the identification of their tethering and soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes that govern membrane fusions;the growth of axons and the membrane *** of potential relevance of these processes for pathology and medicine are also *** developments presented here offer interesting chances for future progress in the field.

关键词： exocytosis Golgi complex vesicles endocytosis

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Space-Time Decomposition of Kalman Filter

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Numerical Mathematics(Theory,Methods and Applications) 2023年第4期16卷 847-882页

作者： Luisa D’Amore rosalba Cacciapuoti University of Naples Federico II NaplesItaly

We present an innovative interpretation of Kalman filter(KF)combining the ideas of Schwarz domain decomposition(DD)and parallel in time(PinT)*** we call it *** contrast to standard DD approaches which are already incorporated in KF and other state estimation models,implementing a straightforward data parallelism inside the loop over time,DD-KF ab-initio partitions the whole model,including filter equations and dynamic model along both space and time directions/*** a consequence,we get local KFs reproducing the original filter at smaller dimensions on local ***,sub problems could be solved in *** order to enforce the matching of local solutions on overlapping regions,and then to achieve the same global solution of KF,local KFs are slightly modified by adding a correction term keeping track of contributions of adjacent subdomains to overlapping *** a correction term balances localization errors along overlapping regions,acting as a regularization constraint on local ***,such a localization excludes remote observations from each analyzed location improving the conditioning of the error covariance *** dynamic model we consider shallow water equations which can be regarded a consistent tool to get a proof of concept of the reliability assessment of DD-KF in monitoring and forecasting of weather systems and ocean currents.

关键词： Data assimilation Kalman filter domain decomposition filter localization model reduction numerical algorithm

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Can foods influence the onset and progress of neurodegenerative diseases?

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Neural Regeneration Research 2022年第11期17卷 2443-2444页

作者： Luca Piemontese Leonardo Brunetti rosalba Leuci Department of Pharmacy and Pharmaceutical Sciences University of Bari Aldo Moro

Over the course of the last few years,the advertisement and marketing of commercial food products in the European market has seen an increasing focus on the beneficial effects of such products for consumer health(Regulation,2006).These so-called"health claims", which can be found on the label of some food products,have become a very important medium,aiming to reach the maximum amount of potential consumers possible,and the delivery of these promises has become a crucial objective for food companies or ***,in most cases,the evidence backing up such claims(and their coveted acknowledgment on the product label) has often been cited as insufficient by institutions such as the European Food and Safety Authority (EFSA,Parma,Italy).

关键词： companies Authority claims

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Topographic effects observed at Amatrice hill during the 2016-2017 Central Italy seismic sequence

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 63-78页

作者： Gerardo Grelle Laura Bonito Maresca rosalba Silvia Iacurto Claudia Madiai Paola Revellino Giuseppe Sappa Department of Civil Building and Environmental EngineeringSapienza University of RomeItaly Department of Sciences and Technologies University of SannioItaly Department of Civil and Environmental Engineering University of FlorenceItaly

The estimate of seismic site effects by experimental approaches is based on different assumptions aimed at simplifying the complex actual site conditions and related ***,the reliability of the results can increase if the experimental data is focused on quite strong seismic sequences and the on-site acquisition of a large number of signals is deemed strategic for the assessment of the expected *** on these considerations,the ground motion at the Red Zone sector of Amatrice hill,violently struck by the 2016-2017 Central Italy seismic sequence,was analyzed via an observational approach.A large set of weak motions(moment magnitude Mw 2.5-3.9)was analyzed in this study by means of standard(SSR)and horizontal to vertical(HVSR)spectral ratio *** results from the experimental analysis of the site effects by using weak motion and noise signals show a significant amplification at the top of Amatrice hill with a remarkable polarization of the motion and changes in spectral shapes according to the topographic setting of the relief.

关键词： topographic effects standard spectra ratio(SSR) horizontal and vertical spectral ratio(HVSR) directional effects

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Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges

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World Journal of Gastroenterology 2014年第16期20卷 4516-4525页

作者： rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio Unit of Medical Statistics Biometry and BioinformaticsFondazione IRCCS Istituto Nazionale Tumori20133 MilanItaly Medical Oncology Division Azienda Istituti Ospitalieri di Cremona26100 CremonaItaly Medical Oncology Department Fondazione IRCCS Istituto Nazionale Tumori20133 MilanItaly

Gastric cancer still represents one of the major causes of cancer mortality *** survival is mainly related to stage,with a high proportion of patients with metastatic disease at ***,the cure rate largely depend upon surgical *** the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment ***,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual *** choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United *** the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and *** most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall *** finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment.

关键词： Gastric cancer Adjuvant chemotherapy Radiotherapy Randomized trial

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Electrocatalytic production of glycolic acid via oxalic acid reduction on titania debris supported on a TiO_(2)nanotube array

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Journal of Energy Chemistry 2022年第5期31卷 669-678页

作者： Francesco Pio Abramo Federica De Luca rosalba Passalacqua Gabriele Centi Gianfranco Giorgianni Siglinda Perathoner Salvatore Abate Department of ChiBioFarAM(Industrial Chemistry) University of MessinaERIC aisbl and INSTM/CASPEV.le F.Stagno d’Alcontres 31Messina 98166Italy University of Calabria Department of Environmental EngineeringLaboratory of Industrial Chemistry and Catalysis Via P.Bucci87036 RendeCSItaly

Electrodes prepared by anodic oxidation of Ti foils are robust and not toxic materials for the electrocatalytic reduction of oxalic acid to glycolic acid, allowing the development of a renewable energy-driven process for producing an alcoholic compound from an organic acid at low potential and room temperature. Coupled with the electrochemical synthesis of the oxalic acid from CO_(2),this process represents a new green and low-carbon path to produce added value chemicals from CO_(2). Various electrodes prepared by anodic oxidation of Ti foils were investigated. They were characterized by the presence of a TiO_(2) nanotube array together with the presence of small patches, debris, or TiO_(2) nanoparticles. The concentration of oxygen vacancies, the amount of Ti^(3+) measured by X-ray photoelectron spectroscopy(XPS) and the intensity of the anodic peak measured by cyclic voltammetry, were positively correlated with the achieved oxalic acid conversion and glycolic acid yield. The analysis of the results indicates the presence of small amorphous TiO_(2) nanoparticles(or surface patches or debris) interacting with TiO_(2) nanotubes, the sites responsible for the conversion of oxalic acid and glycolic acid yield. By varying this structural characteristic of the electrodes, it is possible to tune the glycolic acid to glyoxylic acid relative ratio. A best cumulative Faradaic efficiency(FE) of about 84% with FE to glycolic acid around 60% and oxalic conversion about 30% was observed.

关键词： Oxalic acid TiO_(2)nanotubes Glyoxylic acid Glycolic acid Electrocatalysis

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Semiconductor,molecular and hybrid systems for photoelectrochemical solar fuel production

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Journal of Energy Chemistry 2017年第2期26卷 219-240页

作者： rosalba Passalacqua Siglinda Perathoner Gabriele Centi Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaV.le F.Stagno d’Alcontres 3198166 MessinaItaly Department of Mathematics and Computational Sciences Physical Sciences and Earth SciencesUniversity of MessinaV.le F.Stagno d’Alcontres 3198166 MessinaItaly CASPE(INSTM Laboratory of Catalysis for Sustainable Production&Energy)/ERIC aisbl(European Research Institute of Catalysis) University of MessinaV.le F.Stagno d’Alcontres 3198166 MessinaItaly

The paper shortly reviews the basic direct approaches applied in searching for viable solutions to solar fuel production. These are generally distinguished in molecular and semiconductor(non-molecular)systems, however, hybrid strategies, proposed recently, have also been included. The most promising efforts are considered, highlighting key aspects and emerging critical issues. Special attention is paid to aspects such as electrode architecture, device design, and main differences in the scientific vision and challenges to directly produce solar fuels. This overview could be useful to orientate the readers in the wide panorama of research activities concerning water splitting, natural and artificial photosynthesis, and solar fuel production through the identification of common aspects, specialties and potentialities of the many initiatives and approaches that are developing worldwide in this field with the final aim to meet world energy demand.

关键词： Solar fuels production CO2 reduction Artificial photosynthesis PEC cells Semiconductor systems Molecular systems Hybrid nanobiocatalytic systems

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Induction of oxidative stress in human aqueous and vitreous humors by Nd:YAG laser posterior capsulotomy

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1145-1151页

作者： Loredana BergANDi Oleksii A Skorokhod Federica Franzone rosalba La Grotta Evelin Schwarzer Raffaele Nuzzi Department of Oncology University of Torino Department of Molecular Biosciences the Wenner-Gren Institute Stockholm University Eye Clinic Section and Specialization School in Ophthalmology Department of Surgical Sciences University of Torino

AIM： To evaluate whether the Q-switched Nd：YAG laser treatment applied in routine capsulotomy elicits oxidative stress in aqueous and vitreous humors. METHODS： Thirty-six patients who had to undergo a 25 gauge pars plana vitrectomy due to vitreoretinal disorders were enrolled, 15 of them underwent a Q-switched Nd：YAG laser capsulotomy 7 d before vitrectomy due to posterior capsule opacification（PCO）（Nd：YAG laser group） while the remaining 21 patients were not laser treated before vitrectomy（no Nd：YAG laser group）. Samples of the aqueous and vitreous humors were collected during vitrectomy from all patients for the assessment of oxidative parameters which were compared between the Nd：YAG laser group and no Nd：YAG laser group. Thiobarbituric acid reactive substances（TBARS）, a product of membrane lipid peroxidation, nitrite levels, the antioxidative activities of SOD and catalase, the 4-HNE-protein conjugate formation, indicating structural modifications in proteins due to lipoperoxidation, were assessed in aqueous and vitreous samples. RESULTS： In the human vitreous humor TBARS levels are significantly higher in the Nd：YAG laser group compared to the no Nd：YAG laser group and importantly, there is a significant correlation between the TBARS levels and the total energy of Nd：YAG laser used during *** the anti-oxidative activities of SOD and catalase were significantly decreased by Nd：YAG laser treatment, both in aqueous and vitreous humors. In accordance with the TBARS data and anti-oxidative enzyme activities, significantly higher levels of proteins were conjugated with the lipoperoxidation product 4-HNE in the aqueous and vitreous humors in the Nd：YAG laser-treated group in comparison to no Nd：YAG laser group. CONCLUSION： These data, clearly suggest that any change that Q-switched Nd：YAG photo disruption may cause in the aqueous and vitreous compartments, resulting in a higher level of oxidative damage might be of considerable clinical significance

关键词： posterior capsule opacification Q-switched Nd:YAG laser oxidative stress vitrectomy

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