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Everything that is not given is lost

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World Journal of Pediatrics 2021年第6期17卷 566-567页

作者： Javier Arredondo Montero Carlos Bardajf pascual Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 Pamplona.NavarraSpain

A small health center is located in Velingara,*** is approximately 7 o'clock in the *** the old,dusty room that constitutes the operating room,a soft beeping sound,like that of a kettle,begins to be heard between the rhythmic beats of the heart *** oxygen cylinder has started to ***,one of us approaches and applies Teflon,controlling the *** a while,the electrical current is cut ***,the anesthesiologist continues to hand ventilate the patient with her ambu,and we all turn on our *** is no more electric scalpel,but the activity does not stop.

关键词： problem cylinder approximate

Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis

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World Journal of Gastroenterology 2015年第32期21卷 9466-9475页

作者： Paloma Lluch Gloria Segarra pascual Medina Department of Gastroenterology and Hepatology and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia Department of Physiology University of Valencia and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia

Cirrhosis is associated with marked abnormalities in the circulatory function that involve a reduction in systemic vascular resistance. An important cause of this vasodilatation is the increased production or activity of nitric oxide(NO) in the splanchnic circulation. During portal hypertension and cirrhosis an increased endothelial NO synthase(e NOS) activity is demonstrated in splanchnic vessels. In contrast, the activity of e NOS in the cirrhotic liver is decreased, which suggests a different regulation of e NOS in the liver and in the splanchnic vessels. Asymmetric dimethylarginine(ADMA) is an endogenous NO inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk in both the general population and among patients with cirrhosis. It has been demonstrated that the liver is a key player in the metabolism of ADMA. This observation was further supported by investigations in human patients, showing a close correlation between ADMA plasma levels and the degree of hepatic dysfunction. ADMA is degraded to citrulline and dimethylamine by dimethylarginine dimethylaminohydrolases(DDAHs). DDAHs are expressed as type 1 and 2 isoforms and are widely distributed in various organs and tissues, including the liver. In this review, we discuss experimental and clinical data that document the effects of dimethylarginines on vascular function in cirrhosis. Our increasing understanding of the routes of synthesis and metabolism of methylarginines is beginning to provide insights into novel mechanisms of liver disease and allowing us to identify potential therapeutic opportunities.

关键词： Dimethylarginine dimethylaminohydrolase Nitric oxi

Laparoscopic colorectal surgery:current status andimplementation of the latest technological innovations

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World Journal of Gastroenterology 2016年第2期22卷 704-717页

作者： Marta pascual Silvia Salvans Miguel Pera Section of Colon and Rectal Surgery Department of SurgeryHospital del MarMedical Research Institute08003 BarcelonaSpain

The introduction of laparoscopy is an example of surgical innovation with a rapid implementation in many areas of surgery. A large number of controlled studiesand meta-analyses have shown that laparoscopic colorectal surgery is associated with the same benefits than other minimally invasive procedures, including lesser pain, earlier recovery of bowel transit and shorter hospital stay. On the other hand, despite initial concerns about oncological safety, well-designed prospective randomized multicentre trials have demonstrated that oncological outcomes of laparoscopy and open surgery are similar. Although the use of laparoscopy in colorectal surgery has increased in recent years, the percentages of patients treated with surgery using minimally invasive techniques are still reduced and there are also substantial differences among centres. It has been argued that the limiting factor for the use of laparoscopic procedures is the number of surgeons with adequate skills to perform a laparoscopic colectomy rather than the tumour of patients' characteristics. In this regard, future efforts to increase the use of laparoscopic techniques in colorectal surgery will necessarily require more efforts in teaching surgeons. We here present a review of recent controversies of the use of laparoscopy in colorectal surgery, such as in rectal cancer operations, the possibility of reproducing complete mesocolon excision, and the benefits of intracorporeal anastomosis after right hemicolectomy. We also describe the results of latest innovations such as single incision laparoscopic surgery, robotic surgery and natural orifice transluminal endoscopic surgery for colon and rectal diseases.

关键词： Laparoscopy Inflammatory bowel disease Surgical innovations Colorectal cancer Single incisionlaparoscopic surgery Robotic surgery Natural orificetransluminal endoscopic surgery

A Note on Extreme Points in Dual Spaces

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Acta Mathematica Sinica,English Series 2013年第3期29卷 471-476页

作者： Juan Francisco MENA-JURADO Juan Carlos NAVARRO-pascual Departamento de Análisis Matemático Facultad de Ciencias Universidad de Granada Departamento de lgebra y Análisis Matemático Universidad de Almería

Given a normed space X it can be easily proven that every extreme point in Bx＊, the unit ball of X＊, is the restriction of an extreme point in Bx Our purpose is to study when the restrictions of extreme points in B... 详细信息

关键词： Extreme point Ll-predual M-ideal

Individual repeatability in timing and spatial flexibility of migration routes of trans-Saharan migratory raptors

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Current Zoology 2014年第5期60卷 642-652页

作者： pascual LOPEZ-LOPEZ Clara GARCLA-RIPOLLES Vicente URIOS Vertebrates Zoology Research Group CIBIO Research Institute University ofAlicante Edificio Ciencias III Apdo. 99 E-03080Alicante Spain

Satellite-tracking technology has allowed scientists to make a quantum leap in the field of migration ecology. Nowadays, the basic description of migratory routes of many species of birds has been reported. However, the investigation of bird migration at individual level （i.e. repeatability in migratory routes and timing） still remains seldom explored. Here, we investigated repeated migratory trips of a trans-Saharan endangered migratory raptor, the Egyptian Vulture Neophron percnopterus, tracked by GPS satellite telemetry. We compared between- and within-individual variation in migratory routes and timing in order to assess the degree of repeatability （or conversely, the flexibility） in migration. To this end, we analysed a dataset of 48 trips （23 springs and 25 autumns） recorded for six adult birds during 2007-2013. Our results showed consistent migration timing at the individual level, both in spring and autumn. Interestingly, there was a high degree of flexibility in the routes followed by the same individual in different years, probably due to variations in meteorological conditions. Contrary to expectations of a faster migration in spring than in autumn owing to a time-minimization strategy for breeding, birds spent less time in autumn migration （13 ± 2 days, range = 9-18 d） than in spring migration （19 ± 3 days, range = 13-26 d）, which can be explained by differences in environmental con- ditions en route. Egyptian vultures showed a consistent clockwise loop migration through western Africa, following more easterly routes in autumn than in spring. Finally, our results provide supporting evidence of low phenotypic plasticity in timing of migration （i.e. strong endogenous control of migration） and high flexibility in routes [Current Zoology 60 （5）： 642-652, 2014].

关键词： Egyptian vulture Endogenous control GPS Loop migration Neophron percnopterus Random routes Satellite tracking Simulation

Cell senescence,loss of splicing,and lipid metabolism in TDP-43-related neurodegenerative processes

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Neural Regeneration Research 2023年第8期18卷 1725-1726页

作者： pascual Torres Reinald Pamplona Manuel Portero-Otin Metabolic Pathophysiology Research Group Department of Experimental MedicineUniversity of Lleida-IRBLleidaLleidaSpain

In recent work,we have shown that cell senescence of mouse fibroblasts in vitro associates with a build-up of cryptic exons in selected mRNAs,whose level is usually controlled by the activity of TAR DNA binding protein of 43 kDa(Tdp-43)(Torres et al.,2022).In vivo,we also found traits of cell senescence in the motor neuron disease model achieved by overexpressing SOD-G93A,the SOD1 gene(harboring a single amino acid substitution of glycine to alanine at codon 93).

关键词： metabolism degenerative

An execution control method for the Aerostack aerial robotics framework

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Frontiers of Information Technology & Electronic Engineering 2019年第1期20卷 60-75页

作者： Martin MOLINA Alberto CAMPORREDONDO Hriday BAVLE AlejANDro RODRIGUEZ-RAMOS pascual CAMPOY Department of Artificial Intelligence Universidad Politécnica de Madrid Centre for Automation and Robotics Universidad Politécnica de Madrid

Execution control is a critical task of robot architectures which has a deep impact on the quality of the final system. In this study, we describe a general method for execution control, which is a part of the Aerostack software framework for aerial robotics, and present technical challenges for execution control and design decisions to develop the method. The proposed method has an original design combining a distributed approach for execution control of behaviors(such as situation checking and performance monitoring) and centralizes coordination to ensure consistency of the concurrent execution. We conduct experiments to evaluate the method. The experimental results show that the method is general and usable with acceptable development efforts to efficiently work on different types of aerial missions. The method is supported by standards based on a robot operating system(ROS) contributing to its general use, and an open-source project is integrated in the Aerostack framework. Therefore, its technical details are fully accessible to developers and freely available to be used in the development of new aerial robotic systems.

关键词： Aerial robotics Control architecture Behavior-based control Executive system

Approach to Simplify the Development of IoT Systems that Interconnect Embedded Devices Using a Single Program

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Computers, Materials & Continua 2023年第11期77卷 2463-2480页

作者： Enol Matilla Blanco Jordán pascual Espada Rubén Gonzalez Crespo Department of Computer Science University of OviedoOviedo33007Spain Department of Computer Science and Technology Universidad Internacional de La RiojaLogroño26006Spain

Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized ***,there are several commercial and research platforms available to simplify the creation of such IoT ***,developing these systems can often be a tedious *** address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices *** approach is based on an abstraction,integrating the control of the devices in a single program through a programmable ***,the proposal processes the unified script to generate the centralized system code and a controller for each *** adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.

关键词： IoT interconnected devices IoT platform programing devices devices coordination and communication

Tri-axial accelerometry shows differences in energy expenditure and parental effort throughout the breeding season in long-lived raptors

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Current Zoology 2022年第1期68卷 57-67页

作者： pascual LOPEZ-LOPEZ Arturo MPERONA Olga EGEA-CASAS Jon MORANT Vicente URIOS Movement Ecology Laboratory Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of Valencia.C/Catedratico JoseBeltran 2E-46980 PaternaValenciaSpain Department of Ornithology Aranzadi Sciences SocietyDonostia-S.SebastianGuipuzcoa 03690Spain Vertebrates Zoology Research Group University of AlicanteApdo.99Alicante E-03080Spain

Cutting-edge technologies are extremely useful to develop new workflows in studying ecological data,particularly to understand animal behavior and movement trajectories at the individual *** parental care is a well-studied phenomenon,most studies have been focused on direct observational or video recording data,as well as experimental ***,what happens out of our sight still remains *** high-frequency GPS/GSM dataloggers and tri-axial accelerometers we monitored 25 Bonelli’s eagles Aquila fasciata during the breeding season to understand parental activities from a broader *** used recursive data,measured as number of visits and residence time,to reveal nest attendance patterns of biparental care with role specialization between *** data interpreted as the overall dynamic body acceleration,a proxy of energy expenditure,showed strong differences in parental effort throughout the breeding season and between ***,males increased substantially their energetic requirements,due to the increased workload,while females spent most of the time on the ***,during critical phases of the breeding season,a low percentage of suitable hunting spots in eagles’territories led them to increase their ranging behavior in order to find food,with important consequences in energy consumption and mortality *** results highlight the crucial role of males in raptor species exhibiting biparental ***,we exemplify how biologging technologies are an adequate and objective method to study parental care in raptors as well as to get deeper insight into breeding ecology of birds in general.

关键词： biologging GPS movement ecology ODBA space use telemetry