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Psychophysics in the ophthalmological practice—*** acuity

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Annals of Eye Science 2022年第4期7卷 50-64页

作者： Carlo Aleci Claudio rosa Department of Ophthalmology University of TurinMolinette HospitalTurinItaly

Perception is the ability to see,hear,or become aware of external stimuli through the *** stimuli are electromagnetic waves that interact with the eye and elicit a ***,indeed,imply the detection,resolution,and recognition of objects and images,and their accuracy depends on the integrity of the visual *** clinical practice,evaluating the integrity of the visual system relies greatly on the assessment of visual acuity,that is to say on the capacity to identify a *** acuity,indeed,is of utmost importance for diagnosing and monitoring ophthalmological *** acuity is a function that detects the presence of a stimulation(a signal)and resolves its detail(s).This is the case of a symbol like“E”:the stimulus is detected,then it is resolved as three horizontal bars and a vertical *** fact,within the clinical setting visual acuity is usually measured with alphanumeric symbols and is a three-step process that involves not only detection and resolution,but,due to the semantic content of letters and numbers,their *** with subjective(psychophysical)procedures,objective methods that do not require the active participation of the observer have been proposed to estimate visual acuity in non-collaborating subjects,malingerers,or *** paper aims to explain the psychophysical rationale underlying the measurement of visual acuity and revise the most common procedures used for its assessment.

关键词： Visual acuity(VA) Landolt ETDRS preferential looking Oktotype

Effect of low level laser therapy on dental pulp during orthodontic movement

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World Journal of Methodology 2013年第2期3卷 19-26页

作者： ngela Domínguez rosa Emilia Ballesteros Jairo hernán Viáfara Oscar Mario Tamayo Department of Orthodontics Faculty of DentistryUniversidad del ValleCali 76001000Colombia Histology and Anatomy Medicine DepartmentUniversidad Santiago de CaliCali 76001000Colombia

AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's ***: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics.

关键词： Low level laser therapy Pulpal Orthodontic movement Histological protocol Dentin

Variables of Suicidal Behavior in Tenerife Years 2011-2012: Proposals for the Prevention

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Forensic Medicine and Anatomy Research 2014年第2期2卷 37-41页

作者： Sergio Manuel Martínez Aguilar Milagros De la rosa Hormiga Juan Manuel Herrera hernández Francisco Rodríguez Pulido Candelaria de la Merced Díaz-González Forensic Department Tenerife Spain Servicio Canario de la Salud Tenerife Spain Universidad de La Laguna Tenerife Spain

Suicide is treated by society as a taboo subject despite it being the leading cause of unnatural death in Spain. The Tenerife Province is ranked 16th among the 52 Spanish provinces for its suicide rate. From 2007 till 2010, the rate increased from 2007 to 2008, then dropped in 2010. Slight rise occurred in suicide rates in 2010. This rate increased from 2007 to 2008, with a decrease of rate in 2010. Slight rise occurred in suicide rates in 2010. In 2013 the province saw 75 suicides per year. 90% - 98% of suicides are closely related to mental disease with the remaining 10% associated with different poor causes of the subject, according to bibliography. In this retrospective study, it has been found that the highest risk rests with men over 40 years of age in the central and southern part of the island. Among the forms of suicide reported, the most common is hanging followed by jumping from a height. It’s important to understand the reasons behind suicidal behavior from a psychosocial perspective, taking into account “unsafe” indicators and individual profiles. The lethal nature of a suicide attempt also depends on the form of suicide adopted and the possibility of a rescue. Specific protocols to prevent suicide should be promoted and discussed between health and social services.

关键词： Consummated Suicide Autopsy Violent Death Autopsy Psychosocial

Bipartite liver: an incidental rare anomaly of the liver

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 649-650页

作者： Michele De rosa Graziano Ceccarelli Department of General Surgery “San Giovanni Battista”HospitalFolignoPerugiaItaly

Bipartite liver is a rare congenital anomaly without phylogenetic significance,which needs to be known for the potential risk of torsion or internal gastrointestinal herniation and also in the pre-operative planning o... 详细信息

关键词： liver operative rare

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

Positive frequency of autoantibodies in multiple sclerosis patients Are they associated with therapy?

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Neural Regeneration Research 2010年第4期5卷 257-260页

作者： Gerardo Iuliano Luigi Cinquanta Anna Maria Ferruzzi rosa Napoletano Azienda Ospedaliera Ospedali Riuniti di SalernoU.O.NeurologiaCentro Provinciale Sclerosi Multipla Azienda Ospedaliera Ospedali Riuniti di SalernoU.O.Laboratorio Patologia Clinica Azienda Ospedaliera Ospedali Riuniti di Salerno

BACKGROUND： Humoral autoimmunity in patients with multiple sclerosis is often asymptomatic and transient during interferon therapy. OBJECTIVE： To analyze the frequency of positivity to autoantibodies in multiple sclerosis patients and to clarify whether it is modified by immunomodulating therapy. DESIGN： A retrospective *** AND SE＇rrlNG： The study was performed at the Multiple Sclerosis Center, Department of Neurosciences, Salerno Hospital, Italy, between 2005 and 2007. PARTICIPANTS： A total of 169 multiple sclerosis patients were included, 57 males and 112 females Individuals were mainly outpatients and were usually tested yearly for autoantibodies. Patients with previous immunological diseases were excluded from statistical evaluation. METHODS： The frequency of positivity was calculated in patients grouped for gender, multiple sclerosis clinical parameters, magnetic resonance imaging features and disease modifying therapy. A total of 113 patients were treated with beta interferons. MAIN OUTCOME MEASURES： Frequency of positivity to any autoantibody. Prevalences and incidences were ***： The overall prevalence of autoantibodies within 3 years was 47.3%. In multiple sclerosis patients who were untreated or treated with drugs other than interferons, the prevalence was higher, and greater positivity to autoantibodies was seen in patients treated with interferons [odds ratio （95% confidence interval）, 2.87 （1.5 - 5.2）, P 〈 0.05 - 0.01]. Multiple regression analysis showed a significant association of the positivity to autoantibodies with interferon therapy, rather than gender, relapse or magnetic resonance imaging. CONCLUSION： Interferon therapy is associated with significantly higher frequency of autoantibodies in patients with multiple sclerosis. The differences among the therapies are not influenced by other variables such as gender or clinical pattern.

关键词： multiple sclerosis autoimmunity autoantibodies immunomodulation interferon

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Ocular ultrasound evaluation of optic nerve sheath diameter in military environments

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Military Medical Research 2019年第3期6卷 272-274页

作者： Maddalena De Bernardo Livio Vitiello Palmiro Cornetta Nicola rosa Department of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno

In this letter to the Editor, we would like to comment on the article by Betcher et al., concerning the possibility of teaching military trainees to obtain accurate optic nerve sheath diameter measurements, using a brief didactic and a hands-on training session. In particular, this letter notes the importance of the measurement of optic nerve sheath diameter in detecting the eventual elevated intracranial pressure following traumatic brain injury, highlights several limitations in the use of B-scan for such a purpose and suggests a more accurate evaluation with the standardized A-scan.

关键词： Blooming effect Intracranial pressure Optic nerve sheath diameter

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Francis Dov Por(1927–2014):A life dedicated to zoology remembered

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Integrative Zoology 2015年第2期10卷 230-231页

作者： rosa-Maria POLYMENI John BUCKERIDGE Michael SCHMITT Zhibin ZHANG University of Athens Greece RMIT University MelbourneVictoriaAustralia University of Greifswald Germany Institute of Zoology Chinese Academy of SciencesChina

On 25 October 2014,the International Society of Zoological Sciences(ISZS)family lost one of its most eminent members,Professor Francis Dov Por,who passed away at the age of *** was born on 25 May 1927,in Timișoara,a city that is now the capital city of Timis County and is considered the informal capital city of the historical region of Banat,*** obtained a Diploma in Biology in 1956 from the University of *** of his potential as a biologist was demonstrated through his early appointment as a Curator for the Grigore Antipa Museum of Natural History in Bucharest.

关键词： remember capital Fra

Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae

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Journal of Systematics and Evolution 2011年第1期49卷 25-49页

作者： Frdric M.B. JACQUES rosa Del C. ORTIZ Department of Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Missouri Botanical Garden St. Louis MO 63166-0299 USA

The phylogeny of extant Menispermaceae (Ranunculales) is reconstructed based on DNA sequences of two chloroplast genes (rbcL and atpB) from 94 species belonging to 56 genera. Fossilized endocarps represent 34 genera. The positions of these are inferred using 30 morphological characters and the molecular phylogeny as a backbone constraint. Nine of the thirteen nodes that are each dated by a fossil are used as calibration points for the estimates of molecular divergence times. BEAST is used to estimate stem age (121.2 Myr) and crown age (105.4 Myr) for Menispermaceae. This method does not require an input tree topology and can also account for rate heterogeneity among lineages. The sensitivity of these estimates to fossil constraints is then evaluated by a cross-validation procedure. The estimated origin for Menispermaceae is dated to the mid-Jurassic if the customary maximum age of 125 Myr for eudicots is not implemented. All constraints when used alone failed to estimate node ages in some parts of the tree. Fossils from the Palaeocene and Eocene impose strict constraints. Likewise, the use of Prototinomiscium as a dating constraint for Menispermaceae appears to be a conservative approach.

关键词： age calibration cross-validation fossil Menispermaceae molecular scaffold phylogeny.