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Optimize the Transport Cost and Environmental Impact of Whey Collection: A Case Study in the Region Trentino A. A. (Italy)

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American Journal of Ope.ations Research 2017年第3期7卷 153-173页

作者： luca Iseppi franco rosa mario Taverna University of Udine Udine Italy

The scope.of this research is to elaborate a strategy to minimize the logistic cost of the whey collection. The problem consists of the description of the whey collection basin and transport from CP (Cheese plant) to WPP (Whey processing plant). We started with an initial basic solution and proceeded with successive iterations to find the final optimal solution. Two numeric methods are proposed to solve iteratively the problem: the first one emulates the simplex method, the second one is an empirical solution to find the optimal route. Both are solved with an Excel and Google map software and do not require a dedicated lP program for calculus. The results demonstrate that both methods contribute to solve the transport problem and generate valuable information for the achievement of economic and environmental targets.

关键词： Dairy Chain Whey Production Network Theory Transportation Whey Optimization Sustainability

Sorafenib delivery nanoplatform based on supe.para- magnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

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Nano Research 2017年第7期10卷 2431-2448页

作者： Nicoletta Depalo rosa maria lacobazzi Gianpiero Valente Ilaria Arduino Silvia Villa Fabio Canepa Valentino laquintana Elisabetta Fanizza marinella Striccoli Annalisa Cutrignelli Angela lope.ota letizia Porcelli Amalia Azzariti Massimo franco maria lucia Curri Nunzio Denora Istituto pe. i Processi Chimico-Fisici-CNR UOS Bari Via Orabona 4 70125 Bari Italy Istituto Tumori IRCCS Giovanni Paolo II viale O. Flacco 65 70124 Bari Italy Dipartimento di Chimica Universita degli Studi di Bad Aldo Moro Via Orabona70125 Bari Italy Dipartimento di Farmacia-Scienze del Farmaco Universita degli Studi di Bari Aldo Moro Via Orabona 4 70125 Bari Italy Dipartimento di Chimica e Chimica Industriale Universita di Genova Via Dodecaneso 31 16146 Genova Italy

Currently, sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients. Unfortunately, its side effects, particularly its overall toxicity, limit the therape.tic response that can be achieved. Supe.paramagnetic iron oxide nanoparticles （SPIONs） are very attractive for drug delivery because they can be targeted to spe.ific sites in the body through application of a magnetic field, thus improving intratumoral accumulation and reducing adverse effects. Here, nanoformulations based on polyethylene glycol modified phospholipid micelles, loaded with both SPIONs and sorafenib, were successfully prepared and thoroughly investigated by complementary techniques. This nanovector system provided effective drug delivery, had an average hydrodynamic diameter of about 125 nm, had good stability in aqueous medium, and allowed controlled drug loading. Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle. An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver. Human hepatocellular carcinoma （HepG2） cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the supe.paramagnetic micelles loaded with sorafenib. These expe.iments demonstrated that this delivery platform is able to enhance sorafenib＇s antitumor effectiveness by magnetic targeting. The magnetic nanovectors described here represent promising candidates for targeting spe.ific hepatic tumor sites, where selective release of sorafenib can improve its efficacy and safety profile.

关键词： supe.paramagnetic ironoxide nanoparticles poly(ethylene glycol) (pe.)-modified phospholipidmicelles drug delivery magnetic targeting hepatocellular carcinoma sorafenib

Atrial fibrillation in the elderly

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Journal of Geriatric Cardiology 2012年第2期9卷 91-100页

作者： Roberto A. Franken Ronaldo F. rosa Silvio CM Santos Department of Internal Medicine Santa Casa Sao Paulo Medical School R.Dr.Franco da Rocha 163/52 Sao Paulo 050l 5-040 Brazil Brazilian Society of Cardiology Rua Padre bartolomeu Tadei 18 Santos 11035-150 Brazil

This review discusses atrial fibrillation according to the guidelines of Brazilian Society of Cardiac Arrhythmias and the Brazilian Cardiogeriatrics Guidelines. We stress the thromboembolic burden of atrial fibrillation and discuss how to prevent it as well as the best way to conduct cases of atrial fibrillatios in the elderly, reverting the arrhythmia to sinus rhythm, or the option of heart rate control. The new methods to treat atrial fibrillation, such as radiofrequency ablation, new oral direct thrombin inhibitors and Xa factor inhibitors, as well as new antiarrhythmic drugs, are depicted.

关键词： Atrial fibrillation Heart failure Thrombo-embolism Treatment Prevention

Bite force and masticatory efficiency in individuals with different oral rehabilitations

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Ope. Journal of Stomatology 2012年第1期2卷 21-26页

作者： laner B.rosa Cesar Bataglion Selma Siéssere marcelo Palinkas Wilson Mestriner Júnior Osvaldo de Freitas Moara de Rossi lígia franco de Oliveira Simone C.H.Regalo Department of Morphology Stomatologyand PhysiologySchool of DentistryUniversity of Sao PauloRibeirao PretoBrazil Department of Dentistry School of DentistryUniversity of Sao PauloRibeirao PretoBrazil Department of pe.iatric Clinics Preventive and Community DentistryRibeirao Preto Dental SchoolUniversity of Sao PauloRibeirao PretoBrazil Department of Pharmaceutical Sciences Ribeirao Preto School of Pharmaceutical SciencesUniversity of Sao PauloRibeirao PretoBrazil

Objective: This study was analyzed adult individuals rehabilitated with different type. of dentures, with the purpose of verifying the effect that different type. of denture rehabilitation have on maximal bite force and masticatory efficiency. The aim of this study is to facilitate diagnosis and prognosis, bringing contributions to the quality and stability of treatments Materials and Methods: Fifty individuals were divided into five groups: one control group with ten dentate individuals and another four groups formed according to the type.of rehabilitation treatment. Maximal bite force was recorded on the first molar regions, and masticatory efficiency rates were recorded on the right, left and habitual sides. Results: Data related to the maximal bite force recordings were statistically significant across the analyzed groups [ANOVA for p ≤ 0.01]. The data related to masticatory efficiency rates also showed statistical significance across all groups [ANOVA for p ≤ 0.05] in the three tested conditions [mastication on the right, left and habitual sides]. Conclusion: The group of individuals rehabilitated with implants and single crowns showed greater bite force values and masticatory efficiency rates compared to the other groups, and the treatment with implantsupported mandibular overdenture improved the function compared to conventional complete dentures, thus evincing that the stomatognathic system has different functional behaviors depe.ding on the type.of oral rehabilitation.

关键词： Bite Force Masticatory pe.formance Oral Rehabilitation

Dendritic cell deficiencies pe.sist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia maría Trujillo-Rodriguez Ana Serna-Gallego Espe.anza Muñoz-Muela maría de los Reyes Jiménez-leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González luis Fernando lópe.-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera pe.ro Camacho-martínez Carmen Infante-Domínguez marta Carretero-ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel lomas Claudio Bueno rosario Amaya JoséAntonio lepe.Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspe.es Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-lara Cristina Amodeo Javier Ampuero maría Dolores Avilés maribel Asensio Bosco Barón-franco lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-pe.it Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez maría luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-león Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero marta Herrero-Romero luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia lanseros-Tenllado Carmina lópe. Isabel lópe. Álvaro lópe.-Barrios luis F.lópe.-Cortés Rafael luque-Márquez Daniel Macías-García Guillermo martín-Gutiérrez luis martín-Villén JoséMolina Aurora Morillo maría Dolores Navarro-Amuedo Dolores Nieto-martín Francisco Ortega maría Paniagua-García Amelia pe.a-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell long-COVID

Neuropathology of Schizophrenia

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Journal of Pharmacy and Pharmacology 2014年第7期2卷 422-431页

作者： Villeda-Hernandez Juana Sanchez martinez Rodrigo Totxo-Guerrero Sebastian Manzanarez-Colin mariel Carolina Palacios-Escalona Sergio franco-Del Toro pe.la Guadalupe.Cuevas-Nunez Flora Minerva Alonso-Zuniga rosa Emma pe.alta-Rodriguez Brenda Rembao-Bojorquez Daniel Tristan-Agundis Ma.Francisca Department of Neuropathology National Institute of Neurology and Neurosurgery Distrito Federal 14269 Mexico Faculty of Medicine National Autonomous University of Mexico Distrito Federal 03000 Mexico School of Medicine Guadalajara University Guadalajara 44100 Mexico School of Medicine San Luis Potosi University San Luis Potosi 78000 Mexico Department of Pathology Fray Bernardino Alvarez Psychiatric Hospital Distrito Federal 14000 Mexico

The pape. is to study the structural changes in cortex and cerebellum of autopsies of subjects with schizophrenia. In the Pathology Department of the Psychiatric Hospital ＂Fray Bernardino ,Avarez＂, there are 410 autopsy cases with diagnosis of mental disease, from which 52 match schizophrenia. The aim of this work is to describe structural changes in the autopsy material and make markers in order to confirm neurodevelopment alterations. The tissues were preserved in formol, paraffin-embedded; cut into 5-7 μm slices; stained with H-E （Hematoxilin and Eosin）, Bielschowsky, crystal fast of violet. The observed changes were brain asymmetry, cortical dysplasia, neuronal distortion, axon bifurcation, neuronophagia and generalized demyelination. Schizophrenia is the result of several happe.ings, it is important to devise new treatment strategies for prevention and genetic counseling for population.

关键词： Schizophrenia cortical dysplasia heterotopias migration failure.

Comparative study of breast cancer in Mexican and Mexican-American women

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Comparative study of breast cancer in Mexican and Mexican-American women

Health（健康） 2010年第9期

作者： maría Elena martínez luis Enrique Gutiérrez-Millan Melissa Bondy Adrian Daneri-Navarro maría Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio luz maría Adriana Balderas-pe.a José Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes mario Alberto Chávez Zamudio Giovanna Cruz Alicia Del Toro-Arreola mary E. Edgerton maría rosa Flores-marquez Ramon Antonio franco-Tope.e Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn luz margarita Jimenez-pe.ez Ian K. Komenaka Zoila Arelí lópe. Bujanda Dihui lu Gilberto Morgan-Villela James l. Murray Jesse N. Nodora Antonio Oceguera-Villanueva Miguel Angel Ortiz martínez laura Pérez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson

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Health 2010年第9期2卷 1040-1048页

作者： maria Elena martinez luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio luz maria Adriana Balderas-pe.a Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola mary EEdgerton maria rosa Flores-marquez Ramon Antonio franco-Tope.e Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn luz margarita Jimenez-pe.ez Ian KKomenaka Zoila Areli lope. Bujanda Dihui lu Gilberto Morgan-Villela James lMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz martinez laura pe.ez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The EllA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the EllA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States