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Unilateral mimicking bilateral BPPV- a forgotten entity? Characteristics of a largecohort of patients, comparison with posterior canal BPPV and clinical implications

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Journal of Otology 2021年第4期16卷 252-257页

作者： Lea Pollak ronit gilad Tal Michael Neurology and Dizziness Clinic Kupat Cholim Macabi and the Ben GurionUniversity of the NegevBeer ShevaIsrael Neurology Department Kaplan Medical CenterRechovotAffiliated to the HebrewUniversityJerusalemIsrael The Faculty of Health Public Ben Gurion University of the NegevBeerShevaIsrael

Objective: Unilateral mimicking bilateral benign paroxysmal positional vertigo (umb-BPPV) was attributed to inappropriate head positioning during testing of the posterior canal. Despite its inclusion in theDiagnostic criteria for the classification of vestibular disorders of the Barany Society, the clinical characteristics and treatment responsiveness of this BPPV subtype have not been intensively ***: Records of patients with BPPV seen at a single outpatient dizziness clinic during the years 2000e2020 were reviewed. Eighty seven patients with umb-BPPV and 86 random patients with posteriorcanal BPPV (p-BPPV) were retrieved. Their demographics and BPPV characteristics were ***: Patients' and BPPV characteristics were similar in umb- and p-BPPV except for the prevalence ofmales in the umb-BPPV group. No differences were found between treatment responsiveness and recurrences in both groups. The recurrence rate of umb-BPPV was not influenced by age, gender, BPPV side,duration of symptoms or treatment responsiveness during the first ***: In accordance with our hypothesis about mixed canalo- and cupulolithiasis as the underlying mechanism of umb-BPPV, patients did not differ in characteristics and treatment responsivenessfrom p-BPPV patients. Recognition of umb-BPPV is important since inappropriate treatment can cause anunnecessary delay in therapy success.

关键词： Benign paroxysmal positional vertigo Canalo-and cupulolithiasis

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A GHz chirped amplitude-modulated laser for high-contrast plasma gratings

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High Power Laser Science and Engineering 2024年第1期12卷 74-83页

作者： Michael Valdman Amir Hen gilad Marcus Applied Physics Institute Hebrew University of JerusalemJerusalemIsrael

The generation and control of large amplitude plasma gratings and other plasma structures is of paramount importance for the realization of plasma photonics. Autoresonant excitation of such structures by means of chirped amplitude-modulated lasers has been recently discussed and analyzed theoretically. Here we discuss the parameter space for the realization of such a scheme and describe the laser system that was built towards this goal. We also expand our earlier theoretical study to account for the more realistic case of a moderately focused laser beam, instead of the simplified plane wave approximation.

关键词： amplitude modulation high-frequency modulation autoresonance ion acoustic wave

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A simple method for pulse contrast enhancement via self-focusing

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High Power Laser Science and Engineering 2024年第2期12卷 51-61页

作者： Zaharit Refaeli gilad Marcus Yariv Shamir Applied Physics Division Soreq NRCYavneIsrael Applied Physics Institute The Hebrew UniversityThe Edmond J.Safra Campus-Givat RamJerusalemIsrael

Here we report on a simple-to-implement and cost-effective approach for laser pulse contrast enhancement,based on the χ(3)nonlinear self-focusing *** intentionally induced and gently controlled self-focusing in a thin glass transforms the time-dependent intensity into variation in beam *** by a spatial discriminating filter,only the strongly focused fraction traverses the setup,at the expense of efficiency.A numerical model,accounting for the pulse and material parameters via a Gaussian ABCD matrix,provides an estimate for the instantaneous beam waist and transmission efficiency,which enables us to evaluate the resulting contrast *** estimated contrast enhancement spans between 0.5 and 2.5 orders of magnitude,in conjunction with approximately 25%–90%estimated efficiency,depending on the pulse *** a preliminary experiment we demonstrated the effect with 10s-μJ sub GW regime with approximately 40%efficiency and a contrast improvement of more than or equal to 20 dB.

关键词： nonlinear optics pulse contrast self-focusing ultrafast laser

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用药点滴:服用西地那非发生强直阵挛性癫痫发作2例报道

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英国医学杂志中文版 2003年第2期6卷 89-90页

作者： ronit gilad Yair Lampl Yehiel Eshel Menachem Sadeh 薛兆英 Department of Neurology Wolfson Medical Center Holon 58100Israel Correspondence to:R Gilad

西地那非(Sidenafil,万艾可,俗称伟哥)是一种非特异性5型磷酸二酯酶抑制剂,对环鸟苷单磷酸酯合成酶(cGMP)具有抑制作用。一氧化氮释放增多可导致cGMP水平提高。其主要临床效应是促进海绵体平滑肌松弛,进入阴茎血流量增加,有助于勃起功... 详细信息

西地那非(Sidenafil,万艾可,俗称伟哥)是一种非特异性5型磷酸二酯酶抑制剂,对环鸟苷单磷酸酯合成酶(cGMP)具有抑制作用。一氧化氮释放增多可导致cGMP水平提高。其主要临床效应是促进海绵体平滑肌松弛,进入阴茎血流量增加,有助于勃起功能障碍的缓解。较轻的副作用为头痛、潮红、鼻塞、色彩视觉缺陷和严重的心血管、脑血管副作用,均有报道,到目前为止尚未报道属于神经系统副作用的惊厥性癫痫发作。本文作者报告2例病人在服用西地那非不久,首次发生癫痫发作。

关键词：西地那非强直阵挛性癫痫发作非特异性5型磷酸二醋酶抑制剂副作用性功能障碍

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Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

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Cellular & Molecular Immunology 2017年第5期14卷 432-442页

作者： ronit Mazor Devorah Crown Selamawit Addissie Youjin Jang gilad Kaplan Ira Pastan Laboratory of Molecular Biology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Leidos Biomedical Research Inc National Cancer Institute National Institutes of Health Bethesda MD USA

Antibodies against the toxin portion of recombinant immunotoxins （RIT） reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SSIP to produce LMB-T20, a de-immunized RIT that has the eight human T-cell epitopes in SSIP modified or removed. To determine the effect of T-cell epitope removal in vivo we mapped the T-cell epitopes in immune-competent BALB/c mice and found that these mice recognize two epitopes. One corresponds to the human immunodominant T-cell epitope and the other to a human subdominant epitope; both were eliminated in LMB-T20. We found that mice immunized with LMB-T20 did not have T-cell activation and did not develop anti-drug antibodies （ADA）, whereas mice immunized with SSIP, showed T-cell activation, and developed ADA detected by both ELISA and drug neutralizing assays. The ability of the mice treated with LMB-T20 to respond to other antigens was not compromised. We conclude that elimination of T-cell epitopes is sufficient to prevent formation of antibodies to an immunogenic foreign protein.

关键词： anti-drug antibodies deimmunization immunogenicity mouse epitopes T-cell epitopes

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Postnatal therapeutic approaches in genetic neurodevelopmental disorders

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Neural Regeneration Research 2021年第3期16卷 414-422页

作者： gilad Levy Boaz Barak The Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael The School of Psychological Sciences Faculty of Social SciencesTel Aviv UniversityTel AvivIsrael

Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes,affecting individuals *** the subject has been heavily researched,current treatment options relate mostly to alleviating symptoms,rather than targeting the altered genome *** this review,we address the neurogenetic basis of neurodevelopmental disorders,genetic tools that are enabling precision research of these disorders in animal models,and postnatal gene-therapy approaches for neurodevelopmental disorders derived from preclinical studies in the laboratory.

关键词： adeno-associated virus CRISPR-Cas9 developmental window genetic therapy mouse models neurodevelopmental disorders non-human primates preclinical studies

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Comparison of dissimilarity measures for cluster analysis of X-ray diffraction data from combinatorial libraries

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npj Computational Materials 2017年第1期3卷 448-456页

作者： Yuma Iwasaki A.gilad Kusne Ichiro Takeuchi IoT Devices Research Laboratories NEC CorporationTsukuba 305-8501Japan Spin Quantum Rectification Project ERATOJapan Science and Technology AgencySendai 980-8577Japan National Institute of Standards and Technology GaithersburgMD 20899USA Department of Materials Science and Engineering University of MarylandCollege parkMD 20742USA

Machine learning techniques have proven invaluable to manage the ever growing volume of materials research data produced as developments continue in high-throughput materials simulation,fabrication,and *** particular,machine learning techniques have been demonstrated for their utility in rapidly and automatically identifying potential composition-phase maps from structural data characterization of composition spread libraries,enabling rapid materials fabrication-structure-property analysis and functional materials discovery.A key issue in development of an automated phase-diagram determination method is the choice of dissimilarity measure,or kernel *** desired measure reduces the impact of confounding structural data issues on analysis *** issues include peak height changes and peak shifting due to lattice constant change as a function of *** this work,we investigate the choice of dissimilarity measure in X-ray diffraction-based structure analysis and the choice of measure’s performance impact on automatic composition-phase map *** dissimilarity measures are investigated for their impact in analyzing X-ray diffraction patterns for a Fe-Co-Ni ternary alloy composition *** cosine,Pearson correlation coefficient,and Jensen-Shannon divergence measures are shown to provide the best performance in the presence of peak height change and peak shifting(due to lattice constant change)when the magnitude of peak shifting is *** prior knowledge of the maximum peak shifting,dynamic time warping in a normalized constrained mode provides the best *** work also serves to demonstrate a strategy for rapid analysis of a large number of X-ray diffraction patterns in general beyond data from combinatorial libraries.

关键词： alloy shifting analysis

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Associations of Adolescence Exposure to Industrial Air Pollution with Cancer in Young Adults

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环境与健康(英文) 2023年第1期1卷 53-62页

作者： Ruth Lev Bar-Or Yuval gilad Twig David M.Broday Lital Keinan-Boker Ora Paltiel ronit Sinnreich Dorit Tzur Estela Derazne Raanan Raz Braun School of Public Health and Community Medicine The Hebrew University of JerusalemHadassahJerusalem 9112102Israel Faculty of Civil and Environmental Engineering Technion Israel Institute of TechnologyHaifa 32000Israel Technion Center of Excellence in Exposure Sciences and Environmental Health(TCEEH) Haifa 3200003Israel Israel Defense Forces Medical Corps Ramat Gan 5262000Israel Department of Preventive Medicine School of Public HealthSackler Faculty of MedicineTel Aviv UniversityTel Aviv 6997801Israel Institute of Endocrinology and The Gertner Institute for Epidemiology&Health Policy Research Sheba Medical CenterRamat Gan 5262000Israel Israel Center for Disease Control Israel Ministry of HealthSheba Medical CenterRamat Gan 5262000Israel School of Public Health University of HaifaHaifa 3498838Israel Department of Hematology Hadassah Medical OrganizationJerusalem 9112001Israel

There is substantial public concern about the health risks of proximity to petrochemical *** the Haifa Bay Area(HBA),which contains Israel’s densest industrial area,these concerns have been strengthened by elevated cancer mortality rates since the late *** studied the association between adolescent exposure to industrial air pollution in the HBA and adult-onset *** is a historical cohort *** study population comprised 2,187,317 subjects,using the Israeli medical corps data linked to the Israel National Cancer Registry with follow-up of up to 45 *** assessments were estimated by a spatial kriging interpolation model of SO2,serving as a marker for the dispersion of air pollution emitted from the complex during the study *** found increased crude(HR=1.23,95%CI=1.17 to 1.29)and adjusted(HR=1.16,95%CI=1.10 to 1.21)risk of cancer with increased exposure to air pollution in *** associations remained robust in analyses stratified by decade and socio-economic *** found evidence of monotonically increased risk in five of 13 cancer categories(leukemia,melanoma,female breast,central nervous system,and thyroid tumors).Our findings strengthen the hypothesis that this exposure posed a carcinogenic risk during the study period.

关键词： cancer Haifa Bay Area epidemiology public health industrial air pollution

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Leg or antenna injury in Cataglyphis ants impairs survival but does not hinder searching for food

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Current Zoology 2022年第4期68卷 441-450页

作者： Tomer gilad Arik Dorfman Aziz Subach Inon Scharf School of Zoology Faculty of Life SciencesTel Aviv University69978 Tel AvivIsrael

Injury is common in nature resulting,for example,from fighting,partial predation,or the wear of body *** is costly,expressed in impaired performance,failure in competition,and a shorter life span.A survey of the literature revealed the frequent occurrence of injury in ants and its various *** examined whether leg or antenna injury impacts food-discovery time and reduces the likelihood of reaching food in workers of the desert ant Cataglyphis *** examined the search-related consequences of injury in groups of either 4 or 8 workers searching for food in a short arena,a long arena,and a *** conducted a small field survey to evaluate the prevalence of injury in the studied ***,we compared the survival rates of injured versus uninjured workers in the *** was common in the field,with almost 9%of the workers collected out of the nest,found to be *** workers survived shorter than uninjured ones and there was a positive link between injury severity and ***,we could not detect an effect of injury on any of the searching-related response variables,neither in the arenas nor in the mazes *** suggest that workers that survive such injury are only moderately affected by it.

关键词： binary-tree maze desert ants foraging injury movement review survival

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ConfDTree: A Statistical Method for Improving Decision Trees

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Journal of Computer Science & Technology 2014年第3期29卷 392-407页

作者： gilad Katz Asaf Shabtai Lior Rokach Nir Ofek Department of Information Systems Engineering Ben-Gurion University of the NegevBeer Sheva 8410501Israel Telekom Innovation Laboratories Ben-Gurion University of the NegevBeer Sheva 8410501Israel

Decision trees have three main disadvantages： reduced performance when the training set is small; rigid decision criteria; and the fact that a single ＂uncharacteristic＂ attribute might ＂derail＂ the classification process. In this paper we present ConfDTree （Confidence-Based Decision Tree） -- a post-processing method that enables decision trees to better classify outlier instances. This method, which can be applied to any decision tree algorithm, uses easy-to-implement statistical methods （confidence intervals and two-proportion tests） in order to identify hard-to-classify instances and to propose alternative routes. The experimental study indicates that the proposed post-processing method consistently and significantly improves the predictive performance of decision trees, particularly for small, imbalanced or multi-class datasets in which an average improvement of 5%-9% in the AUC performance is reported.

关键词： decision tree confidence interval imbalanced dataset

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