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Effect of transcutaneous electroacupuncture at Neiguan(PC 6) on refractory vomiting in patients in intensive care unit

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Journal of Traditional Chinese Medicine 2017年第4期37卷 554-557页

作者： Benoit Bataille Carine Chan-Shun Bastian Nucci Bernard Verdoux Michel Mora Pierre Cocquet stein Silva Department of Intensive Care Medicine Narbonne HospitalNarbonne F-11100France Centre Hospitalier de Narbonne Service de Réanimation PolyvalenteNarbonne F-11100France Department of Anesthesiology and Critical Care Medicine Purpan University HospitalToulouse F-31059France Department of Intensive Care Vledicine Narbonne HospitalNarbonne F-11 1 00France

OBJECTIVE: To observe the effect of transcutaneous electroacupuncture(TEA) at Neiguan(PC 6) on refractory vomiting in critically ill patients in intensive care(ICU) ***: Ten patients admitted in ICU and presenting vomiting refractory to one or more antiemetic drugs were prospectively included in the study. TEA was applied at acupoint of Neiguan(PC6) during 30 min with a neuromuscular transmission monitor(single-twitch stimulation with 1 Hz at a constant current of 10 m A). Nausea and Vomiting were evaluated at the following intervals: immediately after 30 min of TEA at Neiguan(PC 6),30 min-6h and 6-24 h. The presence of nausea and/or vomiting throughout the observational period was defined as the primary end ***: The presence of nausea or vomiting throughout the observational period was 10% at the end of TEA, 40% between 30 min and 6 h, and50% between 30 min and 24 h(P < 0.001, P = 0.01 and P = 0.03 vs pre-TEA, respectively). There were no complications or side effects related to ***: TEA at Neiguan(PC 6) seems effective in reducing refractory vomiting in the patients in ICU setting, even if larger trials are needed to define optimal modalities.

关键词： Electroacupuncture Point PC 6 (Neiguan) Nausea Vomiting Antiemetics

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Low-overhead distribution strategy for simulation and optimization of large-area metasurfaces

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npj Computational Materials 2022年第1期8卷 735-740页

作者： Jinhie Skarda Rahul Trivedi Logan Su Diego Ahmad-stein Hyounghan Kwon Seunghoon Han Shanhui Fan Jelena Vučković E.L.Ginzton Laboratory Stanford UniversityStanfordCA 94305USA Max-Planck-Institut fur Quantenoptik Hans-Kopfermann-Str.185748 GarchingGermany Department of electrical and computer engineering University of WashingtonSeattle 98195USA Samsung Advanced Institute of Technology Samsung ElectronicsSuwon-siGyeonggi-do 443-803Republic of Korea

Fast and accurate electromagnetic simulation of large-area metasurfaces remains a major obstacle in automating their *** this paper,we propose a metasurface simulation distribution strategy which achieves a linear reduction in the simulation time with the number of compute *** this distribution strategy with a GPU-based implementation of the Transition-matrix method,we perform accurate simulations and adjoint sensitivity analysis of large-area *** demonstrate ability to perform a distributed simulation of large-area metasurfaces(over 600λ×600λ),while accurately accounting for scatterer-scatterer interactions significantly beyond the locally periodic approximation.

关键词： distribution surfaces scatter

Distribution and Sources of Organic Matter in Surface Sediments of the Northern Bering and Chukchi Seas by Using Bulk and Tetraether Proxies

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Journal of Ocean University of China 2019年第3期18卷 563-572页

作者： JI Zhongqiang JIN Haiyan stein Ruediger LI Zhongqiao BAI Youcheng LI Hongliang ZHANG Yang CHEN Jianfang Key Laboratory of Marine Ecosystem and Biogeochemistry State Oceanic Administration Second Institute of Oceanography Ministry of Natural Resources Hangzhou 310012 China State Key Laboratory of Satellite Ocean Environment Dynamics Hangzhou 310012 China Alfred Wegener Institute Helmholtz Center for Polar and Marine Research Bremerhaven 27568 Germany

The organic matter (OM) preserved in Arctic Ocean sediments is of great importance to the global carbon budget. How-ever, works that apply multiple proxies to determine the distribution and concentration of organic carbon (OC) in the surface sedi-ments of the northern Bering and Chukchi Seas remain limited. Here a multiproxy approach based on bulk OM parameters and the branched vs. isoprenoid tetraether (BIT) index was used to investigate the distribution and sources of OM in the surface sediments of the northern Bering and Chukchi Seas. Binary and ternary mixing models were applied to trace the contribution of different OC sources to the total OC in the study area. The δ13C values of the sediments provided by the binary model showed that the proportion of terrestrial OC fell in the range of 27.4%–79.8% (46.2% on average). The BIT index returned the lowest fraction (4.8%–27.3%, 12.0% on average). The ternary mixing model was employed to determine the plant-, soil-, and marine-derived fractions of the total OM. The ternary model showed that 11.5%±6.3%, 31.4%±9.5%, and 57.1%±12.4% of OM in the sediment of the study area was derived from soil, plants, and marine sources, respectively. The differences in OM composition between the west and east sides of the Chukchi Sea were controlled by OM inputs from key water masses (i.e., Anadyr Water and Alaska Coastal Water), river discharge, and the nutrient supply from the Pacific inflow that supports marine productivity.

关键词： northern Bering Sea Chukchi Sea organic matter GDGTs bulk parameters

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Tracking materials science data lineage to manage millions of materials experiments and analyses

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npj Computational Materials 2019年第1期5卷 460-468页

作者： Edwin Soedarmadji Helge S.stein Santosh K.Suram Dan Guevarra John M.Gregoire Joint Center for Artificial Photosynthesis California Institute of TechnologyPasadenaCAUSA Toyota Research Institute Los AltosCA 94022USA

In an era of rapid advancement of algorithms that extract knowledge from data,data and metadata management are increasingly critical to research *** materials science,there are few examples of experimental databases that contain many different types of information,and compared with other disciplines,the database sizes are relatively *** these issues are the challenges in managing and linking data across disparate synthesis and characterization experiments,which we address with the development of a lightweight data management framework that is generally applicable for experimental science and *** years of managing experiments with this system has yielded the Materials Experiment and Analysis Database(MEAD)that contains raw data and metadata from millions of materials synthesis and characterization experiments,as well as the analysis and distillation of that data into property and performance metrics via software in an accompanying open source *** unprecedented quantity and diversity of experimental data are searchable by experiment and analysis attributes generated by both researchers and data processing *** search web interface allows users to visualize their search results and download zipped packages of data with full annotations of their *** enormity of the data provides substantial challenges and opportunities for incorporating data science in the physical sciences,and MEAD’s data and algorithm management framework will foster increased incorporation of automation and autonomous discovery in materials and chemistry research.

关键词： linking distillation autonomous

Dysregulated expression and distribution of Kif5αin neurites of wobbler motor neurons

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Neural Regeneration Research 2023年第1期18卷 150-154页

作者： Kilian Kürten Anne-Christin Gude Aimo Samuel Christian Epplen Jan stein Carsten Theiss Veronika Matschke Department of Cytology Institute of AnatomyMedical FacultyRuhr University BochumBochumGermany

Impaired axonal transport has been observed in patients with amyotrophic lateral sclerosis(ALS)and in animal models,suggesting that transport proteins likely play a critical role in the pathological mechanism of *** of Kinesin-family-member 5α(Kif5α),a neuron-specific isoform of heavy chain kinesin family,has been described in several neurological disorders,in humans and animal models,including *** this study,we determined Kif5αexpression by gene sequencing,quantitative reverse transcription-polymerase chain reaction,and western blot assay in the cervical spinal cord of wobbler mice and immunofluorescence staining in dissociated cultures of the ventral ***,we observed the distribution of Kif5αand mitochondria along motor neuronal branches by confocal *** results showed that Kif5αexpression was greatly dysregulated in wobbler mice,which resulted in altered distribution of Kif5αalong motor neuronal branches with an abnormal mitochondrial ***,our results indicate that dysregulation of Kif5 and therefore abnormal transport in motor neuronal branches in this ALS model could be causative for several pathological findings at the cellular level,like misallocation of cytoskeletal proteins or organelles like mitochondria.

关键词： amyotrophic lateral sclerosis cell culture kinesin mitochondria neurodegeneration spinal cord transport

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To scan or not to scan:Use of transient elastography in an integrated health system

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World Journal of Hepatology 2023年第3期15卷 419-430页

作者： Libby stein Rasham Mittal Hubert Song Joanie Chung Amandeep Sahota Department of Internal Medicine Kaiser Permanente Los Angeles Medical CenterLos AngelesCA 90027United States Department of Transplant Hepatology Kaiser Permanente Los Angeles Medical CenterLos AngelesCA 90027United States Research and Evaluation Kaiser Permanente Southern CaliforniaLos AngelesCA 91101United States

BACKGROUND Non-invasive tests,such as Fibrosis-4 index and transient elastography(com-monly FibroScan),are utilized in clinical pathways to risk stratify and diagnose non-alcoholic fatty liver disease(NAFLD).In 2018,a clinical decision support tool(CDST)was implemented to guide primary care providers(PCPs)on use of FibroScan for *** To analyze how this CDST impacted health care utilization and patient *** We performed a retrospective review of adults who had FibroScan for NAFLD indication from January 2015 to December 2017(pre-CDST)or January 2018 to December 2020(post-CDST).Outcomes included FibroScan result,laboratory tests,imaging studies,specialty referral,patient morbidity and *** We identified 958 patients who had FibroScan,115 before and 843 after the CDST was *** percentage of FibroScans ordered by PCPs increased from 33%to 67.1%.The percentage of patients diagnosed with early F1 fibrosis,on a scale from F0 to F4,increased from 7.8%to 14.2%.Those diagnosed with ad-vanced F4 fibrosis decreased from 28.7%to 16.5%.There were fewer laboratory tests,imaging studies and biopsy after the CDST was *** there were more specialty referrals placed after the CDST was implemented,multivariate analysis revealed that healthcare utilization aligned with fibrosis score,whereby patients with more advanced disease had more *** few patients were hospitalized or *** This CDST empowered PCPs to diagnose and manage patients with NAFLD with appropriate allocation of care towards patients with more advanced disease.

关键词： Non-alcoholic fatty liver disease Transient elastography FibroScan Clinical decision support tool Health care utilization Primary care

Investigation of the Characteristics of the 2008 Wenchuan and 2013 Lushan Earthquakes and Their Relationship

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地质学报 2013年第S1期 6-7页

作者： LIN Jian Shinji TODA Ross S.stein Mustapha MEGHRAOUI Woods Hole Oceanographic Institution Tohoku University U.S.Geological Survey EOST-Institut de Physique du Globe de Strasbourg

This presentation illustrates the characteristics of the 2008 Wenchuan and 2013 Lushan earthquakes, investigates their stress interaction, and discusses the implications on regional seismicity rate changes. In 2008, we calculated that the 12 May 2008 Mw=7.9 Wenchuan earthquake has increased Coulomb failure stress on adjacent major fault systems, including the ends of the 2008 Longmen Shan rupture,

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Observations and geophysical value-added datasets for cold high mountain and polar regions

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Big Earth Data 2022年第4期6卷 381-384页

作者： Yubao Qiu Hanna K.Lappalainen Tao Che stein Sandven Tianjie Zhao International Research Center of Big Data for Sustainable Development Goals China Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina Institute for Atmospheric and Earth System Research University of HelsinkiFinland Finnish Meteorological InstituteHelsinkiFinland Northwest Institute of Eco-Environment and Resources LanzhouChina Nansen Environmental and Remote Sensing Center BergenNorway State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina

The Earth’s cold regions,in particular,the Arctic,Antarctic,and High-Mountain Asia(HMA),are dominated by the changing cryosphere and have inherently fragile environ-ments(Guo,2018;Kulmala,2018;Guo et al.,2020;Li et al.,2020;Yao et al.,2022;Group on Earth Observations(GEO),2022).Warming has reshaped the regions where the cryo-sphere is located;it has also been affecting water availability in lowland downstream areas,opening up northern sea routes,and affecting the stability of roads and infrastruc-ture in permafrost rich areas(Pulliainen et al.,2019).Changes in the phase of water and its consequences have thus had a major impact on the environment and the lives of billions of people.

关键词： Earth geophysical Arctic

Mon enfant,mon idole Aux chiméres de macarriére,j'ai préféré monfils

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法语国家与地区研究 2003年第2期 60-64页

作者：ＢｅｎｊａｍｉｎＳｔｅｉｎ