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亚太地区胃食管反流病的处理共识:更新版

胃肠病学 2008年第7期13卷 421-436页

作者： Kwong Ming Fock Nicholas J Talley ronnie fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 Changi General Hospital Mayo Clinic College of Medicine Rochester University of Arizona Health Sciences Center University of Malaya University of Sydney McMaster University Medical Center Tohoku University Hospital Royal Adelaide Hospital Monash University The Third Hospital Peking University Queen Mary Hospital Prince of Wales Hospital University of Indonesia Korea University College of Medicine University of Santo Tomas National University Hospital Siriraj Hospital

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,... 详细信息

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。

关键词：共识糜烂性食管炎非糜烂性反流病

Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery

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Journal of Integrative Plant Biology 2011年第10期53卷 800-813页

作者： Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel fass Charles Meyer Nicolet Dawei Lin Li Tian Department of Plant Sciences University of California Davis CA 95616 USA Genome Center University of California Davis CA 95616 USA

Pomegranate fruit peel is rich in bioactive plant natural products, such as hydrolyzable tannins and anthocyanins. Despite their documented roles in human nutrition and fruit quality, genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain. Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform. Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies （TAs）（〉200 bp）. Candidate genes for hydrolyzable tannin, anthocyanin, flavonoid, terpenoid and fatty acid biosynthesis and/or regulation were identified. Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts. In addition, 115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers. The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate. This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis, identifying genes controlling important agronomic traits, and discovering molecular markers in non-model specialty crop species.

关键词： hydrolyzable tannin naturat product pomegranate SSR marker transcriptome.

Benign retroperitoneal schwannoma presenting as colitis:A case report

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World Journal of Gastroenterology 2007年第41期13卷 5521-5524页

作者： Gary fass Didier Hossey Michel Nyst Dirk Smets Esmail Najar Saligheh Ruth Duttmann Kathleen Claes Pierre Mendes da Costa Department of Digestive Laparoscopic and Thoracic SurgeryBrugmann University HospitalBrusselsBelgium Department of Radiology Brugmann University HospitalBrusselsBelgium Department of Pathology Brugmann University HospitalBrusselsBelgium Laboratory of Molecular Genetics Centre for Medical GeneticsGhent University HospitalGhentBelgium

We report a case of a patient presenting with clinical,radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed,which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures,which leads to a wide spectrum of non-specific symptoms,including lumbar pain,headache,secondary hypertension,abdominal pain and renal colicky pain. CT and MR findings show characteristic features,but none are specific. Schwannoma can be isolated sporadic lesions,or associated with schwannomatosis or neurofibromatosis type Ⅱ (NF2). Although they vary in biological and clinical behavior,their presence is,in nearly every case,due to alterations or absence of the NF2 gene,which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma.

关键词：大肠炎神经纤维瘤腹膜后腔症状

用数值模拟法按低速非稳态试验结果估算相对渗透率

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世界石油科学 1991年第4期 47-58页

作者： fass.,MR 褚林涛

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稀油注空气开采项目经济分析

采油工艺情报 1997年第2期 34-46页

作者： fass.,MR 韩群业

最近发表许多有关注气开采稀油的工艺和有关注气开采稀油项目的成功与否的衡量准则方面的文章。本文讨论正在进行的，成功的注气开采稀油项目的经济性。文本还论述了为聚积和开采油环位于低压断块注空气开发的经济性分析。

关键词：稀油开发注空气经济评价

糖皮质激素对非内分泌性疾病的治疗:停药和“防护”

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国外医学(儿科学分册) 1980年第5期07卷 257-259页

作者： fass B 葛瑞祥

本文论述有关长程或短期应用糖皮质激素治疗病人的停药及对其应激的防护问题。药理学皮质醇(氢化考的松)是人体分泌的主要糖皮质激素,血循内运转的皮质醇有3种形式:75～80%和运皮质激素蛋白(Transconin)结合成非活性的转运复合物、少量... 详细信息

本文论述有关长程或短期应用糖皮质激素治疗病人的停药及对其应激的防护问题。药理学皮质醇(氢化考的松)是人体分泌的主要糖皮质激素,血循内运转的皮质醇有3种形式:75～80%和运皮质激素蛋白(Transconin)结合成非活性的转运复合物、少量疏松结合的激素-白蛋白及血浆游离皮质醇,后者能弥散入血管外体液中与组织细胞接触。临床应用的可的松和强的松本身并无生物活性,进入机体

关键词：病人应激停药糖皮质激素大剂量皮质醇肾上腺皮质