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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： rosa.ba.leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Can foods influence the onset and progress of neurodegenerative diseases?

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Neural Regeneration Research 2022年第11期17卷 2443-2444页

作者： Luca Piemontese Leonardo Brunetti rosa.ba.leuci Department of Pharmacy and Pharmaceutical Sciences University of Bari Aldo Moro

Over the course of the last few years,the advertisement and marketing of commercial food products in the European market has seen an increasing focus on the beneficial effects of such products for consumer health(Regulation,2006).These so-called"health claims", which can be found on the label of some food products,have become a very important medium,aiming to reach the maximum amount of potential consumers possible,and the delivery of these promises has become a crucial objective for food companies or ***,in most cases,the evidence backing up such claims(and their coveted acknowledgment on the product label) has often been cited as insufficient by institutions such as the European Food and Safety Authority (EFSA,Parma,Italy).

关键词： companies Authority claims

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A group priority earliest deadline first scheduling algorithm

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Frontiers of Computer Science 2012年第5期6卷 560-567页

作者： Qi LI Wei ba School of Control Science and Engineering Dalian University of TechnologyDalian 116024China Science and Technology on Underwater Test and Control Laboratory Dalian 116013China

In most priority scheduling algorithms, the num- ber of priority levels is assumed to be unlimited. However, if a task set requires more priority levels than the system can support, several jobs must in practice be assigned the same priority level. To solve this problem, a novel group priority earliest deadline first （GPEDF） scheduling algorithm is pre- sented. In this algorithm, a schedulability test is given to form a job group, in which the jobs can arbitrarily change their or- der without reducing the schedulability. We consider jobs in the group having the same priority level and use shortest job first （SJF） to schedule the jobs in the group to improve the performance of the system. Compared with earliest deadline first （EDF）, best effort （BE）, and group-EDF （gEDF）, simu- lation results show that the new algorithm exhibits the least switching, the shortest average response time, and the fewest required priority levels. It also has a higher success ratio than both EDF and gEDF.

关键词： real-time system group priority success ratio,switching

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2.5D scattering of incident plane SV waves by a canyon in layered half-space

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Earthquake Engineering and Engineering Vibration 2010年第4期9卷 587-595页

作者： ba Zhenning Liang Jianwen Department of Civil Engineering Tianjin University Tianjin 300072 China Key Laboratory of Coast Civil Structure Safety （ Tianjin University） Ministry of Education

This paper presents a 2.5D scattering of incident plane SV waves by a canyon in a layered half-space by using the indirect boundary element method （IBEM）. A free field response analysis is performed to provide the displacements and stresses on the boundary of the canyon where fictitious uniform moving loads are applied to calculate the Green＇s *** for the displacements and stresses. The amplitudes of the loads are determined by the boundary conditions. The free field displacements are added to the fictitious uniform moving loads induced displacements and the total response is obtained. Numerical calculations are performed for a canyon with homogenous and in one layer over bedrock. The effects of the thickness and stiffness of the layer on the amplification are studied and discussed.

关键词： layered half-space canyon plane SV wave amplification scattering surface layer indirect boundaryelement method

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The effect of propagation delay on the dynamic evolution of the Bitcoin blockchain

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Digital Communications and Networks 2020年第2期6卷 157-166页

作者： Moustapha ba MODAL’X(Laboratoire de Modélisation aléatoire)of UniversitéParis Nanterre(Paris X) MODAL’X is the Mathematics and Computer Sciences laboratory of UniversitéParis Nanterre(Paris X)ministerial label EA 3454UFR SEGMIdépartement Mathématiques-Informatique200 avenue de la République92000NanterreFrance

This paper analyzes the selfish-mine strategy in the Bitcoin blockchain introduced in 2013 by *** and *** strategy could be used by a colluding pool of miners to earn more than their fair share of the mining revenue and in consequence to force other honest miners to join them to decrease the variance of their revenues and make their monthly revenues more *** is a very dangerous dynamic that could allow the rogue pool of miners to go toward a majority by accumulating powers of news adherents and control the entire *** that the propagation delay of information between any two miners in the network,which is not negligible and follows a normal distribution with mean proportional to the physical distance between the two miners,and a constant variance independent of others'delays,we prove that no guarantee can be given about the success or failure of the selfish-mine attack because of the variability of information propagation in the network.

关键词： Blockchain Bitcoin Mining Selfish-mine attack Propagation delay of information

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移植物厚度对角膜内皮失代偿行简易后弹力层角膜内皮移植效果的影响

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中国组织工程研究 2025年第6期29卷 1199-1207页

作者：巴颜红高明宏陈颖欣中国人民解放军北部战区总医院辽宁省沈阳市110000

背景:研究表明较薄移植物视力恢复更快、排斥风险更低,国内缺乏对内皮移植术后不同植片厚度的临床疗效分析,因此,确定最佳移植物厚度对于提高手术疗效至关重要。目的:评价简易后弹力层剥离内皮角膜移植术后不同植片厚度对视力恢复及其... 详细信息

背景:研究表明较薄移植物视力恢复更快、排斥风险更低,国内缺乏对内皮移植术后不同植片厚度的临床疗效分析,因此,确定最佳移植物厚度对于提高手术疗效至关重要。目的:评价简易后弹力层剥离内皮角膜移植术后不同植片厚度对视力恢复及其他预后指标的影响。方法:选取2013年1月至2023年2月在北部战区总医院接受简易后弹力层剥离内皮角膜移植手术治疗的角膜内皮失代偿患者共72例(72眼),其中薄植片组(0.05);③两组患者继发性青光眼、植片免疫排斥、植片移位等术后并发症发生率比较差异无显著性意义(P>0.05);④两组术后1年植片生存率比较差异无显著性意义(93.8%,92.3%,P>0.05);⑤结论:简易后弹力层剥离内皮角膜移植术是一种安全有效的角膜内皮移植手术方式,其术后疗效与传统后弹力层剥离内皮角膜移植术相似,而且植片植入方式更为简便。较薄植片能够更早提供最佳矫正视力,更早完成角膜重塑,因此在治疗角膜内皮失代偿疾病时,优先选择薄移植物来提高恢复时间。

关键词：后弹力层撕除角膜内皮移植术角膜内皮失代偿继发性青光眼植片移位原发移植失败植片排斥角膜内皮细胞数角膜移植

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Characterization of Arithmetic Functions that Preserve the Sum-of-squares Operation

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Acta Mathematica Sinica,English Series 2014年第4期30卷 689-695页

作者： Bojan baI Department of Mathematics and Informatics University of Novi Sad

We characterize all functions f ： N → C such that f（m^2 ＋ n^2） = f（m）^2 ＋ f（n）^2 for all m, n ∈ N. It turns out that all such functions can be grouped into three families, namely f ≡ 0, f（n） = ±n （subject to some restrictions on when the choice of the sign is possible） and f（n） =±l/2（again subject to some restrictions on when the choice of the sign is possible）.

关键词： Arithmetic function functional equation sum of squares

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Natural compounds may contribute in preventing SARS-CoV-2 infection:a narrative review

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Food Science and Human Wellness 2022年第5期11卷 1134-1142页

作者： Maria Eleonora Bizzoca Stefania leuci Michele Davide Mignogna Eleonora Lo Muzio Vito Carlo Alberto Caponio Lorenzo Lo Muzio Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Neurosciences Reproductive and Odontostomatological SciencesFederico Ⅱ University of NaplesNaples 80131Italy Department of Neuroscience and Rehabilitation University of FerraraFerrara 44121Italy C.I.N.B.O.(Consorzio Interuniversitario Nazionale per la Bio-Oncologia) Chieti 66100Italy

Coronavirus pandemic infection is the most important health issue *** disease 2019 is a contagious disease characterized by severe acute respiratory syndrome coronavirus *** date,excluding the possibility of vaccination,against SARS-CoV-2 infection it is possible to act only with supportive care and non-virus-specific treatments in order to improve the patient’s *** industry is investigating effects of medicinal plants,phytochemical extracts and aromatic herbs to find out natural substances which may act as antiviral *** studies have revealed how these substances may interfere with the viral life cycle,viral entry,replication,assembly or discharge,as well as virus-specific host targets or stimulating the host immune system,reducing oxidative stress and inflammatory response.A natural compound can be used as a prophylaxis by people professionally exposed to the risk of contagion and/or positive patients not in intensive *** aim of this paper is to perform a narrative review of current literature in order to summarize the most studied natural compounds and their modes of action.

关键词： Natural compounds SARS-CoV-2 COVID-19 Prevention Infectious disease Phytochemicals Medicinal plants

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Analysis of Heat and Mass Transfer for a Single-Planar-Anode-Supported Solid Oxide Fuel Cell Considering Internal Reforming

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Journal of Thermal Science 2020年第3期29卷 697-707页

作者： ZHANG Zhuqian WANG Yulei ba Liming Institute of Thermal Engineering School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale Beijing 100044China National Institute of Clean-and-Low-Carbon Energy Beijing 102211China

The temperature uniformity and component concentration distributions in solid oxide fuel cells during operating processes can influence the cell electrochemical and thermal characteristics.A three-dimensional thermal-fluid numerical model including electrochemical reactions and water-gas-shift(WGS)reaction for a single channel solid oxide fuel cell was developed to study the steady-state characteristics,which include distributions of the temperature(T),temperature gradient((35)T/(35)x),and fuel *** was shown that the maximum temperature(Tmax)changed with operating voltage and the maximum temperature gradient(((35)T/(35)x)max)occurred at the inlet of the channel of a solid oxide fuel cell by ***,the natural convection condition had a great influence on T and(35)T/(35)*** thermal stress generated by temperature differences was the key parameter and increasing the convection heat-transfer coefficient can greatly reduce the thermal *** addition,the results also showed that there were lower temperature gradients and lower current density at high working voltage;therefore,choosing the proper operating voltage can obtain better cell performance.

关键词： three-dimensional numerical simulation internal reforming reaction solid oxide fuel cell temperature gradient fuel utilization

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Time-dependent diffusion magnetic resonance imaging:measurement,modeling,and applications

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第10期25卷 765-787页

作者： Ruicheng ba Liyi KANG Dan WU Key Laboratory for Biomedical Engineering of Ministry of Education Department of Biomedical EngineeringCollege of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310027China

Increasingly,attention is being directed towards time-dependent diffusion magnetic resonance imaging(TDDMRI),a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues,thereby enabling us to probe related microstructure *** ongoing improvements in hardware and advanced pulse sequences,significant progress has been made in applying TDDMRI to clinical *** development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular *** this review,we introduce the concept and basic physics of TDDMRI,and then focus on the measurement strategies and modeling approaches in short-and long-diffusion-time ***,we discuss the challenges in this field,including the requirement for efficient scanning and data processing technologies,the development of more precise models depicting time-dependent molecular diffusion,and critical clinical applications.

关键词： Time-dependent diffusion Diffusion magnetic resonance imaging(dMRI) Microstructure imaging Microstructural model

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