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High throughput sequencing unravels tomato-pathogen interactions towards a sustainable plant breeding

Horticulture Research 2021年第1期8卷 2416-2427页

作者： Maria Doroteia Campos Maria do rosario Felix Mariana Patanita Patrick Materatski Carla Varanda MED–Mediterranean Institute for Agriculture Environment and DevelopmentInstituto de Investigacao e Formaçao AvancadaUniversidade de EvoraPolo da MitraAp.947006-554 EvoraPortugal MED–Mediterranean Institute for Agriculture Environment and Development&Departamento de FitotecniaEscola de Ciencias e TecnologiaUniversidade de EvoraPolo da MitraAp.947006-554 EvoraPortugal

Tomato(Solanum lycopersicum)is one of the most economically important vegetables throughout the *** is one of the best studied cultivated dicotyledonous plants,often used as a model system for plant research into classical genetics,cytogenetics,molecular genetics,and molecular *** plants are affected by different pathogens such as viruses,viroids,fungi,oomycetes,bacteria,and nematodes,that reduce yield and affect product *** study of tomato as a plant-pathogen system helps to accelerate the discovery and understanding of the molecular mechanisms underlying disease resistance and offers the opportunity of improving the yield and quality of their edible *** use of functional genomics has contributed to this purpose through both traditional and recently developed techniques,that allow the identification of plant key functional genes in susceptible and resistant responses,and the understanding of the molecular basis of compatible interactions during pathogen ***-generation sequencing technologies(NGS),which produce massive quantities of sequencing data,have greatly accelerated research in biological sciences and offer great opportunities to better understand the molecular networks of plant–pathogen *** this review,we summarize important research that used high-throughput RNA-seq technology to obtain transcriptome changes in tomato plants in response to a wide range of pathogens such as viruses,fungi,bacteria,oomycetes,and *** findings will facilitate genetic engineering efforts to incorporate new sources of resistance in tomato for protection against pathogens and are of major importance for sustainable plant-disease management,namely the ones relying on the plant’s innate immune mechanisms in view of plant breeding.

关键词： breeding sustainable quantities

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When the Silence Speaks: The Smile

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Journal of Biosciences and Medicines 2018年第11期6卷 13-20页

作者： Maria do rosário Dias Letícia Garcia Naben Ana Lúcia Monteiro Ana Ferreira Valter Pedroso Alves Ana Delgado Unidade de Investigaç ã o-Centro de Investigaç ã o Multidisciplinar em Psicologia da Saúde Egas Moniz (CIMPSEM) Egas Moniz-Cooperativa de Ensino Superior Monte de Caparica Portugal

Background: Understanding the importance, value and self-image that the smile represents in the daily life of the individual remains a subject of high scientific interest. Aim: The present qualitative and exploratory study aims at understanding the importance of the self-perception of the mouth and smile on the mental representation of self-image and the well-being of the individual. Materials and Methods: The convenience sample consisted of 151 children and youngsters of both genders, ages 8 - 24 years, who used an orthodontic appliance and were invited to draw two portraits of their mouth/smile. Results: The results suggest differences in the mental representation of the mouth and the smile, namely in the investment of the drawings before and after the use of the orthodontic appliance, as well as in the expressiveness and manifestation of emotions. Discussion and Conclusions: The results suggest that the main reason that leads participants to the treatment is related to aesthetic and functional issues in which the maximizing of the mental representation of the Orthodontic Smile emerges as a new categorization of the perfect smile.

关键词： Mental Representation Orthodontic Smile Aesthetic Smile Drawing Content Analysis

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玉米对高温和干旱胁迫的反应

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国外作物育种 1993年第2期12卷 27-28页

作者： ros.,DAD 李素华

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Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年第6期13卷 3266-3272页

作者： Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Castañer Ramon Estruch Emili ros rosa M.Lamuela-Raventós Departament de Nutrició Ciències de l’Alimentaciói GastronomíaFacultat de FarmaciaUniversitat de Barcelon(UB)Barcelona 08028Spain Institut de Nutriciói Seguretat Alimentària(INSA) Universitat de Barcelona(UB)Santa Coloma de Gramanet 08034Spain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos ⅢMadrid 28029Spain Lipid Clinic Endocrinology and Nutrition ServiceInstitut d'Investigacions Biomèdiques August Pi i SunyerHospital ClínicBarcelona 08036Spain Department of Preventive Medicine and Public Health University of NavarraIdiSNAPamplona 31008Spain Unit of Cardiovascular Risk and Nutrition Institut Hospital del Mar de Investigaciones Médicas(IMIM)Barcelona 08007Spain Department of Internal Medicine Hospital ClinicInstitut d’InvestigacióBiomèdica August Pi i Sunyer(IDIBAPS)University of BarcelonaBarcelona 08007Spain Department of Endocrinology Hospital ClinicIDIBAPSBarcelona 08007Spain

With increasing life expectancy,neurodegenerative diseases have become one of the leading causes of illhealth in the *** strategies include following healthy diets,such as the Mediterranean diet,which is particularly rich in polyphenols,bioactive compounds with neuroprotective *** aim of this study was to assess the association of microbial phenolic metabolites(MPM)with *** cross-sectional analysis was performed with 200 participants of the PREDIMED trial(Barcelona-Clinic recruitment center).A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM(protocatechuic acid,enterodiol glucuronide,enterolactone glucuronide,urolithin B glucuronide,and vanillic acid glucuronide),and cognitive function was evaluated with neuropsychological ***-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM,and a score was calculated as the weighted sum of MPM.A higher MPM score was associated with better frontal lobe *** individual metabolites,vanillic acid glucuronide was correlated with frontal cognitive *** with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2.A higher score for urinary multiMPM was associated with better frontal cognitive performance in an older Mediterranean population.

关键词： Polyphenols Neurodegeneration Microbiota Gut-brain axis PREDIMED

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纪念苏珊·沃西基互联网经济的推动者

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商业周刊（中文版） 2024年第13期 18-20页

作者： Mark Bergen ros Krasny 孟洁冰(译) 不详

沃西基是硅谷最受瞩目的女高管之一,正是她塑造了在互联网上创造财富和名望的方式.谷歌(Google)元老级高管、担任视频平台YouTube首席执行官多年的苏珊·沃西基(Susan Wojcicki)去世,终年56岁,正是她塑造了在互联网上创造财富和名望的... 详细信息

沃西基是硅谷最受瞩目的女高管之一,正是她塑造了在互联网上创造财富和名望的方式.谷歌(Google)元老级高管、担任视频平台YouTube首席执行官多年的苏珊·沃西基(Susan Wojcicki)去世,终年56岁,正是她塑造了在互联网上创造财富和名望的方式。

关键词：首席执行官互联网元老级视频平台高管创造财富

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爱尔兰都柏林大运河广场剧院

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中国建筑装饰装修 2011年第3期 82-89页

作者：丹尼尔.里伯斯金 ros Kavanagh Jarek Matla

主持建筑师：丹尼尔里伯斯金地点：爱尔兰达克兰建筑面积：733．

关键词：爱尔兰都柏林剧院广场建筑面积建筑师

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原发性胆汁性肝硬化时骨质疏松的主要危险因素是胆汁郁积的严重程度和组织分期,而非绝经状态

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 61-62页

作者： GuaabensN Parés A ros I 陈瑜 Service of Rheumatology Hospital Clnic University of Barcelona C/Vill arroel 170 08036-Barcelona Spain

Background: Since primary biliary cirrhosis (PBC) is usu- ally diagnosed in postmenopausal women with minor cholestasis, it has been que stioned whether PBC itself represents a further risk for osteoporosis. Aim: To a ssess the prevalence and risk factors for osteoporosis in an unselected series o f women with PBC. Patients and Methods: 142 women with PBC (age: 54.3±0.8 years ) and an age-matched control group. Osteoporosis was established by densitometr y (bone mineral density below -2.5 T-sc- ore). Age, duration and severity of PBC, body mass inde- x, menopausal status, histological stage and markers of bone turnover were ass essed. Results: Prevalence of osteoporosis was higher in PBC (32.4%) than in no rmal women (11. 1%)-(RR: 3.83, 95%CI: 2.59-5.67, Prosis was associated with older age, menopausal status, body mass index, longer PBC durat ion, advanced histological stage, high bilirubin and alkaline phosphatase, and l owalbumin and prothrombin index. Regression analysis identified older age, highe r Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis. Conclusions: Osteop orosis is more prevalent in women with PBC than in the general population. Age a nd severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.

关键词：骨质疏松凝血酶原指数骨密度骨转换独立危险因子高胆红素碱性磷酸酶

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Mechanisms of probiotic Bacillus against enteric bacterial infections

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One Health Advances 2023年第1期1卷 127-148页

作者： Jiajia Zhu Yunsheng Chen Kálmán Imre Damla Arslan-Acaroz Fatih Ramazan Istanbullugil Yuwen Fang Gaspar ros Kui Zhu Ulas Acaroz National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Department of Animal Production and Veterinary Public Health Faculty of Veterinary MedicineUniversity of Life Sciences“King Mihai I”from Timișoara300645 TimisoaraRomania Department of Biochemistry Faculty of Veterinary MedicineAfyon Kocatepe UniversityAfyonkarahisar 03200Turkey Department of Biochemistry Faculty of Veterinary MedicineKyrgyz-Turkish Manas UniversityBishkek KG-720038Kyrgyzstan Department of Food Hygiene and Technology Faculty of Veterinary MedicineKyrgyz-Turkish Manas UniversityBishkek KG-720038Kyrgyzstan Department of Human Nutrition Food Science and TechnologyFaculty of Veterinary MedicineUniversity of MurciaCampus de Espinardo30071 MurciaSpain Department of Food Hygiene and Technology Faculty of Veterinary MedicineAfyon Kocatepe UniversityAfyonkarahisar 03200Turkey

Gastrointestinal infection is a leading cause of gut diseases attracting global health *** emerging antimicrobial resistance in enteric pathogens drives the search of viable and renewable alternatives to antibiotics for the health of both human beings and ***-forming probiotic Bacillus have received extensively interests for their multiple health benefits,including the restoration of microbiota dysbiosis and the reduction of drug-resistant *** promising benefits are mainly attributed to the activity of structurally diverse Bacillus-derived metabolites,such as antibacterial compounds,short-chain fatty acids,and other small *** metabolites show the capacity to directly target either the individual or community of bacterial pathogens,and to potentiate both host cells and gut *** better understanding of the mechanisms by which probiotic Bacillus and the metabolites modulate the metabolism of hosts and microbiota will advance the screening and development of probiotic *** this review,we discuss the interaction among probiotic Bacillus,microbiota and host,and summarize the Bacillus-derived metabolites that act as key players in such interactions,shedding light on the mechanistic understanding of probiotic Bacillus against enteric bacterial infections.

关键词： Probiotics Bacillus Metabolites Microbial interaction

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What we have learned from urinary bladder cancer models

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 51-58页

作者： Carina Bernardo Céu Costa Carlos Palmeira rosário Pinto-Leite Paula Oliveira Rui Freitas Francisco Amado Lúcio L.Santos Experimental Pathology and Therapeutics Group-Research Center Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Mass Spectrometry Group QOPNADepartment of ChemistryUniversity of AveiroCampus Universitário de Santiago3810-193 AveiroPortugal Department of Immunology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal School of Health Sciences Fernando Pessoa University4249-004 PortoPortugal Genetic Service Cytogenetic LaboratoryHospital Center of Trás-os-Montes e Alto Douro5000-508 Vila RealPortugal Department of Veterinary Sciences CITABUniversity of Trás-os-Montes e Alto Douro5001-801 Vila RealPortugal Department of Urology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Department of Surgical Oncology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal

Urinary bladder cancer(UBC)is a heterogeneous disease with highly variable clinical outcomes and responses to *** some advances in the molecular understanding of UBC,this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and treatment of *** urinary bladder tumor models representative of the human disease in terms of histology and behavior are needed to study factors involved in tumor initiation,progression and ***,accurate model systems would facilitate identification of new therapeutic targets and predictive markers that could lead to optimization of existing therapies and development of new *** established cancer cell lines derived from human urinary bladder tumors representing different grades and stages have been used as experimental models for UBC *** cell lines reflect some of the genetic and morphologic alterations observed in human urothelial carcinoma and serve as simplified models to study the behavior of cancer cells in ***,their translational potential is limited due to the artificial conditions,in which the cells are maintained,grown and *** models offer a more complex and realistic model for the establishment,development,and progression of tumors as well as to evaluate new therapeutic *** the years,the authors'group has worked with several UBC cell lines,established and characterized chemically induced UBC models,and patient-derived xenografts *** this study,the authors will provide a summary of the UBC models developed by their group,analyze their translational potential and weaknesses,and define areas that remain to be explored.

关键词： Animal models cell lines tumor behavior urothelial bladder cancer xenografts

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Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode[Invited]

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Photonics Research 2018年第5期6卷 I0048-I0054页

作者： FRANCESCO DA ros ANDRZEJ GAJDA ERIK LIEBIG EDSON P.DA SILVA ANNA PECZEK PETER D.GIROUARD ANDREAS MAI KLAUS PETERMANN LARS ZIMMERMANN MICHAEL GALILI LEIF K.OXENLOWE DTU Fotonik Technical University of DenmarkDK-2800 Kongens LyngbyDenmark IHP Im Technologiepark 2515236 Frankfurt(Oder)Germany IHP Solutions GmbH Im Technologiepark 2515236 Frankfurt(Oder)Germany Institut for Hochfrequenz-und Halbleiter-Systemtechnologien TU BerlinEinsteinufer 2510587 BerlinGermany AMETEK CTS Europe GmbH L unener StraBe 211-21259174 KamenGermany

A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation(QAM) signals at 16 GBd is demonstrated with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence(≤0.5 dB) and the high conversion efficiency(CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due to the reverse-biased p-i-n diode are key in ensuring high CE levels.

关键词： Invited Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode QAM

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