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SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Radl-Husl to counteract DNA replication stress

Journal of Molecular Cell Biology 2018年第5期10卷 460-474页

作者： Xiaoli Xu rongyi shi Li Zheng Zhigang Guo Liangyan Wang Mian Zhou Ye Zhao Bing Tian Khue Truong Yuan Chen Binghui Shen Yuejin Hua Hong Xu Institute of Nuclear-Agricultural Sciences Zhejiang University Hangzhou 310029 China Department of Cancer Genetics and Epigenetics City of Hope National Medical Center and Beckman Research Institute Duarte CA 91010 USA Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences Nanjing Normal University Nanjing 210046 China Department of Molecular Medicine City of Hope National Medical Center and Beckman Research Institute Duarte CA 91010 USA

Human flap endonuclease 1 （FEN1） is a structure-specific, multi-functional endonuclease essential for DNA replication and repair. We and others have shown that during DNA replication, FEN1 processes Okazaki fragments via its interaction with the proliferating cell nuclear antigen （PCNA）. Alternatively, in response to DNA damage, FEN1 interacts with the PCNA-like Radg-Radl-Husl complex instead of PCNA to engage in DNA repair activities, such as homology-directed repair of stalled DNA replication forks. However, it is unclear how FEN1 is able to switch between these interactions and its roles in DNA replication and DNA repair. Here, we report that FEN1 undergoes SUMOylation by SUMO-1 in response to DNA replication fork-staUing agents, such as UV irradiation, hydroxyurea, and mitomycin C. This DNA damage-induced SUMO-1 modification promotes the interaction of FEN1 with the Radg-Rad1-Husl complex. Furthermore, we found that FEN1 mutations that prevent its SUMO-1 modification also impair its ability to interact with HUS1 and to rescue stalled replication forks. These impairments lead to the accumulation of DNA damage and heightened sensitivity to fork-staUing agents. Altogether, our findings suggest an important role of the SUMO-1 modification of FEN1 in regulating its roles in DNA replication and repair.

关键词： flap endonuclease 1 Rad9-Rad1-Hus1 complex replication stress SUMOylation

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论立法腐败

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中共郑州市委党校学报 2006年第6期 105-106,108页

作者：史荣易郑州广播电视学校新闻传媒系河南郑州450052

立法腐败是立法中的“设租”行为。立法腐败严重损害了社会的公平正义理念,损害了人民政权的合法性,也是造成社会不稳定的一个重要因素。要通过构筑违宪审查制度；实行开门立法,建立民众参与机制；推行立法回避制度,建构遏制立法腐败的... 详细信息

立法腐败是立法中的“设租”行为。立法腐败严重损害了社会的公平正义理念,损害了人民政权的合法性,也是造成社会不稳定的一个重要因素。要通过构筑违宪审查制度；实行开门立法,建立民众参与机制；推行立法回避制度,建构遏制立法腐败的程序性屏障；放宽新闻审查制度,加强新闻媒体对国家立法活动的宣传和监督等途径预防和治理立法腐败。

关键词：立法腐败 "设租"行为利益驱动

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论焦裕禄的领导艺术

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中共郑州市委党校学报 2009年第4期 90-92页

作者：史荣易郑州广播电视学校基础教学部河南郑州450002

焦裕禄的领导艺术,是焦裕禄在解决实际问题时表现出来的才能、智慧和技巧,是他对领导科学的创造性运用,是他纯正党性的真实写照。在深入贯彻落实科学发展观的实践中,要认真领会和掌握焦裕禄科学进行决策和实施的领导艺术,团结干部的领... 详细信息

焦裕禄的领导艺术,是焦裕禄在解决实际问题时表现出来的才能、智慧和技巧,是他对领导科学的创造性运用,是他纯正党性的真实写照。在深入贯彻落实科学发展观的实践中,要认真领会和掌握焦裕禄科学进行决策和实施的领导艺术,团结干部的领导艺术,榜样示范、以点带面的领导艺术,善于走群众路线的领导艺术,运用制度建设推动工作的领导艺术。

关键词：焦裕禄领导艺术现代楷模

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Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

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An uncertainty investigation for liner impedance eduction methods

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Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： Weihao shi Xiaodong JING School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

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No Reference Image Sharpness Assessment Based on Global Color Difference Variation

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Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models

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Quantization and Event-Triggered Policy Design for Encrypted Networked Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia shi Ehsan Nekouei the Department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

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Families of Schmidt-number witnesses for high dimensional quantum states

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Communications in Theoretical Physics 2024年第8期76卷 44-51页

作者： Xian shi College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Higher dimensional entangled states demonstrate significant advantages in quantum information processing tasks. The Schmidt number is a quantity of the entanglement dimension of a bipartite state. Here we build families of k-positive maps from the symmetric information complete positive operator-valued measurements and mutually unbiased bases, and we also present the Schmidt number witnesses, correspondingly. At last, based on the witnesses obtained from mutually unbiased bases, we show the distance between a bipartite state and the set of states with a Schmidt number less than k.

关键词： Schmidt number entanglement witness mutually unbiased bases

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The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin YU Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

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Fast nuclear-spin gates and electrons−nuclei entanglement of neutral atoms in weak magnetic fields

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Frontiers of physics 2024年第2期19卷 179-203页

作者： Xiao-Feng shi School of Physics Xidian UniversityXi’an 710071China

We present a novel class of Rydberg-mediated nuclear-spin entanglement in divalent atoms with global laser ***,we show a fast nuclear-spin controlled phase gate of an arbitrary phase realizable either with two laser pulses when assisted by Stark shifts,or with three ***,we propose to create an electrons−nuclei-entangled state,which is named a super bell state(SBS)for it mimics a large Bell state incorporating three small Bell ***,we show a protocol to create a three-atom electrons-nuclei entangled state which contains the three-body W and Greenberger−Horne−Zeilinger(GHZ)states *** protocols possess high intrinsic fidelities,do not require single-site Rydberg addressing,and can be executed with large Rydberg Rabi frequencies in a weak,Gauss-scale magnetic *** latter two protocols can enable measurement-based preparation of Bell,hyperentangled,and GHZ states,and,specifically,SBS can enable quantum dense coding where one can share three classical bits of information by sending one particle.

关键词： nuclear-spin qubit electrons−nuclei entanglement super Bell state Greenberger−Horne−Zeilinger state Rydberg-mediated entanglement quantum dense coding

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