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Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis

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World Journal of Gastroenterology 2008年第43期14卷 6601-6615页

作者： Francesco Feo Maddalena Frau rosa maria pascale Department of Biomedical Sciences Division of Experimental Pathology and OntologyUniversity of SassariSassari 07100Italy

Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma （HCC）. Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats and a G1-S block in lesions of resistant Brown norway （BN） rats. Unrestrained extracellular signal-regulated kinase （ERK） activity linked to proteasomal degradation of dual-specificity phosphatase 1 （DUSP1）, a specific ERK inhibitor, by the CKS1-SKP2 ubiquitin ligase complex occurs in more aggressive HCC of F344 rats and humans. This mechanism is less active in HCC of BN rats and human HCC with better prognosis. Upregulation of iNos cross-talk with IKK/NF-KB and RAS/ERK pathways occurs in rodent liver lesions at higher levels in the most aggressive models represented by HCC of F344 rats and c-Myc-TGF-α transgenic mice. iNOS, IKK/NF-κB, and RAS/ERK upregulation is highest in human HCC with a poorer prognosis and positively correlates with tumor proliferation, genomic instability and microvascularization, and negatively with apoptosis. Thus, cell cycle regulation and the activity of signal transduction pathways seem to be modulated by HCC modifier genes, and differences in their efficiency influence the susceptibility to hepatocarcinogenesis and probably the prognosis of human HCC.

关键词： Hepatocarcinogenesis Genetic predisposition Polygenic disease, Redifferentiation Signal transduction pathways Cell cycle Cell proliferation Apoptosis Proteasomal degradation

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On the Jebsen-Birkhoff Theorem in a Born-Infeld Type Theory of Gravity

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Journal of High Energy Physics, Gravitation and Cosmology 2019年第4期5卷 1051-1056页

作者： Tiago de Oliveira rosa maria Emilia Xavier Guimarã es Rocco pascale Neto Joaquim Lopes Neto Instituto Federal Goiano Campus Urutaí Rodovia Geraldo Silva Nascimento Urutaí Brazil Instituto de Física Universidade Federal Fluminense Niterói Brazil Instituto de Física Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

In this paper we work with a special theory of gravity|the Novello-Di Lorenci-Luciane (hereby called NDL theory) which extends the Feynman-Deser standard theoretical-fi eld approach to General Relativity. In the so-called NDL theory, matter interacts universally with gravity in accordance with the Weak Equivalence Principle, while gravitons have a nonlinear self-interaction. Our main aim in this work is to show that, though the NDL theory does not admit a Schwarzschild solution, the Jebsen-Birkhoff theorem is still valid in this framework.

关键词： Electrostatic Trapping Bootstrap Current Mitigation Peeling-Ballooning Mode

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Ovarian cancer standard of care: are there real alternatives?

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Chinese Journal of Cancer 2015年第1期34卷 17-27页

作者： Chiara Della Pepa Giuseppe Tonini Carmela Pisano Marilena Di Napoli Sabrina Chiara Cecere rosa Tambaro Gaetano Facchini Sando Pignata Department of Medical Oncology Campus BioMedico University of RomeVia Alvaro Del Portillo200Rome 00128Italy Department of Urology and Gynecology Istituto Nazionale Tumori Fondazione Pascale-Istituto Di Ricovero E Cura A Carattere ScientificoVia Mariano Semmola52Naples 80131Italy

Ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-taxane chemotherapy is the current standard of care, but based on several different strategies currently under evaluation, some encouraging data have been published in the last 4 to 5 years. This review provides a state-of-the-art overview of the available alternatives to conventional treatment and the most promising new combinations. For example, neoadjuvant chemotherapy does not seem to be inferior to primary debulking. Despite its outcome improvements, intraperitoneal chemotherapy struggles for acceptance due to the heavy toxicity. Dose-dense chemotherapy, after showing an impressive efficacy in Asian populations, has not produced equal results in a European cohort, and the results of alternative platinum doublets are not superior to those of carboplatin and paclitaxel. In this setting, adherence to a maintenance therapy after first-line treatment and multiple(primarily antiangiogenic) agents appears to be effective. Although many questions, including the duration of maintenance treatment and the use of bevacizumab beyond progression, remain unanswered, new biologic agents, such as poly(ADP-ribose) polymerase(PARP) inhibitors, nintedanib, and mitogen-activated protein/extracellular signal-regulated kinase(MEK) inhibitors, have emerged as potential therapeutic options in the very near future. Based on the multiplicity of available strategies, the histological and molecular features of the tumor, in addition to patient's clinical condition and disease state, continue to gain importance in guiding treatment choices.

关键词：卵巢癌标准护理治疗方案抗血管生成丝裂原活化持续时间生物制剂

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Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

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World Journal of Gastroenterology 2013年第46期19卷 8659-8670页

作者： Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De rosa Department of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate University of Naples"FedericoⅡ" Department of Translational Medical Sciences Section of PediatricsUniversity of Naples"FedericoⅡ" Colorectal Surgical Oncology-Abdominal Oncology Department Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly Endoscopy Unit Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly

AIM: To investigated the molecular cause of very early-onset ulcerative colitis (UC) in an 18-mo-old affected child.

关键词： Inflammatory bowel disease, Ulcerative colitis, Interleukin 10 receptors, Tumour necrosis factor α receptors, Beta catenin

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