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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI Maria DI rosa Luca PANDOLFI Michele MARRONI Dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** D1 phase was testified by rare isoclinal *** D2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** D3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the D1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** D2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

Visions of the 21st Century City:Nature Integrated into Urban Design

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China Today 2024年第7期73卷 35-37页

作者： rosa CERVERA Catedra China a Spanish association

In this era of urban expansion and rapid growth of densely populated cities,it is crucial to ask ourselves how urban models may be improved,so as to create cities that both fulfill their essential functions and enhanc... 详细信息

关键词： Urban urban emotional

Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review

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World Journal of Diabetes 2024年第5期15卷 1001-1010页

作者： Douglas Nitzke Juliana Czermainski Carolina rosa Chaline Coghetto Sabrina Alves Fernandes Randhall B Carteri Department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACKGROUND Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of *** etiology is closely tied to imbalanced dietary practices and sedentary ***,increasing die-tary fiber(DF)intake has consistently demonstrated health benefits in numerous studies,including improvements in glycemic control and weight *** To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus(T2DM).METHODS A systematic literature review was conducted to explore the association between DF intake and the management of *** the inclusion and exclusion criteria,a total of 26 studies were included in this *** The main strategies implied to increased DF intake were:High DF diet plus acarbose(2 studies);DF supplements(14 studies);and high DF diets(10 studies).Overall,most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM *** DF represents a valuable strategy in the treatment of type 2 diabetes,improving health *** intake offers the potential to improve quality of life and reduce complications and mortality associated with ***,through supplements or enriched foods,DF contributes significantly to the control of several markers such as HbA1c,blood glucose,triglycerides,low-density lipoprotein,and body weight.

关键词： Type 2 diabetes mellitus Soluble fibers Insoluble fibers Probiotics Blood glucose Nutrition

Tb^(3+)-nucleic acid probe-based label-free and rapid detection of mercury pollution in food

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Food Science and Human Wellness 2024年第2期13卷 993-998页

作者： Xuhan Xia Chenxi Zhou Yulin Zhu Yi Dong Qiang He Mohammad Rizwan Khan Yuanlong Chi rosa Busquets Ruijie Deng Yao Ren College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610065China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia School of Life Sciences Pharmacy and ChemistryKingston University LondonKingston Upon Thames KT12EEUK

Mercury is a threatening pollutant in food,herein,we developed a Tb^(3+)-nucleic acid probe-based label-free assay for mix-and-read,rapid detection of mercury *** assay utilized the feature of light-up fluorescence of terbium ions(Tb^(3+))via binding with single-strand *** ion,Hg^(2+)induced thymine(T)-rich DNA strand to form a double-strand structure(T-Hg^(2+)-T),thus leading to fluorescence *** on the principle,Hg^(2+)can be quantified based on the fluorescence of Tb^(3+),the limit of detection was 0.0689μmol/L and the linear range was 0.1-6.0μmol/*** to the specificity of T-Hg^(2+)-T artificial base pair,the assay could distinguish Hg^(2+)from other metal *** recovery rate was ranged in 98.71%-101.34%for detecting mercury pollution in three food *** assay is low-cost,separation-free and mix-to-read,thus was a competitive tool for detection of mercury pollution to ensure food safety.

关键词： Mercury pollution Food safety Nucleic acid probe Label-free Terbium

Hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

Chronic Ankle Instability: Therapeutic Exercise and Data Analysis

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Open Journal of Orthopedics 2024年第5期14卷 201-217页

作者： rosa Grazia Bellomo Giulia Barletta Mirco Brunetti Claudia Barbato Department of Biomolecular Sciences University of Study of Urbino Carlo Bo Urbino Italy

Background and Objectives: Ankle injuries are the most common type of injury in healthy active individuals. If not treated properly, recurrent sprains can lead to a condition of chronic ankle instability (CAI). The present paper examines some subjects with a previous history of acute inversion ankle sprain who have developed a subsequent condition of instability, grouping them according to inclusion criteria and analyzing them through four field tests considered objective by the scientific literature: SEBT test, BEES test, TIBT test, SHT test. The data obtained were stored in order to compare them following a re-education protocol aimed at improving proprioception, balance, walking and strengthening the extrinsic and intrinsic muscles of the foot. per year. The subjects were then divided into two categories: subjects with CAI > 1 year and subjects with CAI ≤ 1 year. A protocol lasting 6 weeks was administered to both groups, trying to work on improving balance in single stance, improving static and dynamic stability, strengthening the gluteus medius and maximus (pelvis stabilizers) and strengthening of the intrinsic muscles of the foot. At the end of the protocol the subjects were all re-evaluated with the same field tests used previously and the data obtained were compared both with the pre-protocol data and with the data measured by the control subjects.

关键词： Ankle Instability Ankle Sprain Ankle Injuries Exercise

Histopathological impact of SARS-CoV-2 on the liver:Cellular damage and long-term complications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso Rodriguez-Espada Moises Salgado-de la Mora Briana Mariette Rodriguez-Paniagua Nathaly Limonde la rosa Monica Itzel Martinez-Gutierrez Santiago Pastrana-Brandes Nalu Navarro-Alvarez Department of Molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico Department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEM Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),primarily impacts the respiratory tract and can lead to severe outcomes such as acute respiratory distress syndrome,multiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its impact on the hepatobiliary system remains *** liver injury is commonly indicated by reduced albumin and elevated bilirubin and transaminase levels,the exact source of this damage is not fully *** mechanisms for injury include direct cytotoxicity,collateral damage from inflammation,drug-induced liver injury,and ischemia/***,evidence often relies on blood tests with liver enzyme *** this comprehensive review,we focused solely on the different histopathological manifestations of liver injury in COVID-19 patients,drawing from liver biopsies,complete autopsies,and in vitro liver *** present evidence of the direct impact of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry mechanisms and the actual presence of viral particles in liver samples resulting in a variety of cellular changes,including mitochondrial swelling,endoplasmic reticulum dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encompassing necrosis,steatosis,cholestasis,and lobular *** also discuss the emergence of long-term complications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for improving patient recovery and guiding decision-making.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzyme 2 Histopathology Liver biopsies Liver autopsy In vitro

Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

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Neural Regeneration Research 2023年第8期18卷 1691-1696页

作者： Paula M.Calvo Rosendo G.hernández rosa R.de la Cruz Angel M.Pastor Departamento de Fisiología Facultad de BiologíaUniversidad de SevillaSevillaSpain

Vascular endothelial growth factor(VEGF)was discovered by its angiogenic ***,during evolution,it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates lacking a circulatory *** aimed at reviewing recent evidence indicating that VEGF has neuroprotective effects in neurons exposed to a variety of *** particular interest is the link established between VEGF and motoneurons,especially after the design of the VEGFδ/δmutant *** mice are characterized by low levels of VEGF and develop muscle weakness and motoneuron degeneration resembling amyotrophic lateral *** administration of VEGF through several routes to animal models of amyotrophic lateral sclerosis delays motor impairment and motoneuron degeneration and increases life *** are new recent advances in the role of VEGF in the physiology of *** experimental aims use the extraocular(abducens)motoneurons lesioned by axotomy as a model for studying VEGF *** abducens motoneurons exhibit severe alterations in their discharge activity and a loss of synaptic *** exogenous administration of VEGF to axotomized abducens motoneurons,either from the transected nerve or intraventricularly,fully restores the synaptic and discharge properties of abducens motoneurons,despite being *** addition,when an anti-VEGF neutralizing antibody is delivered from the muscle to intact,uninjured abducens motoneurons,these cells display alterations in their discharge pattern and a loss of synaptic boutons that resemble the state of *** these data indicate that VEGF is an essential neurotrophic factor for motoneurons.

关键词： abducens nucleus amyotrophic lateral sclerosis cell death extracellular single-unit recordings eye movements neurodegeneration oculomotor trophic factors

Efficacy of 1% Permethrin and 2% Permethrin Combined with 1% Piperonyl Butoxide against Rhipicephalus sanguineus Ticks in Naturally Infested Dogs

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Pharmacology & Pharmacy 2024年第7期15卷 237-247页

作者： Andrea Márquez-Aguado Froylán Ibarra-Velarde Joaquín Ambia-Medina rosa Arias-García Departamento de Parasitologa Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autnoma de Mxico Mexico City Mxico Laboratorios Salud Animal S.A de C.V. Mexico City Mxico

The aim of the present study was to compare the ixodicide efficacy of 1% permethrin applied as a shampoo-bath in single treatment and a combined formulation of 2% permethrin + 1% piperonyl butoxide applied as powder in a single treatment against Rhipicephalus sanguineus ticks, in naturally infested dogs. Eighteen adult cross-mixed dogs, harboring to at least 20 ticks/animal, were selected on pre-treatment live tick counts. On day 0, the dogs were then divided in 3 groups of 6 animals each, for treatment: Group 1 (G1) received 1% permethrin applied as shampoo-bath (approximately 10 ml/kg bw), according to label instructions. G2 was treated with 2% permethrin + 1% piperonyl butoxide applied as powder, and rubbed as massage on the body, as recommended by the producer. G3 served as a non-treated control. After the treatment, the dogs were checked out for live ticks counting on days 0, 1, 7, and 14. The ixodicide efficacy was assessed based on the percentage reductions of ticks on the days analyzed post-treatment, with respect to the untreated control. Results showed that permethrin alone removed ticks on 81%, 93.1% and 89.6% for days 1, 7 and 14, respectively. The combined formulation of 2% permethrin + 1% piperonyl butoxide exerted a better efficacy of 98.8, 97.7 and 97.0%, respectively. It is concluded that this combined formulation was highly effective at rapidly repelling and killing Riphicephalus sanguineus ticks on naturally infected dogs, showing a significant effect on days 1, 7 and 14 after tick exposure. The sustained high and quick level of efficacy of this combination may well interfere with the transmission of Riphicephalus sanguineus ticks. It is concluded that the sustained high level of efficacy of the permethrin + piperonyl butoxide combination may well exert an additive effect and could interfere with the transmission of Riphicephalus sanguineus ticks.

关键词： Efficacy Permethrin Permethrin + Piperonyl Butoxide Riphicephalus sanguineus Dogs

元话语在数字化学科研究交流中的再语境化作用:以心理学文摘为例

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Chinese Journal of Applied Linguistics 2024年第2期47卷 178-195,364页

作者：罗莎·洛雷斯萨拉戈萨大学西班牙

元话语(metadiscourse)最初被视作探究学术性、单一书面文本的专属工具。但随着数字话语研究的深入,元话语似乎演变为一个颇具挑战性的探索框架。首先,网络环境下的作者与读者互动变得隐晦难辨,这为元话语的研究带来了一定的困扰;其次,... 详细信息

元话语(metadiscourse)最初被视作探究学术性、单一书面文本的专属工具。但随着数字话语研究的深入,元话语似乎演变为一个颇具挑战性的探索框架。首先,网络环境下的作者与读者互动变得隐晦难辨,这为元话语的研究带来了一定的困扰;其次,数字文本的多模态特性进一步增加了元话语研究的复杂性。本研究旨在深入剖析交互式元语言资源在在线交流环境中所扮演的关键角色。因此,该研究聚焦于英国心理学会官方网站上发布的数字研究文摘语料库,该网站是英国心理学界最具权威性和代表性的机构之一。本研究专注于互动元话语的功能性探讨,视其为一种重构语境的重要工具,以助力非专业读者更好地理解复杂学科知识。经过深入研究,该研究确定了几类关键的互动资源,包括代码词汇、证据、过渡标记以及框架标记。这些资源通过战略性的运用,有效地促进了专业信息的传递和中介作用,同时充分利用了数字平台所赋予的各项能力。

关键词：互动元话语在线研究文摘专家学科知识再语境化