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Journal of Pharmaceutical Analysis 2016年第3期6卷 184-189页

作者： rongshan li Ruixue Ran Quansheng li Yurong Huang Yuan Gu Duanyun Si Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) School of Pharmacy Tianjin Medical University State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research

Deoxyglycychloxazol （TY501） is a glycyrrhetinic acid derivative which exhibits high anti-inflammatory activity and reduced pseudoaldosteronism compared to glycyrrhetinic acid. In this study, a sensitive and rapid liquid chromatography-tandem mass spectrometry （LC-MS/MS） method was established for the quantitation of TY501 in rat plasma. Plasma samples were treated by precipitating protein with methanol and supernatants were separated by a Symmetry C8 column with the mobile phase consisting of methanol and 10 mM ammonium formate （containing 0.1% of formic acid）（90：10, v/v）. The selected reaction monitoring （SRM） transitions were performed at m/z 647.4→191.2 for TY501 and m/z 473.3→143.3 for astragaloside aglycone （IS） in the positive ion mode with atmospheric pressure chemical ionization （APCI） source. Calibration curve was linear over the concentration range of 5-5000 ng/mL. The lower limit of quantification was 5 ng/mL. The mean recovery was over 88%. The intra- and inter-day precisions were lower than 6.0% and 12.8%, respectively, and the accuracy was within ± 1.3%. TY501 was stable under usual storage conditions and handling procedure. The validated method has been successfully applied to a pharmacokinetic study after oral administration of TY501 to rats at a dosage of 10 mg/kg.

关键词： Deoxyglycychloxazol (TY501) LC-MS/MS APCI Pharmacokinetics Rat plasma

Inonotus obliquus(Chaga)against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway

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Chinese Journal of Natural Medicines 2024年第7期22卷 619-631页

作者： FENG Yating liU Jing GONG Le HAN Zhaodi ZHANG Yan li rongshan liAO Hui School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China Drug Clinical Trial Institution The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China Department of Nephrology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China

Our prior investigations have established that Inonotus obliquus(Chaga)possesses hypoglycemic *** hyperglycemia is known to precipitate renal function *** functionality of the kidneys is intricately linked to the levels of cyclic guanosine-3',5'-monophosphate(cGMP),which are influenced by the activities of nitric oxide synthase(NOS)and phosphodiesterase(PDE).Enhanced cGMP levels can be achieved either through the upregulation of NOS activity or the downregulation of PDE *** objective of the current study is to elucidate the effects of Chaga on disorders of glucolipid metabolism and renal abnormalities in rats with type 2 diabetes mellitus(T2DM),while concurrently examining the NOS-cGMP-PDE5 signaling pathway.A model of T2DM was developed in rats using a high-fat diet(HFD)combined with streptozotocin(STZ)administration,followed by treatment with Chaga extracts at doses of 50 and 100 mg·kg^(−1)for eight *** findings revealed that Chaga not only mitigated metabolic dysfunctions,evidenced by improvements in fasting blood glucose,total cholesterol,triglycerides,and insulin resistance,but also ameliorated renal function markers,including serum creatinine,urine creatinine(UCr),blood urea nitrogen,24-h urinary protein,and estimated creatinine ***,enhancements in glomerular volume,GBM thickness,podocyte foot process width(FPW),and the mRNA and protein expressions of podocyte markers,such as nephrin and wilms tumor-1,were *** was found to elevate cGMP levels in both serum and kidney tissues by increasing mRNA and protein expressions of renal endothelial NOS and neural NOS,while simultaneously reducing the expressions of renal inducible NOS and *** summary,Chaga counteracts HFD/STZ-induced glucolipid metabolism and renal function disturbances by modulating the NOS-cGMP-PDE5 signaling *** research supports the potential application of Chaga in the clinical prevention and treatment of T2DM and

关键词： Inonotus obliquus Diabetic nephropathy Glucolipid metabolism disorders Renal functions NOS-cGMP-PDE5 signaling

Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese popula- tion： a cross-section study

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Frontiers of Medicine 2014年第4期8卷 477-483页

作者： Jie Zheng Yuzhen Gao Yuejuan Jing Xiaoshuang Zhou Yuanyuan Shi Yanhong li lihua Wang Ruiying Wang Maolian li Chuanshi Xiao Yafeng li rongshan li School of Nursing Shanxi Medical University Taiyuan 030001 China Department of Cardiology Second Hospital of Shanxi Medical University Taiyuan 030001 China Department of Nephrology and Hemodialysis Center Second Hospital of Shanxi Medical University Taiyuan 030001 China Shanxi Renal Disease Research Institution Taiyuan 030001 China Department of Cardiology First Hospital of Shanxi Medical University Taiyuan 030001 China Department of Nephrology and Hemodialysis Center Shanxi Provincial People's Hospital Taiyuan 030012 China

The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose （FPG） levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects （1027 men, and 2433 women, aged 35-75 years old） who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose （IFG） was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels （lowest tertiles, FPG： 5.376 ± 0.018; middle tertiles, 5.324± 0.018; highest tertiles, 5.276±0.018mmol/L; P = 0.001）. Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level （OR： 1.75; 95% CI： 1.20-2.56）. In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.

关键词： dyslipidemia plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes

MicroRNA-21 in the pathogenesis of acute kidney injury

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Protein & Cell 2013年第11期4卷 813-819页

作者： Ya-Feng li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan liu lihua Wang rongshan li Department of Nephrology and Hemodialysis Center Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Shanxi Renal Disease Research Institution Taiyuan 030001China Department of Blood Purifi cation General Hospital of Jinan Military Command of PLAJinan 250031China Nephrology Institute of PLA Changzheng Hospital of Second Military Medical UniversityShanghai 200003China Department of Neuroscience and Neurovirology Temple University School of MedicinePhiladelphiaPA 19140USA Department of Urology Shanghai First People’s HospitalShanghai 200080China Department of Nephrology and Hemodialysis Center Shanxi Provincial People’s HospitalTaiyuan 030012China

Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or ***,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat ***,the mech-anisms modulating the pathogenesis of AKI still remain largely ***(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene ***-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in *** a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing *** article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI.

关键词： microRNA microRNA-21 gene expression acute kidney injury

Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment

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Bioactive Materials 2021年第11期6卷 3865-3878页

作者： Tao Zhang Hui liu ling li Zhaoyang Guo Jia Song Xiaoying Yang Guoyun Wan rongshan li Yinsong Wang Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of PharmaceuticsSchool of PharmacyTianjin Medical UniversityTianjin300070China The Key Laboratory of Biomedical Material School of Life Science and TechnologyXinxiang Medical UniversityXinxiang453003China

Triple-negative breast cancer(TNBC)is an aggressive subset of breast cancer and currently lacks effective therapeutic *** two main phototherapeutic methods,photothermal therapy(PTT)and photodynamic therapy(PDT)show many advantages in TNBC treatment,and their combination with chemotherapy can achieve synergistic therapeutic *** the present study,a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane(LPHM)and dendritic large pore mesoporous silicon nanoparticles(DLMSNs).A near infrared(NIR)fluorescent dye IR780 and a chemotherapeutic drug doxorubicin(DOX)were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780(DDI)nanoparticles(NPs),followed by camouflage with LPHM to obtain LPHM@DDI *** the mediation of LPHM,LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances in vitro and in *** NIR laser irradiation,LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells,and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and *** synergistic effects were sourced from the combination of PTT/PDT and ***,this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment.

关键词： Leukocyte/platelet hybrid membrane Dendritic large pore mesoporous silica nanoparticles Triple-negative breast cancer Phototherapy Chemotherapy

权力与伦理:韦伯支配社会学中的国家理由问题

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社会 2020年第3期40卷 1-31页

作者：李荣山上海大学社会学院

韦伯在权力与伦理之间的纠结,鲜明地体现了马基雅维里主义"国家理由"学说的双重性。和马基雅维里一样,韦伯看到,随着近代国家的兴起,政治成为一个独立的价值领域,与其他价值领域相冲突,但又不能彻底脱离其他价值领域。因此,他拒绝纯粹... 详细信息

韦伯在权力与伦理之间的纠结,鲜明地体现了马基雅维里主义"国家理由"学说的双重性。和马基雅维里一样,韦伯看到,随着近代国家的兴起,政治成为一个独立的价值领域,与其他价值领域相冲突,但又不能彻底脱离其他价值领域。因此,他拒绝纯粹信念伦理,主张效果取向的责任伦理。不仅如此,他还直面马基雅维里时代尚未凸显的现代官僚制问题,把政体伦理降格为行政管理的正当性,从而使官僚制与伦理的关系问题走向前台。从这个意义上说,韦伯是一位"新马基雅维里主义者"。韦伯没能也无意彻底解决权力与伦理的冲突,他接受政治的"手段-目的"在伦理上的不一致之非理性现实,但他留下的官僚制与伦理的关系问题早已不只是一个德国问题,更是一个当代政治的普遍问题。今后中国的国家和社会治理研究不仅要从制度层面,还要从观念层面解释中国如何从传统伦理性的"家产官僚制"演变成今天的官僚制。

关键词：权力伦理支配国家理由官僚制

社会文化科学的有效性问题——马克斯·韦伯论因果关系的客观性

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学海 2010年第4期 70-75页

作者：李荣山江苏省社会科学院社会政策研究所

韦伯的科学学说,本质上是一种因果学说。在韦伯那里,社会文化科学的有效性取决于因果关系的客观性。本文考察了两种因果关系(因果法则与具体因果关系)的逻辑形式,以及与之对应的两种客观性(法则的客观性与价值关联的客观性),指出价值关... 详细信息

韦伯的科学学说,本质上是一种因果学说。在韦伯那里,社会文化科学的有效性取决于因果关系的客观性。本文考察了两种因果关系(因果法则与具体因果关系)的逻辑形式,以及与之对应的两种客观性(法则的客观性与价值关联的客观性),指出价值关联客观性对保证具体因果解释客观性的关键作用,并比较了李凯尔特与韦伯对价值关联客观性的论述,最终澄清了韦伯对社会文化科学有效性的看法。

关键词：社会文化科学因果关系价值关联客观性

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自然状态的历史化与共同体学说的兴起

广东社会科学 2019年第6期 185-193页

作者：李荣山上海大学社会学院

社会理论中共同体学说的兴起,是现代政治哲学历史化的产物。现代政治哲学的核心概念“自然状态”首先在政治哲学内部经历了历史化,继而在历史主义取向的历史哲学中经历了激进的历史化。历史主义决定性地颠倒了自然状态的性质,用历史的... 详细信息

社会理论中共同体学说的兴起,是现代政治哲学历史化的产物。现代政治哲学的核心概念“自然状态”首先在政治哲学内部经历了历史化,继而在历史主义取向的历史哲学中经历了激进的历史化。历史主义决定性地颠倒了自然状态的性质,用历史的自然状态取代了虚构的自然状态,提出了自然状态即是社会状态的主张。历史的自然状态是家庭状态,家庭成了共同体的原型。这种思想的形成标志着共同体学说的兴起,也是此后种种共同体学说的基本前提。共同体学说的兴起,代表着西方重寻“家园感”的努力。

关键词：自然状态历史化共同体家庭

从共生到共识:费孝通晚年的“补课”——兼论文化自觉的文明比较维度

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学海 2022年第1期 38-50页

作者：李荣山上海大学社会学院上海200444

费孝通先生晚年的"补课",既包括中学也包括西学,分别对应文化自觉内外用力的两个方面,本文着重考察了其补西学的一面。费先生之所以在耄耋之年花费极大的精力从帕克入手补西学,是因为文明比较是文化自觉的内在维度。费先生回顾帕克一生... 详细信息

费孝通先生晚年的"补课",既包括中学也包括西学,分别对应文化自觉内外用力的两个方面,本文着重考察了其补西学的一面。费先生之所以在耄耋之年花费极大的精力从帕克入手补西学,是因为文明比较是文化自觉的内在维度。费先生回顾帕克一生学行,看到族群接触中有共生无共识的问题是美国移民社会面临的根本困难。在全球化时代,这个美国的特殊问题已经演变成了全世界面临的共同问题:全球在经济层面已经连接成一个共生体系,在文化价值层面却远没有达成共识,反倒有陷入"文明冲突"之虞。如何再造一个与全球共生体系相配的共识体系?这是费先生晚年文化自觉念兹在兹的核心问题。他看到西方的社会团结模式有其内在缺陷,无法提供再造共识的恰切方案,转而反求诸己,在儒家文明的根本理念和中华民族多元一体格局的历史经验中看到了希望,在全球化时代取中西之长,激活"克己复礼"的中国智慧,提出全球礼治秩序的"和而不同"原则,倡导创建一个"和而不同"的全球社会。

关键词：费孝通文化自觉文明比较和而不同帕克

文明比较与文化自觉:迈向和而不同的比较历史社会学

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中国社会科学 2022年第9期 162-182,208页

作者：李荣山上海大学社会学院上海手200444

长期以来,比较历史社会学研究深陷“非西方社会为什么没有发展出现代资本主义”的韦伯式问题意识,错失了基于中国文明主体的提问。有必要立足中国文明自身重新发问,批判地检讨韦伯比较历史社会学的得失,以期讲出中国道理。这就需要采取... 详细信息

长期以来,比较历史社会学研究深陷“非西方社会为什么没有发展出现代资本主义”的韦伯式问题意识,错失了基于中国文明主体的提问。有必要立足中国文明自身重新发问,批判地检讨韦伯比较历史社会学的得失,以期讲出中国道理。这就需要采取中国文明的内部视角,从“世界图像”和“利益”两个层次重构中国文明的“理念型”。中国文明由于人性论上的优长,能够开辟出一条“将心比心”的“礼”治之路,为世界贡献一种真正和而不同的普遍主义,有助于再造文明间共识,构建一个和而不同的全球社会。

关键词：虚实相生和而不同文明比较文化自觉