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Associations of Adolescence Exposure to Industrial Air Pollution with Cancer in Young Adults

环境与健康(英文) 2023年第1期1卷 53-62页

作者： Ruth Lev Bar-Or Yuval Gilad Twig David M.Broday Lital Keinan-Boker Ora Paltiel ronit sinnreich Dorit Tzur Estela Derazne Raanan Raz Braun School of Public Health and Community Medicine The Hebrew University of JerusalemHadassahJerusalem 9112102Israel Faculty of Civil and Environmental Engineering Technion Israel Institute of TechnologyHaifa 32000Israel Technion Center of Excellence in Exposure Sciences and Environmental Health(TCEEH) Haifa 3200003Israel Israel Defense Forces Medical Corps Ramat Gan 5262000Israel Department of Preventive Medicine School of Public HealthSackler Faculty of MedicineTel Aviv UniversityTel Aviv 6997801Israel Institute of Endocrinology and The Gertner Institute for Epidemiology&Health Policy Research Sheba Medical CenterRamat Gan 5262000Israel Israel Center for Disease Control Israel Ministry of HealthSheba Medical CenterRamat Gan 5262000Israel School of Public Health University of HaifaHaifa 3498838Israel Department of Hematology Hadassah Medical OrganizationJerusalem 9112001Israel

There is substantial public concern about the health risks of proximity to petrochemical *** the Haifa Bay Area(HBA),which contains Israel’s densest industrial area,these concerns have been strengthened by elevated cancer mortality rates since the late *** studied the association between adolescent exposure to industrial air pollution in the HBA and adult-onset *** is a historical cohort *** study population comprised 2,187,317 subjects,using the Israeli medical corps data linked to the Israel National Cancer Registry with follow-up of up to 45 *** assessments were estimated by a spatial kriging interpolation model of SO2,serving as a marker for the dispersion of air pollution emitted from the complex during the study *** found increased crude(HR=1.23,95%CI=1.17 to 1.29)and adjusted(HR=1.16,95%CI=1.10 to 1.21)risk of cancer with increased exposure to air pollution in *** associations remained robust in analyses stratified by decade and socio-economic *** found evidence of monotonically increased risk in five of 13 cancer categories(leukemia,melanoma,female breast,central nervous system,and thyroid tumors).Our findings strengthen the hypothesis that this exposure posed a carcinogenic risk during the study period.

关键词： cancer Haifa Bay Area epidemiology public health industrial air pollution

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