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Materials sciences and Applications 2010年第4期1卷 247-252页

作者： Lígia maria Manzine Costa ros.rio Elida suman Bretas Rinaldo Gregorio 不详

A study was conducted regarding the effect of concentration of poly (vinylidene fluoride) (PVDF)/N,N-dimethylformamide (DMF) and PVDF/DMF/acetone solutions on the transition between electros.ray and electros.inning and on the formation of the ? and ? crystalline phases of PVDF. The crystalline phases present in the samples, crystallinity and morphology were determined by Fourier transform infrared spectros.opy (FTIR), differential scanning calorimetry (DsC) and scanning electron micros.opy (sEM), respectively. Low concentration solutions resulted in films consisting of small droplets (electros.ray) containing predominantly the ? phase. High concentration solutions resulted in a non-woven mesh of nano-to-micron diameter fibers (electros.inning) containing exclusively the ? phase. These results showed that, the formation of this phase in the electros.inning is related mainly to the solvent evaporation rate, and not to drawing experienced by the polymer during the process. solvent type affected the amount of crystalline phase present, the boundary concentration between the two processes and the average diameter of fibers. Meshes processed by electros.inning display a degree of crystallinity higher than the films obtained by electros.ray.

关键词： Poly(Vinylidene Fluoride) (PVDF) Electros.inning Electros.ray Crystalline Phase Fibers Morphology

A Clinical study on Diabetes, Cholesteremia and Hyperlipemia

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中国针灸 1995年第S2期15卷 388-389页

作者： Luz maria ros.Centre Integral de saludMedicina Traditional Chinasagitario 198Fracc.Con fry, CP 64860Monterrey, Nuevo Leon, Mexico)

ＡＣｌｉｎｉｃａｌＳｔｕｄｙｏｎＤｉａｂｅｔｅｓ，ＣｈｏｌｅｓｔｅｒｅｍｉａａｎｄＨｙｐｅｒｌｉｐｅｍｉａ￥ＬｕｚＭａｒｉａＲｏｓ（ＣｅｎｔｒｅＩｎｔｅｇｒａｌｄｅＳａｌｕｄＭｅｄｉｃｉｎａＴｒａｄｉｔｉｏｎａｌＣｈ... 详细信息

ＡＣｌｉｎｉｃａｌＳｔｕｄｙｏｎＤｉａｂｅｔｅｓ，ＣｈｏｌｅｓｔｅｒｅｍｉａａｎｄＨｙｐｅｒｌｉｐｅｍｉａ￥ＬｕｚＭａｒｉａＲｏｓ（ＣｅｎｔｒｅＩｎｔｅｇｒａｌｄｅＳａｌｕｄＭｅｄｉｃｉｎａＴｒａｄｉｔｉｏｎａｌＣｈｉｎａＳａｇｉｔａｒｉｏ１９８Ｆｒ...

关键词： A Clinical study on Diabetes Cholesteremia and Hyperlipemia

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Nitric oxide and hydrogen sulfide share regulatory functions in higher plant events

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BIOCELL 2022年第1期46卷 1-5页

作者： FRANCIsCO J.CORPAs sALVADOR GONZÁLEZ-GORDO marTA RODRÍGUEZ-RUIZ marÍA A.MUÑOZ-VARGAs JOsÉM.PALMA Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstación Experimental del Zaidín(Spanish National Research CouncilCSIC)Granada18008Spain

Nitric oxide(NO)and hydrogen sulfide(Hs)are two molecules that share signaling properties in plant and animal cells NO and H2s originate two farmilies of de rived mol ecules designated reactive nitrogen and sulfur species(RNs and Rss,respectively).These molecules are responsible for certain protein regulatory processes through posttranslational modifications(PTMs),being the most remarkable s nitros.tion and persufidation,which afect the thiol group of cysteine *** and H2s can also exert regulatory functions due to their interaction through the iron present in proteins that contain heme groups or iron-sulfur dlusters,as reported mainly in animal ***,the available information in plant cells is still very limited thus *** higher plants,NO and H2s are involved in a myriad of physiological events from seed germination to fruit ripening,but also the mec hanism of response to biotic and abiotic stress *** vie wpoint manuscript highlights the functional regulatory parllelism of these two molecules which also interact with the metabolism of reactive oxygen species(ros.in plant cells.

关键词： Ascorbate peroxidase Hydrogensulfide Nitricoxide Persulfidation s-nitros.tion signaling

IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

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Chinese Chemical Letters 2024年第1期35卷 305-309页

作者： songtao Zhou Hao Tian Jie Yan Zhan Zhang Guohao Wang Xinying Yu Wei sang Bei Li Greta s.P.Mok Jie song Yunlu Dai Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers science Center for Precision Oncology University of MacaoMacao 999078China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Biomedical Imaging Laboratory(BIG) Department of Electrical and Computer EngineeringFaculty of Science and TechnologyUniversity of MacaoMacao 999078China

Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ros. to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

关键词： Metal phenolic network IR780 Photodynamic therapy Breast cancer Gemcitabine

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桃红酒待字闺中的少女

城色 2012年第11期 130-133页

作者： ros. Wine

有爱酒人将桃红酒形容为葡萄酒中的"牛仔裤"——花样繁多并且百搭。在欧洲,不管年轻人还是资深酒友,都喜欢桃红酒。樱桃粉、三文鱼肉红、浅桃红、杏桃色、浆果红……各种高雅又有个性的颜色,光视觉上就能够很好地为你开开胃。

关键词：葡萄酒消费干红食材酿酒师红葡萄酒优质葡萄酒烹饪方式法国波尔多品酒师葡萄酒业

Medical schools that received the PROMED (program for the encouragement of curricular changes in medical courses)—Preconditions and change process

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Health 2012年第5期4卷 279-284页

作者： Patricia Alves de souza marco Aurélio Da ros.Angélica maria Bicudo Zeferino Universidade do Vale do Itajaí (UNIVALI) Itajaí Brazil Universidade Estadual de Campinas (UNICAMP) Campinas

since the Curriculum Guidelines (CG) which were created in 2001 and PROMED (Program for the Encouragement of Curricular Changes in Medical Courses), several schools have applied for this incentive. Medical schools (Ms) have faced important changes in their curriculum throughout the years. The purpose is to verify if medical schools that received PROMED already had a historical of curricular changes. several interviews, which were carried out with PROMED coordinators, were recorded, transcribed and analyzed according to the Bardin’s content analysis technique. Later, these interviews were later categorized into nine themes. This paper analyses the Medical school History category which encompasses three subcategories: existence of a former changing history;need to overcome the model and changing period. It is highlighted that medical schools that received PROMED had a previous changing historical which was sometimes located in anti-hegemonic niches. It is noticeable, however, that such changes were not enough to affect the comprehension of healthillness process and its consequent results. PROMED was, effectively, the reference for medical schools implementing the C.G. which represents, now, a benchmarking for all new and old schools in the country.

关键词： Curriculum Guidelines Medical schools

Bone disorders in experimentally induced liver disease in growing rats

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World Journal of Gastroenterology 2005年第45期11卷 7169-7173页

作者： Viktória Ferencz Csaba Horváth Béla Kári János Gaál szilvia Mészáros.Zsuzsanna Wolf Dalma Heged(?)s Andrea Horváth Anikó Folhoffer Ferenc szalay 1st Department of Internal Medicine Department of Diagnostic Radiology and Oncotherapy Department of Polymer Engineering and Textile Technology

AIM： To investigate the change of bone parameters in a new model of experimentally induced liver cirrhosis and hepatocellular carcinoma （HCC） in growing rats. METHODs： Fischer-344 rats （n = 55） were used. Carbon tetrachloride （CCh）, phenobarbital （PB）, and a single diethylnitros.mine （DEN） injection were used. Animals were killed at wk 8 and 16. Bone mineral content, femoral length, cortical index （quotient of cortical thickness and whole diameter） and ultimate bending load （Fmax） of the femora were determined. The results in animals treated with DEN＋PB＋CCh （DPC, n = 21） were com- pared to those in untreated animals （UNT, n = 14） and in control group treated only with DEN＋PB （DP, n = 20）. REsULTs： Fatty liver and cirrhosis developed in each DPC-treated rat at wk 8 and HCC was presented at wk 16. No skeletal changes were found in this group at wk 8, but each parameter was lower （P〈0.05 for each） at wk 16 in comparison to the control group. Neither fatty liver nor cirrhosis was observed in DP-treated animals at any time point. Femoral length and Fmax values were higher （P〈0.05 for both） in DP-treated animals at wk 8 compared to the UNT controls. However, no difference was found at wk 16. CONCLUsION： Experimental liver cirrhosis and HCC are accompanied with inhibited skeletal growth, reduced bone mass, and decreased mechanical resistance in growing rats. Our results are in concordance withthe data of other studies using different animal models. A novel finding is the transiently accelerated skeletal growth and bone strength after a 8-wk long phenobarbital treatment following diethylnitros.mine injection.

关键词： Bone disorder Bone mineral content Mechanical resistance Experimental liver cirrhosis Growingrat

双极紊乱中的机能评估短期测试(FAsT)的有效性和可靠性

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医疗保健器具 2007年第9期14卷 24-25页

作者： Adriane R ros.）

背景:很多研究已经证明,双极紊乱(BD)病人即使在减轻阶段都有很高比率的机能损伤。然而,大多数可用来评估机能的器具都集中在机能恢复的全方位测量而不是社会心理机能的特定区域。在这种情况下,机能评估短期测试(FAsT)是一种为评估精神... 详细信息

背景:很多研究已经证明,双极紊乱(BD)病人即使在减轻阶段都有很高比率的机能损伤。然而,大多数可用来评估机能的器具都集中在机能恢复的全方位测量而不是社会心理机能的特定区域。在这种情况下,机能评估短期测试(FAsT)是一种为评估精神病病人(特别是双极病人)所经历的主要机能问题而设计的便利器具。它包括24个项目,评估了6个特定机能区域的损伤或无能:自治、职业机能、认知机能、财政问题、人际关系和闲暇时间。方法:巴塞罗纳医院门诊部的双极紊乱项目评估了101个有DsM-IVTR双极紊乱的病人和61个健康对照个体,分析了FAsT(可行性、内在连贯性、并发的有效性、判别有效性、要素分析、测试-再测试的可靠性)的心理测量特性。结果:获得的内在连贯性很高,Cronbach的阿尔法高达0.909。我们还获得非常重要的与GAF相反的数据(r=-0.903;p﹤0.001),这指出并发有效性的合理程度。测试-再测试的可靠性分析显示出相隔一星期进行的两个测量间的强有力关联(ICC=0.98;p﹤0.001)。比起狂躁病人(40.44±9.15)和郁闷病人(43.21±13.34),euthymic病人(18.55±13.19;F=35.43;psT总分都较低。结论:FAsT显示出强烈的心理测验特性,能够察觉eu-thymic和急性BD病人间的差异。此外,这是一个简短的(6分钟)治疗器具,使用简单、快捷。

关键词：可靠性分析心理机能项目评估有效性测试双极紊乱 FAsT

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匈牙利的地震危险性

防灾减灾工程学报 1995年第S1期 45-46页

作者： Tibor Zsíros

1 地震危险性评定历史匈牙利为工业服务的地震危险性评定工作始于1960年。大约近20年来,这些研究的目的仅是为了估计有关场地的最大地面预测烈度,其结果虽没有发表,但各个公司可以使用。si-mon(1939)等编制了该国的地震活动性与最大观... 详细信息

1 地震危险性评定历史匈牙利为工业服务的地震危险性评定工作始于1960年。大约近20年来,这些研究的目的仅是为了估计有关场地的最大地面预测烈度,其结果虽没有发表,但各个公司可以使用。si-mon(1939)等编制了该国的地震活动性与最大观测或预测烈度。Zsíros.1985 b)编制了匈牙利第一幅危险性概率图。1987年,对Paks核电站场地评定首先进行了综合研究。Mónus(1990),Tóth(1990)和Zsíros.1990)发表了一些研究成果。

关键词：地震危险性地震活动性烈度衰减匈牙利