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Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

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Food Science and Human Wellness 2024年第1期13卷 225-240页

作者： Linzi Li Xueying Lei Lin Chen ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng College of Food Science and Engineering Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Synergetic Innovation Center of Food Safety and Nutrition Key Laboratory of Meat Processing and Quality ControlMinistry of EducationCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological *** exposure to acrylamide(AA)can cause liver injury and endanger human ***,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not ***,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in *** vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated *** vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ros)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced ***,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant *** conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.

关键词： Quercetin compounds Acrylamide Protection mechanism Oxidative stress Antioxidant activity

MoS2 as a cocatalyst applied in advanced oxidation processes for enhancing degradation of organic pollutants: a review

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Tungsten 2024年第3期6卷 473-487页

作者： Ming-Hao Fan Cong-Hui Wang Xiang Yu Jun Ding Ao-Qi Xiao Yue Li Wei-ya Huang School of Material Science and Engineering Henan Polytechnic University School of Chemical and Printing-Dyeing Engineering Henan International Joint Laboratory of Rare Earth Composite Materials Henan University of Engineering School of Chemistry and Chemical Engineering Jiangxi University of Science and Technology Department of Chemical and Environmental Engineering University of Cincinnati

Fenton technology,as a typical advanced oxidation processes（AOPs）,can generate reactive oxygen species（ros） of strong oxidation capacity to degrade organic pollutants,which has attracted wide ***,it is accompanied by the slow Fe3+/Fe2+cycle rate,easy to generate iron sludge and so ***,it has been proven that the inorganic cocatalysts represented by MoS2can effectively solve the above ***,MoS2can accelerate the activation of peroxy mono sulfate（PMS） and peroxodisulfate（PDS） by Fe2+.In this paper,MoS2as the cocatalyst in H2O2+Fe2+,PMS+Fe2+and PDS+Fe2+were comprehensively ***,the cycling processes of Fe3+/Fe2+in different systems,the cocatalytic effect of MoS2by the exposed active sites,the ros generation mechanism as well as the microscopic mechanism during the reaction were elaborated *** results indicate that the reductive active sites on the surface of MoS2can promote the regeneration of Fe2+through the cycle between Fe3+/Fe2+and Mo4+/Mo5+/Mo6+.Thus,ros such as ·OH,SO4·-and1O2with strong oxidizing property can be produced to improve the degradation efficiency of organic *** last,the challenges and developments of MoS2cocatalysts in AOPs for practical applications were *** review contributes to a deeper understanding of the cocatalytic effect of two-dimensional metal sulfides in AOPs and facilitates their industrial application.

关键词： Cocatalyst Fenton reaction Degradation of organic pollutant Molybdenum disufide Reactive oxygen species

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H:quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第1期22卷 75-88页

作者： SONG Jiangzhou ZOU Guiqing ZHAO Zhou ZHU ya XUE Jiayu AO Lanjia SUN Huiyong HAO Haiping ZHANG Bo XU Xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer ***1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ros)*** ros generation results in extensive DNA damage and elevated poly(ADP-ribose)polymerase 1(PARP1)-mediated consumption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately causing cell *** phosphoribosyltransferase(NamPT),the rate-limiting enzyme in the NAD^(+)salvage synthesis pathway,emerges as a critical target in cancer *** concurrent inhibition of NQO1 and NamPT triggers hyperactivation of PARP1 and intensive NAD+*** this study,we designed,synthesized,and assessed a novel series of proqodine A derivatives targeting both NQO1 and *** these,compound T8 demonstrated potent antitumor ***,T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and *** discovery offers a promising new molecular entity for advancing anticancer research.

关键词： NQO1 ros NamPT NAD^(+) T8

Guicao Baidu decoction in mitigating chemotherapy-induced myocardial injury:case report and mechanism investigation

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Natural Therapy Advances 2024年第3期7卷 29-36页

作者： Jia-Qi Fu Run-Jie Sun Man-ya Yu Mu-Yun Wu Xing Cui The First School of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250014China Center of Oncology and Hematology The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001China

To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the *** present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following *** network pharmacology was employed to predict the targets of ***,a DOX-induced apoptosis model of H9C2 cardiomyocytes was established and co-cultured with serum containing GCBD *** viability and myocardial enzyme levels were evaluated using CCK8 assay and ELISA assay,TUNEL was using for apoptosis *** GCBD effect was confirmed by tests of ros andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with ***,the expression levels of apoptosis-related molecules were determined via Western ***,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with *** enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through HE staining while related proteins were detected using *** pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related ***,we demonstrated the effective amelioration of DIC in cardiomyocyte viability,LDH/CK levels,α-actinin and ros levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and *** efficacy of GCBD in enhancing cardiac function in DIC mice has been validated through animal *** together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial *** utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.

关键词： Guicao Baidu decoction chemotherapy-induced myocardial injury case report angiogenesis

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating camP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou Xinhui Huang Chunmei Zhang Yongjie Ma Jinqiu Hu Xiaoyan Bi Junyu Ma Mengyao Li Dong Lu Liang Hu Jiahua Fan Fuli ya Department of Nutrition， School of Public Health， Dali University Department of Laboratory Teaching Center， School of Public Health， Dali University Department of Health Management， Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine School of Integrative Medicine， Shanghai University of Traditional Chinese Medicine School of Public Health， Sun yat-sen University Institute of Translational Medicine for Metabolic Diseases， Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of camP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ros). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the camP/PKA/NOX2 signaling. Thus， through modulating the camP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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脂质体共递送槲皮素与多柔比星通过调控上皮间质转化过程抑制视网膜母细胞瘤的研究

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中国中药杂志 2024年第13期49卷 3515-3525页

作者：林敏刘秀梅冯年平吕雅琪上海中医药大学中药学院上海201203

调控上皮-间质转化(epithelial-mesenchymal transition,EMT)过程是抑制肿瘤生长和转移的重要策略。该研究基于视网膜母细胞瘤的EMT过程,构建同时负载槲皮素(quercetin,QUE)与多柔比星(doxorubicin,DOX)的脂质体,用于研究QUE与DOX联用... 详细信息

调控上皮-间质转化(epithelial-mesenchymal transition,EMT)过程是抑制肿瘤生长和转移的重要策略。该研究基于视网膜母细胞瘤的EMT过程,构建同时负载槲皮素(quercetin,QUE)与多柔比星(doxorubicin,DOX)的脂质体,用于研究QUE与DOX联用对视网膜母细胞瘤的治疗作用及其机制。通过单因素考察对槲皮素与多柔比星双载脂质体(QD Lipo)进行处方工艺优化,最终得到球形,粒径(108.87±1.93)nm,PDI 0.13±0.02,Zeta电位(-34.83±1.92)mV的双载脂质体,其中QUE、DOX包封率分别为96.20%±4.40%、91.17%±4.41%。以人视网膜母细胞瘤Y79作为体外细胞模型,采用共聚焦显微镜证明QD Lipo能提高Y79对其摄取效率。采用CCK-8法证明QUE∶DOX在1∶1~1∶2时具有最佳联合治疗作用。流式细胞技术证明QD Lipo增强了诱导Y79细胞凋亡的能力。通过Western blot技术发现QD Lipo能显著降低EMT通路相关蛋白vimentin和α-SMA的表达,并且荧光法检测到治疗后的Y79细胞内ros水平显著降低。以上结果显示,脂质体共递送QUE与DOX可提高药物向视网膜母细胞瘤的输送效率,通过下调ros水平抑制视网膜母细胞瘤的EMT过程,同时增强DOX对视网膜母细胞瘤的杀伤作用。

关键词：视网膜母细胞瘤脂质体上皮间质转化槲皮素联合治疗

MYB转录因子在调控植物响应逆境胁迫中的作用

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生物技术通报 2024年第6期40卷 5-22页

作者：胡雅丹伍国强刘晨魏明兰州理工大学生命科学与工程学院兰州730050 甘肃烟草工业有限责任公司技术研发中心兰州730050

MYB作为植物中最大的多功能转录因子(transcription factors,TFs)家族之一,在基因转录水平上广泛地参与调控植物生长发育、激素信号转导及逆境胁迫应答等过程。该类转录因子N端含有典型的MYB结构域,根据MYB结构域中R重复序列的数量分为... 详细信息

MYB作为植物中最大的多功能转录因子(transcription factors,TFs)家族之一,在基因转录水平上广泛地参与调控植物生长发育、激素信号转导及逆境胁迫应答等过程。该类转录因子N端含有典型的MYB结构域,根据MYB结构域中R重复序列的数量分为不同的亚组;而C端结构域差异较大,因此功能上具有多样性。大量研究表明,在受到外界环境信号的激活后,MYB可单独或通过和其他蛋白互作后,与下游靶基因启动子区域的顺式作用元件MYBCORE和AC-box结合,参与调控下游胁迫应答相关基因的表达,从而调节植物对逆境胁迫的耐受性。另外,MYB也通过参与脱落酸(abscisic acid,ABA)、油菜素内酯(brassinolide,BR)、茉莉酸(jasmonic acid,JA)和活性氧(reactive oxygen species,ros)等信号通路的方式,对非生物胁迫以及生物胁迫做出应答反应。论文对植物MYB家族的结构与分类及其作用方式进行了归纳,重点对植物MYB参与调控响应盐、干旱、极端温度、营养亏缺、重金属以及病原菌等非生物和生物逆境胁迫的作用机制进行了综述,并对未来重点研究方向提出了展望,为今后农作物的抗逆性遗传改良和生物育种提供优异基因资源和理论支持。

关键词： MYB转录因子转录调控 DNA结合结构域非生物胁迫生物胁迫抗逆性基因表达蛋白互作

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两混合凸体的相对曲率积分不等式

数学学报（中文版） 2024年第4期67卷 732-742页

作者：董旭王亚玲周玉奇曾春娜重庆师范大学数学科学学院重庆401331

曲率积分不等式在几何不等式中有举足轻重的地位.本文主要利用非对称的Green-Osher不等式,获得了两混合凸体高次幂的相对曲率积分界的估计.这些不等式在Green和Osher工作的基础上去掉了对称性条件,为著名的Green-Osher不等式的改进形式... 详细信息

曲率积分不等式在几何不等式中有举足轻重的地位.本文主要利用非对称的Green-Osher不等式,获得了两混合凸体高次幂的相对曲率积分界的估计.这些不等式在Green和Osher工作的基础上去掉了对称性条件,为著名的Green-Osher不等式的改进形式.特别地,当一个凸体为单位圆时,获得了R^(2)中的ros不等式、曲率熵不等式,提供了曲率熵不等式新的简化证明.

关键词： Gage等周不等式 ros不等式 Green-Osher不等式曲率熵不等式

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凸曲线的曲率积分不等式

数学学报（中文版） 2024年第1期67卷 127-136页

作者：王亚玲董旭曾春娜王星星重庆师范大学数学科学学院重庆401331 上海立信会计金融学院统计与数学学院上海201620

曲率积分不等式在几何不等式中有着举足轻重的地位.本文一方面运用傅里叶分析方法得到了一个关于周期函数的积分不等式,进而获得平面上著名的ros不等式的加强形式.另一方面运用获得的引理,结合Green-Osher不等式与Steiner多项式,得到平... 详细信息

曲率积分不等式在几何不等式中有着举足轻重的地位.本文一方面运用傅里叶分析方法得到了一个关于周期函数的积分不等式,进而获得平面上著名的ros不等式的加强形式.另一方面运用获得的引理,结合Green-Osher不等式与Steiner多项式,得到平面凸曲线的高次幂的曲率积分不等式.这些不等式在欧氏平面上为著名的Green-Osher不等式的改进形式.

关键词：曲率积分不等式 ros不等式 Green-Osher不等式傅里叶级数