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Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates:a randomized clinical trial

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World Journal of Pediatrics 2022年第6期18卷 398-403页

作者： Silvia Maya-Enero Montserrat Fàbregas-Mitjans rosa mar.a Llufriu-marquès Júlia Candel-Pau Jordi Garcia-Garcia mar.aÁngeles López-Vílchez Department of neonatology Service of PediatricsHospital del MarParc de Salut MarUniversitat Pompeu FabraPasseig Marítim 25-2908003BarcelonaSpain

Background neonatal pain may affect long-term neurodevelopment and must be *** is a painful procedure wherein a common strategy to relieve pain(sucking)cannot be used because the technique is performed on the *** essential oil(LEO)has sedative and antispasmodic properties and has been successfully used to treat pain during heel puncture and *** aim was to demonstrate if the use of inhaled LEO is effective in reducing pain during frenotomy in healthy,full-term *** We conducted a randomized clinical trial in neonates who underwent a frenotomy between August 2020 and April *** assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and neonatal Infant Pain Scale(nIPS)*** with type 3 tongue tie were randomized into the“experimental group”and“control group”.In both groups,we performed swaddling,administered oral sucrose,and let the newborn suck for two *** the experimental group,we also placed a gauze pad with one drop of LEO under the neonate’s nose for two minutes prior to and during the *** We enrolled 142 patients(71 per group).The experimental group showed significantly lower nIPS scores(1.88 vs 2.92)and cried almost half the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control group,we observed no side effects in either of the *** We observed a significant decrease in crying time and lower nIPS scores in the neonates who received inhaled LEO and underwent a frenotomy for type 3 ***,we recommend using inhaled LEO during neonatal frenotomies.

关键词： Ankyloglossia Aromatherapy Frenotomy Lavender neonate neonatal pain Tongue-tie

Modelling Pathways for Outbreaks in Field Occupational Epidemiology

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Open Journal of Preventive Medicine 2021年第4期11卷 91-112页

作者： Jerónimo Maqueda Agustín Silva rosa-Ana Cortés mar.a-Fe Gamo Health Promotion and Occupational Epidemiology Department National Institute of Safety and Health at Work Madrid Spain Faculty of Medicine and Health Sciences Alcalá de Henares University Madrid Spain national School of Occupational Medicine Institute of Health Carlos III Madrid Spain

Background: The investigation of an occupational outbreak, once the index case has been identified, triggers a stress situation to epidemiologists. Modelling occupational outbreaks will be useful to guide the field investigation. Objective: To identify standard pathways for occupational epidemic outbreaks. Methods: In-depth critical appraisal of 57 occupational outbreaks. Standard pathways of occupational outbreaks were identified by analysing the similarity between out-breaks. The model’s accuracy and homogeneity were established through Fisher’s exact test and the Kappa Index. Results: The analysis allowed synthesizing the occupational outbreaks variability in 4 pathways. 92.98% of the analysed outbreaks could be allocated to one of those 4 types. The theoretical patterns showed a good adjustment with the analysed out-breaks: Type I (Kappa = 0.94 - 0.60), Type II (Kappa = 1.00), Type III (Kappa = 1.00 - 0.68) and Type IV (Kappa = 0.94 - 0.87). The probability of a given outbreak fitting with its three components in any of the theoretical pathways was 0.83. Conclusions: The incorporation of those pathways to the field occupational epidemiology will allow: 1) to provide early guidance to epidemiological, clinical and environmental studies focused on specific hypothesis of causality;2) to anticipate preventive measures;3) to contribute to an earlier and more efficient outbreak resolution.

关键词： Occupational Outbreak Occupational Diseases Working Exposure Field Epidemiology

Minimum inhibitory but maximum non-hemolytic concentration of plasma-treated catheters coated with *** and *** extracts

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Plasma Science and Technology 2023年第12期25卷 83-96页

作者： Francisco Javier ALOnSO-MOnTEMAYOR Miriam Desirée DÁVILA-MEDInA Alejandro ZUGASTI-CRUZ rosa Idalia nARRO-CÉSPEDES mar.a Guadalupe nEIRA-VELÁZQUEZ AidéSÁEnZ-GALInDO Eduardo ALOnSO-CAMPOS Autonomous University of Coahuila Saltillo 25280Mexico Center for Research in Applied Chemistry Saltillo 25294Mexico University of Monterrey San Pedro Garza García 66238Mexico

Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts,but their hemocompatibility and thermal stability must be *** bacteria have developed resistance to conventional ***,the minimum inhibitory but non-hemolytic concentration(MIC-nH)and the thermal stability of Larrea tridentata(***)and Origanum vulgare(***)extract-coated catheters were ***,plasma pretreatment was performed to enhance the extract ***,the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using *** and *** extracts at MIC-nH(5000 and 2500μg ml~(-1),respectively).Moreover,it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion,***,this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.

关键词： antibacterial activity biocompatibility blood-contact device cold plasma nosocomial bacteria

Concentration of Fluoride and Arsenic in Bottled Drinking Water in Durango City, Mexico

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Journal of Environmental Protection 2013年第12期4卷 8-13页

作者： mar.a Adriana martínez-Prado mar.a Elena Pérez-López mar.a Guadalupe Vicencio-de la rosa Cecilia Corazón González-nevarez Chemical Engineering Department Technological Institute of Durango (ITD) Durango Mexico national Polytechnic Institute Interdisciplinary Research Center for Regional Integral Development at Durango (IPn-CIIDIR-DGO) Durango Mexico

Arsenic and fluoride are elements known to cause human health problems and it has been documented that both elements are found in high concentrations in the Guadiana Valley aquifer, in the state of Durango, Mexico. Since underground water is the source for potable water bottling companies commercialized in Durango City;such high concentrations reduced the quality of bottled water for human consumption according to nOM-041-SSA1-1993. Legislation establishes a maximum permissible limit (MPL) of 0.7 mg/L for fluoride and 0.025 mg/L for arsenic. In this research the main objective was to evaluate the quality of bottled water expended in Durango City with respect to the well from which water is extracted. Findings showed that the highest fluoride concentration was 5.86 mg/L (8.4 times MPL), with 100% of sampled brands exceeding the MPL (range: 1.09 to 5.86 mg/L). On the other hand, for arsenic, the highest concentration was 0.076 mg/L (threefold), with 38% exceeding the MPL (range: 0.001 to 0.076 ppm). Statistical analysis showed significant differences only for fluoride, according to Fisher LSD (Least Significant Difference) test, with an F value of 14.5 at a p value of 0.0005. According to the comparison between the quantified concentrations in bottled water and groundwater, it was found that groundwater was subjected to treatment;however, although a significant decrease in fluoride and arsenic concentration was observed, the removal processes used were not efficient to meet set standards.

关键词： Arsenic Bottled Water Quality Fluoride Guadiana Valley Aquifer Groundwater

The Influence of Meteorology and Atmospheric Transport Patterns on the Sulfate Levels in Raiwater in Orizaba Valley, Veracruz, Mexico

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Journal of Environmental Protection 2019年第6期10卷 821-837页

作者： rosa mar.a Cerón Bretón Jonathan Kahl Julia Griselda Cerón Bretón José Angel Solís Canul Chemistry Faculty Autonomous University of Carmen Ciudad del Carmen Mexico Department of Mathematical Sciences University of Wisconsin-Milwaukee Milwaukee WI USA

This work assessed the relationship between synoptic circulation patterns, meteorological conditions and sulfate levels in rainwater in Orizaba Valley, Veracruz, Mexico during 2015. Samples were collected by using an automatic deposition sampler considering three climatic periods: Cold fronts or nortes, Dry and Rainy seasons. Sulfate in rainwater was determined by turbidimetry (nMX-AA-SCFI-074-1981). A backward trajectory model (HYSPLIT) was used to characterize the potential source regions and transport pathways for air parcels arriving to Orizaba Valley;trajectories extended five days during 2015 were calculated. Mean concentrations of sulfate were 105.33, 37.5, and 52.5 μEq·l-1, for Cold Fronts, Dry and Rainy seasons, respectively. An evident dilution pattern was observed with lower concentration levels when rainfall increased. Mean values for sulfate concentration exceeded the background hemispheric value reported by Galloway et al. (1982) for remote sites (10 μEq·l-1), exceeding almost 10, 3.7 and 5.2 times, during the nortes, Rainy and Dry seasons, respectively. From the obtained results, it was concluded that the high sulfate levels in the rainwater measured in Orizaba Valley had their origin in different upwind regional sources as a result of long-range transport during Rainy and nortes seasons.

关键词： Atmospheric Transport Rainwater Sulfate

Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation

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World Journal of Gastroenterology 2014年第42期20卷 15820-15829页

作者： Xabier García-Albéniz rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés rosa Miquel mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio mar.a de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel Department of Epidemiology Harvard School of Public Health Department of Medical Oncology Hospital Clínic ICMHO IDIBAPS CIBEREHD University of Barcelona Interdisciplinary Tumor Center Mannheim and Ⅲ Medical Clinic University Hospital Mannheim University of Heidelberg Department of Gastroenterology Endoscopy Unit Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of Radiology Hospital Clínic CDI IDIBAPS University of Barcelona Department of Pathology Hospital Clínic IDIBAPS University of Barcelona Department of Radiation Oncology Hospital Clínic ICMHO University of Barcelona Department of Gastrointestinal Surgery Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of Gastroenterology Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of nursing and Health University of Applied Sciences of the Saarland Department for Hematology and Oncology Clinic for Internal Medicine Ⅱ Jena University Hospital

AIM: To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.

关键词： Exercise Follow-up Gastrointestinal diseases Irritable bowel syndrome Physical activity

Personality Styles,Psychological Adjustment and Gender Differences in Parents of Children with Congenital Disabilities

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Health 2015年第11期7卷 1492-1505页

作者： rosa M.Liminana-Gras mar.a del Pilar Sánchez-López mar.a Teresa Calvo-Llena Francisco Javier Corbalán Research Group Personality and Health:A Intercultural and Gender Perspective MurciaSpain Universidad de Murcia MurciaSpain Universidad Complutense de Madrid MadridSpain Red Hygeia(Health&Gender International Alliance) MadridSpain

The present study analyzes the psychological adaptation of parents with children having congenital disabilities. The study included 83 men and 96 women, who were parents of children with severe spina bifida, cerebral palsy, cleft lip and cleft palate. The Millon Index of Personality Styles was used to identify the most distinctive personality styles of parents caring for a child with a chronic disability and parental psychological adjustment. We also investigated if personality profiles differ by gender, and educational and socioeconomic level. The personality styles identified may serve as indicators of the way parents adapt to the child with a congenital disability. The results also suggest that a child’s disability has a differential impact on men and women. Gender issues are evaluated, as well as any repercussions these may have on women.

关键词： Personality Styles Congenital Disability Parental Psychological Adjustment Gender Differences

Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2018年第24期24卷 2537-2554页

作者： Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer mar.a JoséFerri Maite Albiol-Quer Rafael de Llorens rosa Peracaula Department of Biology Biochemistry and Molecular Biology UnitUniversity of GironaGirona 17003Spain Biomedical Research Institute of Girona(IdIBGi).Parc Hospitalari martíi Julià-Edifici M2 Salt 17190Spain Clinic Laboratory University Hospital Dr Josep TruetaGirona 17007Spain Department of Surgery Hepato-biliary and Pancreatic Surgery UnitUniversity Hospital Dr Josep TruetaGirona 17007Spain

Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease.

关键词： Pancreatic cancer Aberrant glycosylation Glycoproteins Biomarkers Diagnosis

Study of Trace Ions in Wet Deposition of an Industrial Site in Monterrey’s Metropolitan Area, Mexico

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Open Journal of Ecology 2016年第1期6卷 1-12页

作者： Evangelina Ramírez-Lara rosa mar.a Cerón-Bretón Julia Griselda Cerón-Bretón Ulrico López-Chuken Jonathan Kahl Facultad de Ciencias Químicas Universidad Autónoma de Nuevo León San Nicolás de los Garza México Facultad de Química Universidad Autónoma del Carmen Ciudad del Carmen México Department of Mathematical Science University of Wisconsin-Milwaukee Milwaukee USA

The chemistry of rainwater has been subject to numerous investigations during the last two decades due to the increase of environmental problems caused by the acid deposition. The present study focuses on one aspect of air pollution, the chemical composition of wet deposition of an industrial zone. The sampling period was from march to December 2009. The station was located on the roof of the Chemistry School at the University of nuevo León, an area in the north of Monterrey where the majority of pollution is generated. Twenty-five wet precipitation samples were collected with an automatic sampler and analyzed for pH, ions (, , Cl-, Ca2+, Mg2+, na+, K+) and conductivity. The results show that the average pH is higher than 5.6;the characteristics of the rainwater studied are of alkaline nature due to the values of pH found;there is an evident anthropogenic source contributing to the alkaline of rain water. In order to find possible association between ions and consequently the possible sources of pollutants correlation study was applied using the program SPSS v.12. Good correlations were found between ions and along with Ca2+ and Mg2+. The local extraction industry and surrounding aerosols might be causing of alkaline rain which may be due to the neutralization effect of particulate matter. This study represents a continuation of the studies of rainwater chemistry in the northeast of Mexico.

关键词： Wet Deposition Air Quality Monterrey Air Pollution