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Evaluation of several recently developed sampling strategies within the coarse pixel scale for validation of coarse-resolution satellite albedo products

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International Journal of Digital Earth 2022年第1期15卷 2319-2334页

作者： rongqi tang Xiaodan Wu Jingping Wang Qicheng Zeng Zheng Li Jianguang Wen College of Earth and Environmental Sciences Lanzhou UniversityLanzhouPeople’s Republic of China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China

Due to the spatial heterogeneity and the spatial scale mismatch between in situ and satellite-based measurements,optimal ground sampling should be made to increase the representativeness of in situ observations. Therefore,many ground sampling strategies have been proposed,but their performance within the coarse pixel has not been evaluated. Hence,this study evaluated four typical methods regarding their ability to obtain pixel scale ground ‘truth’. Random combination (RC) performs best,with the always fewest samples to satisfy representativeness errors (REs) of 3% in the case of a small number of samples. When the goal of sampling is to obtain in situ measurements with REs close to 0 at the expense of increasing the number of samples,cumulative representativeness sampling (CRS) is more effective than RC in less heterogeneous areas. Geo-statistical model-based sampling (GSS) does not work well because the number of samples within the coarse pixel scale cannot support a robust semi-variogram model. Stratified sampling (SS) is highly dependent on spatial heterogeneity and does not work well in the case of small sample sizes. This study gives important guidance for ground sample deployment within the coarse pixel for validation of coarse-resolution satellite albedo products over a heterogeneous surface.

关键词： Sampling spatial heterogeneity validation representative observations coarse-pixel scale

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自由旋气动窗口设计原理及其工作性能的初步实验研究

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中国激光 2000年第1期27卷 23-27页

作者：刘天华姜宗福韦成华唐荣奇陈金宝赵伊君国防科技大学应用物理系长沙410073

论述了自由旋气动窗口（ＦＡＤＷ）的基本工作原理，并对为万瓦级ＣＯ２气动激光器配置的３０ｍｍ ×３０ｍｍ大口径自由旋气动窗口的工作性能进行了实验研究。研究表明，此气动窗口在其工作范围内，密封压比ＰＲ（环境大气压Ｐ... 详细信息

论述了自由旋气动窗口（ＦＡＤＷ）的基本工作原理，并对为万瓦级ＣＯ２气动激光器配置的３０ｍｍ ×３０ｍｍ大口径自由旋气动窗口的工作性能进行了实验研究。研究表明，此气动窗口在其工作范围内，密封压比ＰＲ（环境大气压ＰＡＭＢ／密封腔压ＰＣ）＞２０，最大可达到２８；而且该气动窗口具有良好的启动性能和对光束质量影响小的特点。因此对于大口径、低腔压的大功率气体激光器来说，自由旋气动窗口是替代输出镜最有效的手段之一。

关键词：自由旋气动窗口气动激光器密封压比

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基于空气源热泵的开闭一体式消防水带干燥装置节能性研究

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可再生能源 2023年第7期41卷 899-905页

作者：黄晨刘龙唐荣琪于昊李永振罗思义左宗良青岛理工大学环境与市政工程学院山东青岛266000

针对闭环热泵预热时间长、冬季开环热泵运行能耗高的问题,提出一种开闭一体式消防水带干燥装置。通过TRNSYS(Transient System Simulation)数值模拟和实验验证的方法,分析了开闭一体式消防水带干燥装置在预热阶段的节能性,确定了开环、... 详细信息

针对闭环热泵预热时间长、冬季开环热泵运行能耗高的问题,提出一种开闭一体式消防水带干燥装置。通过TRNSYS(Transient System Simulation)数值模拟和实验验证的方法,分析了开闭一体式消防水带干燥装置在预热阶段的节能性,确定了开环、闭环热泵节能运行切换的温湿度分界带。结果表明:相对于闭环预热,采用辅助预热模式可节省能耗60%以上;当环境温度上升时,开环、闭环热泵的单位能耗除湿量均升高;当环境湿度上升时,开环热泵的单位能耗除湿量降低;结合温湿度分界带对开闭一体式热泵系统进行智能控制,全年运行时,较闭环热泵运行可节能40%,较开环热泵运行可节能53%。

关键词：消防水带干燥装置 TRNSYS 单位能耗除湿量

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基于中温热泵的消防水带干燥装置性能研究

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可再生能源 2023年第6期41卷 757-765页

作者：唐荣琪刘龙黄晨李永振于昊罗思义左宗良青岛理工大学山东青岛266000

为研究消防水带的干燥特性曲线,实现低能耗、快速干燥的目的,文章研发了以R134A为制冷剂的中温热泵消防水带干燥装置。通过实验方法分析消防水带干燥特性,并对该中温热泵消防水带干燥装置的性能开展研究,对比不同送风温度、风速下,系统... 详细信息

为研究消防水带的干燥特性曲线,实现低能耗、快速干燥的目的,文章研发了以R134A为制冷剂的中温热泵消防水带干燥装置。通过实验方法分析消防水带干燥特性,并对该中温热泵消防水带干燥装置的性能开展研究,对比不同送风温度、风速下,系统性能系数(COP)、制热量、干燥时间、干燥过程耗电量、单位能耗除湿量(SMER)、单位时间除湿量(MER)的变化规律。结果表明,在一定范围内,随着送风温度的增加,COP降低、SMER和MER均升高。风速不变,送风温度为70℃时,干燥性能最优,SMER为0.427 kg/(kW·h),MER为1.584 kg/h,比送风温度为40℃时提高了10.9%和62.1%。送风温度不变,风速为4 m/s时,干燥效果最好,SMER为0.543 kg/(kW·h),MER为1.137 kg/h,比风速为2 m/s时提高了20.4%和50.2%。送风温度为50℃时,比消防水带吹干机节能约52%。

关键词：中温热泵热泵干燥干燥特性性能分析

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： Yun-Chuan Yang Zhi-Tao Chen Da-Long Wan Hui tang Mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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