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What did the bronze eye-like prism tell us?

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Science China(Life Sciences) 2014年第4期57卷 445-447页

作者： he RongDing he rongqiao The Fine Arts College Chengdu University Institute of Biophysics Chinese Academy of Sciences

In 1986, the Sanxingdui （＂Three-Star Mound＂） Relics were discovered in Guanghan City of Sichuan Province in China. Two major sacrificial pits were excavated and thousands of treasures were discovered, including bronze artifacts, jade wares and potteries. These relics have unveiled the history of the ancient Shu Kingdom during the era of the Shang Dynasty, which ruled about 3000-4000 years ago [1]. Amongst the bronze artifacts were human heads （13 from Pit 1, and 44 from Pit 2） and faces （one from Pit 1 and 20 from Pit 2） with their eyes divided along a dorsoventral borderline, suggesting that the people of the Shu Kingdom had a unique point of view on human eye.

关键词：青铜器棱镜青铜文物四川省广汉市三星级三星堆眼睛

A novel molecular mechanism for nitrated α-synuclein-induced cell death

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分子细胞生物学报:英文版 2011年第4期3卷 239-249页

作者： Yanying Liu Min Qiang Yan Wei rongqiao he State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China Key Laboratory of Mental health Institute of PsychologyChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China

Although previous studies have demonstrated the involvement of nitrated a-synuclein in neurodegenerative disorders(synucleinopathies),the effects of nitrated α-synuclein and the molecular mechanisms underlying its toxicity are still *** the present study,nitrated α-synuclein with four 3-nitrotyrosines(Tyr^(39),Tyr^(125),Tyr^(133),and Tyr^(136))was obtained non-enzymatically by incubation with *** nitrated protein existed as a mixture of monomers,dimers,and polymers in *** nitrated a-synuclein could induce cell death in a time-and concentration-dependent manner when SH-SY5Y cells(a human neuroblastoma cell line)were incubated with the dimers and *** with anti-integrin α5β1 antibody partially rescued the SH-SY5Y cells from the cell *** blotting and immunoprecipitation revealed that the nitrated protein bound to integrin on the cell *** of nitric oxide(NO)and calcium-independent inducible NO synthase(iNOS)activity increased during the initial stages of the *** expression of phosphorylated focal adhesion kinase(FAK)decreased in the ***,an increase in caspase 3 activity was observed in SH-SY5Y *** results demonstrate that activation of iNOS and inhibition of FAK may both be responsible for the cell death induced by nitrated α-*** data suggest that the cytotoxicity of nitrated a-synuclein is mediated via an integrin-iNOS/-FAK signaling pathway,and that the nitration of α-synuclein plays a role in neuronal degeneration.

关键词： nitric oxide nitration neuronal death toxicity focal adhesion kinase calcium-independent inducible nitric oxide synthase

Human neuronal tau promoting the melting temperature of DNA

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Chinese Science Bulletin 2000年第11期45卷 999-1002页

作者： Qian Hua rongqiao he Acad Sinica Inst Biophys Lab Visual Informat Proc Beijing 100101 Peoples R China

The hyperchromic effect of ultraviolet spectroscopy shows that adding recombinant human neuronal tau to the solution of calf thymus DNA will promote the melting temperature (Tm) from 67℃ to 81 ℃. Similar result has been detected when adding tau to plasmid pBluescript-Ⅱ SK, by raising Tm from 75℃ to 85℃. The kinetics of thermal denaturation of DNA with tau is much slower than that of control. It suggests that tau may stabilize the double helix conformation of DNA.

关键词： human neuronal tau DNA Tm of DNA double helix of DNA denaturation.

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Formaldehyde stress

Science China(Life Sciences) 2010年第12期53卷 1399-1404页

作者： he rongqiao LU Jing MIAO JunYe State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China

Formaldehyde,one of the most toxic organic compounds,is produced and processed in human *** level of human endogenous formaldehyde is maintained at a low concentration(0.01-0.08 mmol L-1 in blood) under physiological conditions,but the concentration increases during ageing(over 65 years old).Clinical trials have shown that urine formaldehyde concentrations are significantly different between elderly Alzheimer’s patients(n=91) and normal elderly volunteers(n=38)(Phe concentration of *** impairments of the brain resulted from formaldehyde stress could be one of the mechanisms involved in the process of senile dementia during ageing.

关键词： formaldehyde Alzheimer’s disease senile dementia stress cognition impairment hyperphosphorylation

Introduction to the thematic issue “From brain function to therapy”

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Science China(Life Sciences) 2014年第4期57卷 363-365页

作者： BARTLETT Perry F he rongqiao Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

This thematic issue of Science China Life Sciences, ＂From brain function to therapy＂, highlights some of the exciting research being undertaken in the Joint Laboratory of Neu- roscience and Cognition, an international scientific collabo- ration between the Queensland Brain Institute （QBI） at The University of Queensland and the Institute of Biophysics （IBP） within the Chinese Academy of Sciences.

关键词：脑功能治疗中国社科院物理研究所生命科学专题联合实验室昆士兰

Hypomagnetic field,an ignorable environmental factor in space?

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Science China(Life Sciences) 2014年第7期57卷 726-728页

作者： MO WeiChuan LIU Ying he rongqiao State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences

All living organisms on the earth have been exposed to the geomagnetic field （GMF, -50 μT）, a nature component of the habitability environment, throughout the evolutionary history. However,

关键词：环境因素空间组成部分居住环境进化史

Formation of a new fluorescence of human neuronal tau protein

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Chinese Science Bulletin 1999年第3期44卷 233-236页

作者： Jianying Luo Wei Li rongqiao he Chinese Acad Sci Inst Biophys Grp Mol Neurobiol & Dev Biol Lab Visual Informat Proc Beijing 100101 Peoples R China McGill Univ Dept Neurol & Neurosurg Montreal PQ H3A 2T5 Canada

A new fluorescence at 333 nm formed when the solution of human neuronal tau protein was incubated at 37℃. The maximum excitation was at 230 and 280 nm respectively with the quantum yield of about 0.02. It took about 30 h for the complete formation of the new fluorescence and the light scattering increased with the formation procedure. It suggests that the fluorescence resulted from the aggregation of tau molecules in solution.

关键词： tau protein fluorescence paired helical filaments (PHF) Alzheimer’s disease (AD).

The role of the N-methyl-D-aspartate receptor in the proliferation of adult hippocampal neural stem and precursor cells

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Science China(Life Sciences) 2014年第4期57卷 403-411页

作者： TAYLOR Chanel J he rongqiao BARTLETT Perry F Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

New neurons are continuously generated from resident pools of neural stem and precursor cells(NSPCs)in the adult *** are multiple pathways through which adult neurogenesis is regulated,and here we review the role of the N-methyl-D-aspartate receptor(NMDAR)in regulating the proliferation of NSPCs in the adult ***-dependent learning tasks,enriched environments,running,and activity-dependent synaptic plasticity,all potently up-regulate hippocampal NSPC *** first consider the requirement of the NMDAR in activity-dependent synaptic plasticity,and the role the induction of synaptic plasticity has in regulating NSPCs and newborn *** address how specific NMDAR agonists and antagonists modulate proliferation,both in vivo and in vitro,and then review the evidence supporting the hypothesis that NMDARs are present on *** believe it is important to understand the mechanisms underlying the activation of adult neurogenesis,given the potential that endogenous stem cell populations have for repopulating the hippocampus with functional new *** conditions such as age-related memory decline,neurodegeneration and psychiatric disease,mature neurons are lost or become defective;as such,stimulating adult neurogenesis may provide a therapeutic strategy to overcome these conditions.

关键词： adult neurogenesis stem cell precursor cell NMDA receptor hippocampus synaptic plasticity long-term potentiation(LTP)

The potential role of albumin glycation by ribose in diabetes mellitus

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Science China(Life Sciences) 2022年第12期65卷 2552-2555页

作者： Lixian Mou Xiao Cao Tao he rongqiao he Basic College of Medicine Southwest Medical UniversityLuzhou 646099China Institute of Biophysics University of Chinese Academy of SciencesBeijing 100101China

Human serum albumin (HSA) is one of the most abundant plasma proteins and accounts for 50%–60%of total plasma proteins. HSA has various physiological and biochemical properties, undergoing different structural and conformational changes, which involves transport and ligand-binding characteristics, enzyme activities, and antioxidant properties(Rabbani and Ahn, 2019).

关键词： mellitus diabetes potential