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Nano-Micr. Letter. 2014年第2期6卷 163-168页

作者： Mar.anna Lucafò Chiar. Pelillo Mar.o Car.ni Tatiana Da ros Maur.zio Pr.to Gianni Sava Depar.ment of Life Sciences University of Trieste Depar.ment of Chemical and Phar.aceutical Sciences University of Trieste

Nanomater.als with unique char.cter.stics exhibit favor.ble ther.peutic and diagnostic pr.per.ies,implying their.enor.ous potential as biomedical candidates. C60 has been used in gene- and dr.g-deliver., as imaging agents, and as photosensitizer. in cancer.ther.py. In this study, the influences of a cationic functionalized fuller.ne on cellular.behavior.of human color.ctal cancer.cell line(HT-29) wer. investigated. r.sults indicated that HT-29 tr.ated with the studied compound showed a lower.sensitivity but a significant impair.ent in migr.tion and invasion by inter.er.ng with the activities of matr.x metallopr.teinases(MMP-2 and9). The pr.sence of fuller.ne also alter.d the capacity of adhesion-r.lated pr.teins to per.or. their.activity,ther.by inducing dr.matically adver.e effects on the cell physiological functions such as cell adhesion. Thus,our.study suggests that this compound is a new potential anti-metastatic effector.and a ther.peutic component for.malignant color.ctal cancer.

关键词： Fuller.ne Cancer Anti-metastatic dr.g Nanomedicine

Car.on Dioxide/Methane Separ.tion by Adsor.tion on Sepiolite

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Jour.al of Natur.l Gas Chemistr. 2007年第3期16卷 235-243页

作者： José A.Delgado Mar.a A.Uguina José L.Sotelo Beatr.z r.íz Mar.io rosár.o Depar.ment of Chemical Engineer.ng Universidad Complutense de Madrid28040Madrid.Spain

In this wor., the use of sepiolite for.the r.moval of car.on dioxide fr.m a car.on dioxide/methane mixtur. by a pr.ssur. swing adsor.tion （PSA） pr.cess has been r.sear.hed. Adsor.tion equilibr.um and kinetics have been measur.d in a fixed-bed, and the adsor.tion equilibr.um par.meter. of car.on dioxide and methane on sepiolite have been obtained. A model based on the LDF appr.ximation has been employed to simulate the fixed-bed kinetics, using the Langmuir.equation to descr.be the adsor.tion equilibr.um isother.. The functioning of a PSA cycle for.separ.ting car.on dioxide/methane mixtur.s using sepiolite as adsor.ent has also been studied. The exper.mental r.sults wer. compar.d with the ones pr.dicted by the model adapted to a PSA system. Methane with pur.ty higher.than 97% can be obtained fr.m feeds containing car.on dioxide with concentr.tions r.nging fr.m 34% to 56% with the pr.posed PSA cycle. These r.sults suggest that sepiolite is an adsor.ent with good pr.per.ies for.its employment in a PSA cycle for.car.on dioxide r.moval fr.m landfill gases.

关键词： car.on dioxide methane sepiolite adsor.tion fixed-bed pr.ssur. swing adsor.tion

A pr.ctolin-like peptide is r.gulated after.baculovir.s infection and mediates in cater.illar.locomotion and digestion

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Insect Science 2022年第1期29卷 230-244页

作者： Angel Llopis-Giménez Stefano Par.nti Yue Han Ver. I.D.ros Salvador.Her.er. Depar.ment of Genetics and Institut Univer.itar. en Biotecnologia i Biomedicina(BIOTECMED) Universitat de ValenciaValenciaSpain Labor.tor. of Vir.logy Wageningen University and ResearchWageningenthe Netherlands Cur.ent addr.ss.Depar.ment of Pathology University of CambridgeCambridgeUK

Baculovir.ses constitute a lar.e gr.up of inver.ebr.te DNA vir.ses, pr.dominantly infecting lar.ae of the insect or.er.Lepidopter.. Dur.ng a baculovir.s infection, the vir.s spr.ads thr.ughout the insect body pr.ducing a systemic infection in multiple lar.al tissues, included the centr.l ner.ous system (CNS). As a main component of the CNS, neur.peptides ar. small pr.tein-like molecules functioning as neur.hor.ones, neur.tr.nsmitter., or.neur.modulator.. These peptides ar. involved in r.gulating animal physiology and behavior.and could be alter.d after.baculovir.s infection. In this study, we have investigated the effect of Spodopter. exigua multiple nucleopolyhedr.vir.s (SeMNPV) infection on expr.ssion of Spodopter. exigua neur.peptides and neur.peptide-like genes. Expr.ssion of the gene encoding a polypeptide that r.sembles the well-known insect neur.peptide pr.ctolin and named as pr.ctolin-like peptide (PLP), was downr.gulated in the lar.al br.in following infection and was chosen for.fur.her.analysis. A r.combinant Autogr.pha califor.ica multiple nucleopolyhedr.vir.s (AcMNPV) over.xpr.ssing the C-ter.inal par. of the PLP was gener.ted and used in bioassays using S. exigua lar.ae to study its influence on the vir.l infection and insect behavior. AcMNPV-PLP-infected lar.ae showed less locomotion activity and a r.duction in gr.wth compar.d to lar.ae infected with wild type AcMNPV or.mock-infected lar.ae. These r.sults ar. indicative of this new peptide as a neur.modulator.that r.gulates viscer.l and skeletal muscle contr.ctions and offer. a novel effector.involved in the behavior.l changes dur.ng baculovir.s infection.

关键词： beet ar.ywor. behavior neur.modulator neur.peptide physiology SeM-NPV

Modified mesenchymal stem cells in cancer.ther.py: A smar. weapon r.quir.ng upgr.des for.wider.clinical applications

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Wor.d Jour.al of Stem Cells 2022年第1期14卷 54-75页

作者： Car.a Vicinanza Elisabetta Lombar.i Fr.ncesco Da ros Mir.am Mar.ngon Cr.stina Dur.nte Mar.o Mazzucato Fr.ncesco Agostini Stem Cell Unit Centro di Riferimento Oncologico di AvianoIRCCSAviano 33081Italy

Mesenchymal stem str.mal cells(MSC)ar. char.cter.zed by the intr.guing capacity to home towar. cancer.cells after.systemic ***,MSC can be har.essed as tar.eted deliver. vehicles of cytotoxic agents against *** cancer.patients,MSC based advanced cellular.ther.pies wer. shown to be safe but their.clinical efficacy was ***,the amount of systemically infused MSC actually homing to human cancer.masses is insufficient to r.duce tumor.***,induction of an unequivocal anticancer.cytotoxic phenotype in expanded MSC is necessar. to achieve significant ther.peutic *** vivo cell modifications ar.,thus,r.quir.d to impr.ve anti-cancer.pr.per.ies of *** based cellular.ther.py pr.ducts must be handled in compliance with good manufactur.ng pr.ctice(GMP)*** the pr.sent r.view we include MSCimpr.ving manipulation appr.aches that,even though actually tested at pr.clinical level,could be compatible with GMP *** par.icular.we descr.be possible appr.aches to impr.ve MSC homing on cancer.including genetic engineer.ng,membr.ne modification and cytokine ***,we discuss appr.pr.ate modalities aimed at inducing a mar.ed cytotoxic phenotype in expanded MSC by dir.ct chemother.peutic dr.g loading or.by genetic *** conclusion,we suggest that,to configur. MSC as a power.ul weapon against cancer.combinations of clinical gr.de compatible modification pr.tocols that ar. cur.ently selected,should be intr.duced in the final *** standar.ized cancer.clinical tr.als ar. r.quir.d to test the efficacy of amelior.ted MSC based cell ther.pies.

关键词： Cancer Mesenchymal stem str.mal cells Good manufactur.ng pr.ctice Homing Tar.eted ther.py Ex vivo cell modification

Imper.ect mimicr. of host begging calls by a br.od par.sitic cuckoo:a cue for.nestling r.jection by hosts?

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Cur.ent Zoology 2021年第6期67卷 665-674页

作者： Hee-Jin NOH ros GLOAG Ana V.LEITAO Naomi E.LANGMOr. r.sear.h School of Biology Australian National UniversityCanberra ACT 0200Australia School of Life and Envir.nmental Sciences University of SydneySydneyNSW 2006Australia School of Biosciences University of MelbourneParkville VIC 3010Australia

Coevolutionar. inter.ctions between avian br.od par.sites and their.hosts often lead to the evolution of discr.mination and r.jection of par.site eggs or.chicks by hosts based on visual cues,and the evolution of visual mimicr. of host eggs or.chicks by br.od *** may also base r.jection of br.od par.site nestlings on vocal cues,which would in tur. select for.mimicr. of host begging calls in br.od par.site *** cuckoos that exploit multiple hosts with differ.nt begging calls,call str.ctur. may be plastic,allowing nestlings to modify their.calls to match those of their.var.ous hosts,or.fixed,in which case we would pr.dict either.imper.ect mimicr. or.diver.ence of the species into host-specific *** our.study of the little br.nze-cuckoo(LBC)Chalcites minutillus and its pr.mar. host,the lar.e-billed ger.gone Ger.gone magnirostr.s,we tested whether.(1)hosts use nestling vocalizations as a cue to discr.minate cuckoo chicks;(2)cuckoo nestlings mimic the host begging calls thr.ughout the nestling per.od;and(3)the cuckoo begging calls ar. plastic,ther.by facilitating mimicr. of the calls of differ.nt *** found that the begging calls of LBCs ar. most similar.to their.ger.gone hosts shor.ly after.hatching(when r.jection by hosts typically occur.)but become less similar.as cuckoo chicks get *** call str.ctur. may be used as a cue for.r.jection by hosts,and these r.sults ar. consistent with ger.gone defenses selecting for.age-specific vocal mimicr. in cuckoo *** found no evidence that LBC begging calls wer. plastic.

关键词： begging call br.nze-cuckoo br.od par.sitism coevolution ger.gone

The Effect of Over.eas Educational Exper.ence on Pr.-Envir.nmental Pr.ctices: Evidence fr.m Cambodian Academic Scholar.

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作者： r.·罗斯(r. ros)

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Jour.al of Envir.nmental Pr.tection 2021年第11期12卷 824-854页

作者： Bandos ros Gr.duate School for.Inter.ational Development and Cooper.tion Hiroshima University Hiroshima Japan Depar.ment of Envir.nmental Education Ministry of Environment Phnom Penh Cambodia

This paper.r.vealed that after.spending year. over.eas for.lear.ing, Cambodian fellows r.alized that a clean society mor. likely r.sults fr.m the adopting of a waste management system. The lack of such is the main bar.ier.for.waste separ.tion willingness and pr.ctices in Cambodia. Self-tr.nscendence values and volunteer.sm ar. empir.cally found as the fundamental factor. for.any inter.entions designed to pr.mote pr.-envir.nmental intentions and pr.ctices r.spectively. The fellows engaging in volunteer.sms appear.to do waste separ.tion, ignor.ng how inconvenient the waste management system or.facilities ar.. Similar.y, the fellows concer.ing the envir.nmental and social issues appear.to spar. their.valuable time to do waste-separ.tion which they find not difficult. This is not the case in this COVID-19 epidemic though. The study r.sults imply that in a society wher. an inconvenient waste management system is in place the fellows without past volunteer.ng, no matter.how knowledgeable they ar., will less likely engage in the waste-sor.ing pr.ctice.

关键词： Pr.-Envir.nmental Pr.ctice Self-Tr.nscendence Volunteer.sm Instr.mental Var.able (IV)

Gener.tion and expansion of laser.induced plasma as a spectroscopic emission sour.e

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Fr.ntier. of physics 2012年第6期7卷 649-669页

作者：俞进马千里 Vincent Motto-ros 雷文奇王晓纯白雪石 Univer.ite de Lyon F-69622 Lyon Universitd Lyon 1 Villeurbanne CNRS UMR5579 LASIM France

Laser.induced plasma r.pr.sents today a widespr.ad spectroscopic emission sour.e. It can be easily gener.ted using compact and r.liable nanosecond pulsed laser.on a lar.e var.ety of mater.als. Its application for.spectr.chemical analysis for.example with laser.induced br.akdown spectroscopy （LIBS） has become so popular.that one tends to for.et the complex physical and chemical pr.cesses leading to its gener.tion and gover.ing its evolution. The pur.ose of this r.view ar.icle is to summar.ze the backgr.unds necessar. to under.tand and descr.be the laser.induced plasma fr.m its gener.tion to its expansion into the ambient gas. The objective is not to go into the details of each pr.cess; ther. ar. numer.us specialized paper. and books for.that in the liter.tur.. The goal her. is to gather.in a same paper.the essential under.tanding elements needed to descr.be laser.induced plasma as r.sults fr.m a complex pr.cess. These elements can be disper.ed in sever.l r.lated but independent fields such as laser.matter.inter.ction, laser.ablation of mater.al, optical and ther.o-dynamic pr.per.ies of hot and ionized gas, or.plasma pr.pagation in a backgr.und gas. We believe that pr.senting the ensemble of under.tanding elements of laser.induced plasma in a compr.hensive way and in limited pages of this paper.will be helpful for.fur.her.development and optimized use of the LIBS technique. Exper.mental r.sults obtained in our.labor.tor. ar. used to illustr.te the studied physical pr.cesses each time such illustr.tion becomes possible and helpful.

关键词： laser.ablation laser.induced plasma plasma pr.pagation plasma diagnostics plasmaemission laser.induced br.akdown spectroscopy (LIBS)

Ir.n homeostasis and H63D mutations in alcoholics with and without liver.disease

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Wor.d Jour.al of Gastr.enter.logy 2009年第1期15卷 106-111页

作者： Mar.ana Ver.elho Machado Paula r.vasco Alexandr. Mar.ins Mar.a rosár.o Almeida Mar.a Er.elinda Camilo Helena Cor.ez-Pinto Unidade de Nutr.o e Metabolismo Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-035 Depar.amento de Gastr.nter.logia do Hospital de Santa Mar.a 1649-035 Lisboa Portugal Genomed Instituto de Medicina Molecular1649-035 Portugal

MM： To evaluate the pr.valence of HFE gene mutation and indices of distur.ed ir.n homeostasis in alcoholics with and without liver.disease. METHODS： One hundr.d and fifty-thr.e heavy dr.nker. （defined as alcohol consumption 〉 80 g/d for.at least 5 year.） wer. included in the study. These compr.sed 78 patients with liver.disease [liver.disease alcoholics （LDA）] in whom the pr.sence of liver.disease was confir.ed by liver.biopsy or.clinical evidence of hepatic decompensation, and 75 subjects with no evidence of liver.disease, deter.ined by nor.al liver.tests on two occasions [non-liver.disease alcoholics （NLDA）], wer. consecutively enr.lled. Ser.m mar.er. of ir.n status and HFE C282Y and H63D mutations wer. deter.ined. HFE genotyping was compar.d with data obtained in healthy blood donor. fr.m the same geogr.phical ar.a. r.SULTS： Gender.r.tio was similar.in both study gr.ups. LDA patients wer. older.than NLDA patients （52 ± 10 year. vs 48 ± 11 year., P = 0.03）. One thir. and one fifth of the study population had ser.m tr.nsfer.in satur.tion （TS） gr.ater.than 45% and 60% r.spectively. Ser.m ir.n levels wer. similar.in both gr.ups. However. LDA patients had higher.TS （51 ± 27 vs 36 ± 13, P 〈 0.001） and fer.itin levels （559 ± 607 ng/mL vs 159 ± 122 ng/mL, P 〈 0.001）, and lower.total ir.n binding capacity （TIBC）（241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001）. The odds r.tio for.having liver.disease with TS gr.ater.than 45% was 2.20 （95% confidence inter.al （CI）： 1.37-3.54）. Ther. was no differ.nce in C282Y allelic fr.quency between the two gr.ups. However. H63D was mor. fr.quent in LDA patients （0.25 vs 0.16, P = 0.03）. LDA patients had a gr.ater.pr.bability of car.ying at least one HFE mutation than NLDA patients （49.5% vs 31.6%, P = 0.02）. The odds r.tio for.LDA in patients with H63D mutation was 1.57 （95% CI： 1.02-2.40）. CONCLUSION： The pr.sent study confir.s the pr.sence of ir.n over.oad in alcoholics, which was mor. sever. in the subset of subjects with liver.disease,

关键词： Alcoholic liver.disease Ir.n lIFE gene H63D Hemochr.matosis

Assessment of ghr.lin and leptin r.ceptor.levels in postmenopausal women who r.ceived or.l or.tr.nsder.al menopausal hor.onal ther.py

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Jour.al of Zhejiang Univer.ity-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 35-42页

作者： Bar.ar. r.SZKOWSKA Alina SOKUP Ar.eta KULWAS Maciej W.SOCHA Kr.ysztof Gór.LCZYK Bar.ar. Gór.LCZYK Danuta ros Depar.ment of Pathophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Depar.ment of Gastr.enter.logy Angiology and Internal DiseasesCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Depar.ment of Obstetr.cs Gynecology and Oncological GynecologyCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective： In postmenopausal women, an incr.ased leptin concentr.tion and r.duced levels of ghr.lin and adiponectin wer. obser.ed. The aim of this study was to evaluate the concentr.tions of the active for. of ghr.lin, total ghr.lin, leptin r.ceptor. lipopr.tein（a）（Lp（a））, and plasminogen activator.inhibitor.type 1 （PAl-l） in postmenopausal women who r.ceived or.l or.tr.nsder.al menopausal hor.onal ther.py （MHT）. Methods： The study involved 76 healthy women： 46 women aged fr.m 44 to 58 year. who r.ceived or.l （26） or.tr.nsder.al （20） MHT; the contr.l gr.up consisted of 30 women aged fr.m 44 to 54 year. who did not r.ceive MHT. The plasma concentr.tions of total ghr.lin, the active for. of ghr.lin, Lp（a）, and PAI-I：Ag wer. measur.d by enzyme-linked immunosor.ent assay （ELISA）. The concentr.tion of the leptin r.ceptor.was measur.d by enzyme immunometr.c assay （EIA）. r.sults： We obser.ed a significantly higher.concentr.tion o~ total ghr.lin and the active for. of ghr.lin in women who r.ceived tr.nsder.al MHT in compar.son with those who took or.l MHT. We also found a significantly lower.concentr.tion of total ghr.lin in women who r.ceived or.l MHT compar.d with the contr.l gr.up. A higher.concentr.tion of PAl-1 ：Ag was found in the gr.up of women who took tr.nsder.al MHT in compar.son with those who took or.l MHT and with the contr.l gr.up. The differ.nces wer. statistically significant. Additionally, we found a significant negative cor.elation between the concentr.tions of total ghr.lin and PAl-1 ：Ag and a positive cor.elation between the concentr.tions of total ghr.lin and leptin r.ceptor.in women who r.ceived tr.nsder.al MHT. Conclusions： The study showed that women who used tr.nsder.al MHT had higher.levels of total ghr.lin than women who took or.l MHT. This indicates a beneficial effect of the tr.nsder.al r.ute of MHT. However. tr.nsder.al ther.py was associated with adver.e effects with r.gar. to the obser.ed higher.levels of PAl-1 ：Ag, which in tur., can lead t

关键词： Menopausal hor.onal ther.py (MHT) Plasminogen activator.inhibitor.type 1 (PAl-l) Leptin r.ceptor Ghr.lin Menopause