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Dl-3-n butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance

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Stroke & Vascular Neurology 2022年第3期7卷 222-236页

作者： Kangping Song Xiuli Zeng Xiaomei xie rongxuan Zhu Jianye Liang Guobing Chen Li’an Huang Department of Neurology Jinan University First Affiliated HospitalGuangzhouChina Medical Imaging Center Jinan University First Affiliated HospitalGuangzhouChina Institute of Geriatric Immunology Medical college of Jinan UniversityGuangzhouChina

Background Cerebral venous disorder may have a harmful effect on ischaemic stroke;however,the underlying mechanism remains to be elucidated.Although Dl-3-n butylphthalide is a multitarget agent for antiischaemic stroke,its neuroprotective role in brain ischaemia accompanied by brain venous disturbance remains unclear.In this study,we induced cerebral venous disturbance by the occlusion of bilateral external jugular veins(EJVs)to explore the potential mechanism of the adverse effects of cerebrovenous disorders in cerebral infarction and explore the protective effect of Dl-3-n butylphthalide on cerebral infarction accompanied through cerebral venous disturbance.Methods Cerebral venous disturbance was induced in Sprague-Dawley rats through the permanent occlusion of bilateral EJVs,and cerebral ischaemic stroke was induced through the permanent occlusion of the right cortical branches of the middle cerebral artery.2,3,5-triphenyltetrazolium chloride staining,MRI,Evans blue extravasation and behavioural test were performed to evaluate infarction volume,cerebral blood flow(CBF),blood-brain barrier(BBB)integrity and neurological function.Immunofluorescence staining and western blot analysis were performed to detect loss of neuron,endothelial cells,pericytes and tight junctions.Results Bilateral EJVs occlusion did not cause cerebral infarction;however,it increased the infarction volume compared with the simple middle cerebral artery occlusion(MCAO)group,accompanied by severe neuron loss,worse neurological function,lower CBF,increased EJVs pressure,exacerbated Evans blue extravasation and brain oedema,as well as attenuated angiogenesis.Dl-3-n butylphthalide displayed a neuroprotective effect in rats with MCAO accompanied by EJVs occlusion by reducing neuron loss,accelerating CBF restoration,promoting angiogenesis and relieving BBB damage.Conclusion Bilateral EJVs occlusion did not significantly affect normal rats but aggravated brain damage in the case of ischaemic stroke.Dl-3-n butylphthalide treatment plays a neuroprote

关键词： protective infarction disturbance

One-step laser induced conversion of a gelatin-coated polyimide film into graphene:Tunable morphology,surface wettability and microsupercapacitor applications

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Science China(Technological Sciences) 2021年第5期64卷 1030-1040页

作者： WANG WenTao LU LongSheng xie YingXi LI ZeHong WU WeiBin LIANG rongxuan TANG Yong School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510641China College of Engineering South China Agricultural UniversityGuangzhou 510642China

Latest advances have witnessed the laser induction process on polyimide(PI)films for the formation of porous graphene.Herein,a fully converted graphene film was prepared by Nd:YAG laser scribing a gelatin coated PI film.It was found that the gelatin played the role of"shield"well in absorbing intense laser impact and benefit for the surface morphology modulation.Laser treatment lower than a critical fluence point of~4.00 J mm^(-2) contributed to a crater-like surface morphology due to the dispersed nature of Nd:YAG laser beam.By tuning laser fluence above the threshold,carbonized surface turned into continuous morphology.A fluid dynamics process accompanied by outgassing occurred during the carbonization,and the surface morphology gradually varied from stretched droplets to porous strips and finally to amorphous porous structures.The morphology evolution in combination with surface chemistry is responsible for the significant wettability transition from superhydrophobic to superhydrophilic,and a Janus superhydrophobic/superhydrophilic surface wettability was achieved under a laser fluence of~8.00 J mm^(-2).Eventually,microsupercapacitors(MSCs)were fabricated to show the great potential of our prepared graphene in flexible electronics.

关键词： laser-induced graphene gelatin morphology transition microsupercapacitor flexible electronics

Controlling the laser induction and cutting process on polyimide films for kirigami-inspired supercapacitor applications

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Science China(Technological Sciences) 2021年第3期64卷 651-661页

作者： WANG WenTao LU LongSheng xie YingXi WU WeiBin LIANG rongxuan LI ZeHong TANG Yong School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510641China College of Engineering South China Agricultural UniversityGuangzhou 510642China

The recently emerging laser-induced graphene(LIG)technology,with one-step processing and designable features,has been widely used in the fabrication of wearable/portable electronics.Herein,by taking inspiration from kirigami,we designed a stretchable supercapacitor(SC)step by step through controlling laser induction and cutting process on the polyimide(PI)film,with the use of one single CO_(2) laser source.Firstly,the carbonized basic geometric units of lines were produced on PI films to investigate the processing-structure relationships.Then,the complex photothermal conversion and heat transfer progress involved in the carbonized process were simulated by a photothermal model.Both experimental and theoretical results suggested that the laser power,scan rate and focus condition have great influence on the size,shape and morphology of the carbonized lines.Finally,we optimized the parameters of laser induction and cutting process to fabricate the kirigami-inspired SCs with reliable electrochemical properties and editable mechanical flexibility,showing great potential in the field of flexible electronics.

关键词： laser-induced grapheme laser cutting photothermal conversion model kirigami supercapacitor

An easy-to-implement method for fabricating superhydrophobic surfaces inspired by taro leaf

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Science China(Technological Sciences) 2021年第12期64卷 2676-2687页

作者： LI KaiKai LEI Jiang xie YingXi LU LongSheng ZHANG ShaoHui ZHOU PeiYang LIANG rongxuan WAN ZhenPing TANG Yong School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510641China Division of Interdisciplinary and Comprehensive Research Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700China College of Engineering South China Agricultural UniversityGuangzhou 510642China

An easy-to-implement method by which to fabricate superhydrophobic surfaces inspired taro leaf was successfully applied on316 L stainless steel via combining nanosecond laser(NL)processing and spin-coating techniques.The laser-textured surface composed of microscale frameworks and central bumps was fabricated by NL processing based on properly designed biomimetic patterns,and a layer of nanoscale carbon black/polydimethylsiloxane(CB/PDMS)particles was covered on it by spin-coating.The effect of pattern parameters(i.e.,the inscribed circle radius of framework and the radius of central bump)on wettability of biomimetic surface was investigated.All as-prepared biomimetic surfaces with micro-nano hierarchical structures showed excellent superhydrophobicity with the water contact angle of~155°and contact angle hysteresis of~2°.By comparing the untreated surface,the wetting behavior and evaporation mode of the biomimetic surface occurred an obvious transformation.Meanwhile,experiments indicated that the biomimetic surface not only had liquid-repelling and self-cleaning functions,but also maintained remarkable mechanical robustness and superhydrophobic durability.The method is efficient for fabricating biomimetic superhydrophobic surfaces applied to liquid-repelling,evaporation-transforming and self-cleaning fields.

关键词： taro leaf superhydrophobic surface micro-nano hierarchical structures robustness durability

绿色矿山建设探索与实践：以江西下垄钨业樟斗矿区为例

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中国矿业 2019年第12期28卷 77-81页

作者：谢琳龙立学赖荣旋明小泉江西省地质调查研究院江西南昌330001 大余县自然资源局江西大余341500 江西省地矿局九一二地质大队江西鹰潭335001

为践行习近平总书记提出的“绿水青山就是金山银山”的理念,矿产资源开发作为生态文明建设的重要组成部分,保护矿产资源就是保护生态环境的具体体现,矿产资源绿色开发也是促进经济社会可持续发展的关键途径。本文介绍江西下垄钨业樟斗... 详细信息

为践行习近平总书记提出的“绿水青山就是金山银山”的理念,矿产资源开发作为生态文明建设的重要组成部分,保护矿产资源就是保护生态环境的具体体现,矿产资源绿色开发也是促进经济社会可持续发展的关键途径。本文介绍江西下垄钨业樟斗矿区在绿色矿山建设过程中所取得的经验和产生的成效,以及利用促进资源绿色开发带动矿业转型升级所取得的综合效益,具有推广示范意义,充分体现了绿色矿山建设是我国矿业经济发展的重要手段也是必要措施,随着我国生态环境的日趋恶化,矿业开发必须走绿色发展道路。

关键词：绿色矿山矿业开发樟斗矿区

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基于变分贝叶斯推理的多目标无源定位算法

南京邮电大学学报（自然科学版） 2018年第2期38卷 48-53,59页

作者：余东平何谢齐扬阳赖荣煊袁健陆军工程大学通信工程学院江苏南京210007 中国人民解放军91605部队福建厦门361101 中国人民解放军73903部队福建厦门361100 国防信息学院湖北武汉430010

为提高多目标无源定位的精度和鲁棒性,文中提出了一种基于变分贝叶斯推理的多目标无源定位算法。该算法首先建立分层的混合高斯先验模型以诱导目标位置向量的稀疏性;然后,利用变分贝叶斯推理的方法估计该先验模型中隐藏变量的后验分布;... 详细信息

为提高多目标无源定位的精度和鲁棒性,文中提出了一种基于变分贝叶斯推理的多目标无源定位算法。该算法首先建立分层的混合高斯先验模型以诱导目标位置向量的稀疏性;然后,利用变分贝叶斯推理的方法估计该先验模型中隐藏变量的后验分布;最后,根据目标位置向量的后验分布估计目标的位置。仿真结果表明,该算法较传统的基于压缩感知的多目标无源定位算法具有更高的定位精度以及更好的鲁棒性。

关键词：无线传感器网络多目标无源定位压缩感知变分贝叶斯推理

平顶山瘦煤煤焦固定床二氧化碳催化气化动力学研究

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煤炭转化 2019年第3期42卷 34-39页

作者：赵志刚余可查荣轩解乐乐张小勇凌强崔平安徽工业大学化学与化工学院安徽马鞍山博士副教授243002 安徽科达洁能股份有限公司安徽马鞍山博士后243071

以K_2CO_3负载后的平顶山瘦煤煤焦为研究对象,在内径为20mm的固定床反应器中对其二氧化碳催化气化反应动力学进行了研究。考察了K_2CO_3的负载对平顶山瘦煤黏结性的影响,确定了消除气化反应内外扩散影响的实验条件。在750℃～900℃范围... 详细信息

以K_2CO_3负载后的平顶山瘦煤煤焦为研究对象,在内径为20mm的固定床反应器中对其二氧化碳催化气化反应动力学进行了研究。考察了K_2CO_3的负载对平顶山瘦煤黏结性的影响,确定了消除气化反应内外扩散影响的实验条件。在750℃～900℃范围内,测定了平顶山瘦煤煤焦的碳转化率与时间的关系。采用均相模型和缩核模型对实验结果进行拟合,得到了焦样二氧化碳催化气化反应的反应速率常数、反应活化能和指前因子。结果表明,K_2CO_3对平顶山瘦煤具有显著的破黏和催化气化效果。利用均相模型和缩核模型均能对平顶山瘦煤煤焦的二氧化碳催化气化反应动力学起到较好的预测效果。

关键词：固定床催化气化气化反应动力学碳转化率均相模型

2020—2022年湖北省生猪屠宰场伪狂犬病病毒的分离鉴定及遗传进化分析

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畜牧兽医学报 2023年第7期54卷 2972-2981页

作者：陈宏建曹艳樊杰甘荣萱宋文博喻盛炜杨婷赵艳霞魏春燕谢锐华琳彭忠吴斌华中农业大学动物医学院农业微生物学国家重点实验室武汉430070 生猪健康养殖协同创新中心武汉430070 湖北洪山实验室武汉430070

旨在监测湖北省生猪屠宰场中伪狂犬病病毒(pseudorabies virus,PRV)的流行情况。采集2020—2022年湖北省4个区域(鄂东、鄂北、鄂西、鄂中)共9个县市不同规模屠宰场的1795份血液样品和2081份肺样品(肺、肺门淋巴结),分别使用靶向PRV gE... 详细信息

旨在监测湖北省生猪屠宰场中伪狂犬病病毒(pseudorabies virus,PRV)的流行情况。采集2020—2022年湖北省4个区域(鄂东、鄂北、鄂西、鄂中)共9个县市不同规模屠宰场的1795份血液样品和2081份肺样品(肺、肺门淋巴结),分别使用靶向PRV gE基因的ELISA和PCR方法检测血清中的抗体和肺样品中的病原,同时对阳性样品进行病原分离鉴定、全基因组测序和遗传进化分析。血清学检测结果显示,共有104份样品为阳性,平均阳性检出率为5.79%。病原学检测结果显示,共有82份样品为阳性,平均阳性检出率为3.94%。按不同因素对检出率进行分析,显示抗体和病原都在春季检出率最高,分别为18.57%和9.74%;湖北省东部的抗体检出率最高(10.77%),中部的病原检出率最高(4.93%);A类小型屠宰场的病原和抗体检出率都显著高于其他3个类型,分别为16.28%和6.01%。从病原阳性样品中共分离到PRV 17株,经全基因组和gB、gC、gE基因遗传进化分析结果显示均属于基因Ⅱ型变异株,与Bartha、NIA-3、Becker等早期国外分离株处于不同的遗传进化分支。其中HBXG疑似发生了基因Ⅰ型毒株与基因Ⅱ型毒株的重组,与早期报道的重组病毒HuB1/CHN2017同处于独立的clade2.2遗传分支。综上所述,湖北省屠宰场关联的猪场中主要流行PRV变异毒株,且免疫过疫苗的猪场还在发生疫苗株与野毒的重组与变异,因此本研究对PRV的持续监测与新型疫苗的研发工作有十分重要的意义。

关键词：伪狂犬病病毒生猪屠宰场血清学检测病原学检测遗传进化分析

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粘结性烟煤预氧化破粘技术的研究进展

广东化工 2018年第7期45卷 145-146页

作者：赵志刚解乐乐查荣轩谢瑞伦潘罗成安徽工业大学化学与化工学院"煤洁净转化与综合利用"安徽省重点实验室安徽马鞍山243002

预氧化技术是一种可以有效的破除烟煤粘结性的方法,可扩大粘结性烟煤的应用范围,提高企业的经济效益。本文对国内外预氧化破粘工艺的特点、破粘效果、破粘机理及存在的问题进行了综述,可以为相关的研究提供一定的借鉴。

关键词：烟煤破粘预氧化进展