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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu Lan Yang Min Li Haozhou Shu Na Jia Yunzhen Gao rongying shi Xiaojia Yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate from<5%by 5-FU alone to~80.1%.This nanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

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A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2263-2280页

作者： Leilei Wang Shanshan He Rong Liu Yuan Xue Yuan Quan rongying shi Xueying Yang Qing Lin Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer ***,the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment(TME).Here,we developed a pH/reactive oxygen species(ROS)dual-response system to enhance chemoimmunotherapy for *** system productively accumulated in tumors by specific binding of phenylboronic acid(PBA)to sialic acids(SA).The nanoparticles(NPs)rapidly swelled and released quercetin(QUE)and doxorubicin(DOX)upon the stimulation of tumor microenvironment(TME).The in vitro and in vivo results consistently demonstrated that the NPs improved anti-tumor efficacy and prolonged survival of mice,significantly enhancing the effects of the *** study revealed DOX was an ICD inducer,stimulating immune responses and promoting maturation of dendritic cells(DCs).Additionally,QUE served as a TME regulator by inhibiting the cyclooxygenase-2(COX2)-prostaglandin E2(PGE2)axis,which influenced various immune cells,including increasing cytotoxic T cells(CLTs)infiltration,promoting M1 macrophage polarization,and reducing regulatory T cells(Tregs)*** combination synergistically facilitated chemoimmunotherapy efficacy by remodeling the immunosuppressive *** work presents a promising strategy to increase anti-tumor efficiency of chemotherapeutic agents.

关键词： Quercetin Nanoparticle Responsiveness Chemoimmunotherapy Tumor immune microenvironment

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The Influence of Third-party Evaluation on the Development of Detergent Products in China

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China Detergent & Cosmetics 2019年第2期4卷 24-30页

作者： shi rongying shi Aiqin Shanghai Hutchison Whitecat Co.Ltd.

The development and function of the third-party testing platform and the evaluation of detergent products by domestic professional third-party evaluation organizations were summarized. The evaluation methods and indexes of hand washing dish detergent and fabric detergent by different third-party evaluation organizations were also concluded. The influence of third-party evaluation on the development of detergent products in China is presented.

关键词： dish detergent laundry detergent laundry powder third-party evaluation

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Ecological Design of Household Detergent

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China Detergent & Cosmetics 2019年第4期4卷 25-29页

作者： shi rongying shi Aiqin Shanghai Hutchison Whitecat Co. Ltd.

This paper analyze the current domestic and foreign situation of ecological environment and elaborate the ecological design ideas of household detergent,from the perspective of consumer concerns and product life cycle... 详细信息

关键词： environmentally friendly green formula ecological package green production tag mark

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Formula Development of Special Detergent for Automatic Household Dishwasher

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China Detergent & Cosmetics 2020年第2期5卷 57-60页

作者： Gao Juan shi rongying Shanghai Hutchison Whitecat Co. Ltd.China

The composition of raw materials in the formula was determined by the fluidity and stability tests of the dishwashing ***,chelators and polymers were determined for the dishwashing powder formulated with specific *** detergency of the final formula was tested in laboratory and the feedback from consumers was also obtained,the results of which indicated that the dishwashing powder formula showed good detergency.

关键词： dishwashing powder automatic dishwasher formula detergency

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高效液相色谱-电雾式检测器(HPLC-CAD)法测定洗洁精中多种表面活性剂

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环境化学 2022年第11期41卷 3828-3830页

作者：徐艳丽石荣莹杨艳上海和黄白猫有限公司上海200231 赛默飞世尔科技中国有限公司上海20000

建立了高效液相色谱-电雾式检测器(HPLC-CAD)法测定洗洁精中多种表面活性剂含量.使用了Acclaim Surfactant Plus表面活性剂专用柱(150 mm×3.0 mm,3μm),乙腈-10 mmol·L^(−1)乙酸铵水溶液为流动相,流速0.6 mL·min^(−1),采集频率10 Hz... 详细信息

建立了高效液相色谱-电雾式检测器(HPLC-CAD)法测定洗洁精中多种表面活性剂含量.使用了Acclaim Surfactant Plus表面活性剂专用柱(150 mm×3.0 mm,3μm),乙腈-10 mmol·L^(−1)乙酸铵水溶液为流动相,流速0.6 mL·min^(−1),采集频率10 Hz.各表面活性剂分离情况良好,标准曲线线性关系良好(R2≥0.99),平均回收率95.4%—105.3%,RSD为0.90%—1.65%,定量测定了洗洁精中多种表面活性剂含量.

关键词：高效液相色谱-电雾式检测器 Surfactant 表面活性剂柱表面活性剂洗洁精.

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Quantitative Evaluation Method of Amylase Performance in Detergents for Hand Dishwashing

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China Detergent & Cosmetics 2019年第4期4卷 66-68页

作者： Ye Xiao shi rongying Shanghai Hutchison Whitecat Co. Ltd.

An evaluation method was designed for reference in the experiment,which was further verified by investigating the changes of various factors,including additive amount of enzyme,washing temperature,soaking time,pH value and amylase source,*** on tests and comparison,it is confirmed that this method can effectively and quantitatively evaluate the performance of amylase in detergents for hand dishwashing.

关键词： detergents for hand dishwashing amylase performance evaluation

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