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Sex differences in muscle health in simulated micro-and partial-gravity environments in rats

Sports Medicine and Health Science 2023年第4期5卷 319-328页

作者： Megan E.rosa-Caldwell Marie Mortreux anna Wadhwa Ursula B.Kaiser Dong-Min Sung Mary L.Bouxsein Seward B.Rutkove Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School330 Brookline AvenueBostonMA02215USA Department of Nutrition and Food Sciences University of Rhode IslandKingstonRI02881USA Division of Endocrinology Diabetes and HypertensionBrigham and Womenʼs Hospital and Harvard Medical SchoolBostonMA02215USA Center for Advanced Orthopedic Studies Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA02215USA

Skeletal muscle size and strength are important for overall health for ***,how male and female muscle may respond differently to micro-and partial-gravity environments is not fully *** purpose of this study was to determine how biological sex and sex steroid hormones influence the progression of muscle atrophy after long term exposure to micro and partial gravity environments in male and female *** and female Fisher rats(n=120)underwent either castration/ovariectomy or sham *** two weeks recovery,animals were divided into microgravity(0g),partial-gravity(40%of weight bearing,0.4g),or full weight bearing(1g)interventions for 28 *** of muscle size and strength were evaluated prior to and after *** 0g,females lost more dorsiflexion strength,plantar flexion strength,and other metrics of muscle size compared to males;castration/ovariectomy did not influence these ***,at 0.4g,females lost more dorsiflexion strength,plantar flexion strength,and other metrics of muscle strength compared to males;castration/ovariectomy did not influence these *** have greater musculoskeletal aberrations during exposure to both microgravity and partial-gravity environments;these differences are not dependent on the presence of sex steroid ***,additional interventions may be necessary to mitigate musculoskeletal loss in female astronauts to protect occupational and overall health.

关键词： Sex differences Atrophy Muscle strength Plantar flexion Dorsiflexion

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Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： Alessandro Mantovani rosa Lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine C and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic

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国际护理知识网络建设的调查研究

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International Journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： Margareth Santos Zanchetta Suzanne Fredericks Kateryna Metersky Geraldine Martorella Pammla Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina rosa Soares Lavareda Baixinho Cristianne Maria Famer Rocha Sara Campagna Sally Zhang He Márcia Teles de Oliveira Gouveia Marcelo Medeiros Denize Bouttelet Munari Daniel Gonzalo Eslava Albarracin Carlos Aguilera-Serrano Walterlania Silva Santos Toronto Metropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of Regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of Malaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

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The impact of biophilic design in Maggie’s Centres:A meta-synthesis analysis

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Frontiers of Architectural Research 2023年第1期12卷 188-207页

作者： Bekir Huseyin Tekin Rhiannon Corcoran rosa Urbano Gutierrez School of Architecture University of LiverpoolLiverpoolUK Institute of Psychology Health and Society University of LiverpoolLiverpoolUK

This paper presents a meta-synthesis conducted to identify,compare and synthesize published qualitative data related to the Maggie’s Centres,as a paradigmatic architectural example in the provision of non-institutional cancer *** centres are internationally renowned for their unique architecture,where the careful design of indoors and outdoors spaces plays a critical role in their agenda for supporting *** research has thoroughly analysed this approach to therapeutic environments,not only confirming the importance of designed space as originally conceived in Maggie’s philosophy but also identifying precise supporting effects associated with specific elements within their *** paper aims to provide a new reading of Maggie’s contribution to cancer support by offering an examination of all these data through the lens of biophilia,which clarifies the impact of design decisions connected to nature on cancer patients’*** analytic process included a systematic search strategy,extraction and classification of salient concepts using an opencoding approach,and lastly an interpretive *** systematically selected data helped to identify and rank the biophilic design parameters that appear the most critical for promoting and supporting human health and wellbeing in non-clinical therapeutic environments,from the user’s *** also provided a compilation of distinctive design interventions related to biophilic parameters,which provides benchmark information for future research and design guidance in these environments.

关键词： Biophilic design Therapeutic environment Maggie’s Centres Meta-synthesis

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Initial coin offerings(ICOs):Why do they succeed?

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Financial Innovation 2022年第1期8卷 233-267页

作者： JoséCampino Ana Brochado Álvaro rosa Instituto Universitário de Lisboa(ISCTE-IUL) Business Research Unit(BRU-IUL)LisbonPortugal Instituto Universitário de Lisboa(ISCTE-IUL) DINÂMIA’CETLisbonPortugal

Recent literature has addressed initial coin offering(ICO)projects,which are an innovative form of venture financing through cryptocurrencies using blockchain *** features of ICOs remain unexplored,leaving much room for additional research,including the success factors of ICO *** investigate the success of ICO projects,with our main purpose being to identify factors that influence a project’s *** a literature review,from which several potential variables were collected,we used a database comprising 428 ICO projects in the banking/financial sector to regress several econometric *** confirmed the impacts of several variables and obtained particularly valuable results concerning project and campaign *** confirmed the importance of a well-structured and informative *** proximity to certain markets with high availability of financial and human capital is also an important determinant of the success of an *** also confirm the strong dependency on cryptocurrency and the impact of cryptocurrency valuations on the success of a ***,we confirm the importance of social media in ICO projects,as well as the importance of human capital *** research contributes to the ICO literature by capturing most of the success factors previously identified and testing their impacts based on a large *** current research contributes to the building of systems theory and signaling theory by adapting their frameworks to the ICO *** results are also important for regulators,as ICOs are mainly unregulated and have vast future potential,and for investors,who can benefit from our analysis and use it in their due diligence.

关键词： Initial coin offering(ICO) Fintech Bank Financial services Technology Blockchain Innovation Venture capital Crowdfunding Success

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Is Takotsubo cardiomyopathy still looking for its own nosological identity?

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World Journal of Cardiology 2022年第10期14卷 557-560页

作者： Riccardo Scagliola Gian Marco rosa Cardiovascular Disease Unit IRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

Despite several efforts to provide a proper nosological framework for Takotsubo cardiomyopathy(TCM),this remains an unresolved matter in clinical *** clinical,pathophysiologic and histologic findings support the conceivable hypothesis that TCM could be defined as a unique pathologic entity,rather than a distinct subset of myocardial infarction with non-obstructive coronary *** investigations are needed in order to define TCM with the most appropriate disease taxonomy.

关键词： Takotsubo cardiomyopathy Myocardial infarction with non-obstructive coronary arteries Disease classification

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Large-Scale Group Decision Making:A Systematic Review and a Critical Analysis

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 949-966页

作者： Diego García-Zamora Alvaro Labella Weiping Ding rosa M.Rodríguez Luis Martínez Department of Computer Science University of JaénJaén 23071Spain IEEE School of Information Science and Technology Nantong UniversityNantong 226019China

The society in the digital transformation era demands new decision schemes such as e-democracy or based on social *** novel decision schemes require the participation of many experts/decision makers/stakeholders in the decision *** a result,large-scale group decision making(LSGDM)has attracted the attention of many researchers in the last decade and many studies have been conducted in order to face the challenges associated with the ***,this paper aims at reviewing the most relevant studies about LSGDM,identifying the most profitable research trends and analyzing them from a critical point of *** do so,the Web of Science database has been consulted by using different *** these results a total of 241 contributions were found and a selection process regarding language,type of contribution and actual relation with the studied topic was then carried *** 87 contributions finally selected for this review have been analyzed from four points of view that have been highly remarked in the topic,such as the preference structure in which decision-makers’opinions are modeled,the group decision rules used to define the decision making process,the techniques applied to verify the quality of these models and their applications to real world problems ***,a critical analysis of the main limitations of the existing proposals is ***,taking into account these limitations,new research lines for LSGDM are proposed and the main challenges are stressed out.

关键词： Challenges large-scale consensus models large-scale group decision making(LSGDM) systematic review

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Status quo of implementation of advance care planning: a review

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Frontiers of Nursing 2022年第2期9卷 123-133页

作者： Min Liu Ronnell D.Dela rosa School of Nursing Philippine Women’s UniversityMalateManila1004 Metro ManilaPhilippines Department of Nursing The First People’s Hospital of YanchengYanchengJiangsu 224000China College of Nursing and Midwifery Bataan Peninsula State UniversityBalangaBataan 2100Philippines

Optimum care for patients with a terminal illness is dependent on understanding their values,beliefs,and preferences on end-of-life issues and providing service that meets their *** the only way to explore patients’living wills,advance care planning(ACP)is an important means to honor patient autonomy and respect their human rights and *** has been recognized as a key indicator for quality palliative care and endorsed into national health systems by many high-income countries;however,it is little known in China's *** is now facing a growing aging and terminally ill population with many unmet needs for end-of-life care;therefore,it is imperative to implement ACP in *** this review,we clarify the relevant concept and suitable population for ACP,describe the current situation of implementation in high-income countries,and provide better suggestions for the future development of ACP in the mainland of China.

关键词： Advance care planning Advance directives China End-of-life care Palliative care

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Materials for the study of the locus operandi in the search for missing persons in Italy

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Forensic Sciences Research 2022年第3期7卷 371-377页

作者： Pier Matteo Barone rosa Maria Di Maggio Silvia Mesturini Archaeology and Classics Program American University of RomeRomeItaly Geoscienze Forensi ItaliaVR-Forensic Geoscience RomeItaly Comitato Scientifico Ricerca Scomparsi RomeItaly Studio Legale e Criminologico Mesturini LivornoItaly

Geographic profiling,or locus operandi,is a scientific approach that has been applied to forensic investigations for several ***,it has never been applied to a phenomenon as complex as the search for missing *** article presents three Italian case studies in which geographic profiling was used to narrow the areas to search for missing *** geographical data were mapped and processed on a geographic information system platform using computational geometry ***,these disappearances occurred during the Italian lockdown period,imposed to address the COVID-19 outbreak,which made the searches slower and more complex than usual.

关键词： Forensic sciences geographic profiling locus operandi geographic information systems missing persons

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Rifaximin,but not growth factor 1,reduces brain edema in cirrhotic rats

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World Journal of Gastroenterology 2012年第17期18卷 2084-2091页

作者： Gemmaòdena Mireia Miquel anna Serafín Amparo Galan rosa Morillas Ramon Planas Ramon Bartolí Hepatology Unit Department of GastroenterologyGermans Trias i Pujol Health Science Research Institute08916 BadalonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) 08036 BarcelonaSpain Department of Gastroenterology CorporacióSanitària Parc Taulí08208 SabadellSpain Platform of Laboratory Animal Applied Research Parc Científic de Barcelona08028 BarcelonaSpain Department of Biochemistry Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Liver Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol08916 BadalonaSpain

AIM:To compare rifaximin and insulin-like growth factor(IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal ***:Rats with CCl4-induced cirrhosis with ascites plus portal vein occlusion and controls were randomized into six groups:Cirrhosis;Cirrhosis + IGF-1;Cirrhosis + rifaximin;Controls;Controls + IGF-1;and Controls + *** oral glutamine-challenge test was performed,and plasma and cerebral ammonia,glucose,bilirubin,transaminases,endotoxemia,brain water content and ileocecal cultures were measured and liver histology was ***:Rifaximin treatment significantly reduced bacterial overgrowth and endotoxemia compared with cirrhosis groups,and improved some liver function parameters(bilirubin,alanine aminotransferase and aspartate aminotransferase).These effects were associated with a significant reduction in cerebral water *** and cerebral ammonia levels,and area-underthe-curve values for oral glutamine-challenge tests were similar in rifaximin-treated cirrhotic rats and control group *** contrast,IGF-1 administration failed to improve most alterations observed in ***:By reducing gut bacterial overgrowth,only rifaximin was capable of normalizing plasma and brain ammonia and thereby abolishing low-grade brain edema,alterations associated with hepatic encephalopathy.

关键词：生长因子1 肝硬化脑水肿大鼠 IGF-1 胰岛素样生长因子内毒素血症谷氨酰胺

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