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Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： Alessandro Mantovani rosa lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine C and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic

PNPLA3 I148M polymorphism and progressive liver disease

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World Journal of Gastroenterology 2013年第41期19卷 6969-6978页

作者： Paola Dongiovanni Benedetta Donati Roberta Fares rosa lombardi Rosellina Margherita Mancina Stefano Romeo Luca Valenti Internal Medicine Fondazione IRCCS Ca’ Granda Ospedale Policlinico MilanoDepartment of Pathophysiology and TransplantationUniversità degli Studi di Milano20122 MilanoItaly Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory Department of Molecular and Clinical MedicineUniversity of Gothenburg40530 GothenburgSweden Clinical Nutrition Unit Department of Medical and Surgical SciencesUniversity Magna Graecia88100 CatanzaroItaly

The 148 Isoleucine to Methionine protein variant(I148M)of patatin-like phospholipase domain-containing 3(PNPLA3),a protein is expressed in the liver and is involved in lipid metabolism,has recently been identified as a major determinant of liver fat *** studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver:from simple steatosis to steatohepatitis and progressive ***,the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis,and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis,and possibly chronic hepatitis B virus hepatitis,hereditary hemochromatosis and primary sclerosing *** in all,studies suggest that the I148M polymorphism may represent a general modifier of fibrogenesis in liver ***,the effect of the I148M variant on fibrosis was independent of that on hepatic steatosis and inflammation,suggesting that it may affect both the quantity and quality of hepatic lipids and the biology of non-parenchymal liver cells besides hepatocytes,directly promoting ***,PNPLA3 is a key player in liver disease *** of the I148M polymorphism will possibly inform clinical practice in the future,whereas the determination of the effect of the 148M variant will reveal mechanisms involved in hepatic fibrogenesis.

关键词： Alcoholic liver disease Chronic hepatitis C virus hepatitis Fibrogenesis Genetics Hepatocellular carcinoma Liver disease Nonalcoholic fatty liver disease Patatin-like phospholipase domain-containing 3 Single nucleotide polymorphism Steatosis

Evaluating and Measuring Relational Capital by Defining Knowledge

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Journal of Modern Accounting and Auditing 2013年第3期9卷 392-397页

作者： Raffaele Trequattrini Giuseppe Russo rosa lombardi University of Cassino and Southern Lazio Cassino Italy

As we are in the knowledge economy, the main purpose of this research is to define the value of relational capital by measuring it with an innovative model. To this end, this paper will explain the meaning of intellectual capital （human capital, structural capital, and relational capital） in the field of knowledge economy and what relational capital is and how we can measure its value. The research is qualitative in nature and was developed through the study of the international literature. The research presents some theoretical evidences that permit defining a method for the evaluation of relational capital. In this direction, the above method will need to have some integration in the future research. Moreover, this approach should consider some empirical evidences to establish the practical value of the method. In fact, the method presented encourages debate and a critical attitude towards the evaluations of relational capital and intellectual capital.

关键词： relational capital intellectual capital evaluation performance knowledge

Alpine tundra species phenology is mostly driven by climate-related variables rather than by photoperiod

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Journal of Mountain Science 2020年第9期17卷 2081-2096页

作者： QUAGLIA Elena RAVETTO ENRI Simone PEROTTI Elisa PROBO Massimiliano lombardi Giampiero LONATI Michele Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095Grugliasco(To)Italy Grazing Systems AgroscopeRoute de Duillier 501260NyonSwitzerland

The study of plant phenology has frequently been used to link phenological events to various factors,such as temperature or *** the high-alpine environment,proper timing of the phenological cycle has always been crucial to overcome harsh conditions and potential extreme events(*** frosts)but little is known about the response dynamics of the vegetation,which could shape the alpine landscape in a future of changing *** tundra vegetation is composed by an array of species belonging to different phytosociological optima and with various survival strategies,and snowbed communities are a relevant expression of such an extreme-climate adapted *** set eight permanent plots with each one in a snowbed located on the Cimalegna plateau in Northwestern Italy and then we selected 10 most recurring species among our plots,all typical of the alpine tundra environment and classified in 3different pools:snowbed specialists,grassland species and rocky debris *** 3 years we registered the phenophases of each species during the whole growing season using an adaptation of the BBCH *** later focused on the three most biologically relevant phenophases,i.e.,flower buds visible,full flowering,and beginning of seed *** important season-related variables were chosen to investigate their relationship with the phenological cycle of the studied species:(i)the Day Of Year(DOY),the progressive number of days starting from the 1 st of January,used as a proxy of photoperiod,(ii)Days From Snow Melt(DFSM),selected to include the relevance of the snow dynamics,and(iii)Growing Degree Days(GDD),computed as a thermal *** analysis highlighted that phenological development correlated better with DFSM and GDD than with ***,models showed that DOY was always a worse predictor since it failed to overcome interannual variations,while DFSM and marginally GDD were better suited to predict the phenological development of most of the species,desp

关键词： Alpine plants Climate change Growing degree days Italian Alps Salix herbacea Snowbed vegetation