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A Case Report of Hypothyroidism and Pericardial Effusion

Case Reports in Clinical Medicine 2020年第12期9卷 408-420页

作者： Cacelín Garza José Ramón Cacelín Miranda Rafael Sebastián Cacelín Miranda Ariadna rosalba Meléndez Ordoñ ez Jesús Alberto Servicio de Medicina Interna Hospital General de Nativitas Tlax Mexico Departamento de Medicina Interna Unidad de Cuidados Intensivos Hospital General de Zona No. 1 Instituto Mexicano del Seguro Social Tlax Mexico Facultad de Medicina Universidad Popular Autónoma del Estado de Puebla Puebla México Residente de la Especialidad de Anestesiología Hospital Juárez de México Ciudad de México México

The pericardial sac is made of two layers: the visceral and parietal pericardium. Located between these two layers, the pericardial cavity is found. It contains around 15 to 50 mL of a liquid secreted by mesothelial cells. Pericardial effusion is described as the accumulation of liquid within the pericardial cavity, exceeding the previous mentioned quantity. It has multiple causes, such as malignancy, infectious origins, inflammation, and others, such as hypothyroidism. One of the multiple clinical manifestations associated with hypothyroidism is pericardial effusion. It is related to the severity and duration of the disease, being more frequent in congenital hypothyroidism or cases of a long history of hypothyroidism, as well as clinical hypothyroidism. It can present a clinical challenge mainly due to the discordance between the total volume of the effusion and the clinical symptoms shown by the patient. The main objective of this work is to present a case of a forty-two-year-old male with hypothyroidism-associated pericardial effusion which resolved satisfactorily with hormone replacement therapy.

关键词： Hypothyroidism Pericardial Effusion Echocardiogram Levothyroxin

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Correlation between therapy and lipid profile of leprosy patients:is there a higher risk for developing cardiovascular diseases after treatment?

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Infectious Diseases of Poverty 2017年第1期6卷 721-727页

作者： rosalba V.G.Silva Rafael Sde Araujo Tinara L.S.Aarao Paulo Diovanne da Silva Costa Jorge R.Sousa Juarez A.S.Quaresma Bettina Ferro de Souza Hospital Federal do Para UniversityBelemParaBrazil Center of Health and Biological Science Para State UniversityBelemParaBrazil Tropical Medicine Center Federal do Para UniversityAv.Generalissimo Deodoro 92UmarizalBelemPara66055-190Brazil

Background:The impact of leprosy reduces health-related quality of life of affected patients,interfering with different factors such as *** study investigated the lipid profile,nutritional status,and risk for cardiovascular disease(CVD)in patients who underwent leprosy treatment in ***:Eighty-four adult patients of both genders ranging in age from 20 to 60 years and diagnosed with paucibacillary(PB)or multibacillary(MB)leprosy were selected after undergoing multidrug *** following data were collected:sociodemographic and clinical data;food intake;anthropometric measures(weight,height,and waist circumference);and lipid profile components(total cholesterol,high-density lipoprotein cholesterol[HDL-c],low-density lipoprotein cholesterol[LDL-c],and triglycerides).Results:Among the study population,there was a predominance of males(65.48%)aged 50 to 60 years,patients with an income of 248-496 American dollars(63.10%),patients who completed elementary school(65.48%),inactive patients(76.19%),non-smokers(46.43%),and non-drinking patients(69.05%).The levels(mean±standard deviation)of total cholesterol were 193.8±29.4 mg/dL in the PB form and 203.5±41.7 mg/dL in the MB *** mean LDL-c was 116.9±22.7 mg/dL in PB patients and 121±31.3 mg/dL in MB *** triglyceride levels were 123.4±45.2 mg/dL in the PB form and 147.4±88.9 mg/dL in the MB *** evaluation of nutritional status showed that 41.67%of the patients were eutrophic,while 55.96%had excess *** intake was significantly associated with HDL-c in male patients(P=0.0264)and with triglycerides in patients above the ideal weight(P=0.0049).Conclusions:The risk of acquiring CVDs was observed to be high due to patients’excess weight and increased waist *** study will guide clinicians in the adequate treatment of patients with leprosy in order to avoid adverse cardiovascular events.

关键词： Leprosy Post-leprosy treatment Nutritional status Total cholesterol Triglycerides Cardiovascular disease Brazil

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Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array

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Light(Science & Applications) 2016年第1期5卷 855-861页

作者： Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera CNR-IPCF Istituto per i Processi Chimico Fisici98158 MessinaItaly Dipartimento di Fisica e Astronomia Universitàdi Catania95123 CataniaItaly CNR-MATIS IMM Istituto per la Microelettronica e Microsistemi95123 CataniaItaly Dipartimento di Fisica Universitàdegli Studi di Pavia27100 PaviaItaly Dipartimento di Scienze Matematiche e Informatiche Scienze Fisiche e Scienze della TerraUniversitàdi Messina98166 MessinaItaly Scuola Superiore di Catania Universitàdi Cataniavia Valdisavoia995123 CataniaItaly

We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si *** structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the *** show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright *** strong emissions are correlated on all length scales according to the refractive index *** relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications.

关键词： light trapping multiple scattering Raman enhancement random fractal silicon nanowires

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G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用:FPR促进胶质瘤细胞的成瘤性

G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用...

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第三届中国肿瘤学术大会

作者：卞修武周烨乐颖英龚旺华张夏 Pablo Iribarren rosalba Salcedo O.M.Zack Howard WilliamFarrar 王吉民第三军医大学西南医院病理学研究所第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院实验免疫学实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院基础研究计划室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚... 详细信息

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚。本研究探讨FPR在胶质瘤生长和血管生成中的作用。方法:本研究首先采用免疫组织（细胞）化学和RT-PCR方法,检测不同分化程度的人胶质瘤组织和细胞系中FPR基因和蛋白表达;采用FMLP结合（激活）FPR后,用细胞趋化试验检测瘤细胞迁移情况,用Western免疫印迹、电泳运动漂移分析（EMSA）、ELASIA等技术检测细胞检测信号转导通路相关信号分子磷酸化改变、HIF1α和NFkB核转位、DNA-NFkB复合物形成以及VEGF产生。应用荧光显微分光技术检测Ca2+流变化,用流式细胞术检测细胞FPR,小管形成试验观察肿瘤细胞诱导内皮细胞HUVEC小管形成情况。用siRNA干扰胶质瘤细胞FPR的功能性表达,观察受干扰细胞在无胸腺裸小鼠的移植瘤形成和生长情况。结果:在人高度恶性的胶质瘤（WHO Ⅲ级和Ⅳ级）组织中的瘤细胞检测到了FPR表达,但在低级别（WHO Ⅱ级）胶质瘤表达阴性;体外研究结果与原位肿瘤相似,即,仅高度恶性起源的胶质瘤细胞系表达该受体（mRNA和蛋白）。激活胶质瘤细胞FPR后,瘤细胞的趋化运动增强,细胞信号转导MAPKs和PI3K通路激活,包括ERK1/2、JNK和Akt.快速磷酸化;FPR激活还诱导了NFkB核转位、形成了DNA-NFkB复合物,并刺激了HIF-1α核转位,使瘤细胞血管内皮细胞生长因子（VEGF）基因和蛋白表达增多。胶质母细胞瘤瘤细胞培养上清能诱导内皮细胞迁移和小管形成,而这种作用可被抗VEGF抗体阻断,提示FPR激活后瘤细胞所产生的VEGF在启动恶性胶质瘤的血管生成中有重要作用。进一步的体内实验显示,高表达FPR的胶质母细胞瘤细胞系U87接种到元胸腺裸小鼠后成瘤性和生长速率高于低表达FPR的SHG-44细胞。采用siRNA干扰FPR表达和功能后,肿瘤生长明显受抑制,进一步验证了上述结果。此外,本研究还证明,坏死的胶质瘤细胞释放出可激活存活胶质瘤细胞所表达的FPR的因子,提示FPR可能还是肿瘤微环境中FPR激动剂的感受器,以利肿瘤生长。结论:高度恶性的胶质瘤细胞表达功能性FPR,并对该瘤成瘤、生长和血管生成有促进作用密切关系。上述结果对于我们认识恶性胶质瘤侵袭生长和血管生成特性以及基于FPR设计治疗措施可能有重要意义。

关键词：胶质瘤坏死小干扰RNA (siRNA)血管生成趋化作用

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Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda Univ Texas MD Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor Coll Med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich Alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St Jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St Jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化

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