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Applied Mathematics and Mechanics(English Edition) 2023年第1期44卷 1-20页

作者： Jianlin YI Zheng WU rongyu xia Zheng LI State Key Laboratory for Turbulence and Complex Systems College of EngineeringPeking UniversityBeijing 100871China

Elastic wave absorption at subwavelength scale is of significance in many engineering applications.Non-Hermitian metamaterials show the ability in high-efficiency wave absorption.However,the single functionality of metamaterials is an important limitation on their practical applications for lack of tunability and reconfigurability.Here,we propose a tunable and reconfigurable non-Hermitian piezoelectric metamaterial bar,in which piezoelectric bars connect with resonant circuits,to achieve asymmetric unidirectional perfect absorption(UPA)and symmetric bidirectional perfect absorption(PA)at low frequencies.The two functions can be arbitrarily switched by rearranging shunted circuits.Based on the reverberation-ray matrix(RRM)method,an approach is provided to achieve UPA by setting an exceptional point(EP)in the coupled resonant bandgap.By using the transfer matrix method(TMM)and the finite element method(FEM),it is observed that a non-Hermitian pseudo-band forms between two resonant bandgaps,and the EP appears at the bottom of the pseudo-band.In addition,the genetic algorithm is used to accurately and efficiently design the shunted circuits for desired low-frequency UPA and PA.The present work may provide new strategies for vibration suppression and guided waves manipulation in wide potential applications.

关键词： non-Hermitian metamaterial exceptional point(EP) unidirectional perfect absorption(UPA) piezoelectric metamaterial reverberation-ray matrix(RRM)method genetic algorithm

Theoretical analysis of surface waves in piezoelectric medium with periodic shunting circuits

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1287-1304页

作者： Youqi ZHANG rongyu xia Jie XU Kefu HUANG Zheng LI State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering SciencePeking UniversityBeijing 100871China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina

The investigations of surface waves in the piezoelectric medium bring out great possibility in designing smart surface acoustic wave(SAW)devices.It is important to study the dispersion properties and manipulation mechanism of surface waves in the semi-infinite piezoelectric medium connected with periodic arrangement of shunting circuits.In this study,the extended Stroh formalism is developed to theoretically analyze the dispersion relations of surface waves under different external circuits.The band structures of both the Rayleigh wave and the Bleustein-Gulyaev(BG)wave can be determined and manipulated with proper electrical boundary conditions.Furthermore,the electromechanical coupling effects on the band structures of surface waves are discussed to figure out the manipulation mechanism of adjusting electric circuit.The results indicate that the proposed method can explain the propagation behaviors of surface waves under the periodic electrical boundary conditions,and can provide an important theoretical guidance for designing novel SAW devices and exploring extensive applications in practice.

关键词： metamaterial phononic crystal surface wave piezoelectricity electromechanical coupling Stroh formalism

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南海北部海面高度的季节内变异及其传播特征

热带海洋学报 2019年第3期38卷 1-12页

作者：王霞方文东陈荣裕中国科学院广州地球化学研究所广东广州510640 热带海洋环境国家重点实验室(中国科学院南海海洋研究所) 广东省海洋遥感重点实验室广东广州510301 中国科学院大学北京100049

利用25年(1993-2017)的卫星高度计资料,采用复经验正交函数(complex empirical orthogonal function, CEOF)方法,分析南海北部海区海面高度季节内变异的时空分布及传播特征。标准差分析表明,南海北部海面高度的季节内变异(intra-seasona... 详细信息

利用25年(1993-2017)的卫星高度计资料,采用复经验正交函数(complex empirical orthogonal function, CEOF)方法,分析南海北部海区海面高度季节内变异的时空分布及传播特征。标准差分析表明,南海北部海面高度的季节内变异(intra-seasonal variability of sea level anomalies, SLA-ISV)在沿陆坡外侧区较强,且 SLA-ISV 表现出明显的季节性变化,冬半年强于夏半年。 CEOF 前两个主要模态能较好地揭示研究海区 SLA-ISV 的时空分布及其传播特征,并表明 SLA-ISV的强度受到季节性变化和年际变化的调制。全年 CEOF 的第一模态揭示 SLA-ISV 从台湾岛西南至西沙群岛以东区域的冬半年西南向传播特征;而全年 CEOF 的第二模态则表现了 SLA-ISV 分别在台湾岛西南和东沙群岛西南的西南向传播特征。南海北部中尺度涡季节变化统计分析表明, CEOF 的分解结果与南海北部的涡旋活动一致。

关键词：南海北部海面高度异常季节内变异复经验正交函数分解中尺度涡

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ARL4C的生物功能及其与肿瘤的相关性

泌尿外科杂志（电子版） 2023年第1期15卷 82-87页

作者：张培志崔子连康维亭韩荣雨夏庆华山东大学山东省立医院泌尿外科山东济南250021 山东第一医科大学附属省立医院(山东省立医院)泌尿外科山东济南250021

癌症是目前威胁人类健康的最常见的疾病之一。越来越多的证据表明,癌症是一种人类基因组疾病。因此,探究导致癌症的相关基因及其发病机制成为目前癌症治疗研究的热点。ADP-核糖基化因子4c(ADP-ribosylation factor-like 4c,ARL4C)属于... 详细信息

癌症是目前威胁人类健康的最常见的疾病之一。越来越多的证据表明,癌症是一种人类基因组疾病。因此,探究导致癌症的相关基因及其发病机制成为目前癌症治疗研究的热点。ADP-核糖基化因子4c(ADP-ribosylation factor-like 4c,ARL4C)属于三磷酸鸟苷(guanosine triphosphate,GTP)结合蛋白家族,在1999年由Jacobs等首次从人膀胱上皮细胞中检测到该分子cDNA的全长编码序列。本文概述了ARL4C分子结构及生物学功能,同时总结了其在肺癌、结直肠癌、胃癌、胰腺癌、原发性人胶质母细胞瘤、卵巢癌、肾癌等肿瘤中的研究进展。希望通过本文的概述,能够为研究ARL4C与癌症的发生、发展的相关性及相关信号通路提供思路,进而为肿瘤的治疗提供新的靶点以及预后标记物。

关键词： ARL4C 分子生物学肿瘤靶向治疗

三氟苯嘧啶与呋虫胺对贵州褐飞虱种群的增效作用及田间防效

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世界农药 2022年第4期44卷 49-54页

作者：石宇贺民荣吴帅夏福金李荣玉廖逊李明贵州大学作物保护研究所贵阳550025 贵州大学贵州省山地农业病虫害重点实验室贵阳550025 贵州大学农学院贵阳550025

为明确贵州褐飞虱田间种群对三氟苯嘧啶与呋虫胺的敏感性,采用稻苗浸渍法测定了三氟苯嘧啶、呋虫胺及两者混用组合对贵州黄平、湄潭、惠水3地褐飞虱田间种群的室内毒力。结果表明,湄潭田间褐飞虱种群对三氟苯嘧啶产生了低水平抗性,另外... 详细信息

为明确贵州褐飞虱田间种群对三氟苯嘧啶与呋虫胺的敏感性,采用稻苗浸渍法测定了三氟苯嘧啶、呋虫胺及两者混用组合对贵州黄平、湄潭、惠水3地褐飞虱田间种群的室内毒力。结果表明,湄潭田间褐飞虱种群对三氟苯嘧啶产生了低水平抗性,另外2个地区褐飞虱种群对三氟苯嘧啶仍处于敏感水平。黄平和惠水褐飞虱种群对呋虫胺表现为中等水平抗性,抗性倍数分别为59和27.64,而湄潭褐飞虱种群则表现为高抗水平,抗性倍数为177.43。当三氟苯嘧啶与呋虫胺以质量比为1∶5组合时,增效作用最为显著,其共毒系数(CTC)为751.03,LC50为0.2819 mg/L;田间施用后7 d对褐飞虱的防效高达96.21%,显著高于呋虫胺(77.62%)和三氟苯嘧啶(80.61%)单剂;田间施用后21 d防效仍高达98.04%,显示出比呋虫胺或三氟苯嘧啶单剂更好的持续防效。该结果可为褐飞虱的增效组合用药以减缓褐飞虱抗药性、农药减量增效及科学合理使用提供参考。

关键词：褐飞虱三氟苯嘧啶呋虫胺增效作用防治效果

模块化高温超导磁储能系统辅助微网模式切换的应用研究

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低温与超导 2018年第4期46卷 23-26,38页

作者：夏亚君宋萌李媛媛张立晖苏荣宇广东电网有限责任公司电力科学研究院广州510080 华中科技大学强电磁工程与新技术国家重点实验室武汉430074

超导磁储能系统(SMES)由于具有快速响应能力和较高的储能密度,能够有效地平衡微电网中分布式电源与负荷之间的不平衡功率。近年来随着微电网规模的扩大,单台SMES由于容量限制,难以满足储能需求。本文引入模块化超导磁储能系统,并在Matla... 详细信息

超导磁储能系统(SMES)由于具有快速响应能力和较高的储能密度,能够有效地平衡微电网中分布式电源与负荷之间的不平衡功率。近年来随着微电网规模的扩大,单台SMES由于容量限制,难以满足储能需求。本文引入模块化超导磁储能系统,并在Matlab/Simulink平台搭建微网模型,进行仿真实验,仿真结果显示模块化SMES能够增大微电网在并网/孤岛运行模式切换过程中的惯性,提高微电网的功率调节能力,保证微电网的安全稳定运行。

关键词：模块化SMES 微电网模式切换功率调节

巫山李家滩出土大口折肩青铜尊探微——兼据同类尊的风格和关键工艺探讨其年代和扩散

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南方民族考古 2017年第1期 131-187页

作者：苏荣誉中国科学院自然科学史研究所中国科学院大学南京艺术学院

巫山李家滩出土的大口折肩尊应是迄今所知峡江地区发现的时代最早的青铜器,属于具有牺首和鸟饰的高浮雕纹类型,牺首以贴片铸铆式后铸而纹饰由模一芯合作而成,具有典型的商代南方型青铜器特点,与六安淠河、岳阳费家河、江陵八姑台、枣阳... 详细信息

巫山李家滩出土的大口折肩尊应是迄今所知峡江地区发现的时代最早的青铜器,属于具有牺首和鸟饰的高浮雕纹类型,牺首以贴片铸铆式后铸而纹饰由模一芯合作而成,具有典型的商代南方型青铜器特点,与六安淠河、岳阳费家河、江陵八姑台、枣阳新店、广汉三星堆出土的,以及颐和园、东京国立博物馆、上海博物馆、赛克勒博物馆等收藏的造型、纹饰和工艺一致。本文即是通过对器物所蕴含的风格和技术要素进行提取和分析,揭示它们间的内在联系,展现它们在风格和技术上的同源性以及制作年代的同时性。本文尝试依据尊肩部装饰对大口折肩尊进行类型划分和分析,通过这些尊铸铆式后铸牺首和高浮雕纹饰在器内壁相应下凹两个代表性特征,爬梳源流,将其年代推定在中商中、晚期,它们同铸于南方作坊,出自两、三代铸工之手。其广泛的分布可以看作中商时期文化扩展的遗产,也曾深刻影响了殷墟青铜器的风格和工艺。殷墟青铜器接受了南方风格和工艺,尊有高浮雕纹饰但内壁却不下凹,牺首不用铸铆式后铸而是榫接式,铸铆式后铸用于其他器物,这些技术选择应体现了一些青铜铸造的组织状况。与商代南方青铜器风格的形成、发展和式微相应,安阳青铜工业迅即臻于鼎盛当和南方的影响有关,迁入工匠或是重要一途,南方铸铜作坊也被同时毁弃。

关键词：青铜器大口折肩尊铸铆式后铸模芯合作纹

Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial

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Cancer Communications 2021年第9期41卷 889-903页

作者： Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang xiaohong Wu xiaoli Zhu Shuhua Han Qisen Guo rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021P.R.China Department of Oncology Yibin Second People’s HospitalYibinSichuan 644000P.R.China Department of Oncology Liuzhou People’s HospitalLiuzhouGuangxi 545006P.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFuzhouFujian 350014P.R.China Oncology Department the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233030P.R.China Department of Oncology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510030P.R.China Department of Internal medicine Linyi Cancer HospitalLinyiShandong 276002P.R.China Department of Thoracic Surgery the Affiliated Cancer Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510095P.R.China Department of Internal Medicine-Oncology/Department of thoracic oncology Henan Chest HospitalZhengzhouHenan 450003P.R.China The Second Department of Radiotherapy Wuwei Cancer Hospital of Gansu ProvinceWuweiGansu 730000P.R.China Department of Oncology the People’s Hospital of Jiangsu ProvinceNanjingJiangsu 210000P.R.China Respiratory Medicine Department Shanghai East HospitalShanghai 200120P.R.China The Second Department of Internal Medicine-Oncology Xuzhou Central HospitalXuzhouJiangsu 221009P.R.China Oncology Department Tangshan People’s HospitalTangshanHebei 063001P.R.China Respiratory Medicine Department West China Hospital of Sichuan UniversityChengduSichuan 610041P.R.China Thoracic Surgery the Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515051P.R.China Internal Medicine-Oncology Hunan Cancer HospitalChangshaHunan 410013P.R.China Department of Oncology Xiangyang Central HospitalXiangyangHubei 441021P.R.China Respiratory Department Lishui Central HospitalLishuiZ

Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically m

关键词： anti-angiogenesis anti-VEGF monoclonal antibody avastin bevacizumab biosimilar nonsmall cell lung cancer LY01008 vascular endothelial growth factor

一种防水功能手术包在泌尿外科腔内手术中的设计与应用

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中华腔镜泌尿外科杂志（电子版） 2021年第4期15卷 309-312页

作者：宋丽刘燕杰李沪生郭澍颜容宇陆益盛夏海军军医大学长海医院泌尿外科上海200433 海军军医大学长海医院骨关节外科上海200433

目的探讨自行改良设计的一种腔内手术用防水功能手术包,在泌尿外科手术中的应用效果。方法选取2019年5月至8月在我院行电切手术的240例患者为研究对象,便利抽样法分为观察组(n=120)和对照组(n=120);观察组使用改良后防水功能手术包,... 详细信息

目的探讨自行改良设计的一种腔内手术用防水功能手术包,在泌尿外科手术中的应用效果。方法选取2019年5月至8月在我院行电切手术的240例患者为研究对象,便利抽样法分为观察组(n=120)和对照组(n=120);观察组使用改良后防水功能手术包,对照组使用传统布类手术包,比较两组患者的手术区域污染情况、术后低体温发生率、术后手术间清整时间以及术后医护人员使用的满意程度。结果观察组手术区域污染率(手术室地面、患者切口周围、术者衣物、患者衣物、手术床)、术后患者感染、术中低体温、术中皮肤潮红、术后手术间清整时间以及术后手术医师满意度评分、护士护理满意度评分、分别为(6.67%、7.50%、13.33%、10%、11.67%)、10.83%(13/120)、7.50%(9/120)、6.67%(8/120)(、10.6±1.5)min(、91±3)分(,92±4)分,而对照组分别为(18.33%、18.33%、27.50%、23.33%、8.33%)、22.5%(27/120)、23.33%(28/120)、20.83%(25/120)(、19.5±2.6)min(、80±3)分、(90±5)分;两组间的差异均有统计学意义(P<0.05)。结论自行改良泌尿外科防水功能手术包实用性强,减少了污染,提高了护理工作效率,推荐在腔内手术中广泛使用。

关键词：手术包防水传统布料感染低体温

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辛丰九号辣椒的选育

长江蔬菜 2015年第20期 46-47页

作者：顾朝兵夏承东方大伟陈六胜周容羽王亚男安徽徽大农业有限公司合肥230088

辛丰九号是以不育系A11-086为母本,恢复系R11-056为父本,配制而成的中(晚)熟辣椒杂种一代。生长势特强,抗性好,适应性广,坐果能力强,果实线形,嫩果深绿色,成熟果深红色,商品性好。

关键词：辣椒辛丰九号杂交一代选育